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EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Diseases associated with EIF3C include Colon Squamous Cell Carcinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF3CL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003743 | contributes_to translation initiation factor activity | IBA,IDA | 17581632 |
GO:0005515 | protein binding | IPI | 10504338 |
GO:0031369 | translation initiation factor binding | IBA | 21873635 |
GO:0043022 | ribosome binding | IDA | 8995409 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005852 | eukaryotic translation initiation factor 3 complex | IBA,IDA | 17322308 |
GO:0016282 | eukaryotic 43S preinitiation complex | IEA | -- |
GO:0033290 | eukaryotic 48S preinitiation complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
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2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Translational Control | ||
4 | RNA transport | ||
5 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001732 | formation of cytoplasmic translation initiation complex | IEA | -- |
GO:0002183 | cytoplasmic translational initiation | IEA | -- |
GO:0006412 | translation | IEA | -- |
GO:0006413 | translational initiation | TAS | -- |
GO:0045727 | positive regulation of translation | IPI | 24092755 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | ||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||||||||||||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
EIF3C 30 |
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Cow (Bos Taurus) |
Mammalia | EIF3C 31 |
|
OneToMany | |
EIF3CL 30 |
|
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Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Eif3c 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Eif3c 30 |
|
||
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif3c 30 |
|
||
MGC75608 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7935 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eif3c 30 31 |
|
OneToMany | |
Dr.28312 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | eIF3-S8 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | EIF3C_ANOGA 30 |
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||
Worm (Caenorhabditis elegans) |
Secernentea | eif-3.C 30 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL344C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F03014g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NIP1 30 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | EIF3C 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0124500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07831 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif33 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3491 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769420 | Benign: not provided | 28,723,156(+) | G/T | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
colon squamous cell carcinoma |
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