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This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. Diseases associated with EIF2D include Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0003743 | translation initiation factor activity | IEA,IDA | 20566627 |
GO:0038023 | signaling receptor activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | TAS,IDA | 20566627 |
GO:0005829 | cytosol | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
GO:0022627 | colocalizes_with cytosolic small ribosomal subunit | IBA,IDA | 20713520 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001731 | formation of translation preinitiation complex | IEA,IDA | 20713520 |
GO:0006412 | translation | IEA | -- |
GO:0006413 | translational initiation | IEA | -- |
GO:0006886 | intracellular protein transport | TAS | -- |
GO:0032790 | ribosome disassembly | IDA | 20713520 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EIF2D 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EIF2D 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EIF2D 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Eif2d 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Eif2d 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | EIF2D 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EIF2D 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EIF2D 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EIF2D 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif2d 30 |
|
||
MGC76058 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | eif2d 30 31 |
|
OneToOne | |
zgc63669 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13929 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ligatin 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011804 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | CELE_C25H3.4 30 |
|
||
C25H3.4 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TMA64 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G71350 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0557600 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35252702 | - | p.Thr210Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|