Aliases for EIF2D Gene
Aliases for EIF2D Gene
External Ids for EIF2D Gene
- HGNC: 6583
- Entrez Gene: 1939
- Ensembl: ENSG00000143486
- OMIM: 613709
- UniProtKB: P41214
Previous GeneCards Identifiers for EIF2D Gene
- GC01M206745
Summaries for EIF2D Gene
-
This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for EIF2D Gene
EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF2D Gene
-
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2D Gene
Genomics for EIF2D Gene
GeneHancer (GH) Regulatory Elements for EIF2D Gene
Promoters and enhancers for EIF2D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EIF2D on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EIF2D Gene
Genomic Locations for EIF2D Gene
- chr1:206,571,292-206,612,551
- (GRCh38/hg38)
- Size:
- 41,260 bases
- Orientation:
- Minus strand
- chr1:206,744,620-206,785,904
- (GRCh37/hg19)
Genomic View for EIF2D Gene
Genes around EIF2D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
EIF2D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF2D Gene
Proteins for EIF2D Gene
-
Protein details for EIF2D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41214-EIF2D_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 2D
- Protein Accession:
- P41214
- Q5SY40
- Q8IXV3
- Q96DG3
- Q96TG7
- Q9NR27
- Q9NSN0
- Q9NV18
- Q9NZ21
Protein attributes for EIF2D Gene
- Size:
- 584 amino acids
- Molecular mass:
- 64706 Da
- Quaternary structure:
- No Data Available
Protein Expression for EIF2D Gene
Post-translational modifications for EIF2D Gene
Other Protein References for EIF2D Gene
Antibody Products
-
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-
Abcam antibodies for EIF2D
-
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-
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Protein Products
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Cloud-Clone Corp. Proteins for EIF2D
- antibodies-online: Search results for 8 available EIF2D Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for EIF2D
Assay Products
No data available for DME Specific Peptides for EIF2D Gene
Domains & Families for EIF2D Gene
Gene Families for EIF2D Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for EIF2D Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EIF2D Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P41214- Family:
-
- Belongs to the eIF2D family.
Function for EIF2D Gene
Molecular function for EIF2D Gene
- UniProtKB/Swiss-Prot Function:
- Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Phenotypes From GWAS Catalog for EIF2D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003743 | translation initiation factor activity | IDA | 20566627 |
| GO:0004872 | receptor activity | TAS | 2482295 |
Phenotypes for EIF2D Gene
- GenomeRNAi human phenotypes for EIF2D:
Animal Model Products
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miRNA for EIF2D Gene
- miRTarBase miRNAs that target EIF2D
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2D Gene
Localization for EIF2D Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF2D Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nuclear bodies (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS,IDA | 20566627 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
| GO:0022627 | colocalizes_with cytosolic small ribosomal subunit | IDA | 20713520 |
Pathways & Interactions for EIF2D Gene
No Data Available
Interacting Proteins for EIF2D Gene
Selected Interacting proteins:
P41214-EIF2D_HUMAN
ENSP00000271764
for EIF2D Gene via
IID
MINT
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001731 | formation of translation preinitiation complex | IDA | 20713520 |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA | -- |
| GO:0006886 | intracellular protein transport | TAS | 2482295 |
| GO:0032790 | ribosome disassembly | IDA | 20713520 |
No data available for Pathways by source and SIGNOR curated interactions for EIF2D Gene
Transcripts for EIF2D Gene
mRNA/cDNA for EIF2D Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (228) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EIF2D Gene
CRISPR Products
-
OriGene CRISPR knockouts for EIF2D
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF2D
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EIF2D
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-
ViGene Biosciences ready-to-package AAV shRNAs for EIF2D gene
Clone Products
- Sino Biological Human cDNA Clone for EIF2D
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EIF2D
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for EIF2D Gene
This gene is overexpressed in Breast (24.6) and Esophagus (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF2D Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EIF2D Gene:
EIF2DSOURCE GeneReport for Unigene cluster for EIF2D Gene:
Hs.497581Evidence on tissue expression from TISSUES for EIF2D Gene
- Nervous system(2.9)
Primer Products
-
OriGene qPCR primer pairs for EIF2D
-
OriGene qPCR primer pairs and template standards for EIF2D
- genomics-online: primer clones - Search results for 94 available EIF2D gene related products
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2D Gene
Orthologs for EIF2D Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EIF2D 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | EIF2D 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | EIF2D 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Eif2d 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Eif2d 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EIF2D 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | EIF2D 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EIF2D 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EIF2D 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eif2d 33 |
|
||
| MGC76058 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | eif2d 33 34 |
|
||
| zgc63669 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13929 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ligatin 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011804 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_C25H3.4 33 |
|
||
| C25H3.4 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TMA64 34 36 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G71350 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0557600 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for EIF2D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EIF2D Gene
No data available for Paralogs for EIF2D Gene
Variants for EIF2D Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000085991 | -- | 206,577,586(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000146813 | -- | 206,576,059(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000261220 | -- | 206,613,354(-) | G/C | upstream_transcript_variant | |
| rs1000315833 | -- | 206,607,032(-) | T/C | intron_variant | |
| rs1000371563 | -- | 206,607,295(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.57;
56.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF2D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EIF2D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EIF2D Gene
Disorders for EIF2D Gene
Additional Disease Information for EIF2D
No disorders were found for EIF2D Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2D Gene
Publications for EIF2D Gene
- GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. (PMID: 20566627) Dmitriev SE … Shatsky IN (The Journal of biological chemistry 2010) 2 3 4 58
- Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin MA … Pestova TV (Genes & development 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PMID: 12097419) Wang Y … Chen WF (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 58
- Molecular cloning of the cDNA for ligatin. (PMID: 2482295) Jakoi ER … Snyderman R (Journal of cell science 1989) 3 4 58
Products for EIF2D Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available EIF2D Antibodies ranked by validation data
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Sources for EIF2D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
