This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both o... See more...

Aliases for EIF2A Gene

Aliases for EIF2A Gene

  • Eukaryotic Translation Initiation Factor 2A 2 3 4 5
  • Eukaryotic Translation Initiation Factor 2A, 65kDa 2 3
  • 65 KDa Eukaryotic Translation Initiation Factor 2A 3 4
  • EIF-2A 3 4
  • MSTP004 3
  • MSTP089 3
  • MST089 3
  • CDA02 3

External Ids for EIF2A Gene

Previous GeneCards Identifiers for EIF2A Gene

  • GC03P151748
  • GC03P150264
  • GC03P147638

Summaries for EIF2A Gene

Entrez Gene Summary for EIF2A Gene

  • This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for EIF2A Gene

EIF2A (Eukaryotic Translation Initiation Factor 2A) is a Protein Coding gene. Among its related pathways are Photodynamic therapy-induced unfolded protein response and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity and ribosome binding.

UniProtKB/Swiss-Prot Summary for EIF2A Gene

  • Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Gene Wiki entry for EIF2A Gene

Additional gene information for EIF2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF2A Gene

Genomics for EIF2A Gene

GeneHancer (GH) Regulatory Elements for EIF2A Gene

Promoters and enhancers for EIF2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF2A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF2A

Top Transcription factor binding sites by QIAGEN in the EIF2A gene promoter:
  • AML1a
  • C/EBPalpha
  • CBF(2)
  • CHOP-10
  • GATA-2
  • NF-1
  • Pbx1a
  • POU3F2
  • SRY

Genomic Locations for EIF2A Gene

Genomic Locations for EIF2A Gene
chr3:150,546,678-150,586,016
(GRCh38/hg38)
Size:
39,339 bases
Orientation:
Plus strand
chr3:150,264,465-150,303,803
(GRCh37/hg19)
Size:
39,339 bases
Orientation:
Plus strand

Genomic View for EIF2A Gene

Genes around EIF2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2A Gene

Proteins for EIF2A Gene

  • Protein details for EIF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY44-EIF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2A
    Protein Accession:
    Q9BY44
    Secondary Accessions:
    • A8MPS6
    • B4DF96
    • B4DQ14
    • D3DNI9
    • Q5QTR2
    • Q7Z4E9
    • Q8NFM1
    • Q96EW9
    • Q96K81

    Protein attributes for EIF2A Gene

    Size:
    585 amino acids
    Molecular mass:
    64990 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK14926.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAM83402.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAQ13506.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAQ13612.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EIF2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2A Gene

Post-translational modifications for EIF2A Gene

  • Ubiquitination at Lys115 and Lys127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF2A Gene

Domains & Families for EIF2A Gene

Gene Families for EIF2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF2A Gene

Blocks:
  • Eukaryotic translation initiation factor 2A, central region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF2A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57962, highly similar to Homo sapiens eukaryotic translation initiation factor (eIF) 2A (eIF2A), mRNA (B4DF96_HUMAN)
  • cDNA FLJ58035, highly similar to Homo sapiens eukaryotic translation initiation factor (eIF) 2A (eIF2A), mRNA (B4DQ14_HUMAN)
  • 65 kDa eukaryotic translation initiation factor 2A (EIF2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BY44

UniProtKB/Swiss-Prot:

EIF2A_HUMAN :
  • Belongs to the WD repeat EIF2A family.
Family:
  • Belongs to the WD repeat EIF2A family.
genes like me logo Genes that share domains with EIF2A: view

Function for EIF2A Gene

Molecular function for EIF2A Gene

UniProtKB/Swiss-Prot Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Phenotypes From GWAS Catalog for EIF2A Gene

Gene Ontology (GO) - Molecular Function for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IMP 12133843
GO:0003743 translation initiation factor activity IMP,IEA 12133843
GO:0005515 protein binding IPI,IEA 18816594
GO:0043022 ribosome binding IMP,IBA 12133843
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with EIF2A: view
genes like me logo Genes that share phenotypes with EIF2A: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for EIF2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2A Gene

Localization for EIF2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2A gene
Compartment Confidence
cytosol 4
mitochondrion 3
peroxisome 2
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005737 cytoplasm IDA 12133843
GO:0005850 eukaryotic translation initiation factor 2 complex IDA 12133843
GO:0022627 cytosolic small ribosomal subunit IBA 21873635
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with EIF2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF2A Gene

Pathways & Interactions for EIF2A Gene

genes like me logo Genes that share pathways with EIF2A: view

Pathways by source for EIF2A Gene

2 Qiagen pathways for EIF2A Gene
  • eIF2 Pathway
  • GSK3 Signaling

SIGNOR curated interactions for EIF2A Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IEA,IMP 12133843
GO:0006468 protein phosphorylation IEA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with EIF2A: view

Drugs & Compounds for EIF2A Gene

(3) Drugs for EIF2A Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Sal 003 Pharma Cellular phosphatase complex inhibitor 0
Salubrinal Pharma Selective eIF2α inhibitor 0

(2) ApexBio Compounds for EIF2A Gene

Compound Action Cas Number
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
Salubrinal Selective eIF2α inhibitor 405060-95-9
genes like me logo Genes that share compounds with EIF2A: view

Drug Products

Transcripts for EIF2A Gene

mRNA/cDNA for EIF2A Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for EIF2A

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2A Gene

No ASD Table

Relevant External Links for EIF2A Gene

GeneLoc Exon Structure for
EIF2A

Expression for EIF2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF2A Gene

This gene is overexpressed in Nasal epithelium (9.2) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF2A Gene



Protein tissue co-expression partners for EIF2A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF2A

SOURCE GeneReport for Unigene cluster for EIF2A Gene:

Hs.655782

mRNA Expression by UniProt/SwissProt for EIF2A Gene:

Q9BY44-EIF2A_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.

Evidence on tissue expression from TISSUES for EIF2A Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Heart(4.3)
  • Intestine(2.4)
  • Stomach(2.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with EIF2A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2A Gene

Orthologs for EIF2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2A 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2A 31 30
  • 93.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2A 31 30
  • 92.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2a 17 31 30
  • 89.69 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF2A 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2a 30
  • 88.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2A 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2A 31 30
  • 79.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2A 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2a 30
  • 72.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398445 30
zebrafish
(Danio rerio)
Actinopterygii eif2a 31 30
  • 66.25 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7414 31 30
  • 46.99 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002525 30
  • 46.12 (n)
worm
(Caenorhabditis elegans)
Secernentea E04D5.1 31 30
  • 49.68 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02761g 30
  • 46.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL286C 30
  • 44.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR054W 30
  • 43.88 (n)
-- 31
  • 26 (a)
OneToOne
-- 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73180 30
  • 46.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4B4.04 30
  • 49.17 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06099 30
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Species where no ortholog for EIF2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2A Gene

ENSEMBL:
Gene Tree for EIF2A (if available)
TreeFam:
Gene Tree for EIF2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF2A: view image

Paralogs for EIF2A Gene

(1) SIMAP similar genes for EIF2A Gene using alignment to 10 proteins:

  • EIF2A_HUMAN
  • B4DF96_HUMAN
  • B4DQ14_HUMAN
  • C9IZE1_HUMAN
  • F8WAE5_HUMAN
  • F8WAT3_HUMAN
  • F8WF18_HUMAN
  • H7C5Q3_HUMAN
  • H7C5Q4_HUMAN
  • H7C5R5_HUMAN

Pseudogenes.org Pseudogenes for EIF2A Gene

genes like me logo Genes that share paralogs with EIF2A: view

No data available for Paralogs for EIF2A Gene

Variants for EIF2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF2A Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1132979 - p.Thr97Ser
rs17850813 - p.Glu582Lys

Additional dbSNP identifiers (rs#s) for EIF2A Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF2A Gene

Variant ID Type Subtype PubMed ID
nsv1123697 CNV deletion 24896259
nsv507130 OTHER sequence alteration 20534489
nsv511101 OTHER complex 20534489

Variation tolerance for EIF2A Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2A Gene

Disorders for EIF2A Gene

Additional Disease Information for EIF2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2A Gene

Publications for EIF2A Gene

  1. Characterization of mammalian eIF2A and identification of the yeast homolog. (PMID: 12133843) Zoll WL … Merrick WC (The Journal of biological chemistry 2002) 2 3 4 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Mechanism and regulation of eukaryotic protein synthesis. (PMID: 1620067) Merrick WC (Microbiological reviews 1992) 2 3 54
  5. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3 54

Products for EIF2A Gene

  • Addgene plasmids for EIF2A

Sources for EIF2A Gene