Aliases for EIF3C Gene

Aliases for EIF3C Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C 2 3 4 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 8 3 4
  • EIF3-P110 2 3
  • EIF3 P110 3 4
  • EIF3S8 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit C 2
  • Cell Migration-Inducing Protein 17 3
  • EIF3CL 3
  • EIF3C 5
  • EIF3c 4

External Ids for EIF3C Gene

Previous HGNC Symbols for EIF3C Gene

  • EIF3S8

Previous GeneCards Identifiers for EIF3C Gene

  • GC16P028631
  • GC16P028723
  • GC16M026450
  • GC16P028700
  • GC16P028689

Summaries for EIF3C Gene

GeneCards Summary for EIF3C Gene

EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Diseases associated with EIF3C include Colon Squamous Cell Carcinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot Summary for EIF3C Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3C Gene

Additional gene information for EIF3C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3C Gene

Genomics for EIF3C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028711 Promoter 0.7 EPDnew Ensembl 600.4 +23.3 23343 2.6 EIF3C SULT1A2 piR-40180-002 CDC37P1 NPIPB9 ENSG00000261419 lnc-SULT1A1-2
GH16J028688 Promoter 0.3 Ensembl 600.7 +0.3 343 1.4 EIF3C piR-55926-002 SULT1A2 TUFM piR-47374-002 NPIPB9 lnc-SULT1A1-2 ENSG00000261419
GH16J028950 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 14.9 +262.9 262883 2.7 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 RFX1 SIX5 IKZF1 NFATC2IP EIF3C SULT1A2 SMG1P2 SGF29 EIF3CL KCTD13 TMEM219 MIR4517 SPNS1
GH16J028258 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 14.4 -428.0 -427992 4.9 ZSCAN4 ZNF24 POLR2A ZFHX2 GLI4 ZNF16 ZMYM3 TAF1 ZFP36 EZH2 ENSG00000283662 SBK1 EIF3CL EIF3C ENSG00000246465 GTF3C1 XPO6 piR-32214-254 NPIPB6
GH16J029028 Enhancer 1.2 Ensembl ENCODE dbSUPER 14.4 +340.2 340157 2.6 SP1 PRDM10 ZNF629 LEF1 KDM1A JUND PRDM1 ZIC2 PATZ1 IKZF2 EIF3CL EIF3C PRRT2 TAOK2 SMG1P2 RRN3P2 ENSG00000260517 lnc-LAT-1 piR-39678-007 LAT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3C

Top Transcription factor binding sites by QIAGEN in the EIF3C gene promoter:
  • c-Myb
  • GATA-1
  • GATA-2
  • GATA-3
  • HSF1 (long)
  • HSF1short
  • HSF2
  • NF-1
  • NF-1/L
  • PPAR-alpha

Genomic Locations for EIF3C Gene

Genomic Locations for EIF3C Gene
chr16:28,688,558-28,735,730
(GRCh38/hg38)
Size:
47,173 bases
Orientation:
Plus strand
chr16:28,699,879-28,747,051
(GRCh37/hg19)
Size:
47,173 bases
Orientation:
Plus strand

Genomic View for EIF3C Gene

Genes around EIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3C Gene

Proteins for EIF3C Gene

  • Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99613-EIF3C_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Protein Accession:
    Q99613
    Secondary Accessions:
    • A8K7Z0
    • B2RXG3
    • B4E1D5
    • H3BRV0
    • O00215
    • Q9BW98

    Protein attributes for EIF3C Gene

    Size:
    913 amino acids
    Molecular mass:
    105344 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3C Gene

    Alternative splice isoforms for EIF3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3C Gene

Post-translational modifications for EIF3C Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for EIF3C

No data available for DME Specific Peptides for EIF3C Gene

Domains & Families for EIF3C Gene

Gene Families for EIF3C Gene

Protein Domains for EIF3C Gene

InterPro:
Blocks:
  • Domain in components of the proteasome, COP9-complex and eIF3 (PCI)
  • Eukaryotic translation initiation factor 3 subunit 8, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for EIF3C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54488, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DDN4_HUMAN)
  • cDNA FLJ55750, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DRU0_HUMAN)
  • cDNA FLJ55450, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVQ5_HUMAN)
  • cDNA FLJ53378, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVU3_HUMAN)
  • EIF3C protein (Q3B7B9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99613

UniProtKB/Swiss-Prot:

EIF3C_HUMAN :
  • Belongs to the eIF-3 subunit C family.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3C: view

Function for EIF3C Gene

Molecular function for EIF3C Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Phenotypes From GWAS Catalog for EIF3C Gene

Gene Ontology (GO) - Molecular Function for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003743 contributes_to translation initiation factor activity IBA,IDA 17581632
GO:0005515 protein binding IPI 10504338
GO:0031369 translation initiation factor binding IBA 21873635
GO:0043022 ribosome binding IDA 8995409
genes like me logo Genes that share ontologies with EIF3C: view
genes like me logo Genes that share phenotypes with EIF3C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene

Localization for EIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3C gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IBA,IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3C: view

Pathways & Interactions for EIF3C Gene

genes like me logo Genes that share pathways with EIF3C: view

Pathways by source for EIF3C Gene

2 Qiagen pathways for EIF3C Gene
  • eIF2 Pathway
  • mTOR Pathway
1 Cell Signaling Technology pathway for EIF3C Gene

Gene Ontology (GO) - Biological Process for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IEA --
GO:0002183 cytoplasmic translational initiation IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0045727 positive regulation of translation IPI 24092755
genes like me logo Genes that share ontologies with EIF3C: view

No data available for SIGNOR curated interactions for EIF3C Gene

Drugs & Compounds for EIF3C Gene

No Compound Related Data Available

Transcripts for EIF3C Gene

mRNA/cDNA for EIF3C Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3C Gene

GeneLoc Exon Structure for
EIF3C

Expression for EIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3C Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3C Gene



Protein tissue co-expression partners for EIF3C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3C

SOURCE GeneReport for Unigene cluster for EIF3C Gene:

Hs.567374

Evidence on tissue expression from TISSUES for EIF3C Gene

  • Nervous system(5)
  • Liver(4.7)
  • Skin(4.7)
  • Lung(4.4)
  • Intestine(4.3)
  • Kidney(4.2)
  • Eye(3.9)
  • Pancreas(3.9)
  • Blood(3.6)
  • Muscle(3.6)
  • Stomach(3.3)
  • Heart(3.3)
  • Spleen(2.2)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with EIF3C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3C Gene

Orthologs for EIF3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
EIF3C 30
  • 91.75 (n)
Cow
(Bos Taurus)
Mammalia EIF3C 31
  • 98 (a)
OneToMany
EIF3CL 30
  • 91.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
ManyToMany
-- 31
  • 93 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 91 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Eif3c 30 17 31
  • 89.24 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Eif3c 30
  • 89.1 (n)
Chicken
(Gallus gallus)
Aves -- 31
  • 87 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 87 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif3c 30
  • 74.71 (n)
MGC75608 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7935 30
Zebrafish
(Danio rerio)
Actinopterygii eif3c 30 31
  • 73.28 (n)
OneToMany
Dr.28312 30
Fruit Fly
(Drosophila melanogaster)
Insecta eIF3-S8 30 31
  • 60.38 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3C_ANOGA 30
  • 57.38 (n)
Worm
(Caenorhabditis elegans)
Secernentea eif-3.C 30 31
  • 52.56 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL344C 30
  • 46.21 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03014g 30
  • 44.53 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 30 31 33
  • 43.45 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EIF3C 30
  • 52.75 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0124500 30
  • 51.08 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU07831 30
  • 53.55 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif33 30
  • 49.02 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3491 30
Species where no ortholog for EIF3C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF3C Gene

ENSEMBL:
Gene Tree for EIF3C (if available)
TreeFam:
Gene Tree for EIF3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3C: view image

Paralogs for EIF3C Gene

Paralogs for EIF3C Gene

(1) SIMAP similar genes for EIF3C Gene using alignment to 14 proteins:

  • EIF3C_HUMAN
  • A1KYQ7_HUMAN
  • B3KNZ4_HUMAN
  • B4DDN4_HUMAN
  • B4DRU0_HUMAN
  • B4DVQ5_HUMAN
  • B4DVU3_HUMAN
  • B4E1D5_HUMAN
  • B4E2Z6_HUMAN
  • H3BPE3_HUMAN
  • H3BPE4_HUMAN
  • H3BRV0_HUMAN
  • H3BTY8_HUMAN
  • Q3B7B9_HUMAN
genes like me logo Genes that share paralogs with EIF3C: view

Variants for EIF3C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3C Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
769420 Benign: not provided 28,723,156(+) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for EIF3C Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF3C Gene

Variant ID Type Subtype PubMed ID
dgv13n14 CNV gain 18776910
dgv2830n100 CNV gain 25217958
dgv4964n54 CNV loss 21841781
dgv4965n54 CNV loss 21841781
dgv4966n54 CNV loss 21841781
dgv4967n54 CNV loss 21841781
dgv4968n54 CNV loss 21841781
dgv4969n54 CNV loss 21841781
dgv4970n54 CNV loss 21841781
dgv4972n54 CNV loss 21841781
dgv4982n54 CNV loss 21841781
dgv813e212 CNV loss 25503493
esv23667 CNV gain+loss 19812545
esv25666 CNV gain+loss 19812545
esv2758640 CNV gain+loss 17122850
esv2920457 CNV deletion 24192839
esv2921568 CNV deletion 24192839
esv3892824 CNV loss 25118596
esv999954 CNV loss 20482838
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1066415 CNV gain 25217958
nsv1069937 CNV deletion 25765185
nsv1071282 CNV deletion 25765185
nsv1115498 CNV duplication 24896259
nsv1124734 CNV duplication 24896259
nsv1776 CNV deletion 18451855
nsv510683 CNV deletion 20534489
nsv511572 CNV loss 21212237
nsv571724 CNV loss 21841781
nsv571755 CNV gain 21841781
nsv571780 CNV loss 21841781
nsv571783 CNV loss 21841781
nsv571784 CNV loss 21841781
nsv571787 CNV loss 21841781
nsv820432 CNV deletion 20802225
nsv821114 CNV deletion 20802225
nsv833180 CNV loss 17160897
nsv9414 CNV gain+loss 18304495
nsv9419 CNV gain+loss 18304495
nsv952962 CNV deletion 24416366
nsv977947 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv984299 CNV duplication 23825009

Variation tolerance for EIF3C Gene

Gene Damage Index Score: 0.30; 6.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3C Gene

Human Gene Mutation Database (HGMD)
EIF3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene

Disorders for EIF3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF3C Gene - From: DISEASES

Disorder Aliases PubMed IDs
colon squamous cell carcinoma
  • colonic epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search EIF3C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF3C

genes like me logo Genes that share disorders with EIF3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene

Publications for EIF3C Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4
  3. Human ALKBH4 interacts with proteins associated with transcription. (PMID: 23145062) Bjørnstad LG … Falnes PØ (PloS one 2012) 3 4
  4. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M … Hakonarson H (Nature genetics 2009) 3 41
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4

Products for EIF3C Gene

  • Signalway Proteins for EIF3C

Sources for EIF3C Gene