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The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Diseases associated with EIF4G3 include Autosomal Dominant Non-Syndromic Intellectual Disability 24 and Mouth Disease. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000339 | RNA cap binding | TAS,IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0003743 | translation initiation factor activity | IBA | 21873635 |
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0016281 | eukaryotic translation initiation factor 4F complex | TAS,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of the SLBP independent Mature mRNA | ||
2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Translation Insulin regulation of translation
.59
|
Translation Regulation of EIF4F activity
.44
|
3 | RNA transport | ||
4 | Allograft rejection | ||
5 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006413 | translational initiation | IEA | -- |
GO:0006417 | regulation of translation | IEA | -- |
GO:0006446 | regulation of translational initiation | TAS | 9418880 |
GO:0010507 | NOT negative regulation of autophagy | IMP | 18426977 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | |||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Eif4g3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Eif4g3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | EIF4G3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EIF4G3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EIF4G3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100216088 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.20831 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eif4g3b 30 31 |
|
OneToMany | |
EIF4G3 (2 of 2) 31 |
|
OneToMany | |||
Dr.20489 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4652 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10192 32 |
|
|
|
eIF-4G 32 |
|
|
|||
eIF4G 31 |
|
ManyToMany | |||
eIF4G2 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ifg-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF4632 31 33 |
|
ManyToMany | |
TIF4631 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
786717 | Benign: not provided | 20,829,186(-) | A/G | MISSENSE_VARIANT | |
rs193921047 | Uncertain Significance: Malignant tumor of prostate | 20,865,175(-) | C/A | MISSENSE_VARIANT | |
rs2230572 | - | p.Asp1185Glu | |||
rs35176330 | - | p.Pro496Ala | |||
rs35731992 | - | p.Gln378Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1007787 | CNV | insertion | 20482838 |
esv1356855 | CNV | deletion | 17803354 |
esv2669682 | CNV | deletion | 23128226 |
esv2672607 | CNV | deletion | 23128226 |
esv2675549 | CNV | deletion | 23128226 |
esv3387129 | CNV | insertion | 20981092 |
esv3555121 | CNV | deletion | 23714750 |
esv3585432 | CNV | loss | 21293372 |
esv3585433 | CNV | loss | 21293372 |
esv3585434 | CNV | loss | 21293372 |
esv3585436 | CNV | loss | 21293372 |
esv3585437 | CNV | loss | 21293372 |
esv3585439 | CNV | loss | 21293372 |
nsv1009855 | CNV | loss | 25217958 |
nsv1012238 | CNV | loss | 25217958 |
nsv1075300 | CNV | deletion | 25765185 |
nsv1114945 | CNV | deletion | 24896259 |
nsv1125320 | OTHER | inversion | 24896259 |
nsv1133821 | CNV | deletion | 24896259 |
nsv1136066 | CNV | deletion | 24896259 |
nsv1151121 | CNV | deletion | 26484159 |
nsv160811 | CNV | deletion | 16902084 |
nsv474786 | CNV | novel sequence insertion | 20440878 |
nsv834380 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant non-syndromic intellectual disability 24 |
|
|
mouth disease |
|
|