Aliases for EIF3A Gene
- Eukaryotic Translation Initiation Factor 3 Subunit A 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 10 3 4
- EIF-3-Theta 3 4
- EIF3 P167 3 4
- EIF3 P180 3 4
- EIF3 P185 3 4
- EIF3S10 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 150/170kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD 3
- Eukaryotic Translation Initiation Factor 3, Subunit A 2
- Cytoplasmic Protein P167 3
External Ids for EIF3A Gene
Previous HGNC Symbols for EIF3A Gene
Previous GeneCards Identifiers for EIF3A Gene
GeneCards Summary for EIF3A Gene
EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Bardet-Biedl Syndrome. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3A Gene
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
(Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).