Aliases for EIF2B4 Gene
External Ids for EIF2B4 Gene
Previous GeneCards Identifiers for EIF2B4 Gene
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF2B4 Gene
EIF2B4 (Eukaryotic Translation Initiation Factor 2B Subunit Delta) is a Protein Coding gene. Diseases associated with EIF2B4 include Leukoencephalopathy With Vanishing White Matter and Leukodystrophy. Among its related pathways are Viral mRNA Translation and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and translation initiation factor binding. An important paralog of this gene is EIF2B2.
UniProtKB/Swiss-Prot Summary for EIF2B4 Gene
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.