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Aliases for EIF3F Gene

Aliases for EIF3F Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit F 2 3 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa 2 3
  • Deubiquitinating Enzyme EIF3f 3 4
  • EIF-3-Epsilon 3 4
  • EIF3S5 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit F 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 5 4
  • EIF3-Epsilon 3
  • EC 3.4.19.12 4
  • EIF3-P47 3
  • EIF3 P47 4
  • EIF3f 4

External Ids for EIF3F Gene

Previous HGNC Symbols for EIF3F Gene

  • EIF3S5

Previous GeneCards Identifiers for EIF3F Gene

  • GC11P007675

Summaries for EIF3F Gene

GeneCards Summary for EIF3F Gene

EIF3F (Eukaryotic Translation Initiation Factor 3 Subunit F) is a Protein Coding gene. Among its related pathways are Translation Factors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and translation initiation factor binding. An important paralog of this gene is PSMD7.

UniProtKB/Swiss-Prot for EIF3F Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

  • Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Gene Wiki entry for EIF3F Gene

Additional gene information for EIF3F Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3F Gene

Genomics for EIF3F Gene

GeneHancer (GH) Regulatory Elements for EIF3F Gene

Promoters and enhancers for EIF3F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 704.4 +16.9 16938 2.7 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC EIF3F SNORA3B OLFML1 TMEM9B-AS1 RPL27A ST5 CASC23 TUB ZNF214 PIR63023
GH11J008681 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 54.6 +715.6 715604 8.7 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNORA3B RPL27A GC11P008728 GC11P008729 SNORA3A PIR61800 PIR32700 GC11P008732 GC11P008731 GC11P008726
GH11J008869 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.9 +901.2 901169 3.3 ZSCAN4 SIN3A ZNF2 RAD21 RFX5 ZNF335 GLIS2 POLR3A SCRT2 RCOR1 ST5 TMEM9B-AS1 AKIP1 SNORA3B ZNF143 EIF3F TRIM66 ENSG00000202276 GC11M008877 RNA5SP330
GH11J008825 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +857.1 857125 3.7 HDGF PKNOX1 YBX1 TCF12 FOS ATF7 MEF2D ATF4 SMARCA4 ZNF184 AKIP1 TMEM9B-AS1 WEE1 EIF3F SNORA3A RPL27A ENSG00000254665 SCUBE2 RNA5SP330 GC11P008808
GH11J007975 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +7.2 7233 3.2 HDAC1 BRCA1 TCF12 ZNF766 ZNF143 RCOR1 ATF7 CEBPB ATF4 SMARCA4 COX6CP5 EIF3F CASC23 TUB OVCH2 PIR63023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF3F gene promoter:
  • NRSF form 2
  • NRSF form 1
  • ATF
  • Bach2
  • Arnt
  • AML1a
  • Max
  • c-Myc
  • GR
  • GR-alpha

Genomic Locations for EIF3F Gene

Genomic Locations for EIF3F Gene
chr11:7,970,251-8,001,862
(GRCh38/hg38)
Size:
31,612 bases
Orientation:
Plus strand
chr11:7,991,798-8,023,409
(GRCh37/hg19)
Size:
31,612 bases
Orientation:
Plus strand

Genomic View for EIF3F Gene

Genes around EIF3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3F Gene

Proteins for EIF3F Gene

  • Protein details for EIF3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00303-EIF3F_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit F
    Protein Accession:
    O00303
    Secondary Accessions:
    • A8K0S2
    • Q6IB45
    • Q8N978

    Protein attributes for EIF3F Gene

    Size:
    357 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1.

    Three dimensional structures from OCA and Proteopedia for EIF3F Gene

neXtProt entry for EIF3F Gene

Post-translational modifications for EIF3F Gene

  • Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
  • Ubiquitination at Lys214 and isoforms=162
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3F Gene

No data available for DME Specific Peptides for EIF3F Gene

Domains & Families for EIF3F Gene

Gene Families for EIF3F Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for EIF3F Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00303

UniProtKB/Swiss-Prot:

EIF3F_HUMAN :
  • The MPN domain mediates deubiquitinating activity.
  • Belongs to the eIF-3 subunit F family.
Domain:
  • The MPN domain mediates deubiquitinating activity.
Family:
  • Belongs to the eIF-3 subunit F family.
genes like me logo Genes that share domains with EIF3F: view

Function for EIF3F Gene

Molecular function for EIF3F Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
UniProtKB/Swiss-Prot Function:
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for EIF3F Gene

Phenotypes From GWAS Catalog for EIF3F Gene

Gene Ontology (GO) - Molecular Function for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity TAS 9341143
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 21124883
GO:0005515 protein binding IPI 16169070
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with EIF3F: view
genes like me logo Genes that share phenotypes with EIF3F: view

Animal Model Products

Clone Products

  • Addgene plasmids for EIF3F

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3F Gene

Localization for EIF3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3F Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3F gene
Compartment Confidence
cytosol 5
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,TAS 9341143
GO:0016020 membrane HDA 19946888
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IBA --
genes like me logo Genes that share ontologies with EIF3F: view

Pathways & Interactions for EIF3F Gene

genes like me logo Genes that share pathways with EIF3F: view

SIGNOR curated interactions for EIF3F Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination IDA 21124883
GO:0075522 IRES-dependent viral translational initiation IDA 9573242
genes like me logo Genes that share ontologies with EIF3F: view

Drugs & Compounds for EIF3F Gene

(1) Drugs for EIF3F Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental, Investigational Nutra Target Antitumor agent, Non-selective PI 3-kinase inhibitor 42
genes like me logo Genes that share compounds with EIF3F: view

Transcripts for EIF3F Gene

mRNA/cDNA for EIF3F Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1095) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF3F Gene

Eukaryotic translation initiation factor 3, subunit F:
Representative Sequences:

Clone Products

  • Addgene plasmids for EIF3F

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3F Gene

No ASD Table

Relevant External Links for EIF3F Gene

GeneLoc Exon Structure for
EIF3F
ECgene alternative splicing isoforms for
EIF3F

Expression for EIF3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3F Gene



Protein tissue co-expression partners for EIF3F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3F Gene:

EIF3F

SOURCE GeneReport for Unigene cluster for EIF3F Gene:

Hs.516023

Evidence on tissue expression from TISSUES for EIF3F Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Lung(4.8)
  • Muscle(3.8)
  • Intestine(3.6)
  • Pancreas(3.6)
  • Eye(3.2)
  • Skin(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with EIF3F: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3F Gene

Orthologs for EIF3F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3F 34 33
  • 98.99 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3F 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3F 34 33
  • 90.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3f 16 34 33
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia Eif3f 33
  • 87.36 (n)
dog
(Canis familiaris)
Mammalia EIF3F 34 33
  • 87.33 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3F 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3F 34 33
  • 77.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3F 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3f 33
  • 75.59 (n)
zebrafish
(Danio rerio)
Actinopterygii eif3f 34 33
  • 71.25 (n)
OneToOne
Dr.5392 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11217 33
fruit fly
(Drosophila melanogaster)
Insecta CG9769 34 33
  • 55.76 (n)
OneToMany
CG8335 34
  • 35 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3F_ANOGA 33
  • 55.39 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.F 34 33
  • 48.81 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 34
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF2 33
  • 49.94 (n)
rice
(Oryza sativa)
Liliopsida Os05g0104800 33
  • 49.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5333 34
  • 51 (a)
OneToOne
Cin.4777 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4C3.07 33
  • 46.61 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01021 33
  • 46.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4777 33
Species where no ortholog for EIF3F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3F Gene

ENSEMBL:
Gene Tree for EIF3F (if available)
TreeFam:
Gene Tree for EIF3F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3F: view image

Paralogs for EIF3F Gene

Paralogs for EIF3F Gene

(1) SIMAP similar genes for EIF3F Gene using alignment to 6 proteins:

  • EIF3F_HUMAN
  • B3KSH1_HUMAN
  • B4DEW9_HUMAN
  • B4DMT5_HUMAN
  • E9PQV8_HUMAN
  • H0YDT6_HUMAN

Pseudogenes.org Pseudogenes for EIF3F Gene

genes like me logo Genes that share paralogs with EIF3F: view

Variants for EIF3F Gene

Sequence variations from dbSNP and Humsavar for EIF3F Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000913830 -- 7,995,757(+) G/C intron_variant
rs1000975751 -- 7,994,961(+) C/A intron_variant
rs1001029558 -- 7,994,734(+) C/T intron_variant
rs1001074196 -- 7,989,549(+) T/A/G intron_variant
rs1001364128 -- 7,995,696(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3F Gene

Variant ID Type Subtype PubMed ID
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for EIF3F Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3F

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3F Gene

Disorders for EIF3F Gene

Additional Disease Information for EIF3F

No disorders were found for EIF3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3F Gene

Publications for EIF3F Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4 58
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 58
  3. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A … Costa PT (Biological psychiatry 2010) 3 44 58
  4. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. (PMID: 21124883) Moretti J … Brou C (PLoS biology 2010) 3 4 58
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58

Products for EIF3F Gene

Sources for EIF3F Gene

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