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Aliases for EIF3G Gene

Aliases for EIF3G Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit G 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit 3 4
  • EIF3S4 3 4
  • Eukaryotic Translation Initiation Factor 3 Subunit P42 3
  • Eukaryotic Translation Initiation Factor 3, Subunit G 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 4 4
  • EIF-3 RNA-Binding Subunit 4
  • EIF-3-Delta 4
  • EIF3-Delta 3
  • EIF3-P42 3
  • EIF3-P44 3
  • EIF3 P42 4
  • EIF3 P44 4
  • EIF3g 4

External Ids for EIF3G Gene

Previous HGNC Symbols for EIF3G Gene

  • EIF3S4

Previous GeneCards Identifiers for EIF3G Gene

  • GC19M010091
  • GC19M010225
  • GC19M009806

Summaries for EIF3G Gene

Entrez Gene Summary for EIF3G Gene

  • This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

GeneCards Summary for EIF3G Gene

EIF3G (Eukaryotic Translation Initiation Factor 3 Subunit G) is a Protein Coding gene. Diseases associated with EIF3G include Parainfluenza Virus Type 3 and Narcolepsy. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for EIF3G Gene

  • RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.

  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3G Gene

Additional gene information for EIF3G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3G Gene

Genomics for EIF3G Gene

GeneHancer (GH) Regulatory Elements for EIF3G Gene

Promoters and enhancers for EIF3G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010118 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.1 -0.6 -623 3.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 EIF3G KRI1 ZNF266 PPAN ILF3 RAVER1 FBXL12 DNMT1 TIMM29 ZNF699
GH19I010717 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.5 -599.2 -599232 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B DNM2 GC19P010718 MIR638 KRI1 EIF3G ILF3 FBXL12 RAVER1 TIMM29 PPAN
GH19I010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.7 +15.5 15536 8.3 HDGF FOXA2 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 ILF3 LOC100419831 ZNF317 FBXL12 ZNF559 KRI1
GH19I010285 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 33.1 -169.8 -169769 7.6 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ICAM5 ENSG00000267607 GC19P010288 GC19P010291 ICAM4 ILF3 ZNF266 ZNF699 KRI1 FBXL12
GH19I010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.8 -260.6 -260604 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TYK2 GC19P010382 ILF3 KRI1 FBXL12 DNMT1 PPAN RAVER1 LOC100419831 ZNF561
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF3G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF3G gene promoter:

Genomic Locations for EIF3G Gene

Genomic Locations for EIF3G Gene
chr19:10,115,014-10,119,923
(GRCh38/hg38)
Size:
4,910 bases
Orientation:
Minus strand
chr19:10,225,690-10,230,599
(GRCh37/hg19)

Genomic View for EIF3G Gene

Genes around EIF3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3G Gene

Proteins for EIF3G Gene

  • Protein details for EIF3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75821-EIF3G_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit G
    Protein Accession:
    O75821
    Secondary Accessions:
    • O14801
    • Q969U5

    Protein attributes for EIF3G Gene

    Size:
    320 amino acids
    Molecular mass:
    35611 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).

    Three dimensional structures from OCA and Proteopedia for EIF3G Gene

neXtProt entry for EIF3G Gene

Post-translational modifications for EIF3G Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys65 and posLast=180180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3G Gene

Domains & Families for EIF3G Gene

Gene Families for EIF3G Gene

Suggested Antigen Peptide Sequences for EIF3G Gene

Graphical View of Domain Structure for InterPro Entry

O75821

UniProtKB/Swiss-Prot:

EIF3G_HUMAN :
  • Belongs to the eIF-3 subunit G family.
Family:
  • Belongs to the eIF-3 subunit G family.
genes like me logo Genes that share domains with EIF3G: view

Function for EIF3G Gene

Molecular function for EIF3G Gene

UniProtKB/Swiss-Prot Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Phenotypes From GWAS Catalog for EIF3G Gene

Gene Ontology (GO) - Molecular Function for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 25849773
GO:0003743 contributes_to translation initiation factor activity IDA,IEA 17581632
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3G: view
genes like me logo Genes that share phenotypes with EIF3G: view

Animal Model Products

miRNA for EIF3G Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3G Gene

Localization for EIF3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3G Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3G gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IEA,IDA 12426392
GO:0005829 cytosol TAS,IDA --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with EIF3G: view

Pathways & Interactions for EIF3G Gene

genes like me logo Genes that share pathways with EIF3G: view

Gene Ontology (GO) - Biological Process for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0075525 viral translational termination-reinitiation IDA 21347434
genes like me logo Genes that share ontologies with EIF3G: view

No data available for SIGNOR curated interactions for EIF3G Gene

Drugs & Compounds for EIF3G Gene

No Compound Related Data Available

Transcripts for EIF3G Gene

Unigene Clusters for EIF3G Gene

Eukaryotic translation initiation factor 3, subunit G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - -
SP9: - - - -
SP10: -
SP11: - - -
SP12: - -
SP13: - -
SP14:

ExUns: 11b ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3G Gene

GeneLoc Exon Structure for
EIF3G
ECgene alternative splicing isoforms for
EIF3G

Expression for EIF3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3G Gene

Protein differential expression in normal tissues from HIPED for EIF3G Gene

This gene is overexpressed in Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3G Gene



Protein tissue co-expression partners for EIF3G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3G Gene:

EIF3G

SOURCE GeneReport for Unigene cluster for EIF3G Gene:

Hs.529059

Evidence on tissue expression from TISSUES for EIF3G Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(3.7)
  • Lung(3.6)
  • Muscle(2.7)
  • Eye(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with EIF3G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3G Gene

Orthologs for EIF3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3G 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia EIF3G 33 34
  • 92.6 (n)
dog
(Canis familiaris)
Mammalia EIF3G 33 34
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Eif3g 33 16 34
  • 89.17 (n)
rat
(Rattus norvegicus)
Mammalia Eif3g 33
  • 88.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3G 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF3G 33
  • 85.93 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3G 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3s4 33
  • 74.87 (n)
zebrafish
(Danio rerio)
Actinopterygii eif3g 33 34
  • 78.01 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9507 33
fruit fly
(Drosophila melanogaster)
Insecta CG10881 33 34
  • 57.28 (n)
CG8636 34
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3G_ANOGA 33
  • 56.77 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.G 33 34
  • 49.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR189W 33
  • 47.6 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00847g 33
  • 47.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF35 33 34 36
  • 43.9 (n)
rice
(Oryza sativa)
Liliopsida Os02g0788400 33
  • 53.77 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08046 33
  • 54.39 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif35 33
  • 50.5 (n)
Species where no ortholog for EIF3G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3G Gene

ENSEMBL:
Gene Tree for EIF3G (if available)
TreeFam:
Gene Tree for EIF3G (if available)

Paralogs for EIF3G Gene

No data available for Paralogs for EIF3G Gene

Variants for EIF3G Gene

Sequence variations from dbSNP and Humsavar for EIF3G Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs2305795 association, Cataplexy and narcolepsy 10,115,376(-) G/A intron_variant
rs3826784 association, Cataplexy and narcolepsy 10,116,334(-) A/G intron_variant
rs1000422727 -- 10,120,643(-) G/A upstream_transcript_variant
rs1001218919 -- 10,121,872(-) A/G upstream_transcript_variant
rs1001449988 -- 10,120,472(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3G Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for EIF3G Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3G Gene

Human Gene Mutation Database (HGMD)
EIF3G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3G

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3G Gene

Disorders for EIF3G Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF3G Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parainfluenza virus type 3
  • human parainfluenza virus type 3
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search EIF3G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF3G

genes like me logo Genes that share disorders with EIF3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3G Gene

Publications for EIF3G Gene

  1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PMID: 9822659) Block KL … Hershey JW (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee AS … Cate JH (Nature 2016) 3 4 58
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 58
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
  5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E … Leary JA (Molecular & cellular proteomics : MCP 2007) 3 4 58

Products for EIF3G Gene

Sources for EIF3G Gene

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