The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. ... See more...

Aliases for EIF2B3 Gene

Aliases for EIF2B3 Gene

  • Eukaryotic Translation Initiation Factor 2B Subunit Gamma 2 3 5
  • Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa 2 3
  • Translation Initiation Factor EIF-2B Subunit Gamma 3 4
  • EIF-2B GDP-GTP Exchange Factor Subunit Gamma 3 4
  • EIF2Bgamma 2 3
  • EIF-2B 2 3
  • Eukaryotic Translation Initiation Factor 2B, Subunit 3 (Gamma, 58kD) 2
  • EIF2B3 5

External Ids for EIF2B3 Gene

Previous GeneCards Identifiers for EIF2B3 Gene

  • GC01M045043
  • GC01M044316
  • GC01M044746
  • GC01M044729
  • GC01M044985
  • GC01M045089
  • GC01M045316
  • GC01M043428

Summaries for EIF2B3 Gene

Entrez Gene Summary for EIF2B3 Gene

  • The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for EIF2B3 Gene

EIF2B3 (Eukaryotic Translation Initiation Factor 2B Subunit Gamma) is a Protein Coding gene. Diseases associated with EIF2B3 include Leukoencephalopathy With Vanishing White Matter and Leukodystrophy. Among its related pathways are Viral mRNA Translation and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and nucleotidyltransferase activity. An important paralog of this gene is GMPPB.

UniProtKB/Swiss-Prot Summary for EIF2B3 Gene

  • Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Gene Wiki entry for EIF2B3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF2B3 Gene

Genomics for EIF2B3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF2B3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 421 2.2 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 EIF2B3 TOE1 GPBP1L1 MUTYH RPL7AP16 RPS8 RPS15AP10 HECTD3 DMAP1 UROD
GH01J044946 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 11.5 +39.2 39221 4.6 PRDM10 IKZF1 RCOR2 SP1 ZNF600 ZNF341 CEBPA FOXK2 SOX13 TCF7 UROD EIF2B3 PPIAP35 BEST4 BTBD19 piR-57461-007 CCNB1IP1P1 RF00017-191 PTCH2
GH01J045018 Enhancer 0.9 Ensembl ENCODE 10.8 -32.0 -32039 0.7 CTCF PRDM10 LARP7 REST RAD21 YY1 CBX3 SMARCA5 CTBP1 ZNF444 PPIAP35 EIF2B3 MN308941 HECTD3 OSTCP5 ZSWIM5
GH01J045039 Enhancer 0.9 ENCODE 10.2 -52.5 -52462 0.2 LEF1 JUND PKNOX1 RXRB MTA1 REST NR2C1 DPF2 HDAC1 SOX6 TOE1 GPBP1L1 DMAP1 EIF2B3 PPIAP35 ZSWIM5 BEST4 MN308941 HECTD3 OSTCP5
GH01J044924 Enhancer 0.8 Ensembl ENCODE 11 +60.6 60626 3.8 CTCF ZNF512 PKNOX1 JUND EGR1 FOS JUN FOSL1 FOSL2 SAP130 BTBD19 UROD PPIAP35 EIF2B3 BEST4 ENSG00000226499 PTCH2 TCTEX1D4 PLK3 RNA5SP47
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF2B3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF2B3

Top Transcription factor binding sites by QIAGEN in the EIF2B3 gene promoter:
  • CP2
  • E47
  • FOXD3
  • p53
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a
  • Tal-1beta
  • ZIC2

Genomic Locations for EIF2B3 Gene

Genomic Locations for EIF2B3 Gene
chr1:44,850,522-44,986,722
(GRCh38/hg38)
Size:
136,201 bases
Orientation:
Minus strand
chr1:45,316,194-45,452,361
(GRCh37/hg19)
Size:
136,168 bases
Orientation:
Minus strand

Genomic View for EIF2B3 Gene

Genes around EIF2B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2B3 Gene

Proteins for EIF2B3 Gene

  • Protein details for EIF2B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR50-EI2BG_HUMAN
    Recommended name:
    Translation initiation factor eIF-2B subunit gamma
    Protein Accession:
    Q9NR50
    Secondary Accessions:
    • B2RBH8
    • D3DPZ2
    • Q5QP89
    • Q5QP90
    • Q8NDB5
    • Q8WV57
    • Q9H850

    Protein attributes for EIF2B3 Gene

    Size:
    452 amino acids
    Molecular mass:
    50240 Da
    Quaternary structure:
    • Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

    Three dimensional structures from OCA and Proteopedia for EIF2B3 Gene

    Alternative splice isoforms for EIF2B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2B3 Gene

Post-translational modifications for EIF2B3 Gene

  • Ubiquitination at Lys259
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF2B3 Gene

Domains & Families for EIF2B3 Gene

Gene Families for EIF2B3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for EIF2B3 Gene

InterPro:
Blocks:
  • Nucleotidyl transferase
ProtoNet:

Suggested Antigen Peptide Sequences for EIF2B3 Gene

GenScript: Design optimal peptide antigens:
  • eIF-2B GDP-GTP exchange factor subunit gamma (EI2BG_HUMAN)
  • Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa (Q5QP91_HUMAN)
  • cDNA FLJ12337 fis, clone MAMMA1002236, highly similar to TRANSLATION INITIATION FACTOR EIF-2B GAMMA SUBUNIT (Q9HA31_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NR50

UniProtKB/Swiss-Prot:

EI2BG_HUMAN :
  • Belongs to the eIF-2B gamma/epsilon subunits family.
Family:
  • Belongs to the eIF-2B gamma/epsilon subunits family.
genes like me logo Genes that share domains with EIF2B3: view

Function for EIF2B3 Gene

Molecular function for EIF2B3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Phenotypes From GWAS Catalog for EIF2B3 Gene

Gene Ontology (GO) - Molecular Function for EIF2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 10900014
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IMP 15054402
GO:0005515 protein binding IPI 15060152
GO:0008135 contributes_to translation factor activity, RNA binding IDA 10900014
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with EIF2B3: view
genes like me logo Genes that share phenotypes with EIF2B3: view

Human Phenotype Ontology for EIF2B3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EIF2B3 Gene

MGI Knock Outs for EIF2B3:
  • Eif2b3 Eif2b3<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for EIF2B3 Gene

miRTarBase miRNAs that target EIF2B3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF2B3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EIF2B3 Gene

Localization for EIF2B3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2B3 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11323413
GO:0005829 cytosol TAS --
GO:0005851 eukaryotic translation initiation factor 2B complex IBA,IDA 11323413
GO:0032045 guanyl-nucleotide exchange factor complex IBA 21873635
genes like me logo Genes that share ontologies with EIF2B3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF2B3 Gene

Pathways & Interactions for EIF2B3 Gene

PathCards logo

SuperPathways for EIF2B3 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 NFAT and Cardiac Hypertrophy
.42
.37
3 Translation Factors
4 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.47
5 Herpes simplex virus 1 infection
genes like me logo Genes that share pathways with EIF2B3: view

Pathways by source for EIF2B3 Gene

2 GeneGo (Thomson Reuters) pathways for EIF2B3 Gene
  • Translation Regulation of EIF2 activity
  • Translation Insulin regulation of translation
5 Qiagen pathways for EIF2B3 Gene
  • eIF2 Pathway
  • GSK3 Signaling
  • IGF1R Signaling
  • Insulin Receptor Pathway
  • Signaling Involved in Cardiac Hypertrophy

SIGNOR curated interactions for EIF2B3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002183 cytoplasmic translational initiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,IDA 10900014
GO:0009058 biosynthetic process IEA --
GO:0009408 response to heat TAS --
genes like me logo Genes that share ontologies with EIF2B3: view

Drugs & Compounds for EIF2B3 Gene

(1) Drugs for EIF2B3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EIF2B3: view

Transcripts for EIF2B3 Gene

mRNA/cDNA for EIF2B3 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF2B3

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2B3 Gene

No ASD Table

Relevant External Links for EIF2B3 Gene

GeneLoc Exon Structure for
EIF2B3

Expression for EIF2B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF2B3 Gene

Protein differential expression in normal tissues from HIPED for EIF2B3 Gene

This gene is overexpressed in Pancreas (10.4), Breast (7.8), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF2B3 Gene



Protein tissue co-expression partners for EIF2B3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF2B3

SOURCE GeneReport for Unigene cluster for EIF2B3 Gene:

Hs.533549

Evidence on tissue expression from TISSUES for EIF2B3 Gene

  • Blood(4.3)
  • Liver(4.3)
  • Lymph node(4.2)
  • Nervous system(3.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2B3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • head
  • pituitary gland
  • skull
Thorax:
  • breast
Abdomen:
  • adrenal gland
Pelvis:
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vulva
Limb:
  • lower limb
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with EIF2B3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF2B3 Gene

Orthologs for EIF2B3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2B3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF2B3 30 31
  • 99.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF2B3 30 31
  • 91.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF2B3 30 31
  • 90.86 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eif2b3 30 17 31
  • 88.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif2b3 30
  • 88.2 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 84 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia EIF2B3 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EIF2B3 30 31
  • 69.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF2B3 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif2b3 30
  • 64.6 (n)
Str.2507 30
African clawed frog
(Xenopus laevis)
Amphibia eif2b3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii eif2b3 30 31
  • 65.25 (n)
OneToOne
zgc56473 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5237 30
Fruit Fly
(Drosophila melanogaster)
Insecta eIF2B-gamma 30 31
  • 48.42 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005210 30
  • 46.5 (n)
Worm
(Caenorhabditis elegans)
Secernentea ppp-1 30 31
  • 43.45 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD1 31 33
  • 19 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G19485 30
  • 45.12 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0338900 30
  • 44.68 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif223 30
  • 46.82 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03548 30
  • 40.72 (n)
Species where no ortholog for EIF2B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF2B3 Gene

ENSEMBL:
Gene Tree for EIF2B3 (if available)
TreeFam:
Gene Tree for EIF2B3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF2B3: view image

Paralogs for EIF2B3 Gene

Paralogs for EIF2B3 Gene

(7) SIMAP similar genes for EIF2B3 Gene using alignment to 4 proteins:

  • EI2BG_HUMAN
  • H0Y580_HUMAN
  • Q5QP88_HUMAN
  • Q9HA31_HUMAN
genes like me logo Genes that share paralogs with EIF2B3: view

Variants for EIF2B3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF2B3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
716801 Conflicting Interpretations: Leukoencephalopathy with vanishing white matter; not provided 44,875,688(-) T/C MISSENSE_VARIANT
733941 Likely Benign: not provided 44,879,872(-) C/T SYNONYMOUS_VARIANT
737736 Likely Benign: not provided 44,981,090(-) G/A SYNONYMOUS_VARIANT
744270 Likely Benign: not provided 44,981,124(-) C/T SYNONYMOUS_VARIANT
745667 Likely Benign: not provided 44,941,531(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for EIF2B3 Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF2B3 Gene

Variant ID Type Subtype PubMed ID
esv2474011 CNV deletion 19546169
esv2630872 CNV deletion 19546169
esv2747774 CNV deletion 23290073
esv3561538 CNV deletion 23714750
nsv546146 CNV loss 21841781
nsv945915 CNV duplication 23825009

Variation tolerance for EIF2B3 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF2B3 Gene

Human Gene Mutation Database (HGMD)
EIF2B3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2B3 Gene

Disorders for EIF2B3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for EIF2B3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukoencephalopathy with vanishing white matter
  • cle
leukodystrophy
  • leukodystrophies
glycogen storage disease xv
  • gsd15
childhood ataxia with central nervous system hypomyelination / vanishing white matter
  • leukoencephalopathy with vanishing white matter
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

EI2BG_HUMAN
  • Leukodystrophy with vanishing white matter (VWM) [MIM:603896]: A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. {ECO:0000269 PubMed:11835386, ECO:0000269 PubMed:19158808, ECO:0000269 PubMed:21484434}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for EIF2B3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with EIF2B3: view

No data available for Genatlas for EIF2B3 Gene

Publications for EIF2B3 Gene

  1. Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. (PMID: 10900014) Kruger M … Wong-Staal F (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4
  2. Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5. (PMID: 21484434) Matsukawa T … Tsuji S (Neurogenetics 2011) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis. (PMID: 18632786) Pronk J … van der Knaap M (Multiple sclerosis (Houndmills, Basingstoke, England) 2008) 3 41
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for EIF2B3 Gene

Sources for EIF2B3 Gene