Aliases for EIF3I Gene
- Eukaryotic Translation Initiation Factor 3 Subunit I 2 3 4 5
- Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
- TGF-Beta Receptor-Interacting Protein 1 3 4
- EIF3S2 3 4
- TRIP-1 3 4
- TRIP1 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
External Ids for EIF3I Gene
Previous HGNC Symbols for EIF3I Gene
Previous GeneCards Identifiers for EIF3I Gene
GeneCards Summary for EIF3I Gene
EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Diseases associated with EIF3I include Stomatitis and Clonorchiasis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Gene Expression. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
UniProtKB/Swiss-Prot Summary for EIF3I Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).