Aliases for EIF3C Gene
Aliases for EIF3C Gene
External Ids for EIF3C Gene
- HGNC: 3279
- Entrez Gene: 8663
- Ensembl: ENSG00000184110
- OMIM: 603916
- UniProtKB: Q99613
Previous HGNC Symbols for EIF3C Gene
- EIF3S8
Previous GeneCards Identifiers for EIF3C Gene
- GC16P028631
- GC16P028723
- GC16M026450
Summaries for EIF3C Gene
GeneCards Summary for EIF3C Gene
EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Among its related pathways are Translation Factors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF3CL.
UniProtKB/Swiss-Prot for EIF3C Gene
-
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3C Gene
Genomics for EIF3C Gene
GeneHancer (GH) Regulatory Elements for EIF3C Gene
Promoters and enhancers for EIF3C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EIF3C on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EIF3C gene promoter:
-
- HSF2
- PPAR-alpha
- GATA-3
- GATA-2
- GATA-1
- NF-1
- NF-1/L
- HSF1 (long)
- HSF1short
- c-Myb
Regulatory Element Products
Genomic Locations for EIF3C Gene
Genomic Locations for EIF3C Gene
- chr16:28,688,558-28,735,730
- (GRCh38/hg38)
- Size:
- 47,173 bases
- Orientation:
- Plus strand
- chr16:28,699,879-28,747,051
- (GRCh37/hg19)
- Size:
- 47,173 bases
- Orientation:
- Plus strand
Genomic View for EIF3C Gene
Genes around EIF3C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
- 16p11.2 by Ensembl
EIF3C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF3C Gene
Proteins for EIF3C Gene
-
Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99613-EIF3C_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 3 subunit C
- Protein Accession:
- Q99613
- A8K7Z0
- B2RXG3
- B4E1D5
- H3BRV0
- O00215
- Q9BW98
Protein attributes for EIF3C Gene
- Size:
- 913 amino acids
- Molecular mass:
- 105344 Da
- Quaternary structure:
-
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.
Protein Expression for EIF3C Gene
Post-translational modifications for EIF3C Gene
- Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for EIF3C Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EIF3C
- Novus Biologicals Antibodies for EIF3C
-
Abcam antibodies for EIF3C
- Invitrogen Antibodies for EIF3C
- GeneTex EIF3C Antibody for EIF3C
-
Boster Bio Antibodies for EIF3C
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF3C
Protein Products
-
OriGene Purified Proteins for EIF3C
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3C
- Origene Custom Protein Services for EIF3C
- Search GeneTex for Proteins for EIF3C
Assay Products
No data available for DME Specific Peptides for EIF3C Gene
Domains & Families for EIF3C Gene
Gene Families for EIF3C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EIF3C Gene
Suggested Antigen Peptide Sequences for EIF3C Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54488, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DDN4_HUMAN)
- cDNA FLJ55750, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DRU0_HUMAN)
- cDNA FLJ55450, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVQ5_HUMAN)
- cDNA FLJ53378, highly similar to Eukaryotic translation initiation factor 3 subunit 8 (B4DVU3_HUMAN)
- EIF3C protein (Q3B7B9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99613- Family:
-
- Belongs to the eIF-3 subunit C family.
Function for EIF3C Gene
Molecular function for EIF3C Gene
- UniProtKB/Swiss-Prot Function:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Phenotypes From GWAS Catalog for EIF3C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003743 | contributes_to translation initiation factor activity | IDA | 17581632 |
| GO:0005515 | protein binding | IPI | 10504338 |
| GO:0031369 | translation initiation factor binding | IBA | -- |
Phenotypes for EIF3C Gene
- MGI mutant phenotypes for EIF3C:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for EIF3C:
-
- G0/1 arrest
- Increased G1 DNA content
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased cell death HMECs cells
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased NF-kappaB reporter expression
- Increased cell number in S
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased influenza A/WSN/33 replication
- Increased viability
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EIF3C
-
CRISPR Products
-
OriGene CRISPR knockouts for EIF3C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
- genomics-online: gRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- Applied Biological Materials CRISPR for EIF3C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
- GenScript: Design CRISPR guide RNA sequences for EIF3C
miRNA for EIF3C Gene
- miRTarBase miRNAs that target EIF3C
-
- hsa-mir-155-5p (MIRT020535)
- hsa-mir-16-5p (MIRT031415)
- hsa-mir-320c (MIRT036164)
- hsa-mir-1226-3p (MIRT036476)
- hsa-mir-877-3p (MIRT036996)
- hsa-mir-99b-3p (MIRT038530)
- hsa-mir-425-5p (MIRT039309)
- hsa-mir-615-3p (MIRT039669)
- hsa-mir-423-3p (MIRT042529)
- hsa-mir-361-5p (MIRT044100)
- hsa-mir-320a (MIRT044779)
- hsa-mir-186-5p (MIRT044937)
- hsa-mir-149-5p (MIRT045450)
- hsa-mir-181b-5p (MIRT047297)
- hsa-mir-92a-3p (MIRT049027)
- hsa-let-7f-5p (MIRT051357)
- hsa-let-7c-5p (MIRT051775)
- hsa-let-7b-5p (MIRT051944)
- hsa-let-7a-5p (MIRT052417)
- hsa-mir-7155-3p (MIRT458084)
- hsa-mir-3136-3p (MIRT458085)
- hsa-mir-3937 (MIRT458086)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
- genomics-online: shRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
Clone Products
-
OriGene ORF clones in human for EIF3C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF3C
- VectorBuilder custom plasmid, inducible vectors for EIF3C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF3C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
- Applied Biological Materials Clones for EIF3C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EIF3C
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene
Localization for EIF3C Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005852 | eukaryotic translation initiation factor 3 complex | IDA | 17322308 |
| GO:0016282 | eukaryotic 43S preinitiation complex | IEA | -- |
| GO:0033290 | eukaryotic 48S preinitiation complex | IEA | -- |
Pathways & Interactions for EIF3C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | RNA transport | ||
| 4 | Translational Control | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.60
|
|
Pathways by source for EIF3C Gene
1 BioSystems pathway for EIF3C Gene
12 Reactome pathways for EIF3C Gene
1 KEGG pathway for EIF3C Gene
2 Qiagen pathways for EIF3C Gene
1 Cell Signaling Technology pathway for EIF3C Gene
Interacting Proteins for EIF3C Gene
Selected Interacting proteins:
Q99613-EIF3C_HUMAN
ENSP00000332604
for EIF3C Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EIF3C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002183 | cytoplasmic translational initiation | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0045727 | positive regulation of translation | IPI | 24092755 |
| GO:1902416 | positive regulation of mRNA binding | IPI | 24092755 |
No data available for SIGNOR curated interactions for EIF3C Gene
Transcripts for EIF3C Gene
mRNA/cDNA for EIF3C Gene
- (6) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (1582) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000566501 3128 bps (uc010byi.4)
- ENST00000331666 3145 bps (uc002dqs.6)
- ENST00000569690 581 bps (uc059sol.1)
- ENST00000564243 2870 bps (uc010vcy.4)
- ENST00000566866 2986 bps (uc002dqu.7)
Unigene Clusters for EIF3C Gene
- Eukaryotic translation initiation factor 3, subunit C:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for EIF3C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
- genomics-online: gRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- Applied Biological Materials CRISPR for EIF3C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
- GenScript: Design CRISPR guide RNA sequences for EIF3C
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
- genomics-online: shRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
Clone Products
-
OriGene ORF clones in human for EIF3C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF3C
- VectorBuilder custom plasmid, inducible vectors for EIF3C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF3C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
- Applied Biological Materials Clones for EIF3C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: |
Expression for EIF3C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EIF3C Gene:
EIF3CSOURCE GeneReport for Unigene cluster for EIF3C Gene:
Hs.567374Evidence on tissue expression from TISSUES for EIF3C Gene
- Nervous system(5)
- Liver(4.7)
- Skin(4.6)
- Lung(4.3)
- Intestine(4.1)
- Eye(3.9)
- Kidney(3.9)
- Pancreas(3.8)
- Muscle(3.3)
- Blood(3.1)
- Heart(2.9)
- Stomach(2.9)
- Spleen(2.2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for EIF3C
-
OriGene qPCR primer pairs for EIF3C
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3C Gene
Orthologs for EIF3C Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| EIF3C 33 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | EIF3C 34 |
|
OneToMany | |
| EIF3CL 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Eif3c 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Eif3c 33 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eif3c 33 |
|
||
| MGC75608 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7935 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eif3c 34 33 |
|
OneToMany | |
| Dr.28312 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | eIF3-S8 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | EIF3C_ANOGA 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | eif-3.C 34 33 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL344C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F03014g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NIP1 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | EIF3C 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0124500 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.3491 33 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07831 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif33 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3491 33 |
|
- Species where no ortholog for EIF3C was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EIF3C Gene
- ENSEMBL:
- Gene Tree for EIF3C (if available)
- TreeFam:
- Gene Tree for EIF3C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EIF3C: view image
Paralogs for EIF3C Gene
(1) SIMAP similar genes for EIF3C Gene using alignment to 14 proteins:
- EIF3C_HUMAN
- A1KYQ7_HUMAN
- B3KNZ4_HUMAN
- B4DDN4_HUMAN
- B4DRU0_HUMAN
- B4DVQ5_HUMAN
- B4DVU3_HUMAN
- B4E1D5_HUMAN
- B4E2Z6_HUMAN
- H3BPE3_HUMAN
- H3BPE4_HUMAN
- H3BRV0_HUMAN
- H3BTY8_HUMAN
- Q3B7B9_HUMAN
Variants for EIF3C Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000487710 | -- | 28,710,493(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001092220 | -- | 28,694,722(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1001253504 | -- | 28,692,755(+) | G/A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1001347881 | -- | 28,703,175(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1001465565 | -- | 28,700,619(+) | CCCC/CCC | genic_upstream_transcript_variant, intron_variant |
Gene Damage Index Score:
0.30;
6.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF3C Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene
Disorders for EIF3C Gene
Additional Disease Information for EIF3C
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for EIF3C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene
Publications for EIF3C Gene
- Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4 58
- eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 58
- Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M … Hakonarson H (Nature genetics 2009) 3 44 58
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M … Robinson CV (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E … Leary JA (Molecular & cellular proteomics : MCP 2007) 3 4 58
Products for EIF3C Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for EIF3C
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EIF3C
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3C
- Origene Custom Protein Services for EIF3C
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF3C
- Browse OriGene Inhibitory RNA Products For EIF3C
- OriGene qPCR primer pairs and template standards for EIF3C
- OriGene qPCR primer pairs for EIF3C
- OriGene CRISPR knockouts for EIF3C
- OriGene ORF clones in human for EIF3C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EIF3C
- GenScript: Next-day shipping of latest version cDNA ORF clones for EIF3C in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EIF3C
- GenScript Custom Assay Services for EIF3C
- GenScript Custom overexpressing Cell Line Services for EIF3C
- GenScript: Design CRISPR guide RNA sequences for EIF3C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EIF3C
- Sino Biological Human cDNA Clone for EIF3C
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EIF3C
- Novus Biologicals proteins and lysates for EIF3C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for EIF3C
- Find your target
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- VectorBuilder custom plasmid, inducible vectors for EIF3C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF3C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 63 available EIF3C Antibodies ranked by validation data
- Compare Top EIF3C Antibodies
- antibodies-online: Search results for available EIF3C related products ranked by validation data
- antibodies-online: Search results for 4 available EIF3C Proteins ranked by validation data
- Compare Top EIF3C Proteins
- GeneTex EIF3C Antibody for EIF3C
- Search GeneTex for Proteins for EIF3C
- Santa Cruz Biotechnology (SCBT) Antibodies for EIF3C
- Search Santa Cruz Biotechnology (SCBT) for EIF3C siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EIF3C
- Horizon Cell Lines for EIF3C
- genomics-online: cdna clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- orf clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- genomics-online: gRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- genomics-online: primer clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- genomics-online: shRNA clones - Search results for 121 available EIF3C gene related products
- Overview of 121 available EIF3C gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF3C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF3C
- GeneCopoeia miRNA 3'UTR Target clone products for EIF3C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3C
- Boster Bio Antibodies for EIF3C
- Browse Boster Bio ELISA Kits
Sources for EIF3C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt