Aliases for EIF4A2 Gene

Aliases for EIF4A2 Gene

  • Eukaryotic Translation Initiation Factor 4A2 2 3 5
  • DDX2B 2 3 4
  • Eukaryotic Initiation Factor 4A-II 3 4
  • ATP-Dependent RNA Helicase EIF4A-2 3 4
  • EIF-4A-II 3 4
  • EIF4A-II 3 4
  • BM-010 2 3
  • EIF4A 2 3
  • EIF4F 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 2 2
  • EC 3.6.4.13 4
  • EC 3.6.1 51
  • EIF4A2 5

External Ids for EIF4A2 Gene

Previous HGNC Symbols for EIF4A2 Gene

  • EIF4F

Previous GeneCards Identifiers for EIF4A2 Gene

  • GC03P183276
  • GC03P187758
  • GC03P187903
  • GC03P187822
  • GC03P187984
  • GC03P186503
  • GC03P186522
  • GC03P186528
  • GC03P186533
  • GC03P186539
  • GC03P186548
  • GC03P186556
  • GC03P186574

Summaries for EIF4A2 Gene

GeneCards Summary for EIF4A2 Gene

EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Ovary Sarcoma and Noonan Syndrome 6. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot Summary for EIF4A2 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A2 Gene

Additional gene information for EIF4A2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4A2 Gene

Genomics for EIF4A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF4A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4A2

Top Transcription factor binding sites by QIAGEN in the EIF4A2 gene promoter:
  • E2F
  • Elk-1
  • Evi-1
  • Lmo2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SREBP-1b
  • SREBP-1c
  • STAT5A

Genomic Locations for EIF4A2 Gene

Genomic Locations for EIF4A2 Gene
chr3:186,783,205-186,789,897
(GRCh38/hg38)
Size:
6,693 bases
Orientation:
Plus strand
chr3:186,500,994-186,507,689
(GRCh37/hg19)
Size:
6,696 bases
Orientation:
Plus strand

Genomic View for EIF4A2 Gene

Genes around EIF4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A2 Gene

Proteins for EIF4A2 Gene

  • Protein details for EIF4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14240-IF4A2_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-II
    Protein Accession:
    Q14240
    Secondary Accessions:
    • D3DNU9
    • Q53XJ6
    • Q96B90
    • Q96EA8

    Protein attributes for EIF4A2 Gene

    Size:
    407 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1.
    • (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 protein Vhs.

    Three dimensional structures from OCA and Proteopedia for EIF4A2 Gene

    Alternative splice isoforms for EIF4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A2 Gene

Selected DME Specific Peptides for EIF4A2 Gene

Q14240:
  • EEWKLDTL
  • DEMLSRGF
  • EFRSGSSR
  • HACIGGT
  • GRGGRFG
  • PTRELAQQ
  • FEKPSAIQQR
  • LLSATMP
  • RKVDWLT
  • FVLDEAD
  • QAQSGTGKTATF
  • QVVLLSAT
  • VGTPGRV
  • TKKFMRDP
  • LEVTKKFM
  • VTEEDKR
  • LAPTREL
  • TTDLLARG
  • DPIRILVK
  • ELTLEGI
  • LLRGIYAY
  • LRDIETFYNT
  • GVIESNWNEIVD
  • EMPMNVADL
  • AQAQSGTGKT
  • LARGIDV
  • GRFGRKGV
  • ARDFTVSA
  • IVVGTPG
  • GRKGVAI
  • ARGIDVQQ
  • RILRDIE
  • VINYDLP
  • ETQALVL
  • GVAINFV
  • APTRELA
  • GTPGRVFDM
  • VVGTPGR
  • QFYINVE
  • EGIKQFY
  • DEADEML
  • TDLLARGID
  • YIHRIGR

Post-translational modifications for EIF4A2 Gene

  • Ubiquitination at Lys310 and Lys370
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for EIF4A2

Domains & Families for EIF4A2 Gene

Gene Families for EIF4A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4A2 Gene

Suggested Antigen Peptide Sequences for EIF4A2 Gene

GenScript: Design optimal peptide antigens:
  • ATP-dependent RNA helicase eIF4A-2 (IF4A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14240

UniProtKB/Swiss-Prot:

IF4A2_HUMAN :
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A2: view

Function for EIF4A2 Gene

Molecular function for EIF4A2 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.
GENATLAS Biochemistry:
eukaryotic,cap structure,translation initiation factor EIF4A,isoform 2,involved in the binding of mRNA to ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family

Enzyme Numbers (IUBMB) for EIF4A2 Gene

Phenotypes From GWAS Catalog for EIF4A2 Gene

Gene Ontology (GO) - Molecular Function for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,HDA 22658674
GO:0003724 RNA helicase activity IBA --
GO:0003743 translation initiation factor activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with EIF4A2: view
genes like me logo Genes that share phenotypes with EIF4A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EIF4A2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4A2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A2 Gene

Localization for EIF4A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4A2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 8521730
GO:0048471 perinuclear region of cytoplasm IDA 11922617
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A2 Gene

Pathways & Interactions for EIF4A2 Gene

genes like me logo Genes that share pathways with EIF4A2: view

Pathways by source for EIF4A2 Gene

3 GeneGo (Thomson Reuters) pathways for EIF4A2 Gene
  • Translation Regulation of EIF4F activity
  • Translation Insulin regulation of translation
  • Translation Translation regulation by Alpha-1 adrenergic receptors
4 Qiagen pathways for EIF4A2 Gene
  • eIF2 Pathway
  • Insulin Receptor Pathway
  • mTOR Pathway
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for EIF4A2 Gene

Gene Ontology (GO) - Biological Process for EIF4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002183 cytoplasmic translational initiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation TAS 8521730
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EIF4A2: view

No data available for SIGNOR curated interactions for EIF4A2 Gene

Drugs & Compounds for EIF4A2 Gene

(3) Drugs for EIF4A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for EIF4A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with EIF4A2: view

Transcripts for EIF4A2 Gene

mRNA/cDNA for EIF4A2 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4A2

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20:
SP21: - - -
SP22: - - - -
SP23: - -
SP24:
SP25:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19: - -
SP20: - -
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for EIF4A2 Gene

GeneLoc Exon Structure for
EIF4A2

Expression for EIF4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4A2 Gene



Protein tissue co-expression partners for EIF4A2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4A2

SOURCE GeneReport for Unigene cluster for EIF4A2 Gene:

Hs.518475

Evidence on tissue expression from TISSUES for EIF4A2 Gene

  • Nervous system(5)
  • Muscle(5)
  • Lung(4.9)
  • Liver(4.8)
  • Intestine(4.7)
  • Kidney(4.7)
  • Heart(4.7)
  • Bone marrow(4.6)
  • Stomach(4.6)
  • Blood(4.4)
  • Pancreas(4.4)
  • Eye(3.8)
  • Skin(3.7)
  • Spleen(3.6)
  • Lymph node(3)
  • Thyroid gland(3)
  • Adrenal gland(2.8)
  • Bone(2.7)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with EIF4A2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4A2 Gene

Orthologs for EIF4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF4A2 30 31
  • 99.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF4A2 30 31
  • 96.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF4A2 30 31
  • 96.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF4A2 31
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif4a2 30
  • 94.43 (n)
Mouse
(Mus musculus)
Mammalia Eif4a2 30 17 31
  • 94.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 77 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves EIF4A2 30 31
  • 88.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF4A2 31
  • 98 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.2528 30
Zebrafish
(Danio rerio)
Actinopterygii eif4a2 31
  • 96 (a)
OneToOne
wufd50g11 30
Fruit Fly
(Drosophila melanogaster)
Insecta eIF-4a 30 31 32
  • 66.92 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009863 30
  • 65.08 (n)
Worm
(Caenorhabditis elegans)
Secernentea inf-1 30 31 32
  • 64.01 (n)
ManyToMany
F57B9.3 31 32
  • 52 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAL1 31
  • 57 (a)
OneToMany
TIF2 33
TIF1 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EIF4A-2 30
  • 68.68 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0701100 30
  • 68.07 (n)
Corn
(Zea mays)
Liliopsida Zm.437 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10997 31
  • 80 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1890 30
Species where no ortholog for EIF4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF4A2 Gene

ENSEMBL:
Gene Tree for EIF4A2 (if available)
TreeFam:
Gene Tree for EIF4A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF4A2: view image

Paralogs for EIF4A2 Gene

(41) SIMAP similar genes for EIF4A2 Gene using alignment to 8 proteins:

  • IF4A2_HUMAN
  • C9JUF0_HUMAN
  • E7EMV8_HUMAN
  • E7EQG2_HUMAN
  • E9PBH4_HUMAN
  • F8WE11_HUMAN
  • J3KSN7_HUMAN
  • Q9NZE6_HUMAN

Pseudogenes.org Pseudogenes for EIF4A2 Gene

genes like me logo Genes that share paralogs with EIF4A2: view

Variants for EIF4A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF4A2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
VAR_035838 A breast cancer sample p.Val181Leu
rs11538616 - p.Gln93His

Additional dbSNP identifiers (rs#s) for EIF4A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF4A2 Gene

Variant ID Type Subtype PubMed ID
dgv5005n100 CNV gain 25217958
esv2759206 CNV loss 17122850
esv34136 CNV loss 18971310
esv3893839 CNV gain 25118596
nsv1012615 CNV gain 25217958
nsv10365 CNV loss 18304495
nsv526938 CNV gain 19592680
nsv963390 CNV duplication 23825009

Variation tolerance for EIF4A2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF4A2 Gene

Human Gene Mutation Database (HGMD)
EIF4A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4A2 Gene

Disorders for EIF4A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF4A2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovary sarcoma
  • sarcoma of ovary
noonan syndrome 6
  • ns6
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with EIF4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF4A2 Gene

Publications for EIF4A2 Gene

  1. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. (PMID: 8521730) Sudo K … Nakamura Y (Cytogenetics and cell genetics 1995) 2 3 4
  2. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. (PMID: 16014927) Feng P … Read GS (Journal of virology 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. (PMID: 11922617) Kyono K … Taguchi I (Biochemical and biophysical research communications 2002) 3 23
  5. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. (PMID: 11408474) Li W … Proud CG (The Journal of biological chemistry 2001) 3 4

Products for EIF4A2 Gene

Sources for EIF4A2 Gene