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Aliases for EIF4A2 Gene

Aliases for EIF4A2 Gene

  • Eukaryotic Translation Initiation Factor 4A2 2 3 5
  • ATP-Dependent RNA Helicase EIF4A-2 3 4
  • EIF-4A-II 3 4
  • EIF4A-II 3 4
  • EIF4F 3 4
  • DDX2B 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 2 2
  • Eukaryotic Initiation Factor 4A-II 3
  • EC 3.6.4.13 4
  • EC 3.6.1 56
  • BM-010 3
  • EIF4A 3

External Ids for EIF4A2 Gene

Previous HGNC Symbols for EIF4A2 Gene

  • EIF4F

Previous GeneCards Identifiers for EIF4A2 Gene

  • GC03P183276
  • GC03P187758
  • GC03P187903
  • GC03P187822
  • GC03P187984
  • GC03P186503
  • GC03P186522
  • GC03P186528
  • GC03P186533
  • GC03P186539
  • GC03P186548
  • GC03P186556
  • GC03P186574

Summaries for EIF4A2 Gene

GeneCards Summary for EIF4A2 Gene

EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot for EIF4A2 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A2 Gene

Additional gene information for EIF4A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A2 Gene

Genomics for EIF4A2 Gene

GeneHancer (GH) Regulatory Elements for EIF4A2 Gene

Promoters and enhancers for EIF4A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I186782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.1 +2.5 2541 7.1 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SNORA4 ENSG00000200418 SNORA81 EIF4A2 ENSG00000263826 GC03P186785 GC03P186828 GC03P186831 GC03P186832 GC03P186834
GH03I186824 Promoter/Enhancer 1.5 Ensembl ENCODE 11.4 +43.3 43316 3.3 ATF1 ARID4B SIN3A BRCA1 ZNF48 TCF12 POLR2B GLIS2 ZNF143 ZNF207 ENSG00000231982 LINC02043 ENSG00000200418 RFC4 TRA2B TBCCD1 SNORA63 SNORA81 EIF4A2 ADIPOQ-AS1
GH03I187038 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 +258.5 258461 7.3 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 JUNB ADIPOQ RFC4 EIF4A2 ENSG00000200418 SNORA63 SNORA81 ADIPOQ-AS1 ST6GAL1 PIR46786 GC03P186996
GH03I187129 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11 +347.4 347375 2.4 IRF2 FOXA2 JUN MAX BATF KLF5 ZNF507 FOSL1 GATA3 ZNF26 SNORA81 ENSG00000200418 SNORA63 SNORA4 TBCCD1 RPL39L EIF4A2 ADIPOQ RFC4 RTP4
GH03I186752 Enhancer 1.1 Ensembl ENCODE 11 -29.1 -29067 3.9 FOXA2 ARID4B BRCA1 YY1 TCF12 ZNF121 ZNF143 ATF7 FOS REST LOC105374259 KNG1 EIF4A2 SNORA63 SNORA81 ENSG00000200418 RFC4 FETUB ENSG00000231724 AHSG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF4A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4A2 gene promoter:

Genomic Locations for EIF4A2 Gene

Genomic Locations for EIF4A2 Gene
chr3:186,783,205-186,789,900
(GRCh38/hg38)
Size:
6,696 bases
Orientation:
Plus strand
chr3:186,500,994-186,507,689
(GRCh37/hg19)

Genomic View for EIF4A2 Gene

Genes around EIF4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A2 Gene

Proteins for EIF4A2 Gene

  • Protein details for EIF4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14240-IF4A2_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-II
    Protein Accession:
    Q14240
    Secondary Accessions:
    • D3DNU9
    • Q53XJ6
    • Q96B90
    • Q96EA8

    Protein attributes for EIF4A2 Gene

    Size:
    407 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.

    Three dimensional structures from OCA and Proteopedia for EIF4A2 Gene

    Alternative splice isoforms for EIF4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A2 Gene

Selected DME Specific Peptides for EIF4A2 Gene

Q14240:
  • EEWKLDTL
  • DEMLSRGF
  • EFRSGSSR
  • HACIGGT
  • GRGGRFG
  • PTRELAQQ
  • FEKPSAIQQR
  • LLSATMP
  • RKVDWLT
  • FVLDEAD
  • QAQSGTGKTATF
  • QVVLLSAT
  • VGTPGRV
  • TKKFMRDP
  • LEVTKKFM
  • VTEEDKR
  • LAPTREL
  • TTDLLARG
  • DPIRILVK
  • ELTLEGI
  • LLRGIYAY
  • LRDIETFYNT
  • GVIESNWNEIVD
  • EMPMNVADL
  • AQAQSGTGKT
  • LARGIDV
  • GRFGRKGV
  • ARDFTVSA
  • IVVGTPG
  • GRKGVAI
  • ARGIDVQQ
  • RILRDIE
  • VINYDLP
  • ETQALVL
  • GVAINFV
  • APTRELA
  • GTPGRVFDM
  • VVGTPGR
  • QFYINVE
  • EGIKQFY
  • DEADEML
  • TDLLARGID
  • YIHRIGR

Post-translational modifications for EIF4A2 Gene

  • Ubiquitination at posLast=310310 and Lys370
  • Modification sites at PhosphoSitePlus

Domains & Families for EIF4A2 Gene

Gene Families for EIF4A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EIF4A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14240

UniProtKB/Swiss-Prot:

IF4A2_HUMAN :
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A2: view

Function for EIF4A2 Gene

Molecular function for EIF4A2 Gene

GENATLAS Biochemistry:
eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Enzyme Numbers (IUBMB) for EIF4A2 Gene

Phenotypes From GWAS Catalog for EIF4A2 Gene

Gene Ontology (GO) - Molecular Function for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003743 translation initiation factor activity TAS,IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 8521730
genes like me logo Genes that share ontologies with EIF4A2: view
genes like me logo Genes that share phenotypes with EIF4A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EIF4A2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A2 Gene

Localization for EIF4A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4A2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 8521730
GO:0048471 perinuclear region of cytoplasm IDA 11922617
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A2 Gene

Pathways & Interactions for EIF4A2 Gene

genes like me logo Genes that share pathways with EIF4A2: view

Gene Ontology (GO) - Biological Process for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation TAS 8521730
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for SIGNOR curated interactions for EIF4A2 Gene

Drugs & Compounds for EIF4A2 Gene

(3) Drugs for EIF4A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for EIF4A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EIF4A2: view

Transcripts for EIF4A2 Gene

mRNA/cDNA for EIF4A2 Gene

Unigene Clusters for EIF4A2 Gene

Eukaryotic translation initiation factor 4A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20:
SP21: - - -
SP22: - - - -
SP23: - -
SP24:
SP25:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19: - -
SP20: - -
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for EIF4A2 Gene

GeneLoc Exon Structure for
EIF4A2
ECgene alternative splicing isoforms for
EIF4A2

Expression for EIF4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF4A2 Gene



Protein tissue co-expression partners for EIF4A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4A2 Gene:

EIF4A2

SOURCE GeneReport for Unigene cluster for EIF4A2 Gene:

Hs.518475

Evidence on tissue expression from TISSUES for EIF4A2 Gene

  • Nervous system(5)
  • Lung(4.9)
  • Muscle(4.9)
  • Liver(4.7)
  • Intestine(4.6)
  • Kidney(4.6)
  • Bone marrow(4.5)
  • Heart(4.5)
  • Stomach(4.5)
  • Blood(4.2)
  • Pancreas(4.2)
  • Eye(3.6)
  • Spleen(3.1)
  • Skin(2.8)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with EIF4A2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4A2 Gene

Orthologs for EIF4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4A2 33 34
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia EIF4A2 33 34
  • 96.89 (n)
cow
(Bos Taurus)
Mammalia EIF4A2 33 34
  • 96.31 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF4A2 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4a2 33
  • 94.43 (n)
mouse
(Mus musculus)
Mammalia Eif4a2 16 34 33
  • 94.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EIF4A2 33 34
  • 88.37 (n)
lizard
(Anolis carolinensis)
Reptilia EIF4A2 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2528 33
zebrafish
(Danio rerio)
Actinopterygii eif4a2 34
  • 96 (a)
OneToOne
wufd50g11 33
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 35 33 34
  • 66.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009863 33
  • 65.08 (n)
worm
(Caenorhabditis elegans)
Secernentea inf-1 35 33 34
  • 64.01 (n)
F57B9.3 35 34
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAL1 34
  • 57 (a)
OneToMany
TIF2 36
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4A-2 33
  • 68.68 (n)
rice
(Oryza sativa)
Liliopsida Os06g0701100 33
  • 68.07 (n)
corn
(Zea mays)
Liliopsida Zm.437 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 34
  • 80 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1890 33
Species where no ortholog for EIF4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4A2 Gene

ENSEMBL:
Gene Tree for EIF4A2 (if available)
TreeFam:
Gene Tree for EIF4A2 (if available)

Paralogs for EIF4A2 Gene

Variants for EIF4A2 Gene

Sequence variations from dbSNP and Humsavar for EIF4A2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_035838 A breast cancer sample p.Val181Leu
rs1000181570 -- 186,783,198(+) G/T upstream_transcript_variant
rs1000369195 -- 186,786,981(+) T/C/G intron_variant
rs1000742171 -- 186,786,795(+) G/C intron_variant
rs1001137050 -- 186,785,598(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4A2 Gene

Variant ID Type Subtype PubMed ID
dgv5005n100 CNV gain 25217958
esv2759206 CNV loss 17122850
esv34136 CNV loss 18971310
esv3893839 CNV gain 25118596
nsv1012615 CNV gain 25217958
nsv10365 CNV loss 18304495
nsv526938 CNV gain 19592680
nsv963390 CNV duplication 23825009

Variation tolerance for EIF4A2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4A2 Gene

Human Gene Mutation Database (HGMD)
EIF4A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4A2 Gene

Disorders for EIF4A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF4A2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 29
  • rp29
x-linked hereditary ataxia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF4A2

genes like me logo Genes that share disorders with EIF4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4A2 Gene

Publications for EIF4A2 Gene

  1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PMID: 8521730) Sudo K … Nakamura Y (Cytogenetics and cell genetics 1995) 2 3 4 58
  2. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PMID: 16014927) Feng P … Read GS (Journal of virology 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PMID: 11922617) Kyono K … Taguchi I (Biochemical and biophysical research communications 2002) 3 22 58
  5. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PMID: 11408474) Li W … Proud CG (The Journal of biological chemistry 2001) 3 4 58

Products for EIF4A2 Gene

Sources for EIF4A2 Gene

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