Aliases for EIF4E2 Gene

Aliases for EIF4E2 Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 2 2 3 5
  • Eukaryotic Translation Initiation Factor 4E-Like 3 2 3 4
  • Eukaryotic Translation Initiation Factor 4E Homologous Protein 3 4
  • Eukaryotic Translation Initiation Factor 4E Type 2 3 4
  • MRNA Cap-Binding Protein Type 3 3 4
  • EIF4E-Like Protein 4E-LP 3 4
  • EIF-4E Type 2 3 4
  • EIF4EL3 3 4
  • H4EHP 3 4
  • EIF4E-Like Cap-Binding Protein 3
  • MRNA Cap-Binding Protein 4EHP 4
  • EIF4E Type 2 4
  • 4E-LP 3
  • 4EHP 3
  • IF4e 3

External Ids for EIF4E2 Gene

Previous HGNC Symbols for EIF4E2 Gene

  • EIF4EL3

Previous GeneCards Identifiers for EIF4E2 Gene

  • GC02P233240
  • GC02P233123
  • GC02P233414
  • GC02P225267

Summaries for EIF4E2 Gene

GeneCards Summary for EIF4E2 Gene

EIF4E2 (Eukaryotic Translation Initiation Factor 4E Family Member 2) is a Protein Coding gene. Among its related pathways are Longevity regulating pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is EIF4E.

UniProtKB/Swiss-Prot Summary for EIF4E2 Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).

Gene Wiki entry for EIF4E2 Gene

Additional gene information for EIF4E2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4E2 Gene

Genomics for EIF4E2 Gene

GeneHancer (GH) Regulatory Elements for EIF4E2 Gene

Promoters and enhancers for EIF4E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J232549 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.6 644 3 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C SIN3A TCF12 NRF1 TIGD1 EIF4E2 MIR5001 piR-31754 PRSS56 ENSG00000251485 CHRND SCARNA6 DIS3L2 ENSG00000261096
GH02J232572 Enhancer 1 Ensembl ENCODE 35.7 +24.0 24030 2.7 POLR2G NCOR1 SKI FOXA2 TBP SAP130 ZBTB33 ZNF205 MXD4 JUND NONHSAG030797.2 EIF4E2 TIGD1 ECEL1 GIGYF2
GH02J232592 Enhancer 0.8 Ensembl ENCODE 28.2 +43.1 43143 2 CTCF FOS RFX1 FOSL2 CEBPB STAT3 RAD21 ATF4 JUN HLF EIF4E2 TIGD1 RF00017-3458 piR-57535 ENSG00000237126
GH02J232587 Enhancer 0.8 Ensembl ENCODE 21.9 +37.7 37744 4 REST ZNF316 FOS SPI1 NFE2 JUND MAFK NFE2L1 MAFG RAD21 EIF4E2 CHRNG piR-57535 RF00017-3458 ENSG00000237126
GH02J232523 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 5.3 -23.4 -23378 6.2 CTCF GABPA ZBTB26 EZH2 DEAF1 PCBP1 SMC3 SP2 ZBTB17 ZNF524 CHRND CHRNG PRSS56 TIGD1 EIF4E2 SCARNA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4E2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4E2

Top Transcription factor binding sites by QIAGEN in the EIF4E2 gene promoter:
  • AP-4
  • COMP1
  • FOXI1
  • GR
  • GR-alpha
  • HFH-3
  • IRF-2
  • NRSF form 1
  • NRSF form 2
  • STAT1beta

Genomic Locations for EIF4E2 Gene

Genomic Locations for EIF4E2 Gene
chr2:232,550,057-232,583,645
(GRCh38/hg38)
Size:
33,589 bases
Orientation:
Plus strand
chr2:233,414,762-233,448,354
(GRCh37/hg19)
Size:
33,593 bases
Orientation:
Plus strand

Genomic View for EIF4E2 Gene

Genes around EIF4E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E2 Gene

Proteins for EIF4E2 Gene

  • Protein details for EIF4E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60573-IF4E2_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 2
    Protein Accession:
    O60573
    Secondary Accessions:
    • B8ZZJ9
    • O75349

    Protein attributes for EIF4E2 Gene

    Size:
    245 amino acids
    Molecular mass:
    28362 Da
    Quaternary structure:
    • Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (PubMed:15153109, PubMed:17368478). Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3) (By similarity). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931). Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct (PubMed:22751931).

    Three dimensional structures from OCA and Proteopedia for EIF4E2 Gene

    Alternative splice isoforms for EIF4E2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E2 Gene

Post-translational modifications for EIF4E2 Gene

  • Ubiquitinated by ARIH1 (PubMed:14623119, PubMed:25624349). The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report ubiquitination leads to its subsequent degradation (PubMed:14623119).
  • ISGylation enhances its cap structure-binding activity and translation-inhibition activity.
  • Ubiquitination at Lys239
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4E2 Gene

Domains & Families for EIF4E2 Gene

Gene Families for EIF4E2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4E2 Gene

Blocks:
  • Eukaryotic translation initiation factor 4E (eIF-4E)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF4E2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59146, moderately similar to Eukaryotic translation initiation factor 4E type 3 (B4E1E4_HUMAN)
  • mRNA cap-binding protein type 3 (IF4E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60573

UniProtKB/Swiss-Prot:

IF4E2_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E2: view

Function for EIF4E2 Gene

Molecular function for EIF4E2 Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).
GENATLAS Biochemistry:
eukaryotic transcription factor 4E2,intron less,identified from chromosome 4-specific genome library

Phenotypes From GWAS Catalog for EIF4E2 Gene

Gene Ontology (GO) - Molecular Function for EIF4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9582349
GO:0000340 RNA 7-methylguanosine cap binding IBA 21873635
GO:0003723 RNA binding HDA,IEA 22681889
GO:0003743 translation initiation factor activity IBA,IEA 21873635
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF4E2: view
genes like me logo Genes that share phenotypes with EIF4E2: view

Animal Models for EIF4E2 Gene

MGI Knock Outs for EIF4E2:

Animal Model Products

CRISPR Products

miRNA for EIF4E2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4E2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF4E2 Gene

Localization for EIF4E2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4E2 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex IDA 17368478
GO:0016281 eukaryotic translation initiation factor 4F complex IBA 21873635
genes like me logo Genes that share ontologies with EIF4E2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4E2 Gene

Pathways & Interactions for EIF4E2 Gene

genes like me logo Genes that share pathways with EIF4E2: view

Gene Ontology (GO) - Biological Process for EIF4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
GO:0017148 negative regulation of translation IMP 22751931
genes like me logo Genes that share ontologies with EIF4E2: view

No data available for SIGNOR curated interactions for EIF4E2 Gene

Drugs & Compounds for EIF4E2 Gene

(2) Drugs for EIF4E2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4E1RCat Pharma Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 0
4EGI-1 Pharma Competitive eIF4E/eIF4G interaction inhibitor 0

(1) Additional Compounds for EIF4E2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4E2 Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4E2: view

Drug Products

Transcripts for EIF4E2 Gene

mRNA/cDNA for EIF4E2 Gene

7 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4E2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for EIF4E2 Gene

GeneLoc Exon Structure for
EIF4E2

Expression for EIF4E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4E2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4E2 Gene



Protein tissue co-expression partners for EIF4E2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4E2

SOURCE GeneReport for Unigene cluster for EIF4E2 Gene:

Hs.292026

Evidence on tissue expression from TISSUES for EIF4E2 Gene

  • Nervous system(4.5)
  • Muscle(4.3)
  • Thyroid gland(4.3)
  • Blood(4.1)
  • Lung(2.5)
  • Liver(2.2)
  • Kidney(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with EIF4E2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4E2 Gene

Orthologs for EIF4E2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4E2 31 30
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E2 31 30
  • 96.05 (n)
OneToMany
-- 31
  • 96 (a)
OneToMany
-- 31
  • 95 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia EIF4E2 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4E2 31 30
  • 94.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4e2 17 31 30
  • 93.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E2 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E2 31 30
  • 84.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E2 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89871 30
  • 82.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28437 30
zebrafish
(Danio rerio)
Actinopterygii eif4e2 31 30
  • 80 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta 4EHP 31
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ife-4 31 30
  • 60.08 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 31
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2600 31
  • 66 (a)
OneToOne
Cin.894 30
bread mold
(Neurospora crassa)
Ascomycetes NCU10582 30
  • 55.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.894 30
Species where no ortholog for EIF4E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E2 Gene

ENSEMBL:
Gene Tree for EIF4E2 (if available)
TreeFam:
Gene Tree for EIF4E2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4E2: view image

Paralogs for EIF4E2 Gene

Paralogs for EIF4E2 Gene

(4) SIMAP similar genes for EIF4E2 Gene using alignment to 9 proteins:

  • IF4E2_HUMAN
  • B4E1E4_HUMAN
  • B8ZZ50_HUMAN
  • B8ZZJ9_HUMAN
  • B8ZZL3_HUMAN
  • B9A023_HUMAN
  • B9A044_HUMAN
  • C9JEL3_HUMAN
  • H7BZH2_HUMAN

Pseudogenes.org Pseudogenes for EIF4E2 Gene

genes like me logo Genes that share paralogs with EIF4E2: view

Variants for EIF4E2 Gene

Additional dbSNP identifiers (rs#s) for EIF4E2 Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF4E2 Gene

Variant ID Type Subtype PubMed ID
esv3302484 CNV tandem duplication 20981092
esv3302497 CNV tandem duplication 20981092
esv3322538 CNV duplication 20981092
esv3399554 CNV insertion 20981092
esv3415009 CNV duplication 20981092
esv3594657 CNV loss 21293372
esv3594658 CNV loss 21293372
esv3594659 CNV gain 21293372
esv3594660 CNV gain 21293372
nsv1002306 CNV gain 25217958
nsv3212 CNV deletion 18451855
nsv821918 CNV gain 20364138

Variation tolerance for EIF4E2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF4E2 Gene

Disorders for EIF4E2 Gene

Additional Disease Information for EIF4E2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF4E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E2 Gene

Publications for EIF4E2 Gene

  1. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. (PMID: 9582349) Rom E … Sonenberg N (The Journal of biological chemistry 1998) 2 3 4 23 54
  2. Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. (PMID: 17368478) Rosettani P … Cameron AD (Journal of molecular biology 2007) 3 4 23 54
  3. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 54
  4. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. (PMID: 25624349) von Stechow L … Danen EH (Molecular and cellular biology 2015) 3 4 54
  5. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. (PMID: 22751931) Morita M … Sonenberg N (Molecular and cellular biology 2012) 3 4 54

Products for EIF4E2 Gene

Sources for EIF4E2 Gene