Aliases for EIF3E Gene
- Eukaryotic Translation Initiation Factor 3 Subunit E 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 6 3 4
- Viral Integration Site Protein INT-6 Homolog 3 4
- EIF-3 P48 3 4
- EIF3S6 3 4
- INT6 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit E Isoform 2 Transcript 3
External Ids for EIF3E Gene
Previous HGNC Symbols for EIF3E Gene
Previous GeneCards Identifiers for EIF3E Gene
GeneCards Summary for EIF3E Gene
EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3E Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).