The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants ... See more...

Aliases for EIF4ENIF1 Gene

Aliases for EIF4ENIF1 Gene

  • Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1 2 3 4 5
  • Eukaryotic Translation Initiation Factor 4E Transporter 3 4
  • EIF4E Transporter 3 4
  • 4E-T 3 4
  • 2610509L04Rik 3
  • Clast4 3

External Ids for EIF4ENIF1 Gene

Previous GeneCards Identifiers for EIF4ENIF1 Gene

  • GC22M028531
  • GC22M030159
  • GC22M031835
  • GC22M014796

Summaries for EIF4ENIF1 Gene

Entrez Gene Summary for EIF4ENIF1 Gene

  • The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for EIF4ENIF1 Gene

EIF4ENIF1 (Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1) is a Protein Coding gene. Diseases associated with EIF4ENIF1 include Cone-Rod Dystrophy 11 and Brain Ependymoma. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot Summary for EIF4ENIF1 Gene

  • Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Gene Wiki entry for EIF4ENIF1 Gene

Additional gene information for EIF4ENIF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4ENIF1 Gene

Genomics for EIF4ENIF1 Gene

GeneHancer (GH) Regulatory Elements for EIF4ENIF1 Gene

Promoters and enhancers for EIF4ENIF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4ENIF1

Top Transcription factor binding sites by QIAGEN in the EIF4ENIF1 gene promoter:
  • Bach1
  • HOXA9
  • HOXA9B
  • Lmo2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Sp1

Genomic Locations for EIF4ENIF1 Gene

Genomic Locations for EIF4ENIF1 Gene
chr22:31,436,963-31,496,108
(GRCh38/hg38)
Size:
59,146 bases
Orientation:
Minus strand
chr22:31,832,963-31,892,094
(GRCh37/hg19)
Size:
59,132 bases
Orientation:
Minus strand

Genomic View for EIF4ENIF1 Gene

Genes around EIF4ENIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4ENIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4ENIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4ENIF1 Gene

Proteins for EIF4ENIF1 Gene

  • Protein details for EIF4ENIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA8-4ET_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E transporter
    Protein Accession:
    Q9NRA8
    Secondary Accessions:
    • B1AKL2
    • B1AKL3
    • B2RBF1
    • Q8NCF2
    • Q9H708

    Protein attributes for EIF4ENIF1 Gene

    Size:
    985 amino acids
    Molecular mass:
    108201 Da
    Quaternary structure:
    • Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.
    SequenceCaution:
    • Sequence=BAB15092.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4ENIF1 Gene

    Alternative splice isoforms for EIF4ENIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4ENIF1 Gene

Post-translational modifications for EIF4ENIF1 Gene

  • Ubiquitination at Lys492
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4ENIF1 Gene

Domains & Families for EIF4ENIF1 Gene

Gene Families for EIF4ENIF1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4ENIF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4ENIF1 Gene

GenScript: Design optimal peptide antigens:
  • Eukaryotic translation initiation factor 4E nuclear import factor 1 (4ET_HUMAN)
  • Eukaryotic translation initiation factor 4E nuclear import factor 1 (B0QYZ7_HUMAN)
  • cDNA FLJ58249, highly similar to Eukaryotic translation initiation factor 4E transporter (B4DR76_HUMAN)
  • EIF4ENIF1 protein (Q6PJR2_HUMAN)
genes like me logo Genes that share domains with EIF4ENIF1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Function for EIF4ENIF1 Gene

Molecular function for EIF4ENIF1 Gene

UniProtKB/Swiss-Prot Function:
Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Phenotypes From GWAS Catalog for EIF4ENIF1 Gene

Gene Ontology (GO) - Molecular Function for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003729 mRNA binding IBA 21873635
GO:0003743 translation initiation factor activity IEA --
GO:0005049 nuclear export signal receptor activity IDA 10856257
GO:0005515 protein binding IPI 10856257
genes like me logo Genes that share ontologies with EIF4ENIF1: view
genes like me logo Genes that share phenotypes with EIF4ENIF1: view

Animal Model Products

CRISPR Products

miRNA for EIF4ENIF1 Gene

miRTarBase miRNAs that target EIF4ENIF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4ENIF1 Gene

Localization for EIF4ENIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4ENIF1 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IBA,TAS 21873635
GO:0005737 cytoplasm IBA,TAS 21873635
GO:0005829 cytosol IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with EIF4ENIF1: view

Pathways & Interactions for EIF4ENIF1 Gene

PathCards logo

SuperPathways for EIF4ENIF1 Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with EIF4ENIF1: view

Pathways by source for EIF4ENIF1 Gene

1 Cell Signaling Technology pathway for EIF4ENIF1 Gene

SIGNOR curated interactions for EIF4ENIF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4ENIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
GO:0015031 protein transport IEA --
GO:0017148 negative regulation of translation IBA 21873635
GO:0019827 stem cell population maintenance IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with EIF4ENIF1: view

Drugs & Compounds for EIF4ENIF1 Gene

No Compound Related Data Available

Transcripts for EIF4ENIF1 Gene

mRNA/cDNA for EIF4ENIF1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4ENIF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - -
SP2: - - - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - - - - - -
SP8:
SP9:
SP10: -
SP11:

ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for EIF4ENIF1 Gene

GeneLoc Exon Structure for
EIF4ENIF1

Expression for EIF4ENIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4ENIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF4ENIF1 Gene

This gene is overexpressed in Testis (19.5), Peripheral blood mononuclear cells (7.0), Placenta (6.5), and Fetal testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4ENIF1 Gene



Protein tissue co-expression partners for EIF4ENIF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4ENIF1

SOURCE GeneReport for Unigene cluster for EIF4ENIF1 Gene:

Hs.517559

mRNA Expression by UniProt/SwissProt for EIF4ENIF1 Gene:

Q9NRA8-4ET_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for EIF4ENIF1 Gene

  • Nervous system(4.8)
  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with EIF4ENIF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4ENIF1 Gene

Orthologs for EIF4ENIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EIF4ENIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4ENIF1 31 30
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4ENIF1 31 30
  • 92.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4ENIF1 31 30
  • 91.87 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 89 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif4enif1 30
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Eif4enif1 17 31 30
  • 88.64 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF4ENIF1 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4ENIF1 31 30
  • 76.22 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4enif1 30
  • 65.28 (n)
Str.10069 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2368 30
zebrafish
(Danio rerio)
Actinopterygii eif4enif1 31 30
  • 59.53 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToOne
Species where no ortholog for EIF4ENIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4ENIF1 Gene

ENSEMBL:
Gene Tree for EIF4ENIF1 (if available)
TreeFam:
Gene Tree for EIF4ENIF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4ENIF1: view image

Paralogs for EIF4ENIF1 Gene

No data available for Paralogs for EIF4ENIF1 Gene

Variants for EIF4ENIF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF4ENIF1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
739790 Benign: not provided 31,449,456(-) T/G MISSENSE_VARIANT
778916 Benign: not provided 31,454,252(-) G/A SYNONYMOUS_VARIANT
798944 Likely Benign: not provided 31,439,889(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for EIF4ENIF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF4ENIF1 Gene

Variant ID Type Subtype PubMed ID
dgv839e214 CNV loss 21293372
esv3647588 CNV gain 21293372
nsv1060776 CNV gain 25217958
nsv1063634 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv1139057 CNV deletion 24896259
nsv588894 CNV loss 21841781
nsv834176 CNV loss 17160897
nsv9897 CNV gain 18304495

Variation tolerance for EIF4ENIF1 Gene

Residual Variation Intolerance Score: 5.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4ENIF1 Gene

Human Gene Mutation Database (HGMD)
EIF4ENIF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4ENIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4ENIF1 Gene

Disorders for EIF4ENIF1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EIF4ENIF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 11
  • cord11
brain ependymoma
  • ependymal tumor of brain
retinitis pigmentosa, y-linked
  • rpy
premature ovarian failure 1
  • pof1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF4ENIF1

genes like me logo Genes that share disorders with EIF4ENIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4ENIF1 Gene

Publications for EIF4ENIF1 Gene

  1. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. (PMID: 10856257) Dostie J … Sonenberg N (The EMBO journal 2000) 2 3 4 23 54
  2. The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. (PMID: 19850929) Suzuki Y … Minami Y (The Journal of biological chemistry 2009) 3 23 54
  3. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski MJ … Rana TM (PLoS pathogens 2006) 3 4 54
  4. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. (PMID: 16343815) Villaescusa JC … Verrotti AC (Gene 2006) 3 23 54
  5. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. (PMID: 16157702) Ferraiuolo MA … Sonenberg N (The Journal of cell biology 2005) 3 23 54

Products for EIF4ENIF1 Gene

Sources for EIF4ENIF1 Gene