Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF2S1 Gene

Aliases for EIF2S1 Gene

  • Eukaryotic Translation Initiation Factor 2 Subunit Alpha 2 3 4 5
  • Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa 2 3
  • EIF-2-Alpha 3 4
  • EIF-2alpha 3 4
  • EIF-2A 3 4
  • EIF2A 3 4
  • Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ) 2
  • Eukaryotic Translation Initiation Factor 2 Subunit 1 3
  • EIF-2 3
  • EIF2 3

External Ids for EIF2S1 Gene

Previous HGNC Symbols for EIF2S1 Gene

  • EIF2

Previous GeneCards Identifiers for EIF2S1 Gene

  • GC14P065332
  • GC14P061620
  • GC14P065817
  • GC14P066896
  • GC14P067826
  • GC14P047996

Summaries for EIF2S1 Gene

Entrez Gene Summary for EIF2S1 Gene

  • The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

GeneCards Summary for EIF2S1 Gene

EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) is a Protein Coding gene. Diseases associated with EIF2S1 include Vaccinia and Herpes Simplex. Among its related pathways are Translation Factors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for EIF2S1 Gene

  • Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Tocris Summary for EIF2S1 Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for EIF2S1 Gene

Additional gene information for EIF2S1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2S1 Gene

Genomics for EIF2S1 Gene

GeneHancer (GH) Regulatory Elements for EIF2S1 Gene

Promoters and enhancers for EIF2S1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J067356 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.8 -778 5.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ATP6V1D EIF2S1 ZFYVE26 PLEK2 ENSG00000258561 GPHN ENSG00000199755
GH14J066506 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -851.6 -851610 3.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B GPHN ENSG00000258561 FAM71D LINC02290 NCOA4P1 ATP6V1D PLEK2 EIF2S1
GH14J067238 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.8 -119.2 -119179 5 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF207 FOS MPP5 ATP6V1D EIF2S1 ENSG00000258561 ENSG00000258988
GH14J067268 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 7.8 -90.1 -90143 3.6 PKNOX1 MAX SIN3A ZNF384 RFX5 ZNF335 ZNF316 POLR2A PRDM10 ZNF600 MPP5 ATP6V1D PLEK2 EIF2S1 GPHN GC14M067260 GC14M067261 GC14P067341
GH14J067312 Enhancer 0.8 ENCODE 12.3 -47.9 -47918 0.2 PKNOX1 CLOCK FOXA2 NFIB NEUROD1 SIN3A BMI1 ZNF207 FOS RCOR1 ATP6V1D EIF2S1 FAM71D GC14P067341 GC14M067260 GC14M067261 MPP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF2S1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF2S1 gene promoter:

Genomic Locations for EIF2S1 Gene

Genomic Locations for EIF2S1 Gene
chr14:67,359,997-67,386,516
(GRCh38/hg38)
Size:
26,520 bases
Orientation:
Plus strand
chr14:67,826,714-67,853,233
(GRCh37/hg19)

Genomic View for EIF2S1 Gene

Genes around EIF2S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2S1 Gene

Proteins for EIF2S1 Gene

  • Protein details for EIF2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05198-IF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2 subunit 1
    Protein Accession:
    P05198

    Protein attributes for EIF2S1 Gene

    Size:
    315 amino acids
    Molecular mass:
    36112 Da
    Quaternary structure:
    • Heterotrimer composed of an alpha, a beta and a gamma chain (PubMed:23063529). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2 (PubMed:17894550). Associates with ribosomes (PubMed:17894550).

    Three dimensional structures from OCA and Proteopedia for EIF2S1 Gene

neXtProt entry for EIF2S1 Gene

Post-translational modifications for EIF2S1 Gene

  • Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation (PubMed:15207627, PubMed:18032499). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).
  • Ubiquitination at Lys259, isoforms=226, Lys209, isoforms=190, Lys143, isoforms=141, isoforms=123, and isoforms=101
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF2S1 Gene

No data available for DME Specific Peptides for EIF2S1 Gene

Domains & Families for EIF2S1 Gene

Gene Families for EIF2S1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P05198

UniProtKB/Swiss-Prot:

IF2A_HUMAN :
  • Belongs to the eIF-2-alpha family.
Family:
  • Belongs to the eIF-2-alpha family.
genes like me logo Genes that share domains with EIF2S1: view

Function for EIF2S1 Gene

Molecular function for EIF2S1 Gene

UniProtKB/Swiss-Prot Function:
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Gene Ontology (GO) - Molecular Function for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003743 translation initiation factor activity IEA,IDA 16289705
GO:0005515 protein binding IPI 9431994
GO:0043022 ribosome binding IDA 17894550
genes like me logo Genes that share ontologies with EIF2S1: view
genes like me logo Genes that share phenotypes with EIF2S1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2S1 Gene

Localization for EIF2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2S1 Gene

Cytoplasm, Stress granule. Note=Colocalizes with NANOS3 in the stress granules. {ECO:0000250 UniProtKB:Q6ZWX6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2S1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
endoplasmic reticulum 3
mitochondrion 2
peroxisome 2
plasma membrane 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IBA --
GO:0005844 polysome TAS 2948954
genes like me logo Genes that share ontologies with EIF2S1: view

Pathways & Interactions for EIF2S1 Gene

genes like me logo Genes that share pathways with EIF2S1: view

SIGNOR curated interactions for EIF2S1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006417 regulation of translation IEA --
GO:0007568 aging IEA --
GO:0032057 negative regulation of translational initiation in response to stress ISS --
genes like me logo Genes that share ontologies with EIF2S1: view

Drugs & Compounds for EIF2S1 Gene

(34) Drugs for EIF2S1 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Guanosine triphosphate Experimental Pharma 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(20) Additional Compounds for EIF2S1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for EIF2S1 Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with EIF2S1: view

Transcripts for EIF2S1 Gene

mRNA/cDNA for EIF2S1 Gene

Unigene Clusters for EIF2S1 Gene

Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2S1 Gene

No ASD Table

Relevant External Links for EIF2S1 Gene

GeneLoc Exon Structure for
EIF2S1
ECgene alternative splicing isoforms for
EIF2S1

Expression for EIF2S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF2S1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF2S1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF2S1 Gene



Protein tissue co-expression partners for EIF2S1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF2S1 Gene:

EIF2S1

SOURCE GeneReport for Unigene cluster for EIF2S1 Gene:

Hs.151777

Evidence on tissue expression from TISSUES for EIF2S1 Gene

  • Liver(4.5)
  • Nervous system(4.3)
  • Lung(2.8)
  • Blood(2.7)
  • Kidney(2.5)
  • Muscle(2.4)
  • Pancreas(2.4)
  • Heart(2.3)
  • Intestine(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with EIF2S1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2S1 Gene

Orthologs for EIF2S1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2S1 34 33
  • 99.79 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2S1 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF2S1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2S1 34 33
  • 94.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2S1 34 33
  • 94.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2s1 16 34 33
  • 93.33 (n)
rat
(Rattus norvegicus)
Mammalia Eif2s1 33
  • 93.33 (n)
chicken
(Gallus gallus)
Aves EIF2S1 34 33
  • 84.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2S1 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2s1 33
  • 81.27 (n)
Str.6631 33
African clawed frog
(Xenopus laevis)
Amphibia eif2s1-prov 33
zebrafish
(Danio rerio)
Actinopterygii eif2s1a 34
  • 94 (a)
OneToMany
eif2s1b 34 33
  • 77.25 (n)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7988 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011190 33
  • 61.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-2alpha 34 35 33
  • 58.14 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37E3.10 34 35 33
  • 60.77 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI2 36 34 33
  • 61.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11814g 33
  • 60.31 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR320W 33
  • 57.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40290 33
  • 56.12 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7752 33
rice
(Oryza sativa)
Liliopsida Os07g0692800 33
  • 54.78 (n)
Os.11646 33
corn
(Zea mays)
Liliopsida Zm.4283 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif211 33
  • 59.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08277 33
  • 55.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1492 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1492 33
Species where no ortholog for EIF2S1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2S1 Gene

ENSEMBL:
Gene Tree for EIF2S1 (if available)
TreeFam:
Gene Tree for EIF2S1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF2S1: view image

Paralogs for EIF2S1 Gene

No data available for Paralogs for EIF2S1 Gene

Variants for EIF2S1 Gene

Sequence variations from dbSNP and Humsavar for EIF2S1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000004027 -- 67,372,494(+) A/G intron_variant
rs1000043200 -- 67,370,231(+) G/A intron_variant
rs1000102764 -- 67,367,338(+) C/T intron_variant
rs1000249789 -- 67,363,862(+) G/A intron_variant
rs1000284590 -- 67,376,946(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2S1 Gene

Variant ID Type Subtype PubMed ID
esv2751285 CNV gain 17911159
nsv456331 CNV gain 19166990
nsv470651 CNV gain 18288195
nsv509539 CNV insertion 20534489
nsv564961 CNV gain 21841781
nsv832821 CNV gain 17160897

Variation tolerance for EIF2S1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF2S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2S1 Gene

Disorders for EIF2S1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EIF2S1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vaccinia
herpes simplex
  • herpesvirus hominis disease
influenza
  • flu
leukoencephalopathy with vanishing white matter
  • cle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF2S1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EIF2S1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF2S1 Gene

Publications for EIF2S1 Gene

  1. Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. (PMID: 2948954) Ernst H … Hershey JW (The Journal of biological chemistry 1987) 2 3 4 58
  2. eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. (PMID: 23063529) Borck G … Basel-Vanagaite L (Molecular cell 2012) 3 4 58
  3. Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition. (PMID: 20428777) Shiota M … Naito S (International journal of oncology 2010) 3 22 58
  4. Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha. (PMID: 19846675) Backes S … Sutter G (The Journal of general virology 2010) 3 22 58
  5. OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. (PMID: 20154146) Wehner KA … Sarnow P (Molecular and cellular biology 2010) 3 22 58

Products for EIF2S1 Gene

Sources for EIF2S1 Gene

Content
Loading form....