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The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this... See more...
Aliases for EIF4G3 Gene
Aliases for EIF4G3 Gene
External Ids for EIF4G3 Gene
- HGNC: 3298
- Entrez Gene: 8672
- Ensembl: ENSG00000075151
- OMIM: 603929
- UniProtKB: O43432
Previous GeneCards Identifiers for EIF4G3 Gene
- GC01M020703
- GC01M020168
- GC01M020278
- GC01M020602
- GC01M020878
- GC01M021005
- GC01M021132
- GC01M019378
Summaries for EIF4G3 Gene
-
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
GeneCards Summary for EIF4G3 Gene
EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Diseases associated with EIF4G3 include Autosomal Dominant Non-Syndromic Intellectual Disability 24 and Mouth Disease. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G1.
UniProtKB/Swiss-Prot Summary for EIF4G3 Gene
-
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Additional gene information for EIF4G3 Gene
- HGNC(3298)
- Entrez Gene(8672)
- Ensembl(ENSG00000075151)
- OMIM(603929)
- UniProtKB(O43432)
- Open Targets Platform(ENSG00000075151)
- Monarch Initiative
- Search for EIF4G3 at DataMed
- Search for EIF4G3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4G3 Gene
Genomics for EIF4G3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EIF4G3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EIF4G3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4G3
- Top Transcription factor binding sites by QIAGEN in the EIF4G3 gene promoter:
-
- AML1a
- MyoD
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- RP58
- SRF
- SRF (504 AA)
Genomic Locations for EIF4G3 Gene
Genomic Locations for EIF4G3 Gene
- chr1:20,806,292-21,176,897
- (GRCh38/hg38)
- Size:
- 370,606 bases
- Orientation:
- Minus strand
- chr1:21,132,785-21,503,381
- (GRCh37/hg19)
- Size:
- 370,597 bases
- Orientation:
- Minus strand
Genomic View for EIF4G3 Gene
Genes around EIF4G3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.12 by HGNC
- 1p36.12 by Entrez Gene
- 1p36.12 by Ensembl
EIF4G3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF4G3 Gene
Proteins for EIF4G3 Gene
-
Protein details for EIF4G3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43432-IF4G3_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 4 gamma 3
- Protein Accession:
- O43432
- B9EGQ7
- Q15597
- Q504Z1
- Q5SWC3
- Q8NEN1
Protein attributes for EIF4G3 Gene
- Size:
- 1585 amino acids
- Molecular mass:
- 176652 Da
- Quaternary structure:
-
- Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).
Protein Expression for EIF4G3 Gene
Post-translational modifications for EIF4G3 Gene
- Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
-
Ubiquitination at Lys1069
- NX_O43432 (NX_O43432-1)
- Modification sites at PhosphoSitePlus
Other Protein References for EIF4G3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011540658.1
- XP_011540663.1
- XP_011540672.1
- XP_011540673.1
- XP_011540676.1
- XP_011540677.1
- XP_011540683.1
- XP_016858161.1
- XP_016858162.1
- XP_016858163.1
- XP_016858164.1
- XP_016858165.1
- XP_016858166.1
- XP_016858167.1
- XP_016858168.1
- XP_016858170.1
- XP_016858171.1
- XP_016858172.1
- XP_016858173.1
- XP_016858174.1
- XP_016858175.1
- XP_016858176.1
- XP_016858178.1
- XP_016858179.1
- XP_016858180.1
- XP_016858181.1
- XP_016858182.1
- XP_016858183.1
- XP_016858184.1
- XP_016858185.1
- XP_016858186.1
- XP_016858187.1
- XP_016858188.1
- XP_016858189.1
- XP_016858190.1
- XP_016858191.1
- XP_016858192.1
- XP_016858193.1
- XP_016858194.1
- XP_016858195.1
- XP_016858196.1
- XP_016858197.1
- XP_016858198.1
- XP_016858199.1
- XP_016858200.1
- XP_024306301.1
- NP_001185730.1
- NP_001185731.1
- NP_001185732.1
- NP_003751.2
Antibody Products
- Novus Biologicals Antibodies for EIF4G3
-
Abcam antibodies for EIF4G3
- Invitrogen Antibodies for EIF4G3 (AFLGC-EIF4G3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF4G3
Protein Products
-
OriGene Purified Proteins for EIF4G3
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF4G3
- Origene Custom Protein Services for EIF4G3
- antibodies-online: Show 3 available EIF4G3 Proteins ranked by validation data
- Compare Top EIF4G3 Proteins
-
Quality Products:
-
Abcam proteins for EIF4G3
No data available for DME Specific Peptides for EIF4G3 Gene
Domains & Families for EIF4G3 Gene
Gene Families for EIF4G3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EIF4G3 Gene
- InterPro:
- Blocks:
-
- eIF4-gamma/eIF5/eIF2-epsilon
- Initiation factor eIF-4 gamma, middle
- ProtoNet:
Suggested Antigen Peptide Sequences for EIF4G3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60945, highly similar to Eukaryotic translation initiation factor 4gamma 3 (B4DXR2_HUMAN)
- eIF-4-gamma II (IF4G3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43432- Family:
-
- Belongs to the eukaryotic initiation factor 4G family.
Function for EIF4G3 Gene
Molecular function for EIF4G3 Gene
- UniProtKB/Swiss-Prot Function:
- Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Phenotypes From GWAS Catalog for EIF4G3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000339 | RNA cap binding | TAS,IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003729 | mRNA binding | IBA | 21873635 |
| GO:0003743 | translation initiation factor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for EIF4G3 Gene
- MGI mutant phenotypes for EIF4G3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for EIF4G3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF4G3 - Select products 50% OFF >
- * EIF4G3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EIF4G3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF4G3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4G3
miRNA for EIF4G3 Gene
- miRTarBase miRNAs that target EIF4G3
-
- hsa-miR-375 (MIRT019790)
- hsa-miR-24-3p (MIRT030431)
- hsa-miR-16-5p (MIRT031458)
- hsa-miR-221-3p (MIRT046895)
- hsa-miR-17-5p (MIRT050935)
- hsa-miR-3613-3p (MIRT231644)
- hsa-miR-543 (MIRT440730)
- hsa-miR-136-5p (MIRT440731)
- hsa-miR-377-5p (MIRT440732)
- hsa-miR-218-5p (MIRT440733)
- hsa-miR-548c-3p (MIRT614544)
- hsa-miR-4724-3p (MIRT664710)
- hsa-miR-6813-3p (MIRT664711)
- hsa-miR-3200-3p (MIRT664712)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF4G3
- Browse OriGene Inhibitory RNA Products For EIF4G3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4G3
Clone Products
- Applied Biological Materials (abm): Clones for EIF4G3 - Select products 50% OFF >
- * EIF4G3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG212041
- MR212041
- MR212041L3
- MR212041L4
- MR231809
- MR231842
- RC212591
- RC212591L3
- RC212591L4
- RC230898
- RC230898L1
- RC230898L2
- RC230898L3
- RC230898L4
- RC231286
- RC231286L3
- RC231286L4
- RC231488
- RC231488L3
- RC231488L4
- RG212591
- RG230898
- RG231286
- RG231488
- RR210289
- MR212041L3V
- MR212041L4V
- RC212591L3V
- RC212591L4V
- RC230898L1V
- RC230898L2V
- RC230898L3V
- RC230898L4V
- RC231286L3V
- RC231286L4V
- RC231488L3V
- RC231488L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF4G3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF4G3
Cell Line Products
-
Horizon Cell Lines for EIF4G3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4G3 Gene
Localization for EIF4G3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016281 | eukaryotic translation initiation factor 4F complex | TAS,IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4G3 Gene
Pathways & Interactions for EIF4G3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA | ||
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Translation Insulin regulation of translation
.59
|
Translation Regulation of EIF4F activity
.44
|
| 3 | RNA transport | ||
| 4 | Allograft rejection | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
|
Pathways by source for EIF4G3 Gene
1 BioSystems pathway for EIF4G3 Gene
5 Reactome pathways for EIF4G3 Gene
2 KEGG pathways for EIF4G3 Gene
3 GeneGo (Thomson Reuters) pathways for EIF4G3 Gene
- Translation Regulation of EIF4F activity
- Translation Insulin regulation of translation
- Translation Translation regulation by Alpha-1 adrenergic receptors
4 Qiagen pathways for EIF4G3 Gene
- eIF2 Pathway
- Insulin Receptor Pathway
- mTOR Pathway
- Regulation of eIF4 and p70S6K
Interacting Proteins for EIF4G3 Gene
Selected Interacting proteins:
O43432-IF4G3_HUMAN
ENSP00000383274
for EIF4G3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EIF4G3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006446 | regulation of translational initiation | TAS | 9418880 |
| GO:0010507 | NOT negative regulation of autophagy | IMP | 18426977 |
Drugs & Compounds for EIF4G3 Gene
(2) ApexBio Compounds for EIF4G3 Gene
Transcripts for EIF4G3 Gene
mRNA/cDNA for EIF4G3 Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264211 5802 nts (view in UCSC)
- ENST00000602326 6196 nts (view in UCSC)
- ENST00000400422 5762 nts (view in UCSC)
- ENST00000634879 5325 nts (view in UCSC)
- ENST00000435383 616 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF4G3 - Select products 50% OFF >
- * EIF4G3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EIF4G3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF4G3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF4G3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF4G3
- Browse OriGene Inhibitory RNA Products For EIF4G3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4G3
Clone Products
- Applied Biological Materials (abm): Clones for EIF4G3 - Select products 50% OFF >
- * EIF4G3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG212041
- MR212041
- MR212041L3
- MR212041L4
- MR231809
- MR231842
- RC212591
- RC212591L3
- RC212591L4
- RC230898
- RC230898L1
- RC230898L2
- RC230898L3
- RC230898L4
- RC231286
- RC231286L3
- RC231286L4
- RC231488
- RC231488L3
- RC231488L4
- RG212591
- RG230898
- RG231286
- RG231488
- RR210289
- MR212041L3V
- MR212041L4V
- RC212591L3V
- RC212591L4V
- RC230898L1V
- RC230898L2V
- RC230898L3V
- RC230898L4V
- RC231286L3V
- RC231286L4V
- RC231488L3V
- RC231488L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF4G3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF4G3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
| ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: |
Relevant External Links for EIF4G3 Gene
- GeneLoc Exon Structure for
- EIF4G3
Expression for EIF4G3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Urine (25.9), Adrenal (15.9), and Peripheral blood mononuclear cells (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4G3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4G3
SOURCE GeneReport for Unigene cluster for EIF4G3 Gene:
Hs.467084Evidence on tissue expression from TISSUES for EIF4G3 Gene
- Nervous system(4.8)
- Blood(4.5)
- Liver(4.4)
- Kidney(2.4)
- Skin(2.2)
- Muscle(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for EIF4G3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4G3 Gene
Orthologs for EIF4G3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EIF4G3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Eif4g3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Eif4g3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | EIF4G3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | EIF4G3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | EIF4G3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100216088 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20831 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eif4g3b 30 31 |
|
OneToMany | |
| EIF4G3 (2 of 2) 31 |
|
OneToMany | |||
| Dr.20489 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4652 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10192 32 |
|
|
|
| eIF-4G 32 |
|
|
|||
| eIF4G 31 |
|
ManyToMany | |||
| eIF4G2 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ifg-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF4632 31 33 |
|
ManyToMany | |
| TIF4631 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for EIF4G3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for EIF4G3 Gene
- ENSEMBL:
- Gene Tree for EIF4G3 (if available)
- TreeFam:
- Gene Tree for EIF4G3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EIF4G3: view image
Paralogs for EIF4G3 Gene
(3) SIMAP similar genes for EIF4G3 Gene using alignment to 10 proteins:
- IF4G3_HUMAN
- B1AN89_HUMAN
- B1AN91_HUMAN
- B1AN92_HUMAN
- B4DXR2_HUMAN
- F5H564_HUMAN
- F5H8J4_HUMAN
- Q504Z1_HUMAN
- Q5SWD0_HUMAN
- Q5SWD1_HUMAN
Variants for EIF4G3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF4G3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 786717 | Benign: not provided | 20,829,186(-) | A/G | MISSENSE_VARIANT | |
| rs193921047 | Uncertain Significance: Malignant tumor of prostate | 20,865,175(-) | C/A | MISSENSE_VARIANT | |
| rs2230572 | - | p.Asp1185Glu | |||
| rs35176330 | - | p.Pro496Ala | |||
| rs35731992 | - | p.Gln378Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1007787 | CNV | insertion | 20482838 |
| esv1356855 | CNV | deletion | 17803354 |
| esv2669682 | CNV | deletion | 23128226 |
| esv2672607 | CNV | deletion | 23128226 |
| esv2675549 | CNV | deletion | 23128226 |
| esv3387129 | CNV | insertion | 20981092 |
| esv3555121 | CNV | deletion | 23714750 |
| esv3585432 | CNV | loss | 21293372 |
| esv3585433 | CNV | loss | 21293372 |
| esv3585434 | CNV | loss | 21293372 |
| esv3585436 | CNV | loss | 21293372 |
| esv3585437 | CNV | loss | 21293372 |
| esv3585439 | CNV | loss | 21293372 |
| nsv1009855 | CNV | loss | 25217958 |
| nsv1012238 | CNV | loss | 25217958 |
| nsv1075300 | CNV | deletion | 25765185 |
| nsv1114945 | CNV | deletion | 24896259 |
| nsv1125320 | OTHER | inversion | 24896259 |
| nsv1133821 | CNV | deletion | 24896259 |
| nsv1136066 | CNV | deletion | 24896259 |
| nsv1151121 | CNV | deletion | 26484159 |
| nsv160811 | CNV | deletion | 16902084 |
| nsv474786 | CNV | novel sequence insertion | 20440878 |
| nsv834380 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
5.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.48;
55.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF4G3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EIF4G3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4G3 Gene
Disorders for EIF4G3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal dominant non-syndromic intellectual disability 24 |
|
|
| mouth disease |
|
|
Search EIF4G3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EIF4G3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4G3 Gene
Publications for EIF4G3 Gene
- A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A … Sonenberg N (Molecular and cellular biology 1998) 2 3 4 23
- Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. (PMID: 15016848) Gradi A … Belsham GJ (Journal of virology 2004) 3 4 23
- Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H … Edelman AM (The Journal of biological chemistry 2003) 3 4 23
- Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. (PMID: 12663812) Gradi A … Sonenberg N (Journal of virology 2003) 3 4 23
- A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. (PMID: 9857202) Imataka H … Sonenberg N (The EMBO journal 1998) 3 4 23
ExternalLinks
Products for EIF4G3 Gene
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