Aliases for EIF3B Gene
- Eukaryotic Translation Initiation Factor 3 Subunit B 2 3 4 5
- Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 9 3 4
- Prt1 Homolog 3 4
- EIF3S9 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit B 2
- EIF3-P110 3
External Ids for EIF3B Gene
Previous HGNC Symbols for EIF3B Gene
Previous GeneCards Identifiers for EIF3B Gene
GeneCards Summary for EIF3B Gene
EIF3B (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot Summary for EIF3B Gene
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).