Aliases for EIF2S3B Gene
- Eukaryotic Translation Initiation Factor 2 Subunit Gamma B 2 3 5
- Eukaryotic Translation Initiation Factor 2 Subunit Gamma A 2 3 4
- EIF-2-Gamma A 3 4
- EIF-2gA 3 4
- Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa Pseudogene 3
- Putative Eukaryotic Translation Initiation Factor 2 Subunit 3-Like Protein 3
GeneCards Summary for EIF2S3B Gene
EIF2S3B (Eukaryotic Translation Initiation Factor 2 Subunit Gamma B) is a Protein Coding gene. An important paralog of this gene is EIF2S3.
UniProtKB/Swiss-Prot for EIF2S3B Gene
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).