Aliases for EIF4E Gene
External Ids for EIF4E Gene
Previous HGNC Symbols for EIF4E Gene
Previous GeneCards Identifiers for EIF4E Gene
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for EIF4E Gene
EIF4E (Eukaryotic Translation Initiation Factor 4E) is a Protein Coding gene. Diseases associated with EIF4E include Autism 19 and Pervasive Developmental Disorder. Among its related pathways are NFAT and Cardiac Hypertrophy and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF4E1B.
UniProtKB/Swiss-Prot for EIF4E Gene
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.