The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. Th... See more...

Aliases for EIF4G1 Gene

Aliases for EIF4G1 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma 1 2 3 4 5
  • P220 2 3 4
  • EIF-4-Gamma 1 3 4
  • EIF-4G1 3 4
  • EIF4GI 3 4
  • PARK18 2 3
  • EIF4F 3 4
  • EIF4G 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma, 1 2
  • Eucaryotic Translation Initiation Factor 4G 3
  • EIF4-Gamma 3
  • EIF-4G 1 4
  • EIF4G1 5

External Ids for EIF4G1 Gene

Previous HGNC Symbols for EIF4G1 Gene

  • EIF4G
  • EIF4F

Previous GeneCards Identifiers for EIF4G1 Gene

  • GC03M180550
  • GC03P185026
  • GC03P185434
  • GC03P185355
  • GC03P185356
  • GC03P185515
  • GC03P184032
  • GC03P181439

Summaries for EIF4G1 Gene

Entrez Gene Summary for EIF4G1 Gene

  • The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

GeneCards Summary for EIF4G1 Gene

EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma 1) is a Protein Coding gene. Diseases associated with EIF4G1 include Parkinson Disease 18, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G3.

UniProtKB/Swiss-Prot Summary for EIF4G1 Gene

  • Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).

Gene Wiki entry for EIF4G1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4G1 Gene

Genomics for EIF4G1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF4G1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4G1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4G1

Top Transcription factor binding sites by QIAGEN in the EIF4G1 gene promoter:
  • NF-kappaB
  • p53

Genomic Locations for EIF4G1 Gene

Genomic Locations for EIF4G1 Gene
chr3:184,314,495-184,335,358
(GRCh38/hg38)
Size:
20,864 bases
Orientation:
Plus strand
chr3:184,032,283-184,053,146
(GRCh37/hg19)
Size:
20,864 bases
Orientation:
Plus strand

Genomic View for EIF4G1 Gene

Genes around EIF4G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G1 Gene

Proteins for EIF4G1 Gene

  • Protein details for EIF4G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04637-IF4G1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 1
    Protein Accession:
    Q04637
    Secondary Accessions:
    • D3DNT2
    • D3DNT4
    • D3DNT5
    • E9PFM1
    • G5E9S1
    • O43177
    • O95066
    • Q5HYG0
    • Q6ZN21
    • Q8N102

    Protein attributes for EIF4G1 Gene

    Size:
    1599 amino acids
    Molecular mass:
    175491 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA. Directly interacts with EIF4G1 in an RNA-independent manner (PubMed:22872150).
    • (Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.
    • (Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.
    SequenceCaution:
    • Sequence=AAC78444.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC82471.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA02185.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform B]: Produced by alternative initiation at Met-41 of isoform A.
    • [Isoform C]: Produced by alternative initiation at Met-88 of isoform A.
    • [Isoform D]: Produced by alternative initiation at Met-165 of isoform A.
    • [Isoform E]: Produced by alternative initiation at Met-197 of isoform A.
    • [Isoform 7]: Produced by alternative splicing.
    • [Isoform 8]: Produced by alternative splicing.
    • [Isoform 9]: Produced by alternative splicing.

    Three dimensional structures from OCA and Proteopedia for EIF4G1 Gene

    Alternative splice isoforms for EIF4G1 Gene

neXtProt entry for EIF4G1 Gene

Post-translational modifications for EIF4G1 Gene

  • Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Ubiquitination at Lys580, Lys593, Lys597, Lys602, Lys770, Lys795, Lys832, and Lys1059
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4G1 Gene

Domains & Families for EIF4G1 Gene

Gene Families for EIF4G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4G1 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Initiation factor eIF-4 gamma, middle
  • Initiation factor eIF-4 gamma, MA3
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4G1 Gene

GenScript: Design optimal peptide antigens:
  • EIF4G1 protein (B2RU06_HUMAN)
  • EIF4G1 protein (B2RU10_HUMAN)
  • Eukaryotic translation initiation factor 4 gamma, 1, isoform CRA_c (D3DNT2_HUMAN)
  • p220 (IF4G1_HUMAN)
  • Putative regulatory uORF (Q8NG21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04637

UniProtKB/Swiss-Prot:

IF4G1_HUMAN :
  • Belongs to the eukaryotic initiation factor 4G family.
Family:
  • Belongs to the eukaryotic initiation factor 4G family.
genes like me logo Genes that share domains with EIF4G1: view

Function for EIF4G1 Gene

Molecular function for EIF4G1 Gene

UniProtKB/Swiss-Prot Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).
GENATLAS Biochemistry:
eukaryotic translation initiation factor 4 gamma 1,p220 (154kDa),complexing with other EIF,involved in the binding of mRNA cap structure to ribosome,also interacting with the poly (A)-binding protein (PABPx) and increasing its RNA binding activity

Phenotypes From GWAS Catalog for EIF4G1 Gene

Gene Ontology (GO) - Molecular Function for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 25255371
GO:0003729 mRNA binding IDA 24092755
GO:0003743 translation initiation factor activity IBA,TAS 8961935
GO:0005515 protein binding IPI 10523622
GO:0005524 ATP binding IDA 25255371
genes like me logo Genes that share ontologies with EIF4G1: view
genes like me logo Genes that share phenotypes with EIF4G1: view

Human Phenotype Ontology for EIF4G1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EIF4G1 Gene

MGI Knock Outs for EIF4G1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4G1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EIF4G1 Gene

Localization for EIF4G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4G1 Gene

Cytoplasm, Stress granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4G1 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 18426977
GO:0005737 cytoplasm IDA,IMP 18426977
GO:0005829 cytosol TAS --
GO:0005844 polysome IMP 18426977
GO:0010494 cytoplasmic stress granule IEA --
genes like me logo Genes that share ontologies with EIF4G1: view

Pathways & Interactions for EIF4G1 Gene

genes like me logo Genes that share pathways with EIF4G1: view

Pathways by source for EIF4G1 Gene

2 KEGG pathways for EIF4G1 Gene
3 GeneGo (Thomson Reuters) pathways for EIF4G1 Gene
  • Translation Regulation of EIF4F activity
  • Translation Insulin regulation of translation
  • Translation Translation regulation by Alpha-1 adrenergic receptors
3 R&D Systems pathways for EIF4G1 Gene
4 Qiagen pathways for EIF4G1 Gene
  • eIF2 Pathway
  • Insulin Receptor Pathway
  • mTOR Pathway
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for EIF4G1 Gene

Gene Ontology (GO) - Biological Process for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001662 behavioral fear response IEA --
GO:0002191 cap-dependent translational initiation TAS 25765080
GO:0006412 translation IPI 24092755
GO:0006413 translational initiation NAS,TAS 18426977
genes like me logo Genes that share ontologies with EIF4G1: view

No data available for SIGNOR curated interactions for EIF4G1 Gene

Drugs & Compounds for EIF4G1 Gene

(15) Drugs for EIF4G1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(11) Additional Compounds for EIF4G1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4G1 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4G1: view

Drug Products

Transcripts for EIF4G1 Gene

mRNA/cDNA for EIF4G1 Gene

8 REFSEQ mRNAs :
36 NCBI additional mRNA sequence :
38 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4G1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^
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SP21: - - - - - - - - - - - - - - -
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SP25: - - -
SP26: - - - -
SP27: -
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SP31: - -
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SP36: - - -
SP37:

ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^
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SP14: - -
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SP24: - -
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SP32: - -
SP33: -
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ExUns: 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^
SP1: -
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SP16: - - - - -
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SP37:

ExUns: 38a · 38b ^ 39 ^ 40a · 40b · 40c ·
SP1: - -
SP2:
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SP13: - -
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Relevant External Links for EIF4G1 Gene

GeneLoc Exon Structure for
EIF4G1

Expression for EIF4G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF4G1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for EIF4G1 Gene

This gene is overexpressed in Lymph node (6.2) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4G1 Gene



Protein tissue co-expression partners for EIF4G1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4G1

SOURCE GeneReport for Unigene cluster for EIF4G1 Gene:

Hs.433750

Evidence on tissue expression from TISSUES for EIF4G1 Gene

  • Nervous system(5)
  • Skin(4.7)
  • Liver(4.7)
  • Blood(4.6)
  • Lung(4.6)
  • Intestine(4.4)
  • Eye(4)
  • Pancreas(3.8)
  • Kidney(3.8)
  • Muscle(3.8)
  • Heart(3.2)
  • Spleen(2.9)
  • Bone(2.9)
  • Lymph node(2.7)
  • Stomach(2.7)
  • Bone marrow(2.6)
  • Thyroid gland(2.5)
  • Adrenal gland(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4G1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • ear
  • head
  • mouth
  • olfactory bulb
  • pharynx
Thorax:
  • diaphragm
  • esophagus
  • heart
  • lung
Abdomen:
  • stomach
Pelvis:
  • urethra
  • urinary bladder
Limb:
  • foot
  • hand
  • lower limb
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with EIF4G1: view

No data available for mRNA Expression by UniProt/SwissProt for EIF4G1 Gene

Orthologs for EIF4G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF4G1 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF4G1 30 31
  • 91.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF4G1 30 31
  • 90.8 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eif4g1 30 17 31
  • 88.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif4g1 30
  • 87.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF4G1 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EIF4G1 30 31
  • 74.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF4G1 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif4g3 30
  • 64.68 (n)
Zebrafish
(Danio rerio)
Actinopterygii EIF4G1 (2 of 3) 31
  • 67 (a)
OneToMany
EIF4G1 (1 of 3) 31
  • 59 (a)
OneToMany
CABZ01085054.1 31
  • 54 (a)
OneToMany
Dr.16403 30
Fruit Fly
(Drosophila melanogaster)
Insecta eIF4G 31
  • 22 (a)
ManyToMany
eIF4G2 31
  • 16 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ifg-1 31
  • 22 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4632 31
  • 21 (a)
ManyToMany
TIF4631 31
  • 21 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for EIF4G1 was found in the sources mined by GeneCards: