Aliases for EIF2B5 Gene
External Ids for EIF2B5 Gene
Previous GeneCards Identifiers for EIF2B5 Gene
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
GeneCards Summary for EIF2B5 Gene
EIF2B5 (Eukaryotic Translation Initiation Factor 2B Subunit Epsilon) is a Protein Coding gene. Diseases associated with EIF2B5 include Leukoencephalopathy With Vanishing White Matter and Leukodystrophy. Among its related pathways are Viral mRNA Translation and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include binding and translation initiation factor activity. An important paralog of this gene is GMPPA.
UniProtKB/Swiss-Prot Summary for EIF2B5 Gene
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.