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This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016] See more...
Aliases for EIF3G Gene
Aliases for EIF3G Gene
- Eukaryotic Translation Initiation Factor 3 Subunit G 2 3 4 5
- Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa 2 3
- Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit 3 4
- EIF3-Delta 2 3
- EIF3-P44 2 3
- EIF3S4 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit P42 3
- Eukaryotic Translation Initiation Factor 3, Subunit G 2
External Ids for EIF3G Gene
- HGNC: 3274
- Entrez Gene: 8666
- Ensembl: ENSG00000130811
- OMIM: 603913
- UniProtKB: O75821
Previous HGNC Symbols for EIF3G Gene
- EIF3S4
Previous GeneCards Identifiers for EIF3G Gene
- GC19M010091
- GC19M010225
- GC19M009806
Summaries for EIF3G Gene
-
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
GeneCards Summary for EIF3G Gene
EIF3G (Eukaryotic Translation Initiation Factor 3 Subunit G) is a Protein Coding gene. Diseases associated with EIF3G include Narcolepsy. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot Summary for EIF3G Gene
-
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.
-
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Additional gene information for EIF3G Gene
- HGNC(3274)
- Entrez Gene(8666)
- Ensembl(ENSG00000130811)
- OMIM(603913)
- UniProtKB(O75821)
- Open Targets Platform(ENSG00000130811)
- Search for EIF3G at DataMed
- Search for EIF3G at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3G Gene
Genomics for EIF3G Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EIF3G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EIF3G on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3G
- Top Transcription factor binding sites by QIAGEN in the EIF3G gene promoter:
-
- AP-4
- AREB6
- FOXO1
- FOXO1a
- GATA-2
- Ik-2
- LyF-1
- ZIC2
Genomic Locations for EIF3G Gene
Genomic Locations for EIF3G Gene
- chr19:10,115,014-10,119,918
- (GRCh38/hg38)
- Size:
- 4,905 bases
- Orientation:
- Minus strand
- chr19:10,225,690-10,230,599
- (GRCh37/hg19)
- Size:
- 4,910 bases
- Orientation:
- Minus strand
Genomic View for EIF3G Gene
Genes around EIF3G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
EIF3G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF3G Gene
Proteins for EIF3G Gene
-
Protein details for EIF3G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75821-EIF3G_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 3 subunit G
- Protein Accession:
- O75821
- O14801
- Q969U5
Protein attributes for EIF3G Gene
- Size:
- 320 amino acids
- Molecular mass:
- 35611 Da
- Quaternary structure:
-
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus). Interacts with DHX33; the interaction is independent of RNA (PubMed:26100019).
Protein Expression for EIF3G Gene
Post-translational modifications for EIF3G Gene
- Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
-
Ubiquitination at Lys65 and Lys180
- NX_O75821 (NX_O75821-1)
- Modification sites at PhosphoSitePlus
Other Protein References for EIF3G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences EIF3G Antibody
- Novus Biologicals Antibodies for EIF3G
-
Abcam antibodies for EIF3G
- Invitrogen Antibodies for EIF3G (AFLGC-EIF3G)
- antibodies-online: Show 21 available EIF3G Antibodies ranked by validation data
- Compare Top EIF3G Antibodies
-
Recommended
- 70 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 27 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Biorbyt antibodies for EIF3G
-
Boster Bio Antibodies for EIF3G
- Sino Biological Antibodies for EIF3G
Protein Products
-
OriGene Purified Proteins for EIF3G
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3G
- Origene Custom Protein Services for EIF3G
-
Signalway Proteins for EIF3G
No data available for DME Specific Peptides for EIF3G Gene
Domains & Families for EIF3G Gene
Gene Families for EIF3G Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EIF3G Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for EIF3G Gene
- GenScript: Design optimal peptide antigens:
-
- eIF3 p44 (EIF3G_HUMAN)
- Eukaryotic translation initiation factor 3 subunit G (Q6IAM0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75821- Family:
-
- Belongs to the eIF-3 subunit G family.
Function for EIF3G Gene
Molecular function for EIF3G Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Phenotypes From GWAS Catalog for EIF3G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IDA | 25849773 |
| GO:0003743 | contributes_to translation initiation factor activity | IEA,IDA | 17581632 |
| GO:0005515 | protein binding | IPI | 14688252 |
Phenotypes for EIF3G Gene
- GenomeRNAi human phenotypes for EIF3G:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between BLM-/- and BLM+/+
- Synthetic lethal with Ras
- Increased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance
- Decreased NF-kappaB reporter expression
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Decreased human parainfluenza virus type 3 (HPIV3) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased S DNA content
- Decreased viability in colon lineage
- Increased cell death in HCC-1954 cells
- S arrest
- Increased cell death in DLD-1 cells
- Increased cell death in HCT116 cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF3G - Select products 50% OFF >
- * EIF3G CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EIF3G
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3G
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3G
miRNA for EIF3G Gene
- miRTarBase miRNAs that target EIF3G
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3G
- Browse OriGene Inhibitory RNA Products For EIF3G
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3G
Clone Products
- Applied Biological Materials (abm): Clones for EIF3G - Select products 50% OFF >
- * EIF3G as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EIF3G
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3G
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3G Gene
Localization for EIF3G Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF3G Gene
- Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | NOT nucleus | IDA | 12426392 |
| GO:0005737 | cytoplasm | IEA,IDA | 12426392 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005852 | eukaryotic translation initiation factor 3 complex | IEA,IDA | 17322308 |
| GO:0016282 | eukaryotic 43S preinitiation complex | IEA | -- |
Pathways & Interactions for EIF3G Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | RNA transport | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
|
| 5 | p70S6K Signaling |
mTOR Pathway
.54
|
|
Pathways by source for EIF3G Gene
1 BioSystems pathway for EIF3G Gene
12 Reactome pathways for EIF3G Gene
1 KEGG pathway for EIF3G Gene
2 Qiagen pathways for EIF3G Gene
- eIF2 Pathway
- mTOR Pathway
Interacting Proteins for EIF3G Gene
Selected Interacting proteins:
O75821-EIF3G_HUMAN
ENSP00000253108
for EIF3G Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EIF3G
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001732 | formation of cytoplasmic translation initiation complex | IEA | -- |
| GO:0002183 | cytoplasmic translational initiation | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA,TAS | -- |
| GO:0075525 | viral translational termination-reinitiation | IDA | 21347434 |
No data available for SIGNOR curated interactions for EIF3G Gene
Transcripts for EIF3G Gene
mRNA/cDNA for EIF3G Gene
- 1 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000253108 1103 nts (view in UCSC)
- ENST00000593054 453 nts (view in UCSC)
- ENST00000590158 1034 nts (view in UCSC)
- ENST00000589454 873 nts (view in UCSC)
- ENST00000587146 709 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF3G - Select products 50% OFF >
- * EIF3G CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EIF3G
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3G
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3G
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3G
- Browse OriGene Inhibitory RNA Products For EIF3G
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3G
Clone Products
- Applied Biological Materials (abm): Clones for EIF3G - Select products 50% OFF >
- * EIF3G as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EIF3G
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3G
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 11b | ^ | 12 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: |
Relevant External Links for EIF3G Gene
- GeneLoc Exon Structure for
- EIF3G
Expression for EIF3G Gene
This gene is overexpressed in Bone marrow stromal cell (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3G Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3G
SOURCE GeneReport for Unigene cluster for EIF3G Gene:
Hs.529059Evidence on tissue expression from TISSUES for EIF3G Gene
- Nervous system(4.9)
- Liver(4.5)
- Skin(4)
- Lung(3.6)
- Muscle(3.1)
- Intestine(2.4)
- Kidney(2.4)
- Blood(2.3)
- Lymph node(2.2)
- Eye(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for EIF3G
-
OriGene qPCR primer pairs and template standards for EIF3G
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3G Gene
Orthologs for EIF3G Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EIF3G 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EIF3G 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EIF3G 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Eif3g 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Eif3g 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | EIF3G 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | EIF3G 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | EIF3G 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif3s4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eif3g 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9507 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10881 30 31 |
|
OneToMany | |
| CG8636 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | EIF3G_ANOGA 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | eif-3.G 30 31 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR189W 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00847g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF35 30 31 33 |
|
OneToOne | |
| Rice (Oryza sativa) |
Liliopsida | Os02g0788400 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08046 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif35 30 |
|
- Species where no ortholog for EIF3G was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for EIF3G Gene
- ENSEMBL:
- Gene Tree for EIF3G (if available)
- TreeFam:
- Gene Tree for EIF3G (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EIF3G: view image
Paralogs for EIF3G Gene
(75) SIMAP similar genes for EIF3G Gene using alignment to 9 proteins:
- EIF3G_HUMAN
- A8K5K5_HUMAN
- K7EL20_HUMAN
- K7EL60_HUMAN
- K7ENA8_HUMAN
- K7ENH0_HUMAN
- K7EP16_HUMAN
- K7ER90_HUMAN
- K7ERL8_HUMAN
- ARL6IP5
- VPS33A
- TNNT1
- TGM4
- C1orf143
- EIF3S4
- RRM2B
- SPG7
- SMYD4
- NEK4
- KIAA1651
- FLJ00047
- LSM12
- ADCK1
- CDK10
- TBCB
- RPS13
- IK
- AARSD1
- TAF2
- NLRC5
- HC6
- FRG1
- EEF1E1
- COQ5
- ZNF257
- SNRPF
- TUBA1C
- TM2D1
- NDC80
- HEXDC
- DYNC2LI1
- RHBG
- RBP7
- IDNK
- GEMIN6
- ABI2
- SLC24A1
- SH2B3
- LINC00999
- DOCK8
- ATL2
- ZNF799
- ZNF429
- PFKFB3
- C12orf76
- NLN
- ARIH1
- ZNF114
- SEPSECS
- NELFA
- IRF2
- GALK2
- BEAN1
- SEC14L3
- RAD51
- CALCOCO2
- pp12301
- RQCD1
- RARS
- C21orf37
- ATF1
- RPS6KA5
- DPP9
- PTPN22
- SUMO1
- SNRNP70
- CIRBP
- MST132
- HBP1
- FCER1G
- SUV420H1
- RBMY1A1
- RBMX
- PABPC1
No data available for Paralogs for EIF3G Gene
Variants for EIF3G Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3G Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 737795 | Likely Benign: not provided | 10,116,067(-) | C/A | MISSENSE_VARIANT | |
| rs2305795 | Association: Cataplexy and narcolepsy | 10,115,376(-) | G/A | INTRON_VARIANT | |
| rs3826784 | Association: Cataplexy and narcolepsy | 10,116,334(-) | A/G | INTRON_VARIANT |
Residual Variation Intolerance Score:
27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF3G Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3G Gene
Disorders for EIF3G Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| narcolepsy |
|
|
Search EIF3G in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EIF3G
No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3G Gene
Publications for EIF3G Gene
- Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PMID: 9822659) Block KL … Hershey JW (The Journal of biological chemistry 1998) 2 3 4 23
- eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee AS … Cate JH (Nature 2016) 3 4
- The DHX33 RNA Helicase Promotes mRNA Translation Initiation. (PMID: 26100019) Zhang Y … Weber J (Molecular and cellular biology 2015) 3 4
- eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4
ExternalLinks
Products for EIF3G Gene
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- antibodies-online: Show 21 available EIF3G Antibodies ranked by validation data
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- antibodies-online: Search results for available EIF3G related products ranked by validation data
- antibodies-online: Show 20 available EIF3G Proteins ranked by validation data
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- Boster Bio Antibodies for EIF3G
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Sources for EIF3G Gene
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- (71) GenomeRNAi
- (72) LifeMap
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