This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that en... See more...

Aliases for EIF4EBP3 Gene

Aliases for EIF4EBP3 Gene

  • Eukaryotic Translation Initiation Factor 4E Binding Protein 3 2 3 5
  • 4E-BP3 2 3 4
  • Eukaryotic Translation Initiation Factor 4E-Binding Protein 3 3 4
  • EIF4E-Binding Protein 3 3 4
  • Eukaryotic Initiation Factor 4E-Binding Protein 3 3
  • EIF4EBP3 5
  • 4EBP3 3

External Ids for EIF4EBP3 Gene

Previous GeneCards Identifiers for EIF4EBP3 Gene

  • GC05U990081
  • GC05P140365
  • GC05P139765
  • GC05P139810
  • GC05P139812
  • GC05P139766
  • GC05P139928
  • GC05P135072
  • GC05P140549
  • GC05P141467
  • GC05P142379
  • GC05P142485
  • GC05P142598
  • GC05P142824
  • GC05P141532
  • GC05P141682
  • GC05P141785
  • GC05P141874
  • GC05P141963
  • GC05P142090
  • GC05P142196
  • GC05P142296
  • GC05P143019
  • GC05P143229

Summaries for EIF4EBP3 Gene

Entrez Gene Summary for EIF4EBP3 Gene

  • This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]

GeneCards Summary for EIF4EBP3 Gene

EIF4EBP3 (Eukaryotic Translation Initiation Factor 4E Binding Protein 3) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and RNA transport. Gene Ontology (GO) annotations related to this gene include translation repressor activity and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP2.

UniProtKB/Swiss-Prot Summary for EIF4EBP3 Gene

  • Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.

Gene Wiki entry for EIF4EBP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4EBP3 Gene

Genomics for EIF4EBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF4EBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4EBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4EBP3

Top Transcription factor binding sites by QIAGEN in the EIF4EBP3 gene promoter:
  • AREB6
  • E47
  • FOXO4
  • Nkx3-1 v3
  • Pax-4a
  • PPAR-alpha
  • Sox5
  • SRY
  • Tal-1
  • TBP

Genomic Locations for EIF4EBP3 Gene

Latest Assembly
chr5:140,547,662-140,549,576
(GRCh38/hg38)
Size:
1,915 bases
Orientation:
Plus strand

Previous Assembly
chr5:139,927,247-139,929,161
(GRCh37/hg19 by Entrez Gene)
Size:
1,915 bases
Orientation:
Plus strand

chr5:139,927,251-139,929,163
(GRCh37/hg19 by Ensembl)
Size:
1,913 bases
Orientation:
Plus strand

Genomic View for EIF4EBP3 Gene

Genes around EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4EBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4EBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4EBP3 Gene

Proteins for EIF4EBP3 Gene

  • Protein details for EIF4EBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60516-4EBP3_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 3
    Protein Accession:
    O60516

    Protein attributes for EIF4EBP3 Gene

    Size:
    100 amino acids
    Molecular mass:
    10873 Da
    Quaternary structure:
    • EIF4EBP3 interacts with EIF4E.

neXtProt entry for EIF4EBP3 Gene

Post-translational modifications for EIF4EBP3 Gene

Other Protein References for EIF4EBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for EIF4EBP3

No data available for DME Specific Peptides for EIF4EBP3 Gene

Domains & Families for EIF4EBP3 Gene

Gene Families for EIF4EBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4EBP3 Gene

InterPro:
Blocks:
  • Eukaryotic translation initiation factor 4E binding

Suggested Antigen Peptide Sequences for EIF4EBP3 Gene

GenScript: Design optimal peptide antigens:
  • Eukaryotic translation initiation factor 4E-binding protein 3 (4EBP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60516

UniProtKB/Swiss-Prot:

4EBP3_HUMAN :
  • Belongs to the eIF4E-binding protein family.
Family:
  • Belongs to the eIF4E-binding protein family.
genes like me logo Genes that share domains with EIF4EBP3: view

Function for EIF4EBP3 Gene

Molecular function for EIF4EBP3 Gene

UniProtKB/Swiss-Prot Function:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
GENATLAS Biochemistry:
eukariotic translation initiation factor 4E,binding protein 3

Phenotypes From GWAS Catalog for EIF4EBP3 Gene

Gene Ontology (GO) - Molecular Function for EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15153109
GO:0008190 eukaryotic initiation factor 4E binding IBA 21873635
GO:0030371 translation repressor activity NAS 9593750
genes like me logo Genes that share ontologies with EIF4EBP3: view

Phenotypes for EIF4EBP3 Gene

genes like me logo Genes that share phenotypes with EIF4EBP3: view

Animal Models for EIF4EBP3 Gene

MGI Knock Outs for EIF4EBP3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4EBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4EBP3 Gene

Localization for EIF4EBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4EBP3 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0016020 membrane HDA 19946888
GO:0016281 eukaryotic translation initiation factor 4F complex NAS 9593750
genes like me logo Genes that share ontologies with EIF4EBP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EIF4EBP3 Gene

Pathways & Interactions for EIF4EBP3 Gene

PathCards logo

SuperPathways for EIF4EBP3 Gene

SuperPathway Contained pathways
1 Translational Control
2 RNA transport
3 Beta-Adrenergic Signaling
.37
4 TGF-Beta Pathway
.43
5 UVA-Induced MAPK Signaling
.38
genes like me logo Genes that share pathways with EIF4EBP3: view

Pathways by source for EIF4EBP3 Gene

1 BioSystems pathway for EIF4EBP3 Gene
1 KEGG pathway for EIF4EBP3 Gene
3 Qiagen pathways for EIF4EBP3 Gene
  • Insulin Receptor Pathway
  • Regulation of eIF4 and p70S6K
  • UVB-Induced MAPK Signaling
1 Cell Signaling Technology pathway for EIF4EBP3 Gene

SIGNOR curated interactions for EIF4EBP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0017148 negative regulation of translation IEA --
GO:0045947 negative regulation of translational initiation NAS 9593750
genes like me logo Genes that share ontologies with EIF4EBP3: view

Drugs & Compounds for EIF4EBP3 Gene

No Compound Related Data Available

Transcripts for EIF4EBP3 Gene

mRNA/cDNA for EIF4EBP3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4EBP3

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4EBP3 Gene

No ASD Table

Relevant External Links for EIF4EBP3 Gene

GeneLoc Exon Structure for
EIF4EBP3

Expression for EIF4EBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4EBP3 Gene

mRNA differential expression in normal tissues according to GTEx for EIF4EBP3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for EIF4EBP3 Gene

This gene is overexpressed in Ovary (40.5), CD4 Tcells (18.2), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EIF4EBP3 Gene



Protein tissue co-expression partners for EIF4EBP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4EBP3

mRNA Expression by UniProt/SwissProt for EIF4EBP3 Gene:

O60516-4EBP3_HUMAN
Tissue specificity: Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.

Evidence on tissue expression from TISSUES for EIF4EBP3 Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with EIF4EBP3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4EBP3 Gene

Orthologs for EIF4EBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF4EBP3 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF4EBP3 29
  • 95 (n)
Rat
(Rattus norvegicus)
Mammalia Eif4ebp3 29
  • 87.67 (n)
Mouse
(Mus musculus)
Mammalia Eif4ebp3 29 16 30
  • 87.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF4EBP3 30
  • 84 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii eif4ebp3l 29 30
  • 70.33 (n)
OneToMany
eif4ebp3 30
  • 50 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Thor 30
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5022 30
  • 17 (a)
OneToMany
Species where no ortholog for EIF4EBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for EIF4EBP3 Gene

ENSEMBL:
Gene Tree for EIF4EBP3 (if available)
TreeFam:
Gene Tree for EIF4EBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4EBP3: view image
Alliance of Genome Resources:
Additional Orthologs for EIF4EBP3

Paralogs for EIF4EBP3 Gene

Paralogs for EIF4EBP3 Gene

(2) SIMAP similar genes for EIF4EBP3 Gene using alignment to 1 proteins:

  • 4EBP3_HUMAN
genes like me logo Genes that share paralogs with EIF4EBP3: view

Variants for EIF4EBP3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EIF4EBP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for EIF4EBP3 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4EBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4EBP3
Leiden Open Variation Database (LOVD)
EIF4EBP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for EIF4EBP3 Gene

Disorders for EIF4EBP3 Gene

Additional Disease Information for EIF4EBP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for EIF4EBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4EBP3 Gene

Publications for EIF4EBP3 Gene

  1. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. (PMID: 9593750) Poulin F … Sonenberg N (The Journal of biological chemistry 1998) 2 3 4
  2. Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis. (PMID: 17316564) Abiko F … Ishida T (Biochemical and biophysical research communications 2007) 3 22
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. (PMID: 14557257) Poulin F … Sonenberg N (The Journal of biological chemistry 2003) 3 22
  5. Localisation and regulation of the eIF4E-binding protein 4E-BP3. (PMID: 12482586) Kleijn M … Proud CG (FEBS letters 2002) 3 22

Products for EIF4EBP3 Gene

Sources for EIF4EBP3 Gene