Aliases for EIF4EBP2 Gene
External Ids for EIF4EBP2 Gene
Previous GeneCards Identifiers for EIF4EBP2 Gene
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
GeneCards Summary for EIF4EBP2 Gene
EIF4EBP2 (Eukaryotic Translation Initiation Factor 4E Binding Protein 2) is a Protein Coding gene. Diseases associated with EIF4EBP2 include Autism. Among its related pathways are Beta-Adrenergic Signaling and Longevity regulating pathway. Gene Ontology (GO) annotations related to this gene include translation repressor activity and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP1.
UniProtKB/Swiss-Prot Summary for EIF4EBP2 Gene
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).