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Aliases for EIF2A Gene

Aliases for EIF2A Gene

  • Eukaryotic Translation Initiation Factor 2A 2 3 3 5
  • Eukaryotic Translation Initiation Factor 2A, 65kDa 2 3
  • 65 KDa Eukaryotic Translation Initiation Factor 2A 3 4
  • EIF-2A 3 4
  • MSTP004 3
  • MSTP089 3
  • MST089 3
  • CDA02 3

External Ids for EIF2A Gene

Previous GeneCards Identifiers for EIF2A Gene

  • GC03P151748
  • GC03P150264
  • GC03P147638

Summaries for EIF2A Gene

Entrez Gene Summary for EIF2A Gene

  • This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for EIF2A Gene

EIF2A (Eukaryotic Translation Initiation Factor 2A) is a Protein Coding gene. Among its related pathways are Photodynamic therapy-induced unfolded protein response and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity and ribosome binding.

UniProtKB/Swiss-Prot for EIF2A Gene

  • Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Gene Wiki entry for EIF2A Gene

Additional gene information for EIF2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2A Gene

Genomics for EIF2A Gene

GeneHancer (GH) Regulatory Elements for EIF2A Gene

Promoters and enhancers for EIF2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J150543 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 696.9 -0.4 -407 4.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 EIF2A SERP1 COMMD2 SELENOT GC03M150475
GH03J150598 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 52.3 +55.9 55907 8.8 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 MEF2D ZNF610 ZNF585B SELENOT SERP1 EIF2A RPL32P9 LOC730021 COMMD2 TSC22D2 ERICH6-AS1 ERICH6
GH03J149751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.7 -794.4 -794376 1.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC COMMD2 WWTR1 EIF2A
GH03J150702 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.9 +157.0 157010 2.2 HDGF PKNOX1 ARID4B NEUROD1 SIN3A YBX1 ZBTB7B BRCA1 ZNF48 YY1 ERICH6-AS1 ERICH6 EIF2A SIAH2-AS1 COMMD2
GH03J150582 Enhancer 0.6 dbSUPER 52 +36.8 36785 2.4 SRF NR2F1 EBF1 MEF2B DPF2 BATF RELA ZNF24 RUNX3 BCLAF1 EIF2A SELENOT SERP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF2A gene promoter:
  • NF-1
  • SRY
  • CHOP-10
  • C/EBPalpha
  • GATA-2
  • AML1a
  • POU3F2
  • Pbx1a
  • CBF(2)

Genomic Locations for EIF2A Gene

Genomic Locations for EIF2A Gene
chr3:150,546,678-150,586,016
(GRCh38/hg38)
Size:
39,339 bases
Orientation:
Plus strand
chr3:150,264,465-150,303,803
(GRCh37/hg19)
Size:
39,339 bases
Orientation:
Plus strand

Genomic View for EIF2A Gene

Genes around EIF2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2A Gene

Proteins for EIF2A Gene

  • Protein details for EIF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY44-EIF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2A
    Protein Accession:
    Q9BY44
    Secondary Accessions:
    • A8MPS6
    • B4DF96
    • B4DQ14
    • D3DNI9
    • Q5QTR2
    • Q7Z4E9
    • Q8NFM1
    • Q96EW9
    • Q96K81

    Protein attributes for EIF2A Gene

    Size:
    585 amino acids
    Molecular mass:
    64990 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK14926.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAM83402.1; Type=Frameshift; Positions=82, 90; Evidence={ECO:0000305}; Sequence=AAQ13506.1; Type=Frameshift; Positions=513; Evidence={ECO:0000305}; Sequence=AAQ13612.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EIF2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2A Gene

Post-translational modifications for EIF2A Gene

  • Ubiquitination at Lys127 and isoforms=3115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF2A Gene

Domains & Families for EIF2A Gene

Gene Families for EIF2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9BY44

UniProtKB/Swiss-Prot:

EIF2A_HUMAN :
  • Belongs to the WD repeat EIF2A family.
Family:
  • Belongs to the WD repeat EIF2A family.
genes like me logo Genes that share domains with EIF2A: view

Function for EIF2A Gene

Molecular function for EIF2A Gene

UniProtKB/Swiss-Prot Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Phenotypes From GWAS Catalog for EIF2A Gene

Gene Ontology (GO) - Molecular Function for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IMP 12133843
GO:0003729 mRNA binding IBA --
GO:0003743 translation initiation factor activity IMP,IEA 12133843
GO:0005515 protein binding IPI,IEA 18816594
GO:0043022 ribosome binding IMP 12133843
genes like me logo Genes that share ontologies with EIF2A: view
genes like me logo Genes that share phenotypes with EIF2A: view

Animal Model Products

Clone Products

  • Addgene plasmids for EIF2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2A Gene

Localization for EIF2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2A gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005737 cytoplasm IDA 12133843
GO:0005850 eukaryotic translation initiation factor 2 complex IDA 12133843
GO:0022627 cytosolic small ribosomal subunit IBA --
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with EIF2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF2A Gene

Pathways & Interactions for EIF2A Gene

genes like me logo Genes that share pathways with EIF2A: view

Pathways by source for EIF2A Gene

2 Qiagen pathways for EIF2A Gene

Gene Ontology (GO) - Biological Process for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IMP,IEA 12133843
GO:0006468 protein phosphorylation IEA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with EIF2A: view

No data available for SIGNOR curated interactions for EIF2A Gene

Drugs & Compounds for EIF2A Gene

(3) Drugs for EIF2A Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Sal 003 Pharma Cellular phosphatase complex inhibitor 0
Salubrinal Pharma Selective eIF2α inhibitor 0

(2) ApexBio Compounds for EIF2A Gene

Compound Action Cas Number
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
Salubrinal Selective eIF2α inhibitor 405060-95-9
genes like me logo Genes that share compounds with EIF2A: view

Drug Products

Transcripts for EIF2A Gene

Unigene Clusters for EIF2A Gene

Eukaryotic translation initiation factor 2A, 65kDa:
Representative Sequences:

Clone Products

  • Addgene plasmids for EIF2A

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2A Gene

No ASD Table

Relevant External Links for EIF2A Gene

GeneLoc Exon Structure for
EIF2A
ECgene alternative splicing isoforms for
EIF2A

Expression for EIF2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF2A Gene

This gene is overexpressed in Nasal epithelium (9.2) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF2A Gene



Protein tissue co-expression partners for EIF2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF2A Gene:

EIF2A

SOURCE GeneReport for Unigene cluster for EIF2A Gene:

Hs.655782

mRNA Expression by UniProt/SwissProt for EIF2A Gene:

Q9BY44-EIF2A_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.

Evidence on tissue expression from TISSUES for EIF2A Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Heart(4.3)
  • Intestine(2.4)
  • Stomach(2.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with EIF2A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2A Gene

Orthologs for EIF2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2A 34 33
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2A 34 33
  • 93.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2A 34 33
  • 92.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2a 16 34 33
  • 89.69 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF2A 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2a 33
  • 88.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2A 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2A 34 33
  • 79.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2A 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2a 33
  • 72.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398445 33
zebrafish
(Danio rerio)
Actinopterygii eif2a 34 33
  • 66.25 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7414 34 33
  • 46.99 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002525 33
  • 46.12 (n)
worm
(Caenorhabditis elegans)
Secernentea E04D5.1 34 33
  • 49.68 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02761g 33
  • 46.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL286C 33
  • 44.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR054W 33
  • 43.88 (n)
-- 34
  • 26 (a)
OneToOne
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73180 33
  • 46.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4B4.04 33
  • 49.17 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06099 33
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for EIF2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2A Gene

ENSEMBL:
Gene Tree for EIF2A (if available)
TreeFam:
Gene Tree for EIF2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF2A: view image

Paralogs for EIF2A Gene

(1) SIMAP similar genes for EIF2A Gene using alignment to 10 proteins:

  • EIF2A_HUMAN
  • B4DF96_HUMAN
  • B4DQ14_HUMAN
  • C9IZE1_HUMAN
  • F8WAE5_HUMAN
  • F8WAT3_HUMAN
  • F8WF18_HUMAN
  • H7C5Q3_HUMAN
  • H7C5Q4_HUMAN
  • H7C5R5_HUMAN

Pseudogenes.org Pseudogenes for EIF2A Gene

genes like me logo Genes that share paralogs with EIF2A: view

No data available for Paralogs for EIF2A Gene

Variants for EIF2A Gene

Sequence variations from dbSNP and Humsavar for EIF2A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000031954 -- 150,554,140(+) C/T intron_variant
rs1000178655 -- 150,576,738(+) T/G intron_variant
rs1000193747 -- 150,575,588(+) TTGTTGTTGT/TTGTTGT intron_variant
rs1000305073 -- 150,582,801(+) T/C intron_variant
rs1000311511 -- 150,569,012(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2A Gene

Variant ID Type Subtype PubMed ID
nsv1123697 CNV deletion 24896259
nsv507130 OTHER sequence alteration 20534489
nsv511101 OTHER complex 20534489

Variation tolerance for EIF2A Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2A Gene

Disorders for EIF2A Gene

Additional Disease Information for EIF2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2A Gene

Publications for EIF2A Gene

  1. Characterization of mammalian eIF2A and identification of the yeast homolog. (PMID: 12133843) Zoll WL … Merrick WC (The Journal of biological chemistry 2002) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Mechanism and regulation of eukaryotic protein synthesis. (PMID: 1620067) Merrick WC (Microbiological reviews 1992) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EIF2A Gene

  • Addgene plasmids for EIF2A

Sources for EIF2A Gene

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