Aliases for EIF2AK1 Gene
- Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1 2 3 5
- Heme-Regulated Eukaryotic Initiation Factor EIF-2-Alpha Kinase 3 4
- Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1 3 4
- Hemin-Sensitive Initiation Factor 2-Alpha Kinase 3 4
- Heme Regulated Initiation Factor 2 Alpha Kinase 2 3
- Heme-Controlled Repressor 3 4
- Heme-Regulated Inhibitor 3 4
External Ids for EIF2AK1 Gene
Previous GeneCards Identifiers for EIF2AK1 Gene
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for EIF2AK1 Gene
EIF2AK1 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1) is a Protein Coding gene. Diseases associated with EIF2AK1 include Pyriform Sinus Cancer and Chronic Monocytic Leukemia. Among its related pathways are Toll-like Receptor Signaling Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is EIF2AK4.
UniProtKB/Swiss-Prot Summary for EIF2AK1 Gene
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).