Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary c... See more...

Aliases for EIF3D Gene

Aliases for EIF3D Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit D 2 3 4 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 7 Zeta, 66/67kDa 2 3
  • EIF3-Zeta 2 3
  • EIF3-P66 2 3
  • EIF3 P66 3 4
  • EIF3S7 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit D 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 7 4
  • Translation Initiation Factor EIF3 P66 Subunit 3
  • EIF-3-Zeta 4
  • EIF3D 5
  • EIF3d 4

External Ids for EIF3D Gene

Previous HGNC Symbols for EIF3D Gene

  • EIF3S7

Previous GeneCards Identifiers for EIF3D Gene

  • GC22M035221
  • GC22M036891
  • GC22M019874

Summaries for EIF3D Gene

Entrez Gene Summary for EIF3D Gene

  • Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF3D Gene

EIF3D (Eukaryotic Translation Initiation Factor 3 Subunit D) is a Protein Coding gene. Diseases associated with EIF3D include Colon Squamous Cell Carcinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot Summary for EIF3D Gene

  • mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3D Gene

Additional gene information for EIF3D Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3D Gene

Genomics for EIF3D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF3D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3D

Top Transcription factor binding sites by QIAGEN in the EIF3D gene promoter:
  • AML1a
  • Evi-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GATA-1
  • Gfi-1
  • RelA
  • RORalpha1

Genomic Locations for EIF3D Gene

Genomic Locations for EIF3D Gene
chr22:36,510,855-36,529,184
(GRCh38/hg38)
Size:
18,330 bases
Orientation:
Minus strand
chr22:36,906,897-36,925,483
(GRCh37/hg19)
Size:
18,587 bases
Orientation:
Minus strand

Genomic View for EIF3D Gene

Genes around EIF3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3D Gene

Proteins for EIF3D Gene

  • Protein details for EIF3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15371-EIF3D_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit D
    Protein Accession:
    O15371
    Secondary Accessions:
    • A8MWD3
    • B2R7D4
    • B4DTF8
    • B4DVY1
    • Q3MJD9
    • Q5M9Q6

    Protein attributes for EIF3D Gene

    Size:
    548 amino acids
    Molecular mass:
    63973 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
    • (Microbial infection) Interacts with Norwalk virus VPg protein (PubMed:12773399).

    Alternative splice isoforms for EIF3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3D Gene

Post-translational modifications for EIF3D Gene

  • Ubiquitination at Lys35, Lys41, Lys53, Lys142, and Lys204
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3D Gene

No data available for DME Specific Peptides for EIF3D Gene

Domains & Families for EIF3D Gene

Gene Families for EIF3D Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF3D Gene

InterPro:
Blocks:
  • Eukaryotic translation initiation factor 3, subunit 7
ProtoNet:

Suggested Antigen Peptide Sequences for EIF3D Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53917, highly similar to Eukaryotic translation initiation factor 3 subunit 7 (A8MWD3_HUMAN)
  • cDNA FLJ51552, highly similar to Eukaryotic translation initiation factor 3 subunit 7 (B4DVY1_HUMAN)
  • eIF3 p66 (EIF3D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15371

UniProtKB/Swiss-Prot:

EIF3D_HUMAN :
  • The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
  • Belongs to the eIF-3 subunit D family.
Domain:
  • The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Family:
  • Belongs to the eIF-3 subunit D family.
genes like me logo Genes that share domains with EIF3D: view

Function for EIF3D Gene

Molecular function for EIF3D Gene

UniProtKB/Swiss-Prot Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Phenotypes From GWAS Catalog for EIF3D Gene

Gene Ontology (GO) - Molecular Function for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 25849773
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IPI 11369516
GO:0098808 mRNA cap binding IEA,IDA 27462815
genes like me logo Genes that share ontologies with EIF3D: view
genes like me logo Genes that share phenotypes with EIF3D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3D Gene

Localization for EIF3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3D gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016020 membrane HDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3D: view

Pathways & Interactions for EIF3D Gene

genes like me logo Genes that share pathways with EIF3D: view

Gene Ontology (GO) - Biological Process for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IEA --
GO:0002183 cytoplasmic translational initiation IEA --
GO:0002191 cap-dependent translational initiation IEA,IDA 27462815
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
genes like me logo Genes that share ontologies with EIF3D: view

No data available for SIGNOR curated interactions for EIF3D Gene

Drugs & Compounds for EIF3D Gene

(1) Drugs for EIF3D Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
eukaryotic translation initiation factor 3 Pharma Eukaryotic translation initiator 0

(1) ApexBio Compounds for EIF3D Gene

Compound Action Cas Number
eukaryotic translation initiation factor 3 Eukaryotic translation initiator
genes like me logo Genes that share compounds with EIF3D: view

Drug Products

Transcripts for EIF3D Gene

mRNA/cDNA for EIF3D Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3D

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3D Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - -
SP7:

ExUns: 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for EIF3D Gene

GeneLoc Exon Structure for
EIF3D

Expression for EIF3D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3D Gene

Protein differential expression in normal tissues from HIPED for EIF3D Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3D Gene



Protein tissue co-expression partners for EIF3D Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3D

SOURCE GeneReport for Unigene cluster for EIF3D Gene:

Hs.55682

Evidence on tissue expression from TISSUES for EIF3D Gene

  • Nervous system(5)
  • Lung(4.9)
  • Skin(4.9)
  • Blood(4.7)
  • Liver(4.7)
  • Stomach(4.6)
  • Muscle(4.6)
  • Intestine(4.3)
  • Kidney(3.8)
  • Heart(3)
  • Eye(2.9)
  • Spleen(2.7)
  • Lymph node(2.6)
  • Thyroid gland(2.3)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with EIF3D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3D Gene

Orthologs for EIF3D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF3D 30 31
  • 99.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF3D 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF3D 30 31
  • 92.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF3D 30 31
  • 91.24 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eif3d 30 17 31
  • 91.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif3d 30
  • 90.39 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF3D 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EIF3D 30 31
  • 84.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF3D 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif3d 30
  • 79.08 (n)
MGC75703 30
African clawed frog
(Xenopus laevis)
Amphibia eif3s7-prov 30
Zebrafish
(Danio rerio)
Actinopterygii eif3d 30 31
  • 80.78 (n)
OneToOne
eif3s7 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.56 30
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3D_ANOGA 30
  • 63.65 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta eIF-3p66 30 31
  • 63.21 (n)
OneToMany
CG4810 31
  • 53 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea eif-3.D 30 31
  • 52.92 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G20980 30
  • 52.19 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0566500 30
  • 54.69 (n)
Os.11175 30
Barley
(Hordeum vulgare)
Liliopsida Hv.5674 30
Wheat
(Triticum aestivum)
Liliopsida Ta.2841 30
Corn
(Zea mays)
Liliopsida Zm.5251 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5441 31
  • 62 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU07380 30
  • 51.7 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes moe1 30
  • 49.55 (n)
Species where no ortholog for EIF3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3D Gene

ENSEMBL:
Gene Tree for EIF3D (if available)
TreeFam:
Gene Tree for EIF3D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3D: view image

Paralogs for EIF3D Gene

No data available for Paralogs for EIF3D Gene

Variants for EIF3D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3D Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
714839 Benign: not provided 36,525,714(-) G/A INTRON_VARIANT
739587 Benign: not provided 36,519,417(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
780650 Benign: not provided 36,518,920(-) G/A INTRON_VARIANT
780651 Benign: not provided 36,519,398(-) C/T INTRON_VARIANT
rs745920273 - p.Arg310Cys

Additional dbSNP identifiers (rs#s) for EIF3D Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF3D Gene

Variant ID Type Subtype PubMed ID
esv23004 CNV loss 19812545
esv2758836 CNV loss 17122850
esv2760722 CNV gain 21179565
nsv1060004 CNV gain 25217958
nsv3615 CNV insertion 18451855
nsv520497 CNV gain 19592680

Variation tolerance for EIF3D Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3D

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3D Gene

Disorders for EIF3D Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF3D Gene - From: DISEASES

Disorder Aliases PubMed IDs
colon squamous cell carcinoma
  • colonic epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search EIF3D in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EIF3D_HUMAN
  • Note=Defects in EIF3D are associated with some cancers, such as prostate, breast and colon cancers. Disease susceptibility may be associated with variations affecting the gene represented in this entry. Down-regulation inhibits proliferation of cancers (PubMed:25370813, PubMed:25322666, PubMed:25682860, PubMed:26617750, PubMed:26008152, PubMed:26036682, PubMed:27035563). {ECO:0000269 PubMed:25322666, ECO:0000269 PubMed:25370813, ECO:0000269 PubMed:25682860, ECO:0000269 PubMed:26008152, ECO:0000269 PubMed:26036682, ECO:0000269 PubMed:26617750, ECO:0000269 PubMed:27035563}.

Additional Disease Information for EIF3D

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with EIF3D: view

No data available for Genatlas for EIF3D Gene

Publications for EIF3D Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4
  2. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee AS … Cate JH (Nature 2016) 3 4
  3. EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling. (PMID: 27035563) Pan XW … Cui XG (International journal of oncology 2016) 3 4
  4. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4
  5. RNAi-Mediated Silencing of EIF3D Alleviates Proliferation and Migration of Glioma U251 and U87MG Cells. (PMID: 25682860) Ren M … Xu L (Chemical biology & drug design 2015) 3 4

Products for EIF3D Gene

Sources for EIF3D Gene