Aliases for EIF2D Gene
External Ids for EIF2D Gene
Previous GeneCards Identifiers for EIF2D Gene
This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for EIF2D Gene
EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. Diseases associated with EIF2D include Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot Summary for EIF2D Gene
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.