Aliases for EIF3H Gene

Aliases for EIF3H Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit H 2 3 4 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 3 3 4
  • EIF3 P40 Subunit 3 4
  • EIF-3-Gamma 3 4
  • EIF3-Gamma 2 3
  • EIF3-P40 2 3
  • EIF3S3 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit H 2
  • EIF3H 5
  • EIF3h 4

External Ids for EIF3H Gene

Previous HGNC Symbols for EIF3H Gene

  • EIF3S3

Previous GeneCards Identifiers for EIF3H Gene

  • GC08M117727
  • GC08M112983
  • GC08M117654

Summaries for EIF3H Gene

GeneCards Summary for EIF3H Gene

EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type Ii and Prostate Cancer. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is COPS5.

UniProtKB/Swiss-Prot Summary for EIF3H Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3H Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3H Gene

Genomics for EIF3H Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF3H Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J116765 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 262.6 -0.1 -65 3.2 BCLAF1 SP1 ZNF207 MYC SIX5 SSRP1 ZNF592 ATF2 POLR2A CEBPA UTP23 EIF3H HSALNG0067937 RAD21
GH08J116754 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.2 +11.3 11325 2.4 BCLAF1 ZNF207 MYC IKZF1 JUND ZNF580 ATF2 POLR2A BRCA1 YY1 EIF3H HSALNG0067936 lnc-RAD21-3 UTP23 MED30 AB372787 TRPS1
GH08J117519 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12 -754.2 -754157 2.6 SP1 ZNF600 ATF2 CEBPA BRCA1 POLR2A ZIC2 CHD4 ZBTB10 YY1 MED30 HSALNG0067961 LOC105375716 lnc-EXT1-4 UTP23 EIF3H EXT1 RPS10P16 RF00017-6704
GH08J116656 Promoter/Enhancer 1.5 UCNEbase Ensembl ENCODE CraniofacialAtlas 6.4 +108.7 108694 2.9 ZNF341 RAD21 PRDM6 IRF9 ZNF362 ATF4 CTCF BHLHE40 TRIM28 CEBPB EIF3H LOC105375713 lnc-UTP23-4 lnc-RAD21-3 UTP23 TRPS1
GH08J116703 Enhancer 0.5 Ensembl 6.5 +63.6 63604 0.4 IKZF1 CTCF EBF1 RAD21 SMC3 TRIM22 EIF3H UTP23 HSALNG0067935 piR-31937-246 lnc-RAD21-3 TRPS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3H on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3H

Top Transcription factor binding sites by QIAGEN in the EIF3H gene promoter:
  • aMEF-2
  • c-Myc
  • C/EBPalpha
  • FOXI1
  • HFH-3
  • Max1
  • MEF-2A
  • MyoD
  • Sox5
  • Sp1

Genomic Locations for EIF3H Gene

Latest Assembly
chr8:116,642,130-116,766,925
(GRCh38/hg38)
Size:
124,796 bases
Orientation:
Minus strand

Previous Assembly
chr8:117,654,369-117,768,062
(GRCh37/hg19 by Entrez Gene)
Size:
113,694 bases
Orientation:
Minus strand

chr8:117,654,369-117,779,164
(GRCh37/hg19 by Ensembl)
Size:
124,796 bases
Orientation:
Minus strand

Genomic View for EIF3H Gene

Genes around EIF3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3H Gene

Proteins for EIF3H Gene

  • Protein details for EIF3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15372-EIF3H_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit H
    Protein Accession:
    O15372

    Protein attributes for EIF3H Gene

    Size:
    352 amino acids
    Molecular mass:
    39930 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).

    Three dimensional structures from OCA and Proteopedia for EIF3H Gene

neXtProt entry for EIF3H Gene

Post-translational modifications for EIF3H Gene

  • Ubiquitination at Lys5, Lys24, Lys227, Lys259, Lys303, Lys306, Lys331, and Lys340
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3H Gene

Domains & Families for EIF3H Gene

Gene Families for EIF3H Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for EIF3H Gene

InterPro:
Blocks:
  • Mov34 family

Suggested Antigen Peptide Sequences for EIF3H Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35809 fis, clone TESTI2006016, highly similar to Eukaryotic translation initiation factor 3 subunit 3 (B3KS98_HUMAN)
  • eIF3 p40 subunit (EIF3H_HUMAN)
  • EIF3H protein (Q5BKY2_HUMAN)
  • Eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa, isoform CRA_a (Q6IB98_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15372

UniProtKB/Swiss-Prot:

EIF3H_HUMAN :
  • Belongs to the eIF-3 subunit H family.
Family:
  • Belongs to the eIF-3 subunit H family.
genes like me logo Genes that share domains with EIF3H: view

Function for EIF3H Gene

Molecular function for EIF3H Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Phenotypes From GWAS Catalog for EIF3H Gene

Gene Ontology (GO) - Molecular Function for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IEA,IPI 12812986
GO:0008237 NOT metallopeptidase activity IEA,IKR 17559875
GO:0070122 isopeptidase activity IEA --
genes like me logo Genes that share ontologies with EIF3H: view
genes like me logo Genes that share phenotypes with EIF3H: view

Animal Models for EIF3H Gene

MGI Knock Outs for EIF3H:
  • Eif3h Eif3h<tm1a(EUCOMM)Hmgu>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3H

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3H Gene

Localization for EIF3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3H gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016020 membrane HDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with EIF3H: view

Pathways & Interactions for EIF3H Gene

genes like me logo Genes that share pathways with EIF3H: view

Pathways by source for EIF3H Gene

Gene Ontology (GO) - Biological Process for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IEA --
GO:0002183 cytoplasmic translational initiation IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation TAS 9341143
genes like me logo Genes that share ontologies with EIF3H: view

No data available for SIGNOR curated interactions for EIF3H Gene

Drugs & Compounds for EIF3H Gene

No Compound Related Data Available

Transcripts for EIF3H Gene

mRNA/cDNA for EIF3H Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3H

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for EIF3H Gene

GeneLoc Exon Structure for
EIF3H

Expression for EIF3H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3H Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EIF3H Gene



Protein tissue co-expression partners for EIF3H Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3H

SOURCE GeneReport for Unigene cluster for EIF3H Gene:

Hs.492599

Evidence on tissue expression from TISSUES for EIF3H Gene

  • Lung(4.8)
  • Liver(4.7)
  • Intestine(4.5)
  • Nervous system(4.5)
  • Skin(4)
  • Eye(3.7)
  • Pancreas(3)
  • Lymph node(2.8)
  • Kidney(2.7)
  • Muscle(2.6)
  • Heart(2.5)
  • Thyroid gland(2.4)
  • Blood(2.3)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Spleen(2.2)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with EIF3H: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3H Gene

Orthologs for EIF3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3H Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF3H 29 30
  • 99.91 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF3H 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF3H 29 30
  • 93.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF3H 29 30
  • 92.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif3h 29
  • 89.77 (n)
Mouse
(Mus musculus)
Mammalia Eif3h 29 16 30
  • 89.49 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF3H 30
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EIF3H 29 30
  • 82.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF3H 30
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif3h 29
  • 74.53 (n)
MGC75580 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.7704 29
Zebrafish
(Danio rerio)
Actinopterygii eif3hb 29 30
  • 75.84 (n)
OneToOne
wufj02c04 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8437 29
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3H_ANOGA 29
  • 56.98 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta eIF-3p40 29 30
  • 53.97 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea eif-3.H 29 30
  • 51.38 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TIF3H1 29
  • 52.26 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0376500 29
  • 51.91 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2326 30
  • 54 (a)
OneToOne
Species where no ortholog for EIF3H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF3H Gene

ENSEMBL:
Gene Tree for EIF3H (if available)
TreeFam:
Gene Tree for EIF3H (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3H: view image
Alliance of Genome Resources:
Additional Orthologs for EIF3H

Paralogs for EIF3H Gene

Paralogs for EIF3H Gene

(1) SIMAP similar genes for EIF3H Gene using alignment to 8 proteins:

  • EIF3H_HUMAN
  • E5RFH0_HUMAN
  • E5RFW7_HUMAN
  • E5RGU4_HUMAN
  • E5RH59_HUMAN
  • E5RHC7_HUMAN
  • E5RJT0_HUMAN
  • Q5BKY2_HUMAN
genes like me logo Genes that share paralogs with EIF3H: view

Variants for EIF3H Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EIF3H Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EIF3H Gene

Variant ID Type Subtype PubMed ID
esv1006976 CNV insertion 20482838
esv3443500 CNV duplication 20981092
nsv480443 CNV novel sequence insertion 20440878
nsv821264 CNV duplication 20802225
nsv824723 CNV loss 20364138
nsv981975 CNV duplication 23825009

Variation tolerance for EIF3H Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3H Gene

Human Gene Mutation Database (HGMD)
EIF3H
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3H
Leiden Open Variation Database (LOVD)
EIF3H

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3H Gene

Disorders for EIF3H Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF3H Gene - From: COP and GCD

Disorder Aliases PubMed IDs
trichorhinophalangeal syndrome, type ii
  • trps2
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search EIF3H in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF3H

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EIF3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3H Gene

Publications for EIF3H Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4
  3. The DHX33 RNA Helicase Promotes mRNA Translation Initiation. (PMID: 26100019) Zhang Y … Weber J (Molecular and cellular biology 2015) 3 4
  4. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PMID: 20659471) Kupfer SS … Ellis NA (Gastroenterology 2010) 3 40
  5. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PMID: 20437058) Hawken SJ … Little J (Human genetics 2010) 3 40

Products for EIF3H Gene

Sources for EIF3H Gene