Aliases for EIF4ENIF1 Gene
External Ids for EIF4ENIF1 Gene
Previous GeneCards Identifiers for EIF4ENIF1 Gene
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for EIF4ENIF1 Gene
EIF4ENIF1 (Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1) is a Protein Coding gene. Diseases associated with EIF4ENIF1 include Cone-Rod Dystrophy 11 and Brain Ependymoma. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include protein transporter activity.
UniProtKB/Swiss-Prot Summary for EIF4ENIF1 Gene
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.