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Aliases for EIF3C Gene

Aliases for EIF3C Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 8 3 4
  • EIF3 P110 3 4
  • EIF3S8 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit C 2
  • Cell Migration-Inducing Protein 17 3
  • EIF3-P110 3
  • EIF3CL 3
  • EIF3c 4

External Ids for EIF3C Gene

Previous HGNC Symbols for EIF3C Gene

  • EIF3S8

Previous GeneCards Identifiers for EIF3C Gene

  • GC16P028631
  • GC16P028723
  • GC16M026450

Summaries for EIF3C Gene

GeneCards Summary for EIF3C Gene

EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot for EIF3C Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3C Gene

Additional gene information for EIF3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3C Gene

Genomics for EIF3C Gene

GeneHancer (GH) Regulatory Elements for EIF3C Gene

Promoters and enhancers for EIF3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028688 Promoter 1 EPDnew Ensembl 550.8 +0.1 143 0.6 EIF3C PIR49925 SULT1A2 TUFM PIRC86 PIR51067 ENSG00000261419
GH16I028711 Promoter 1 EPDnew Ensembl 550.3 +23.1 23143 1.4 EIF3C PIR33179 CDC37P1 ENSG00000261419 PIRC86
GH16I028703 Promoter 0.5 EPDnew 550.4 +14.5 14472 0.1 CDC37P1 EIF3C PIR33179 PIRC86 ENSG00000261419
GH16I028950 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.9 +262.8 262762 2.4 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B E2F8 ZNF143 NFATC2IP SGF29 ATXN2L ENSG00000260853 SMG1P2 SPNS1 ENSG00000260367 EIF3C SULT1A2 NPIPB8
GH16I029028 Enhancer 1.3 Ensembl ENCODE dbSUPER 14.4 +340.8 340763 1.4 SMAD1 ATF1 GTF3C2 ZNF121 GLIS2 FOS ATF7 RUNX3 JUNB NCOA1 EIF3CL EIF3C TAOK2 SMG1P2 NPIPB10P GC16M028992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF3C gene promoter:

Genomic Locations for EIF3C Gene

Genomic Locations for EIF3C Gene
chr16:28,688,558-28,735,730
(GRCh38/hg38)
Size:
47,173 bases
Orientation:
Plus strand
chr16:28,699,879-28,747,051
(GRCh37/hg19)

Genomic View for EIF3C Gene

Genes around EIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3C Gene

Proteins for EIF3C Gene

  • Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99613-EIF3C_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Protein Accession:
    Q99613
    Secondary Accessions:
    • A8K7Z0
    • B2RXG3
    • B4E1D5
    • H3BRV0
    • O00215
    • Q9BW98

    Protein attributes for EIF3C Gene

    Size:
    913 amino acids
    Molecular mass:
    105344 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3C Gene

    Alternative splice isoforms for EIF3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3C Gene

Post-translational modifications for EIF3C Gene

No data available for DME Specific Peptides for EIF3C Gene

Domains & Families for EIF3C Gene

Gene Families for EIF3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q99613

UniProtKB/Swiss-Prot:

EIF3C_HUMAN :
  • Belongs to the eIF-3 subunit C family.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3C: view

Function for EIF3C Gene

Molecular function for EIF3C Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 10504338
GO:0031369 translation initiation factor binding IBA --
genes like me logo Genes that share ontologies with EIF3C: view
genes like me logo Genes that share phenotypes with EIF3C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene

Localization for EIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3C gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3C: view

Pathways & Interactions for EIF3C Gene

genes like me logo Genes that share pathways with EIF3C: view

Gene Ontology (GO) - Biological Process for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0045727 positive regulation of translation IPI 24092755
GO:1902416 positive regulation of mRNA binding IPI 24092755
genes like me logo Genes that share ontologies with EIF3C: view

No data available for SIGNOR curated interactions for EIF3C Gene

Drugs & Compounds for EIF3C Gene

No Compound Related Data Available

Transcripts for EIF3C Gene

Unigene Clusters for EIF3C Gene

Eukaryotic translation initiation factor 3, subunit C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3C Gene

GeneLoc Exon Structure for
EIF3C
ECgene alternative splicing isoforms for
EIF3C

Expression for EIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3C Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3C Gene



Protein tissue co-expression partners for EIF3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3C Gene:

EIF3C

SOURCE GeneReport for Unigene cluster for EIF3C Gene:

Hs.567374

Evidence on tissue expression from TISSUES for EIF3C Gene

  • Nervous system(5)
  • Liver(4.7)
  • Skin(4.6)
  • Lung(4.3)
  • Intestine(4.1)
  • Eye(3.9)
  • Kidney(3.9)
  • Pancreas(3.8)
  • Muscle(3.3)
  • Blood(3.1)
  • Heart(2.9)
  • Stomach(2.9)
  • Spleen(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with EIF3C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3C Gene

Orthologs for EIF3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
EIF3C 33
  • 91.75 (n)
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 34
  • 98 (a)
OneToMany
EIF3CL 33
  • 91.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif3c 33 16 34
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Eif3c 33
  • 89.1 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3c 33
  • 74.71 (n)
MGC75608 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7935 33
zebrafish
(Danio rerio)
Actinopterygii eif3c 33 34
  • 73.28 (n)
Dr.28312 33
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 33 34
  • 60.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3C_ANOGA 33
  • 57.38 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 33 34
  • 52.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL344C 33
  • 46.21 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03014g 33
  • 44.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 33 34 36
  • 43.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3C 33
  • 52.75 (n)
rice
(Oryza sativa)
Liliopsida Os07g0124500 33
  • 51.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07831 33
  • 53.55 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif33 33
  • 49.02 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3491 33
Species where no ortholog for EIF3C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3C Gene

ENSEMBL:
Gene Tree for EIF3C (if available)
TreeFam:
Gene Tree for EIF3C (if available)

Paralogs for EIF3C Gene

Paralogs for EIF3C Gene

genes like me logo Genes that share paralogs with EIF3C: view

Variants for EIF3C Gene

Sequence variations from dbSNP and Humsavar for EIF3C Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000487710 -- 28,710,493(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001092220 -- 28,694,722(+) C/T genic_upstream_transcript_variant, intron_variant
rs1001253504 -- 28,692,755(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1001347881 -- 28,703,175(+) T/C genic_upstream_transcript_variant, intron_variant
rs1001465565 -- 28,700,619(+) CCCC/CCC genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3C Gene

Variant ID Type Subtype PubMed ID
nsv984299 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv977947 CNV duplication 23825009
nsv952962 CNV deletion 24416366
nsv9419 CNV gain+loss 18304495
nsv9414 CNV gain+loss 18304495
nsv833180 CNV loss 17160897
nsv821114 CNV deletion 20802225
nsv820432 CNV deletion 20802225
nsv571787 CNV loss 21841781
nsv571784 CNV loss 21841781
nsv571783 CNV loss 21841781
nsv571780 CNV loss 21841781
nsv571755 CNV gain 21841781
nsv571724 CNV loss 21841781
nsv511572 CNV loss 21212237
nsv510683 CNV deletion 20534489
nsv1776 CNV deletion 18451855
nsv1124734 CNV duplication 24896259
nsv1115498 CNV duplication 24896259
nsv1071282 CNV deletion 25765185
nsv1069937 CNV deletion 25765185
nsv1066415 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1059555 CNV gain 25217958
esv999954 CNV loss 20482838
esv3892824 CNV loss 25118596
esv2921568 CNV deletion 24192839
esv2920457 CNV deletion 24192839
esv2758640 CNV gain+loss 17122850
esv25666 CNV gain+loss 19812545
esv23667 CNV gain+loss 19812545
dgv813e212 CNV loss 25503493
dgv4982n54 CNV loss 21841781
dgv4972n54 CNV loss 21841781
dgv4970n54 CNV loss 21841781
dgv4969n54 CNV loss 21841781
dgv4968n54 CNV loss 21841781
dgv4967n54 CNV loss 21841781
dgv4966n54 CNV loss 21841781
dgv4965n54 CNV loss 21841781
dgv4964n54 CNV loss 21841781
dgv2830n100 CNV gain 25217958
dgv13n14 CNV gain 18776910

Variation tolerance for EIF3C Gene

Gene Damage Index Score: 0.30; 6.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3C Gene

Human Gene Mutation Database (HGMD)
EIF3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene

Disorders for EIF3C Gene

Additional Disease Information for EIF3C

No disorders were found for EIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene

Publications for EIF3C Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4 58
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 58
  3. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M … Hakonarson H (Nature genetics 2009) 3 44 58
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
  5. Reconstitution reveals the functional core of mammalian eIF3. (PMID: 17581632) Masutani M … Imataka H (The EMBO journal 2007) 3 4 58

Products for EIF3C Gene

Sources for EIF3C Gene

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