Aliases for EIF4E1B Gene

Aliases for EIF4E1B Gene

  • Eukaryotic Translation Initiation Factor 4E Family Member 1B 2 3 5
  • Eukaryotic Translation Initiation Factor 4E Type 1B 3 4

External Ids for EIF4E1B Gene

Previous GeneCards Identifiers for EIF4E1B Gene

  • GC05P176004
  • GC05P176057
  • GC05P170981

Summaries for EIF4E1B Gene

GeneCards Summary for EIF4E1B Gene

EIF4E1B (Eukaryotic Translation Initiation Factor 4E Family Member 1B) is a Protein Coding gene. Among its related pathways are RNA transport and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E.

UniProtKB/Swiss-Prot Summary for EIF4E1B Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.

Additional gene information for EIF4E1B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4E1B Gene

Genomics for EIF4E1B Gene

GeneHancer (GH) Regulatory Elements for EIF4E1B Gene

Promoters and enhancers for EIF4E1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176630 Promoter 1.3 EPDnew Ensembl 750.6 -0.2 -217 0.8 CTCF ZBTB6 MNT SP5 KLF14 GLIS2 PKNOX1 ZIC2 PRDM10 TARDBP EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3 GPRIN1 TSPAN17
GH05J176628 Promoter 0.4 Ensembl 750.6 -0.9 -917 0.2 EZH2 EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3
GH05J176629 Enhancer 0.3 Ensembl 750.6 -1.8 -1817 0.4 ZNF623 ZNF664 EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3 GPRIN1
GH05J177425 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 +798.8 798754 8.6 SIN3A ZNF24 SP1 ZBTB40 SMARCE1 POLR2A CEBPZ HDAC2 ATF1 FOS GRK6 UIMC1 MXD3 FAM193B NSD1 FAF2 ENSG00000247679 ENSG00000246596 DOK3 LMAN2
GH05J176386 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 -242.2 -242196 4.1 E2F8 ZNF785 SIN3A SP1 ZBTB40 SIX5 ZBTB6 RBPJ POLR2A CTBP1 HIGD2A NOP16 lnc-CLTB-1 FAF2 NSD1 UIMC1 ENSG00000251414 ENSG00000250909 ENSG00000240729 ZNF346-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4E1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4E1B gene promoter:
  • NRSF form 1
  • NRSF form 2
  • p53
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for EIF4E1B Gene

Genomic Locations for EIF4E1B Gene
chr5:176,630,618-176,646,644
(GRCh38/hg38)
Size:
16,027 bases
Orientation:
Plus strand
chr5:176,057,683-176,073,642
(GRCh37/hg19)
Size:
15,960 bases
Orientation:
Plus strand

Genomic View for EIF4E1B Gene

Genes around EIF4E1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E1B Gene

Proteins for EIF4E1B Gene

  • Protein details for EIF4E1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMX2-I4E1B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E type 1B
    Protein Accession:
    A6NMX2

    Protein attributes for EIF4E1B Gene

    Size:
    242 amino acids
    Molecular mass:
    27596 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).

neXtProt entry for EIF4E1B Gene

Post-translational modifications for EIF4E1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF4E1B Gene

No data available for DME Specific Peptides for EIF4E1B Gene

Domains & Families for EIF4E1B Gene

Gene Families for EIF4E1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF4E1B Gene

Suggested Antigen Peptide Sequences for EIF4E1B Gene

GenScript: Design optimal peptide antigens:
  • Eukaryotic translation initiation factor 4E type 1B (I4E1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMX2

UniProtKB/Swiss-Prot:

I4E1B_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E1B: view

Function for EIF4E1B Gene

Molecular function for EIF4E1B Gene

UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.

Phenotypes From GWAS Catalog for EIF4E1B Gene

Gene Ontology (GO) - Molecular Function for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000340 RNA 7-methylguanosine cap binding IBA 21873635
GO:0003723 RNA binding IEA --
GO:0003743 translation initiation factor activity IBA 21873635
genes like me logo Genes that share ontologies with EIF4E1B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EIF4E1B Gene

Localization for EIF4E1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4E1B gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005845 mRNA cap binding complex ISS --
GO:0016281 eukaryotic translation initiation factor 4F complex IBA 21873635
genes like me logo Genes that share ontologies with EIF4E1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EIF4E1B Gene

Pathways & Interactions for EIF4E1B Gene

genes like me logo Genes that share pathways with EIF4E1B: view

Gene Ontology (GO) - Biological Process for EIF4E1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with EIF4E1B: view

No data available for SIGNOR curated interactions for EIF4E1B Gene

Drugs & Compounds for EIF4E1B Gene

No Compound Related Data Available

Transcripts for EIF4E1B Gene

mRNA/cDNA for EIF4E1B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E1B Gene

No ASD Table

Relevant External Links for EIF4E1B Gene

GeneLoc Exon Structure for
EIF4E1B
ECgene alternative splicing isoforms for
EIF4E1B

Expression for EIF4E1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4E1B Gene

mRNA differential expression in normal tissues according to GTEx for EIF4E1B Gene

This gene is overexpressed in Brain - Cortex (x10.2), Brain - Frontal Cortex (BA9) (x9.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for EIF4E1B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EIF4E1B Gene



Protein tissue co-expression partners for EIF4E1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4E1B Gene:

EIF4E1B

SOURCE GeneReport for Unigene cluster for EIF4E1B Gene:

Hs.448362
genes like me logo Genes that share expression patterns with EIF4E1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4E1B Gene

Orthologs for EIF4E1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4E1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4E1B 33 32
  • 98.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4E1B 33 32
  • 88.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E1B 33 32
  • 82.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4e1b 32
  • 82.52 (n)
mouse
(Mus musculus)
Mammalia Eif4e1b 17 33 32
  • 80.79 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 79 (a)
OneToMany
-- 33
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E1B 33
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E1B 33
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E1B 33
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e 32
  • 71.64 (n)
zebrafish
(Danio rerio)
Actinopterygii eif4e1b 33 32
  • 69.61 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eIF4E-6 33
  • 42 (a)
ManyToMany
eIF4E-4 33
  • 39 (a)
ManyToMany
eIF4E-5 33
  • 36 (a)
ManyToMany
eIF-4E 33
  • 34 (a)
ManyToMany
eIF4E-3 33
  • 32 (a)
ManyToMany
eIF4E-7 33
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ife-3 33
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 33
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29550 32
  • 50.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6167 33
  • 51 (a)
OneToMany
Species where no ortholog for EIF4E1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E1B Gene

ENSEMBL:
Gene Tree for EIF4E1B (if available)
TreeFam:
Gene Tree for EIF4E1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4E1B: view image

Paralogs for EIF4E1B Gene

Paralogs for EIF4E1B Gene

(3) SIMAP similar genes for EIF4E1B Gene using alignment to 3 proteins:

  • I4E1B_HUMAN
  • D6RHE2_HUMAN
  • H0Y8X3_HUMAN
genes like me logo Genes that share paralogs with EIF4E1B: view

Variants for EIF4E1B Gene

Sequence variations from dbSNP and Humsavar for EIF4E1B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000148037 -- 176,635,496(+) G/C intron_variant
rs1000308166 -- 176,640,888(+) C/T intron_variant
rs1000401913 -- 176,646,544(+) C/T 3_prime_UTR_variant
rs1000524445 -- 176,643,786(+) C/A intron_variant
rs1000865120 -- 176,636,312(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4E1B Gene

Variant ID Type Subtype PubMed ID
nsv600346 CNV loss 21841781

Variation tolerance for EIF4E1B Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4E1B Gene

Human Gene Mutation Database (HGMD)
EIF4E1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4E1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E1B Gene

Disorders for EIF4E1B Gene

Additional Disease Information for EIF4E1B

No disorders were found for EIF4E1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF4E1B Gene

Publications for EIF4E1B Gene

  1. Phylogenetic analysis of eIF4E-family members. (PMID: 16191198) Joshi B … Jagus R (BMC evolutionary biology 2005) 2 3 4 56
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56

Products for EIF4E1B Gene

Sources for EIF4E1B Gene