Aliases for EIF3F Gene
- Eukaryotic Translation Initiation Factor 3 Subunit F 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa 2 3
- Deubiquitinating Enzyme EIF3f 3 4
- EIF-3-Epsilon 3 4
- EIF3S5 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit F 2
External Ids for EIF3F Gene
Previous HGNC Symbols for EIF3F Gene
Previous GeneCards Identifiers for EIF3F Gene
GeneCards Summary for EIF3F Gene
EIF3F (Eukaryotic Translation Initiation Factor 3 Subunit F) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and translation initiation factor binding. An important paralog of this gene is PSMD7.
UniProtKB/Swiss-Prot for EIF3F Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.