Aliases for EIF3I Gene

Aliases for EIF3I Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit I 2 3 4 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
  • TGF-Beta Receptor-Interacting Protein 1 3 4
  • EIF3S2 3 4
  • TRIP-1 3 4
  • TRIP1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit I 2
  • TGFbeta Receptor-Interacting Protein 1 3
  • Predicted Protein Of HQ2242 3
  • EIF-3-Beta 4
  • EIF3-Beta 3
  • EIF3-P36 3
  • EIF3 P36 4
  • PRO2242 3
  • EIF3i 4

External Ids for EIF3I Gene

Previous HGNC Symbols for EIF3I Gene

  • EIF3S2

Previous GeneCards Identifiers for EIF3I Gene

  • GC01P032462
  • GC01P032687
  • GC01P030804

Summaries for EIF3I Gene

GeneCards Summary for EIF3I Gene

EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Diseases associated with EIF3I include Stomatitis and Clonorchiasis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Gene Expression. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot Summary for EIF3I Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3I Gene

Additional gene information for EIF3I Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3I Gene

Genomics for EIF3I Gene

GeneHancer (GH) Regulatory Elements for EIF3I Gene

Promoters and enhancers for EIF3I Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3I on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3I

Top Transcription factor binding sites by QIAGEN in the EIF3I gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • E47
  • FOXD1
  • HSF1 (long)
  • HSF1short
  • Sox5
  • YY1

Genomic Locations for EIF3I Gene

Genomic Locations for EIF3I Gene
chr1:32,221,867-32,231,604
(GRCh38/hg38)
Size:
9,738 bases
Orientation:
Plus strand
chr1:32,687,529-32,697,205
(GRCh37/hg19)
Size:
9,677 bases
Orientation:
Plus strand

Genomic View for EIF3I Gene

Genes around EIF3I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3I Gene

Proteins for EIF3I Gene

  • Protein details for EIF3I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13347-EIF3I_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit I
    Protein Accession:
    Q13347

    Protein attributes for EIF3I Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

neXtProt entry for EIF3I Gene

Post-translational modifications for EIF3I Gene

  • Phosphorylated by TGF-beta type II receptor.
  • Ubiquitination at Lys2, Lys30, Lys65, Lys85, Lys91, Lys148, Lys176, Lys185, Lys208, Lys213, Lys224, Lys264, Lys282, and Lys298
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3I Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3I Gene

Domains & Families for EIF3I Gene

Gene Families for EIF3I Gene

Protein Domains for EIF3I Gene

Blocks:
  • G-protein beta WD-40 repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF3I Gene

GenScript: Design optimal peptide antigens:
  • eIF3 p36 (EIF3I_HUMAN)
  • cDNA FLJ78316, highly similar to Homo sapiens eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa (EIF3S2), mRNA (Q5U0F4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13347

UniProtKB/Swiss-Prot:

EIF3I_HUMAN :
  • Belongs to the eIF-3 subunit I family.
Family:
  • Belongs to the eIF-3 subunit I family.
genes like me logo Genes that share domains with EIF3I: view

Function for EIF3I Gene

Molecular function for EIF3I Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Phenotypes From GWAS Catalog for EIF3I Gene

Gene Ontology (GO) - Molecular Function for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 25849773
GO:0005515 protein binding IEA,IPI 14688252
genes like me logo Genes that share ontologies with EIF3I: view
genes like me logo Genes that share phenotypes with EIF3I: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3I

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3I Gene

Localization for EIF3I Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3I Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3I gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Pathways & Interactions for EIF3I Gene

genes like me logo Genes that share pathways with EIF3I: view

SIGNOR curated interactions for EIF3I Gene

Activates:

Gene Ontology (GO) - Biological Process for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IEA --
GO:0002183 cytoplasmic translational initiation IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with EIF3I: view

Drugs & Compounds for EIF3I Gene

No Compound Related Data Available

Transcripts for EIF3I Gene

mRNA/cDNA for EIF3I Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3I

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for EIF3I Gene

GeneLoc Exon Structure for
EIF3I

Expression for EIF3I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3I Gene

Protein differential expression in normal tissues from HIPED for EIF3I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3I Gene



Protein tissue co-expression partners for EIF3I Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3I

SOURCE GeneReport for Unigene cluster for EIF3I Gene:

Hs.530096

Evidence on tissue expression from TISSUES for EIF3I Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Muscle(4.5)
  • Skin(4.1)
  • Liver(3.6)
  • Blood(2.9)
  • Kidney(2.9)
  • Intestine(2.8)
  • Eye(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with EIF3I: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3I Gene

Orthologs for EIF3I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3I 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3I 31
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3I 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3I 31 30
  • 93.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3I 31 30
  • 92.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3i 30
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Eif3i 17 31 30
  • 91.28 (n)
chicken
(Gallus gallus)
Aves EIF3I 31 30
  • 83.59 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3I 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3i 30
  • 78.46 (n)
Str.5958 30
zebrafish
(Danio rerio)
Actinopterygii eif3i 31 30
  • 75.49 (n)
OneToOne
Dr.895 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10798 30
fruit fly
(Drosophila melanogaster)
Insecta Trip1 31 30
  • 61.52 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3I_ANOGA 30
  • 59.67 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.I 31 30
  • 50.62 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR264C 30
  • 53.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 33 31 30
  • 52.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07403g 30
  • 52.1 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46290 30
  • 53.15 (n)
soybean
(Glycine max)
eudicotyledons Gma.3948 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.282 30
rice
(Oryza sativa)
Liliopsida Os05g0256000 30
  • 54.49 (n)
Os.7231 30
barley
(Hordeum vulgare)
Liliopsida Hv.2368 30
wheat
(Triticum aestivum)
Liliopsida Ta.2846 30
bread mold
(Neurospora crassa)
Ascomycetes NCU03876 30
  • 57.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum1 30
  • 52.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4745 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4745 30
Species where no ortholog for EIF3I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3I Gene

ENSEMBL:
Gene Tree for EIF3I (if available)
TreeFam:
Gene Tree for EIF3I (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3I: view image

Paralogs for EIF3I Gene

(4) SIMAP similar genes for EIF3I Gene using alignment to 2 proteins:

  • EIF3I_HUMAN
  • Q5TFK1_HUMAN

Pseudogenes.org Pseudogenes for EIF3I Gene

genes like me logo Genes that share paralogs with EIF3I: view

No data available for Paralogs for EIF3I Gene

Variants for EIF3I Gene

Additional dbSNP identifiers (rs#s) for EIF3I Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF3I Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for EIF3I Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3I

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3I Gene

Disorders for EIF3I Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF3I Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
stomatitis
clonorchiasis
  • oriental liver fluke disease
- elite association - COSMIC cancer census association via MalaCards
Search EIF3I in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF3I

genes like me logo Genes that share disorders with EIF3I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3I Gene

Publications for EIF3I Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PMID: 7566156) Chen RH … Derynck R (Nature 1995) 2 3 4 54
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 54
  4. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. (PMID: 19329541) Navarro A … Ekekezie II (American journal of physiology. Lung cellular and molecular physiology 2009) 3 23 54
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 54

Products for EIF3I Gene