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Aliases for EIF3C Gene
Aliases for EIF3C Gene
External Ids for EIF3C Gene
- HGNC: 3279
- NCBI Entrez Gene: 8663
- Ensembl: ENSG00000184110
- OMIM®: 603916
- UniProtKB/Swiss-Prot: Q99613
Previous HGNC Symbols for EIF3C Gene
- EIF3S8
Previous GeneCards Identifiers for EIF3C Gene
- GC16P028631
- GC16P028723
- GC16M026450
- GC16P028700
- GC16P028689
- GC16P028709
- GC16P029237
Summaries for EIF3C Gene
GeneCards Summary for EIF3C Gene
EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Diseases associated with EIF3C include Colon Squamous Cell Carcinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF3CL.
UniProtKB/Swiss-Prot Summary for EIF3C Gene
-
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Additional gene information for EIF3C Gene
- HGNC (3279)
- NCBI Entrez Gene (8663)
- Ensembl (ENSG00000184110)
- OMIM® (603916)
- UniProtKB/Swiss-Prot (Q99613)
- Open Targets Platform(ENSG00000184110)
- Alliance of Genome Resources
- Search for EIF3C at DataMed
- Search for EIF3C at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3C Gene
Genomics for EIF3C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EIF3C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EIF3C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3C
- Top Transcription factor binding sites by QIAGEN in the EIF3C gene promoter:
-
- c-Myb
- GATA-1
- GATA-2
- GATA-3
- HSF1 (long)
- HSF1short
- HSF2
- NF-1
- NF-1/L
- PPAR-alpha
Genomic Locations for EIF3C Gene
Latest Assembly
- chr16:28,688,558-28,735,730
- (GRCh38/hg38)
- Size:
- 47,173 bases
- Orientation:
- Plus strand
Previous Assembly
- chr16:28,699,879-28,747,051
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 47,173 bases
- Orientation:
- Plus strand
Genomic View for EIF3C Gene
Genes around EIF3C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
EIF3C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF3C Gene
Proteins for EIF3C Gene
-
Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99613-EIF3C_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 3 subunit C
- Protein Accession:
- Q99613
- A8K7Z0
- B2RXG3
- B4E1D5
- H3BRV0
- O00215
- Q9BW98
Protein attributes for EIF3C Gene
- Size:
- 913 amino acids
- Molecular mass:
- 105344 Da
- Quaternary structure:
-
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.
Three dimensional structures from OCA and Proteopedia for EIF3C Gene
Protein Expression for EIF3C Gene
Post-translational modifications for EIF3C Gene
- Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for EIF3C Gene
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for EIF3C
- Novus Biologicals Antibodies for EIF3C
- Invitrogen Antibodies for EIF3C (AFLGC-Eif3c)
-
Boster Bio Antibodies for EIF3C
-
Custom Antibody ServicesProSci Antibodies for EIF3C
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF3C
- Sino Biological Antibodies for EIF3C
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3C
- Origene Custom Protein Services for EIF3C
Assay products for research
No data available for DME Specific Peptides for EIF3C Gene
Domains & Families for EIF3C Gene
Gene Families for EIF3C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EIF3C Gene
- InterPro:
- Blocks:
-
- Domain in components of the proteasome, COP9-complex and eIF3 (PCI)
- Eukaryotic translation initiation factor 3 subunit 8, N-terminal
Suggested Antigen Peptide Sequences for EIF3C Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54488, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DDN4_HUMAN)
- cDNA FLJ55750, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DRU0_HUMAN)
- cDNA FLJ55450, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVQ5_HUMAN)
- cDNA FLJ53378, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVU3_HUMAN)
- EIF3C protein (Q3B7B9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99613- Family:
-
- Belongs to the eIF-3 subunit C family.
Function for EIF3C Gene
Molecular function for EIF3C Gene
- UniProtKB/Swiss-Prot Function:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Phenotypes From GWAS Catalog for EIF3C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0003743 | contributes_to translation initiation factor activity | IEA,IDA | 17581632 |
| GO:0005515 | protein binding | IPI | 10504338 |
| GO:0031369 | translation initiation factor binding | IEA,IBA | 21873635 |
| GO:0043022 | ribosome binding | IDA | 8995409 |
Phenotypes for EIF3C Gene
- MGI mutant phenotypes for EIF3C:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for EIF3C:
-
- Decreased viability
- no effect
- Increased S DNA content
- Inconclusive
- Decreased nuclei size in G2M
- Decreased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Synthetic lethal with Ras
- Increased cell death HMECs cells
- Decreased viability of wild-type and TP53 knockout cells
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased influenza A/WSN/33 replication
- Decreased cell number
- Increased cell death in DLD-1 cells
- Increased cell death in HCC-1954 cells
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Increased cell death in HCT116 cells
- Decreased replication of vaccinia virus (VACV)
- S arrest
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EIF3C - Starting at $85 >
- * EIF3C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EIF3C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
miRNA for EIF3C Gene
- miRTarBase miRNAs that target EIF3C
-
- hsa-miR-155-5p (MIRT020535)
- hsa-miR-16-5p (MIRT031415)
- hsa-miR-320c (MIRT036164)
- hsa-miR-1226-3p (MIRT036476)
- hsa-miR-877-3p (MIRT036996)
- hsa-miR-99b-3p (MIRT038530)
- hsa-miR-425-5p (MIRT039309)
- hsa-miR-615-3p (MIRT039669)
- hsa-miR-423-3p (MIRT042529)
- hsa-miR-361-5p (MIRT044100)
- hsa-miR-320a (MIRT044779)
- hsa-miR-186-5p (MIRT044937)
- hsa-miR-149-5p (MIRT045450)
- hsa-miR-181b-5p (MIRT047297)
- hsa-miR-92a-3p (MIRT049027)
- hsa-let-7f-5p (MIRT051357)
- hsa-let-7c-5p (MIRT051775)
- hsa-let-7b-5p (MIRT051944)
- hsa-let-7a-5p (MIRT052417)
- hsa-miR-7155-3p (MIRT458084)
- hsa-miR-3136-3p (MIRT458085)
- hsa-miR-3937 (MIRT458086)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
Clone products for research
- Applied Biological Materials (abm): Clones for EIF3C - Starting at $45 >
- * EIF3C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211151
- MR211151
- MR211151L3
- MR211151L4
- RC201705
- RC201705L3
- RC201705L4
- RC221404
- RC221404L1
- RC221404L2
- RC221404L3
- RC221404L4
- RC235024
- RC235026
- RC239757
- RG201705
- RG221404
- RG235024
- RG235026
- RR215246
- RR215246L3
- RR215246L4
- MR211151L3V
- MR211151L4V
- RC201705L3V
- RC201705L4V
- RC221404L1V
- RC221404L2V
- RC221404L3V
- RC221404L4V
- RR215246L3V
- RR215246L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF3C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
Cell Lines for research
-
Horizon Cell Lines for EIF3C
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene
Localization for EIF3C Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005852 | eukaryotic translation initiation factor 3 complex | IEA,IDA | 17322308 |
| GO:0016282 | eukaryotic 43S preinitiation complex | IEA | -- |
| GO:0033290 | eukaryotic 48S preinitiation complex | IEA | -- |
Pathways & Interactions for EIF3C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Translational Control | ||
| 4 | RNA transport | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
|
Pathways by source for EIF3C Gene
1 BioSystems pathway for EIF3C Gene
12 Reactome pathways for EIF3C Gene
1 KEGG pathway for EIF3C Gene
2 Qiagen pathways for EIF3C Gene
- eIF2 Pathway
- mTOR Pathway
1 Cell Signaling Technology pathway for EIF3C Gene
Interacting Proteins for EIF3C Gene
Selected Interacting proteins:
Q99613-EIF3C_HUMAN
ENSP00000332604
for EIF3C Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EIF3C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001732 | formation of cytoplasmic translation initiation complex | IEA | -- |
| GO:0002183 | cytoplasmic translational initiation | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA,TAS | -- |
| GO:0045727 | positive regulation of translation | IPI | 24092755 |
No data available for SIGNOR curated interactions for EIF3C Gene
Transcripts for EIF3C Gene
mRNA/cDNA for EIF3C Gene
- 5 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000331666 2910 nts (view in UCSC)
- ENST00000395587 3137 nts (view in UCSC)
- ENST00000563139 516 nts (view in UCSC)
- ENST00000564243 2870 nts (view in UCSC)
- ENST00000564839 586 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EIF3C - Starting at $85 >
- * EIF3C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EIF3C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
Clone products for research
- Applied Biological Materials (abm): Clones for EIF3C - Starting at $45 >
- * EIF3C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211151
- MR211151
- MR211151L3
- MR211151L4
- RC201705
- RC201705L3
- RC201705L4
- RC221404
- RC221404L1
- RC221404L2
- RC221404L3
- RC221404L4
- RC235024
- RC235026
- RC239757
- RG201705
- RG221404
- RG235024
- RG235026
- RR215246
- RR215246L3
- RR215246L4
- MR211151L3V
- MR211151L4V
- RC201705L3V
- RC201705L4V
- RC221404L1V
- RC221404L2V
- RC221404L3V
- RC221404L4V
- RR215246L3V
- RR215246L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF3C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: |
Relevant External Links for EIF3C Gene
- GeneLoc Exon Structure for
- EIF3C
Expression for EIF3C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3C Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3C
SOURCE GeneReport for Unigene cluster for EIF3C Gene:
Hs.567374Evidence on tissue expression from TISSUES for EIF3C Gene
- Nervous system(5)
- Liver(4.7)
- Skin(4.7)
- Lung(4.4)
- Intestine(4.3)
- Kidney(4.1)
- Eye(3.9)
- Pancreas(3.9)
- Blood(3.6)
- Muscle(3.5)
- Stomach(3.2)
- Heart(3.2)
- Spleen(2.5)
- Lymph node(2.2)
Primer products for research
-
OriGene qPCR primer pairs for EIF3C
-
OriGene qPCR primer pairs and template standards for EIF3C
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3C Gene
Orthologs for EIF3C Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 30 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 30 |
|
OneToMany | |
| EIF3C 29 |
|
||||
| Cow (Bos Taurus) |
Mammalia | EIF3C 30 |
|
OneToMany | |
| EIF3CL 29 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Eif3c 29 16 30 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Eif3c 29 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif3c 29 |
|
||
| MGC75608 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7935 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eif3c 29 30 |
|
OneToMany | |
| Dr.28312 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | eIF3-S8 29 30 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | EIF3C_ANOGA 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | eif-3.C 29 30 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL344C 29 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F03014g 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NIP1 29 30 32 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | EIF3C 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0124500 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07831 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif33 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3491 29 |
|
- Species where no ortholog for EIF3C was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for EIF3C Gene
- ENSEMBL:
- Gene Tree for EIF3C (if available)
- TreeFam:
- Gene Tree for EIF3C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EIF3C: view image
- Alliance of Genome Resources:
- Additional Orthologs for EIF3C
Paralogs for EIF3C Gene
(1) SIMAP similar genes for EIF3C Gene using alignment to 14 proteins:
- EIF3C_HUMAN
- A1KYQ7_HUMAN
- B3KNZ4_HUMAN
- B4DDN4_HUMAN
- B4DRU0_HUMAN
- B4DVQ5_HUMAN
- B4DVU3_HUMAN
- B4E1D5_HUMAN
- B4E2Z6_HUMAN
- H3BPE3_HUMAN
- H3BPE4_HUMAN
- H3BRV0_HUMAN
- H3BTY8_HUMAN
- Q3B7B9_HUMAN
Variants for EIF3C Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3C Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs444518 | Benign: not provided | 28,723,156(+) |
G/T NM_003752.5(EIF3C):c.777-8G>T |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Gene Damage Index Score:
0.30;
6.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF3C Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene
Disorders for EIF3C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colon squamous cell carcinoma |
|
|
Search EIF3C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EIF3C
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene
Publications for EIF3C Gene
- Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4
- eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4
- Human ALKBH4 interacts with proteins associated with transcription. (PMID: 23145062) Bjørnstad LG … Falnes PØ (PloS one 2012) 3 4
- Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M … Hakonarson H (Nature genetics 2009) 3 40
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4
ExternalLinks
Products for EIF3C Gene
- Custom Antibody ServicesOriGene Antibodies for EIF3C
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3C
- Origene Custom Protein Services for EIF3C
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- OriGene qPCR primer pairs for EIF3C
- OriGene qPCR primer pairs and template standards for EIF3C
- OriGene CRISPR knockouts for EIF3C
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- RR215246L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for EIF3C
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- Sino Biological Antibodies for EIF3C
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EIF3C
- Novus Biologicals proteins and lysates for EIF3C
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for EIF3C (AFLGC-Eif3c)
- VectorBuilder Custom and pre-made DNA vectors for EIF3C (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for EIF3C (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for EIF3C (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for EIF3C CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for EIF3C
- antibodies-online: Show 23 available EIF3C Antibodies ranked by validation data
- Compare Top EIF3C Antibodies
- antibodies-online: Search results for available EIF3C related products ranked by validation data
- antibodies-online: Show 4 available EIF3C Proteins ranked by validation data
- Compare Top EIF3C Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for EIF3C
- Search Santa Cruz Biotechnology (SCBT) for EIF3C siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
- Custom Antibody ServicesProSci Antibodies for EIF3C
- Search for EIF3C Proteins at ProSci
- Horizon Cell Lines for EIF3C
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
- Boster Bio Antibodies for EIF3C
- Browse Boster Bio ELISA Kits
Sources for EIF3C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources