Aliases for EIF4A2 Gene
External Ids for EIF4A2 Gene
Previous HGNC Symbols for EIF4A2 Gene
Previous GeneCards Identifiers for EIF4A2 Gene
GeneCards Summary for EIF4A2 Gene
EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Ovary Sarcoma and Fragile X-Associated Tremor/Ataxia Syndrome. Among its related pathways are Beta-Adrenergic Signaling and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A1.
UniProtKB/Swiss-Prot Summary for EIF4A2 Gene
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.