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Aliases for EIF2S3B Gene

Aliases for EIF2S3B Gene

  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma B 2 3
  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma A 2 3 4
  • Putative Eukaryotic Translation Initiation Factor 2 Subunit 3-Like Protein 3 5
  • EIF-2-Gamma A 3 4
  • EIF-2gA 3 4
  • EIF2S3L 3 4
  • Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa Pseudogene 3
  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma Pseudogene 3
  • EIF-2-Gamma2 3
  • AC068775.1 5
  • EIF2gA 3

External Ids for EIF2S3B Gene

Summaries for EIF2S3B Gene

GeneCards Summary for EIF2S3B Gene

EIF2S3B (Eukaryotic Translation Initiation Factor 2 Subunit Gamma B) is a Protein Coding gene. An important paralog of this gene is EIF2S3.

UniProtKB/Swiss-Prot for EIF2S3B Gene

  • As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Additional gene information for EIF2S3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2S3B Gene

Genomics for EIF2S3B Gene

GeneHancer (GH) Regulatory Elements for EIF2S3B Gene

Promoters and enhancers for EIF2S3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010611 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.6 +107.7 107743 2.9 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MAGOHB ENSG00000213443 KLRA1P EIF2S3B TAS2R43 TAS2R50 ENSG00000257027 ENSG00000256682 STYK1 CLEC2D
GH12I010360 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -141.4 -141362 7.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF213 ZNF143 SP3 LOC101928100 KLRK1 DDX12P ENSG00000213443 KLRA1P EIF2S3B ENSG00000257027 ENSG00000256682 CLEC2D ENSG00000255958
GH12I009646 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -853.9 -853869 10 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 IRF4 SLC30A9 ZNF207 ZNF143 LOC105369728 CLEC2D LOC374443 DDX12P KLRB1 CLECL1 CLEC7A M6PR CLEC12A LOC642846
GH12I010501 Enhancer 0.5 ENCODE 0.8 -4.4 -4405 0.1 CTCF ZNF654 SMC3 STAT3 RAD21 RFX5 EIF2S3B GC12M012109 LOC105369657 KLRC1
GH12I010497 Enhancer 0.4 ENCODE 0.4 -7.0 -7015 2 PRDM6 NFATC1 KLRC1 GABARAPL1 ENSG00000255958 KLRA1P EIF2S3B GC12M012109 LOC105369657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF2S3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for EIF2S3B Gene

Genomic Locations for EIF2S3B Gene
chr12:10,505,602-10,523,135
(GRCh38/hg38)
Size:
17,534 bases
Orientation:
Plus strand
chr12:10,658,201-10,675,734
(GRCh37/hg19)

Genomic View for EIF2S3B Gene

Genes around EIF2S3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2S3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2S3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2S3B Gene

Proteins for EIF2S3B Gene

  • Protein details for EIF2S3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VIR3-IF2GL_HUMAN
    Recommended name:
    Putative eukaryotic translation initiation factor 2 subunit 3-like protein
    Protein Accession:
    Q2VIR3
    Secondary Accessions:
    • Q5I0X0
    • Q6KF84

    Protein attributes for EIF2S3B Gene

    Size:
    472 amino acids
    Molecular mass:
    51229 Da
    Quaternary structure:
    • The eukaryotic translation initiation factor 2 complex/eIF2 is a heterotrimer composed of an alpha, a beta and a gamma subunit.
    SequenceCaution:
    • Sequence=ABB92405.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA07331.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305};

    Alternative splice isoforms for EIF2S3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2S3B Gene

Post-translational modifications for EIF2S3B Gene

No Post-translational modifications

Other Protein References for EIF2S3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF2S3B Gene

Domains & Families for EIF2S3B Gene

Gene Families for EIF2S3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EIF2S3B Gene

Graphical View of Domain Structure for InterPro Entry

Q2VIR3

UniProtKB/Swiss-Prot:

IF2GL_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
genes like me logo Genes that share domains with EIF2S3B: view

Function for EIF2S3B Gene

Molecular function for EIF2S3B Gene

UniProtKB/Swiss-Prot Function:
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Gene Ontology (GO) - Molecular Function for EIF2S3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with EIF2S3B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EIF2S3B Gene

Localization for EIF2S3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2S3B gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for EIF2S3B Gene

Pathways & Interactions for EIF2S3B Gene

SuperPathways for EIF2S3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF2S3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF2S3B: view

No data available for Pathways by source and SIGNOR curated interactions for EIF2S3B Gene

Drugs & Compounds for EIF2S3B Gene

No Compound Related Data Available

Transcripts for EIF2S3B Gene

mRNA/cDNA for EIF2S3B Gene

(2) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2S3B Gene

No ASD Table

Relevant External Links for EIF2S3B Gene

GeneLoc Exon Structure for
EIF2S3B
ECgene alternative splicing isoforms for
EIF2S3B

Expression for EIF2S3B Gene

mRNA Expression by UniProt/SwissProt for EIF2S3B Gene:

Q2VIR3-IF2GL_HUMAN
Tissue specificity: Specifically expressed in testis at the mRNA level.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2S3B Gene

Orthologs for EIF2S3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF2S3 34
  • 91 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif2s3x 34
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF2S3 34
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii eif2s3 34
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF-2gamma 34
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.8 34
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD11 34
  • 59 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3195 33
wheat
(Triticum aestivum)
Liliopsida Ta.2663 33
corn
(Zea mays)
Liliopsida Zm.6871 33
rice
(Oryza sativa)
Liliopsida Os.12630 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 78 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5353 33
Species where no ortholog for EIF2S3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for EIF2S3B Gene

ENSEMBL:
Gene Tree for EIF2S3B (if available)
TreeFam:
Gene Tree for EIF2S3B (if available)

Paralogs for EIF2S3B Gene

Paralogs for EIF2S3B Gene

genes like me logo Genes that share paralogs with EIF2S3B: view

Variants for EIF2S3B Gene

Variation tolerance for EIF2S3B Gene

Gene Damage Index Score: 8.91; 87.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF2S3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2S3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for EIF2S3B Gene

Disorders for EIF2S3B Gene

No disorders were found for EIF2S3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for EIF2S3B Gene

Publications for EIF2S3B Gene

  1. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques AC … Kaessmann H (PLoS biology 2005) 2 3 4 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for EIF2S3B Gene

Sources for EIF2S3B Gene

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