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EIF4G3 Gene(Protein Coding)

Eukaryotic Translation Initiation Factor 4 Gamma 3

GCID:
GC01M020878
GIFtS:
50
Genes Participants
UDN Logo

Aliases for EIF4G3 Gene

Aliases for EIF4G3 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 3 2 3 5
  • EIF-4-Gamma II 3 4
  • EIF-4-Gamma 3 3 4
  • EIF-4G 3 3 4
  • EIF4G 3 3 4
  • EIF4GII 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma, 3 2

External Ids for EIF4G3 Gene

Previous GeneCards Identifiers for EIF4G3 Gene

  • GC01M020703
  • GC01M020168
  • GC01M020278
  • GC01M020602
  • GC01M021005
  • GC01M021132
  • GC01M019378

Summaries for EIF4G3 Gene

Entrez Gene Summary for EIF4G3 Gene

  • The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

GeneCards Summary for EIF4G3 Gene

EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G1.

UniProtKB/Swiss-Prot for EIF4G3 Gene

  • Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Gene Wiki entry for EIF4G3 Gene

Additional gene information for EIF4G3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G3 Gene

Genomics for EIF4G3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for EIF4G3 Gene

Promoters and enhancers for EIF4G3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I021173 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.6 1580 3.8 HDGF PKNOX1 CLOCK ARNT ARID4B DMAP1 YY1 POLR2B ZNF213 ZNF548 EIF4G3 USP48 HP1BP3 HSPE1P27
GH01I021073 Promoter 0.5 EPDnew 561.7 +103.5 103495 0.1 EIF4G3 ENSG00000236073 MIR1256 GC01M021094
GH01I021050 Promoter 0.5 EPDnew 550.1 +126.3 126330 0.1 EIF4G3 GC01M021067 GC01P021023
GH01I021259 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.8 -84.6 -84605 4.8 PKNOX1 ATF1 ARNT BRCA1 ZNF121 POLR2B ZNF766 ELK1 ATF7 FOS HP1BP3 EIF4G3 USP48 CDC42-IT1 NBPF3 ENSG00000271428 ECE1 NBPF2P ALPL ENSG00000236936
GH01I020784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.1 +390.5 390453 4.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 HP1BP3 EIF4G3 SH2D5 ENSG00000233069 GC01P020738
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF4G3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4G3 gene promoter:

Genomic Locations for EIF4G3 Gene

Genomic Locations for EIF4G3 Gene
chr1:20,806,292-21,177,320
(GRCh38/hg38)
Size:
371,029 bases
Orientation:
Minus strand
chr1:21,132,785-21,503,381
(GRCh37/hg19)

Genomic View for EIF4G3 Gene

Genes around EIF4G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EIF4G3 Gene

Proteins for EIF4G3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for EIF4G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43432-IF4G3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 3
    Protein Accession:
    O43432
    Secondary Accessions:
    • B9EGQ7
    • Q15597
    • Q504Z1
    • Q5SWC3
    • Q8NEN1

    Protein attributes for EIF4G3 Gene

    Size:
    1585 amino acids
    Molecular mass:
    176652 Da
    Quaternary structure:
    • Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for EIF4G3 Gene

    Alternative splice isoforms for EIF4G3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4G3 Gene

Protein Expression for EIF4G3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for EIF4G3 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Ubiquitination at posLast=10691069
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4G3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF4G3 Gene

Domains & Families for EIF4G3 Gene

Gene Families for EIF4G3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4G3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43432

UniProtKB/Swiss-Prot:

IF4G3_HUMAN :
  • Belongs to the eukaryotic initiation factor 4G family.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
genes like me logo Genes that share domains with EIF4G3: view

Function for EIF4G3 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for EIF4G3 Gene

UniProtKB/Swiss-Prot Function:
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.

Phenotypes From GWAS Catalog for EIF4G3 Gene

Gene Ontology (GO) - Molecular Function for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding IEA --
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003743 translation initiation factor activity IEA --
GO:0008135 translation factor activity, RNA binding TAS 9418880
genes like me logo Genes that share ontologies with EIF4G3: view
genes like me logo Genes that share phenotypes with EIF4G3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4G3 Gene

Localization for EIF4G3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4G3 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9418880
genes like me logo Genes that share ontologies with EIF4G3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G3 Gene

Pathways & Interactions for EIF4G3 Gene

genes like me logo Genes that share pathways with EIF4G3: view

SIGNOR curated interactions for EIF4G3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation TAS 9418880
GO:0010507 NOT negative regulation of autophagy IMP 18426977
genes like me logo Genes that share ontologies with EIF4G3: view

Drugs & Compounds for EIF4G3 Gene

Products:

  1. Drug

(2) Drugs for EIF4G3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(2) ApexBio Compounds for EIF4G3 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4G3: view

Drug Products

Transcripts for EIF4G3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for EIF4G3 Gene

(52) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(268) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4G3 Gene

Eukaryotic translation initiation factor 4 gamma, 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:

Relevant External Links for EIF4G3 Gene

GeneLoc Exon Structure for
EIF4G3
ECgene alternative splicing isoforms for
EIF4G3

Expression for EIF4G3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4G3 Gene

mRNA expression in normal human tissues for EIF4G3 Gene
mRNA expression by GTEx for EIF4G3 GenemRNA expression by BioGPS for EIF4G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF4G3 Gene

This gene is overexpressed in Urine (25.9), Adrenal (15.9), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4G3 Gene



Protein tissue co-expression partners for EIF4G3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4G3 Gene:

EIF4G3

SOURCE GeneReport for Unigene cluster for EIF4G3 Gene:

Hs.467084

Evidence on tissue expression from TISSUES for EIF4G3 Gene

  • Nervous system(4.7)
  • Blood(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with EIF4G3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4G3 Gene

Orthologs for EIF4G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia EIF4G3 34 33
  • 99.66 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia EIF4G3 33 34
  • 92.79 (n)
cow
(Bos Taurus)
 Mammalia EIF4G3 33 34
  • 92.08 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 87 (a)
 OneToMany
-- 34
  • 79 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Eif4g3 33
  • 85.83 (n)
mouse
(Mus musculus)
 Mammalia Eif4g3 33 16 34
  • 85.77 (n)
oppossum
(Monodelphis domestica)
 Mammalia EIF4G3 34
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves EIF4G3 33 34
  • 77.55 (n)
lizard
(Anolis carolinensis)
 Reptilia EIF4G3 34
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100216088 33
  • 68.4 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.20831 33
zebrafish
(Danio rerio)
 Actinopterygii eif4g3b 33 34
  • 64.68 (n)
EIF4G3 (2 of 2) 34
  • 55 (a)
 OneToMany
Dr.20489 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4652 33
fruit fly
(Drosophila melanogaster)
 Insecta CG10192 35
  • 36 (a)
eIF-4G 35
  • 31 (a)
eIF4G 34
  • 21 (a)
 ManyToMany
eIF4G2 34
  • 15 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea ifg-1 34
  • 20 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TIF4631 34
  • 20 (a)
 ManyToMany
TIF4632 34 36
  • 20 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 42 (a)
 OneToMany
Species where no ortholog for EIF4G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G3 Gene

ENSEMBL:
Gene Tree for EIF4G3 (if available)
TreeFam:
Gene Tree for EIF4G3 (if available)

Paralogs for EIF4G3 Gene

Paralogs for EIF4G3 Gene

(3) SIMAP similar genes for EIF4G3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with EIF4G3: view

Variants for EIF4G3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for EIF4G3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193921047 uncertain-significance, Malignant tumor of prostate 20,865,175(-) C/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1000008019 -- 20,903,367(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000013542 -- 21,063,382(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000040589 -- 20,942,337(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000043448 -- 20,974,305(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G3 Gene

Variant ID Type Subtype PubMed ID
esv1007787 CNV insertion 20482838
esv1356855 CNV deletion 17803354
esv2669682 CNV deletion 23128226
esv2672607 CNV deletion 23128226
esv2675549 CNV deletion 23128226
esv3387129 CNV insertion 20981092
esv3555121 CNV deletion 23714750
esv3585432 CNV loss 21293372
esv3585433 CNV loss 21293372
esv3585434 CNV loss 21293372
esv3585436 CNV loss 21293372
esv3585437 CNV loss 21293372
esv3585439 CNV loss 21293372
nsv1009855 CNV loss 25217958
nsv1012238 CNV loss 25217958
nsv1075300 CNV deletion 25765185
nsv1114945 CNV deletion 24896259
nsv1125320 OTHER inversion 24896259
nsv1133821 CNV deletion 24896259
nsv1136066 CNV deletion 24896259
nsv1151121 CNV deletion 26484159
nsv160811 CNV deletion 16902084
nsv474786 CNV novel sequence insertion 20440878
nsv834380 CNV gain 17160897

Variation tolerance for EIF4G3 Gene

Residual Variation Intolerance Score: 5.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G3 Gene

Disorders for EIF4G3 Gene

Additional Disease Information for EIF4G3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF4G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4G3 Gene

Publications for EIF4G3 Gene

  1. A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A … Sonenberg N (Molecular and cellular biology 1998) 2 3 4 22 58
  2. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. (PMID: 15016848) Gradi A … Belsham GJ (Journal of virology 2004) 3 4 22 58
  3. Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PMID: 12663812) Gradi A … Sonenberg N (Journal of virology 2003) 3 4 22 58
  4. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H … Edelman AM (The Journal of biological chemistry 2003) 3 4 22 58
  5. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PMID: 9857202) Imataka H … Sonenberg N (The EMBO journal 1998) 3 4 22 58

Products for EIF4G3 Gene

Sources for EIF4G3 Gene

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