Aliases for EIF4A1 Gene

Aliases for EIF4A1 Gene

  • Eukaryotic Translation Initiation Factor 4A1 2 3 5
  • DDX2A 2 3 4
  • ATP-Dependent RNA Helicase EIF4A-1 3 4
  • Eukaryotic Initiation Factor 4A-I 3 4
  • EIF-4A-I 3 4
  • EIF4A-I 3 4
  • EIF-4A 2 3
  • EIF4A 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 1 2
  • Eukaryotic Translation Initiation Factor 4A 3
  • Eukaryotic Initiation Factor 4AI 3
  • EC 3.6.4.13 4
  • EC 3.6.1 51
  • EIF4A1 5

External Ids for EIF4A1 Gene

Previous HGNC Symbols for EIF4A1 Gene

  • EIF4A

Previous GeneCards Identifiers for EIF4A1 Gene

  • GC17P007880
  • GC17P008215
  • GC17P007418
  • GC17P007676
  • GC17P007416
  • GC17P007404
  • GC17P007476

Summaries for EIF4A1 Gene

GeneCards Summary for EIF4A1 Gene

EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Diseases associated with EIF4A1 include Noonan Syndrome 6. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A2.

UniProtKB/Swiss-Prot Summary for EIF4A1 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF4A1 Gene

Genomics for EIF4A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF4A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF4A1

Top Transcription factor binding sites by QIAGEN in the EIF4A1 gene promoter:
  • AP-1
  • CREB
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for EIF4A1 Gene

Genomic Locations for EIF4A1 Gene
chr17:7,572,706-7,579,006
(GRCh38/hg38)
Size:
6,301 bases
Orientation:
Plus strand
chr17:7,476,024-7,482,324
(GRCh37/hg19)
Size:
6,301 bases
Orientation:
Plus strand

Genomic View for EIF4A1 Gene

Genes around EIF4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A1 Gene

Proteins for EIF4A1 Gene

  • Protein details for EIF4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60842-IF4A1_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-I
    Protein Accession:
    P60842
    Secondary Accessions:
    • B2R6L8
    • D3DTP9
    • J3QLC4
    • P04765
    • Q5U018
    • Q61516

    Protein attributes for EIF4A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    46154 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with DDX3X in an RNA-independent manner (PubMed:18596238).
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL69.

    Three dimensional structures from OCA and Proteopedia for EIF4A1 Gene

    Alternative splice isoforms for EIF4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A1 Gene

Selected DME Specific Peptides for EIF4A1 Gene

P60842:
  • QIYDIFQ
  • EEWKLDTL
  • DEMLSRGF
  • EFRSGSSR
  • HACIGGT
  • PSAIQQRAIL
  • SAMHGDMDQ
  • GRGGRFG
  • PTRELAQQ
  • FEKPSAIQQR
  • LLSATMP
  • RKVDWLT
  • FVLDEAD
  • QAQSGTGKTATF
  • QVVLLSAT
  • VGTPGRV
  • TKKFMRDP
  • LEVTKKFM
  • VTEEDKR
  • LAPTREL
  • TTDLLARG
  • DPIRILVK
  • ELTLEGI
  • LLRGIYAY
  • LRDIETFYNT
  • FTVSAMHGDM
  • GVIESNWNEIVD
  • AQAQSGTGKT
  • LARGIDV
  • GRFGRKGV
  • ARDFTVSA
  • GRKGVAI
  • MEPEGVIES
  • ARGIDVQQ
  • VINYDLP
  • PHIIVGTPGR
  • APTRELA
  • GTPGRVFDM
  • QFYINVE
  • DEADEML
  • TDLLARGID
  • YIHRIGR

Post-translational modifications for EIF4A1 Gene

  • Ubiquitination at Lys146, Lys174, Lys177, Lys193, Lys237, Lys238, Lys309, Lys369, and Lys381
  • Modification sites at PhosphoSitePlus

Domains & Families for EIF4A1 Gene

Gene Families for EIF4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF4A1 Gene

Suggested Antigen Peptide Sequences for EIF4A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58012, moderately similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (B4DKP9_HUMAN)
  • cDNA FLJ57766, moderately similar to Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (B4E102_HUMAN)
  • ATP-dependent RNA helicase eIF4A-1 (IF4A1_HUMAN)
  • Eukaryotic initiation factor 4AI (Q9NZR9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60842

UniProtKB/Swiss-Prot:

IF4A1_HUMAN :
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A1: view

Function for EIF4A1 Gene

Molecular function for EIF4A1 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Helicase activity and function in translation are inhibited by interaction with PDCD4.
GENATLAS Biochemistry:
eukaryotic,cap structure,translocation factor EIF4A,isoform1,involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family,tightly linked to CD8 in same orientation

Enzyme Numbers (IUBMB) for EIF4A1 Gene

Phenotypes From GWAS Catalog for EIF4A1 Gene

Gene Ontology (GO) - Molecular Function for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000339 RNA cap binding TAS 3215517
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,HDA 22658674
GO:0003724 RNA helicase activity IBA --
genes like me logo Genes that share ontologies with EIF4A1: view
genes like me logo Genes that share phenotypes with EIF4A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A1 Gene

Localization for EIF4A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4A1 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9168945
genes like me logo Genes that share ontologies with EIF4A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A1 Gene

Pathways & Interactions for EIF4A1 Gene

genes like me logo Genes that share pathways with EIF4A1: view

Pathways by source for EIF4A1 Gene

1 KEGG pathway for EIF4A1 Gene
3 GeneGo (Thomson Reuters) pathways for EIF4A1 Gene
  • Translation Regulation of EIF4F activity
  • Translation Insulin regulation of translation
  • Translation Translation regulation by Alpha-1 adrenergic receptors
2 R&D Systems pathways for EIF4A1 Gene
4 Qiagen pathways for EIF4A1 Gene
  • eIF2 Pathway
  • Insulin Receptor Pathway
  • mTOR Pathway
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for EIF4A1 Gene

SIGNOR curated interactions for EIF4A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002183 cytoplasmic translational initiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EIF4A1: view

Drugs & Compounds for EIF4A1 Gene

(4) Drugs for EIF4A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 249
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for EIF4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with EIF4A1: view

Transcripts for EIF4A1 Gene

mRNA/cDNA for EIF4A1 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
37 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF4A1

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - -
SP10: -
SP11: -
SP12: -
SP13: -
SP14: - -
SP15: - - - - - - - -
SP16: - - - -
SP17:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for EIF4A1 Gene

GeneLoc Exon Structure for
EIF4A1

Expression for EIF4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4A1 Gene



Protein tissue co-expression partners for EIF4A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF4A1

SOURCE GeneReport for Unigene cluster for EIF4A1 Gene:

Hs.129673

Evidence on tissue expression from TISSUES for EIF4A1 Gene

  • Lung(5)
  • Nervous system(5)
  • Liver(5)
  • Skin(4.9)
  • Pancreas(4.9)
  • Blood(4.9)
  • Intestine(4.8)
  • Heart(4.7)
  • Eye(4.7)
  • Kidney(4.7)
  • Bone marrow(4.6)
  • Stomach(4.3)
  • Bone(4)
  • Muscle(3.9)
  • Spleen(3.1)
  • Lymph node(3)
  • Adrenal gland(2.7)
  • Thyroid gland(2.5)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with EIF4A1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4A1 Gene

Orthologs for EIF4A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF4A1 30 31
  • 99.26 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF4A1 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF4A1 30 31
  • 92.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eif4a1 30 17 31
  • 92.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif4a1 30
  • 92.45 (n)
Dog
(Canis familiaris)
Mammalia EIF4A1 30 31 31
  • 92.12 (n)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF4A1 31
  • 89 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF4A1 31
  • 83 (a)
OneToOne