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Aliases for EIF4EBP1 Gene

Aliases for EIF4EBP1 Gene

  • Eukaryotic Translation Initiation Factor 4E Binding Protein 1 2 3 5
  • Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 2 3 4
  • EIF4E-Binding Protein 1 3 4
  • 4E-BP1 3 4
  • PHAS-I 3 4
  • Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 3
  • 4EBP1 3
  • BP-1 3

External Ids for EIF4EBP1 Gene

Previous GeneCards Identifiers for EIF4EBP1 Gene

  • GC04P9B0162
  • GC04M9B0161
  • GC08M9E0078
  • GC08P037888
  • GC08P036422

Summaries for EIF4EBP1 Gene

Entrez Gene Summary for EIF4EBP1 Gene

  • This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

CIViC summary for EIF4EBP1 Gene

GeneCards Summary for EIF4EBP1 Gene

EIF4EBP1 (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) is a Protein Coding gene. Diseases associated with EIF4EBP1 include Tuberous Sclerosis and Rhabdomyosarcoma. Among its related pathways are Akt Signaling and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include translation initiation factor binding and eukaryotic initiation factor 4E binding. An important paralog of this gene is EIF4EBP2.

UniProtKB/Swiss-Prot for EIF4EBP1 Gene

  • Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Gene Wiki entry for EIF4EBP1 Gene

Additional gene information for EIF4EBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4EBP1 Gene

Genomics for EIF4EBP1 Gene

GeneHancer (GH) Regulatory Elements for EIF4EBP1 Gene

Promoters and enhancers for EIF4EBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J038029 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 763 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5 EIF4EBP1 RPS20P22 ENSG00000254306 FGFR1 LOC102723716 ASH2L RNU6-323P GOT1L1 ERLIN2 ENSG00000260949
GH08J038764 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +738.1 738055 7.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A YBX1 ZNF2 IRF4 YY1 ENSG00000255201 DDHD2 ADGRA2 NSD3 TACC1 FGFR1 TM2D2 LETM2 EIF4EBP1 ADAM5
GH08J037848 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 -180.6 -180562 2.5 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 BRF2 DDHD2 LOC100507403 EIF4EBP1 ENSG00000254290 GC08P037836
GH08J037779 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.3 -246.1 -246129 9.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B YBX1 ZNF2 POLR2B ZNF766 ADGRA2 DDHD2 ERLIN2 ENSG00000255201 RPS20P22 ENSG00000254306 LOC100507403 ENSG00000272128 EIF4EBP1 LOC102723716
GH08J037869 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 -157.6 -157591 6.1 HDGF PKNOX1 BMI1 BATF IRF4 ZNF366 ZNF143 ATF7 RCOR1 FOS RAB11FIP1 ADGRA2 GOT1L1 EIF4EBP1 PLPBP ENSG00000280064
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4EBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4EBP1 gene promoter:
  • STAT3
  • MyoD
  • USF1
  • USF-1
  • Zic1
  • Pax-5
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma

Genomic Locations for EIF4EBP1 Gene

Genomic Locations for EIF4EBP1 Gene
chr8:38,030,341-38,060,365
(GRCh38/hg38)
Size:
30,025 bases
Orientation:
Plus strand
chr8:37,887,859-37,917,883
(GRCh37/hg19)
Size:
30,025 bases
Orientation:
Plus strand

Genomic View for EIF4EBP1 Gene

Genes around EIF4EBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4EBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4EBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4EBP1 Gene

Proteins for EIF4EBP1 Gene

  • Protein details for EIF4EBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13541-4EBP1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 1
    Protein Accession:
    Q13541
    Secondary Accessions:
    • B2R502
    • D3DSW8
    • Q6IBN3

    Protein attributes for EIF4EBP1 Gene

    Size:
    118 amino acids
    Molecular mass:
    12580 Da
    Quaternary structure:
    • Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:12747827).

    Three dimensional structures from OCA and Proteopedia for EIF4EBP1 Gene

neXtProt entry for EIF4EBP1 Gene

Post-translational modifications for EIF4EBP1 Gene

  • Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
  • Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.
  • Ubiquitination at isoforms=57
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF4EBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EIF4EBP1 Gene

Domains & Families for EIF4EBP1 Gene

Gene Families for EIF4EBP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for EIF4EBP1 Gene

Suggested Antigen Peptide Sequences for EIF4EBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13541

UniProtKB/Swiss-Prot:

4EBP1_HUMAN :
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
  • Belongs to the eIF4E-binding protein family.
Domain:
  • The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.
Family:
  • Belongs to the eIF4E-binding protein family.
genes like me logo Genes that share domains with EIF4EBP1: view

Function for EIF4EBP1 Gene

Molecular function for EIF4EBP1 Gene

UniProtKB/Swiss-Prot Function:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
GENATLAS Biochemistry:
eukaryotic translation initiation factor 4E,binding protein 1,implicated in the progression of cancer

Gene Ontology (GO) - Molecular Function for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7651417
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0030371 translation repressor activity IDA 22578813
genes like me logo Genes that share ontologies with EIF4EBP1: view
genes like me logo Genes that share phenotypes with EIF4EBP1: view

Animal Models for EIF4EBP1 Gene

MGI Knock Outs for EIF4EBP1:

Animal Model Products

miRNA for EIF4EBP1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4EBP1 Gene

Localization for EIF4EBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4EBP1 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3
extracellular 2
lysosome 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF4EBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4EBP1 Gene

Pathways & Interactions for EIF4EBP1 Gene

genes like me logo Genes that share pathways with EIF4EBP1: view

Pathways by source for EIF4EBP1 Gene

SIGNOR curated interactions for EIF4EBP1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF4EBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0002192 IRES-dependent translational initiation of linear mRNA IEA --
GO:0006417 regulation of translation IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0017148 negative regulation of translation IEA --
genes like me logo Genes that share ontologies with EIF4EBP1: view

Drugs & Compounds for EIF4EBP1 Gene

(29) Drugs for EIF4EBP1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0

(18) Additional Compounds for EIF4EBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for EIF4EBP1 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
genes like me logo Genes that share compounds with EIF4EBP1: view

Drug Products

Transcripts for EIF4EBP1 Gene

mRNA/cDNA for EIF4EBP1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF4EBP1 Gene

Eukaryotic translation initiation factor 4E binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4EBP1 Gene

No ASD Table

Relevant External Links for EIF4EBP1 Gene

GeneLoc Exon Structure for
EIF4EBP1
ECgene alternative splicing isoforms for
EIF4EBP1

Expression for EIF4EBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4EBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF4EBP1 Gene

This gene is overexpressed in Pancreas (x6.6).

Protein differential expression in normal tissues from HIPED for EIF4EBP1 Gene

This gene is overexpressed in Pancreas (20.7), Skin (14.7), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4EBP1 Gene



Protein tissue co-expression partners for EIF4EBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF4EBP1 Gene:

EIF4EBP1

SOURCE GeneReport for Unigene cluster for EIF4EBP1 Gene:

Hs.411641

Evidence on tissue expression from TISSUES for EIF4EBP1 Gene

  • Nervous system(4.6)
  • Intestine(4.5)
  • Liver(4.5)
  • Blood(4.4)
  • Muscle(3.2)
  • Pancreas(2.6)
  • Heart(2.3)
  • Kidney(2.2)
  • Lung(2.2)
  • Bone marrow(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with EIF4EBP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4EBP1 Gene

Orthologs for EIF4EBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF4EBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4EBP1 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4EBP1 34 33
  • 92.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4ebp1 33
  • 90.88 (n)
mouse
(Mus musculus)
Mammalia Eif4ebp1 16 34 33
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia EIF4EBP1 34 33
  • 89.83 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4EBP1 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4EBP1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4EBP1 34 33
  • 66.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4EBP1 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii eif4ebp1 34 33
  • 60.87 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Thor 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5022 34
  • 18 (a)
OneToMany
Species where no ortholog for EIF4EBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF4EBP1 Gene

ENSEMBL:
Gene Tree for EIF4EBP1 (if available)
TreeFam:
Gene Tree for EIF4EBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4EBP1: view image

Paralogs for EIF4EBP1 Gene

Paralogs for EIF4EBP1 Gene

(2) SIMAP similar genes for EIF4EBP1 Gene using alignment to 1 proteins:

  • 4EBP1_HUMAN

Pseudogenes.org Pseudogenes for EIF4EBP1 Gene

genes like me logo Genes that share paralogs with EIF4EBP1: view

Variants for EIF4EBP1 Gene

Sequence variations from dbSNP and Humsavar for EIF4EBP1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000005389 -- 38,048,874(+) A/G intron_variant
rs1000056597 -- 38,038,743(+) T/C intron_variant
rs1000279508 -- 38,054,640(+) A/T intron_variant
rs1000389744 -- 38,060,643(+) C/G downstream_transcript_variant
rs1000485964 -- 38,045,388(+) GTTGTT/GTTGTTGTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4EBP1 Gene

Variant ID Type Subtype PubMed ID
esv3616914 CNV loss 21293372
nsv610947 CNV loss 21841781
nsv824600 CNV gain 20364138

Variation tolerance for EIF4EBP1 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4EBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4EBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4EBP1 Gene

Disorders for EIF4EBP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF4EBP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • tuberous sclerosis 1
rhabdomyosarcoma
large intestine adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF4EBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EIF4EBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4EBP1 Gene

Publications for EIF4EBP1 Gene

  1. Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes. (PMID: 18442140) Soma H … Sasaki H (Movement disorders : official journal of the Movement Disorder Society 2008) 3 22 44 58
  2. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PMID: 16271312) Tomoo K … Ishida T (Biochimica et biophysica acta 2005) 3 4 22 58
  3. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. (PMID: 12588975) Wang X … Proud CG (Molecular and cellular biology 2003) 3 4 22 58
  4. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PMID: 12150926) Hara K … Yonezawa K (Cell 2002) 3 4 22 58
  5. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. (PMID: 9465032) Burnett PE … Sabatini DM (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58

Products for EIF4EBP1 Gene

Sources for EIF4EBP1 Gene

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