Aliases for EIF3A Gene

Aliases for EIF3A Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit A 2 3 4 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 10 3 4
  • EIF-3-Theta 3 4
  • EIF3-Theta 2 3
  • EIF3-P170 2 3
  • EIF3 P167 3 4
  • EIF3 P180 3 4
  • EIF3 P185 3 4
  • KIAA0139 2 4
  • EIF3S10 3 4
  • TIF32 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 150/170kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD 3
  • Eukaryotic Translation Initiation Factor 3, Subunit A 2
  • Cytoplasmic Protein P167 3
  • Centrosomin Homolog 3
  • EIF3, P180 Subunit 3
  • EIF3A 5
  • EIF3a 4
  • EIF3 3
  • P167 3
  • P180 3
  • P185 3

External Ids for EIF3A Gene

Previous HGNC Symbols for EIF3A Gene

  • EIF3
  • EIF3S10

Previous GeneCards Identifiers for EIF3A Gene

  • GC10M120785
  • GC10M120794
  • GC10M114423

Summaries for EIF3A Gene

GeneCards Summary for EIF3A Gene

EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Brachydactyly, Type E1 and Breast Cancer. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot Summary for EIF3A Gene

  • RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
  • (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).
  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF3A Gene

Genomics for EIF3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF3A

Top Transcription factor binding sites by QIAGEN in the EIF3A gene promoter:
  • Arnt
  • CUTL1
  • E47
  • HOXA3
  • Nkx2-2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for EIF3A Gene

Latest Assembly
chr10:119,033,670-119,080,823
(GRCh38/hg38)
Size:
47,154 bases
Orientation:
Minus strand

Previous Assembly
chr10:120,793,182-120,840,329
(GRCh37/hg19 by Entrez Gene)
Size:
47,148 bases
Orientation:
Minus strand

chr10:120,794,356-120,840,316
(GRCh37/hg19 by Ensembl)
Size:
45,961 bases
Orientation:
Minus strand

Genomic View for EIF3A Gene

Genes around EIF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3A Gene

Proteins for EIF3A Gene

  • Protein details for EIF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14152-EIF3A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit A
    Protein Accession:
    Q14152
    Secondary Accessions:
    • B1AMV5
    • B4DYS1
    • F5H335
    • O00653
    • Q15778

    Protein attributes for EIF3A Gene

    Size:
    1382 amino acids
    Molecular mass:
    166569 Da
    Quaternary structure:
    • Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.
    SequenceCaution:
    • Sequence=BAA09488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3A Gene

    Alternative splice isoforms for EIF3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3A Gene

Post-translational modifications for EIF3A Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys45, Lys13, Lys68, Lys75, Lys351, Lys409, Lys420, Lys672, Lys711, Lys775, and Lys777
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3A Gene

Domains & Families for EIF3A Gene

Protein Domains for EIF3A Gene

InterPro:
Blocks:
  • Domain in components of the proteasome, COP9-complex and eIF3 (PCI)

Suggested Antigen Peptide Sequences for EIF3A Gene

GenScript: Design optimal peptide antigens:
  • eIF3 p185 (EIF3A_HUMAN)
  • EIF3A protein (Q05BS0_HUMAN)
  • Eukaryotic translation initiation factor 3, subunit A (Q24JU4_HUMAN)
  • EIF3A protein (Q3B770_HUMAN)
  • EIF3A protein (Q6P1R0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14152

UniProtKB/Swiss-Prot:

EIF3A_HUMAN :
  • Belongs to the eIF-3 subunit A family.
Family:
  • Belongs to the eIF-3 subunit A family.
genes like me logo Genes that share domains with EIF3A: view

Function for EIF3A Gene

Molecular function for EIF3A Gene

UniProtKB/Swiss-Prot Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Phenotypes From GWAS Catalog for EIF3A Gene

Gene Ontology (GO) - Molecular Function for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 25849773
GO:0003729 mRNA binding IBA 21873635
GO:0003743 contributes_to translation initiation factor activity IBA,IDA 17581632
GO:0005198 structural molecule activity NAS 9150439
GO:0005515 protein binding IPI 11169732
genes like me logo Genes that share ontologies with EIF3A: view
genes like me logo Genes that share phenotypes with EIF3A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3A Gene

Localization for EIF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3A gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm NAS 9150439
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF3A: view

Pathways & Interactions for EIF3A Gene

genes like me logo Genes that share pathways with EIF3A: view

Pathways by source for EIF3A Gene

SIGNOR curated interactions for EIF3A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IBA,IDA 17581632
GO:0002183 cytoplasmic translational initiation IEA --
GO:0002188 translation reinitiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with EIF3A: view

Drugs & Compounds for EIF3A Gene

(8) Drugs for EIF3A Gene - From: PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2791
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3624
Platinum compounds Pharma 0
eukaryotic translation initiation factor 3 Pharma Eukaryotic translation initiator 0

(4) Additional Compounds for EIF3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for EIF3A Gene

Compound Action Cas Number
eukaryotic translation initiation factor 3 Eukaryotic translation initiator
genes like me logo Genes that share compounds with EIF3A: view

Drug products for research

Transcripts for EIF3A Gene

mRNA/cDNA for EIF3A Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF3A

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for EIF3A Gene

GeneLoc Exon Structure for
EIF3A

Expression for EIF3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3A Gene

Protein differential expression in normal tissues from HIPED for EIF3A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF3A Gene



Protein tissue co-expression partners for EIF3A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF3A

SOURCE GeneReport for Unigene cluster for EIF3A Gene:

Hs.523299

Evidence on tissue expression from TISSUES for EIF3A Gene

  • Liver(4.8)
  • Skin(4.5)
  • Nervous system(4.5)
  • Adrenal gland(3.7)
  • Intestine(3.6)
  • Heart(3.5)
  • Spleen(3.1)
  • Lung(3)
  • Muscle(3)
  • Kidney(2.9)
  • Stomach(2.9)
  • Eye(2.7)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Pancreas(2.4)
  • Blood(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with EIF3A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3A Gene

Orthologs for EIF3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF3A 29 30
  • 99.76 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF3A 30
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF3A 29 30
  • 91.04 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF3A 30
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF3A 29 30
  • 90.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif3a 29
  • 88.86 (n)
Mouse
(Mus musculus)
Mammalia Eif3a 29 16 30
  • 88.51 (n)
OneToOne
Chicken
(Gallus gallus)
Aves EIF3A 29 30
  • 75.8 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF3A 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif3a 29
  • 72.74 (n)
Str.7667 29
African clawed frog
(Xenopus laevis)
Amphibia MGC68848 29
Zebrafish
(Danio rerio)
Actinopterygii eif3s10 29 30
  • 71.48 (n)
OneToOne
wufi15c03 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10408 29
Fruit Fly
(Drosophila melanogaster)
Insecta eIF3-S10 29 30
  • 54.05 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3A_ANOGA 29
  • 52.47 (n)
Worm
(Caenorhabditis elegans)
Secernentea egl-45 29 30
  • 51.66 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14498g 29
  • 45.8 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPG1 29 30 32
  • 44.05 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL065W 29
  • 43.94 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EIF3A 29
  • 49.8 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0120800 29
  • 49.03 (n)
Os.28076 29
Barley
(Hordeum vulgare)
Liliopsida Hv.12705 29
Wheat
(Triticum aestivum)
Liliopsida Ta.13478 29
Corn
(Zea mays)
Liliopsida Zm.6558 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1934 30
  • 54 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif32 29
  • 47.57 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00040 29
  • 46.33 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2509 29
Species where no ortholog for EIF3A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3A Gene

ENSEMBL:
Gene Tree for EIF3A (if available)
TreeFam:
Gene Tree for EIF3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF3A: view image
Alliance of Genome Resources:
Additional Orthologs for EIF3A

Paralogs for EIF3A Gene

(1) SIMAP similar genes for EIF3A Gene using alignment to 9 proteins:

  • EIF3A_HUMAN
  • B4DYS1_HUMAN
  • F5H335_HUMAN
  • Q05BS0_HUMAN
  • Q24JU4_HUMAN
  • Q3B770_HUMAN
  • Q6P1R0_HUMAN
  • Q6ZNE1_HUMAN
  • Q7Z5T5_HUMAN

Pseudogenes.org Pseudogenes for EIF3A Gene

genes like me logo Genes that share paralogs with EIF3A: view

No data available for Paralogs for EIF3A Gene

Variants for EIF3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF3A Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs113389368 Benign: not provided 119,042,396(-) T/A
NM_003750.4(EIF3A):c.3124A>T (p.Met1042Leu)
MISSENSE
rs1409729202 Likely Benign: not provided 119,073,768(-) C/T
NM_003750.4(EIF3A):c.219G>A (p.Gln73=)
SYNONYMOUS
rs141022993 Likely Benign: not provided 119,042,384(-) G/A
NM_003750.4(EIF3A):c.3136C>T (p.Arg1046Trp)
MISSENSE
rs143854254 Benign: not provided 119,073,061(-) G/C
NM_003750.4(EIF3A):c.378-8C>G
INTRON
rs144766795 Benign: not provided 119,061,287(-) T/C
NM_003750.4(EIF3A):c.1164A>G (p.Lys388=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EIF3A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EIF3A Gene

Variant ID Type Subtype PubMed ID
esv3624696 CNV loss 21293372
esv990531 CNV deletion 20482838
nsv1041093 CNV gain 25217958
nsv825582 CNV gain 20364138

Variation tolerance for EIF3A Gene

Residual Variation Intolerance Score: 6.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3A
Leiden Open Variation Database (LOVD)
EIF3A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3A Gene

Disorders for EIF3A Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF3A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
brachydactyly, type e1
  • bde1
breast cancer
  • breast cancer, familial
bardet-biedl syndrome
  • bbs
- elite association - COSMIC cancer census association via MalaCards
Search EIF3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF3A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EIF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3A Gene

Publications for EIF3A Gene

  1. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E … Leary JA (Molecular & cellular proteomics : MCP 2007) 3 4 22
  2. Reconstitution reveals the functional core of mammalian eIF3. (PMID: 17581632) Masutani M … Imataka H (The EMBO journal 2007) 3 4 22
  3. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. (PMID: 17468741) Morris C … Jalinot P (EMBO reports 2007) 3 4 22
  4. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. (PMID: 14519125) Mayeur GL … Hershey JW (European journal of biochemistry 2003) 3 4 22
  5. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PMID: 11169732) Lin L … Burger MM (Journal of cellular biochemistry 2001) 3 4 22

Products for EIF3A Gene

Sources for EIF3A Gene