Aliases for EIF4G1 Gene
External Ids for EIF4G1 Gene
Previous HGNC Symbols for EIF4G1 Gene
Previous GeneCards Identifiers for EIF4G1 Gene
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
GeneCards Summary for EIF4G1 Gene
EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma 1) is a Protein Coding gene. Diseases associated with EIF4G1 include Parkinson Disease 18, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Beta-Adrenergic Signaling and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G3.
UniProtKB/Swiss-Prot Summary for EIF4G1 Gene
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).