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Aliases for EIF1AY Gene

Aliases for EIF1AY Gene

  • Eukaryotic Translation Initiation Factor 1A Y-Linked 2 3
  • Eukaryotic Translation Initiation Factor 1A, Y Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A Y Isoform 3 4
  • EIF-4C 3 4
  • Eukaryotic Translation Initiation Factor 1A, Y-Chromosomal 3
  • Eukaryotic Translation Initiation Factor 1A, Y-Linked 5

External Ids for EIF1AY Gene

Previous GeneCards Identifiers for EIF1AY Gene

  • GC0YP021892
  • GC0YP021583
  • GC0YP021584
  • GC0YP021075
  • GC0YP022737
  • GC0YP016322

Summaries for EIF1AY Gene

Entrez Gene Summary for EIF1AY Gene

  • This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for EIF1AY Gene

EIF1AY (Eukaryotic Translation Initiation Factor 1A Y-Linked) is a Protein Coding gene. Among its related pathways are Translation Factors and RNA transport. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AX.

UniProtKB/Swiss-Prot for EIF1AY Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

Gene Wiki entry for EIF1AY Gene

Additional gene information for EIF1AY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AY Gene

Genomics for EIF1AY Gene

GeneHancer (GH) Regulatory Elements for EIF1AY Gene

Promoters and enhancers for EIF1AY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YJ020574 Promoter/Enhancer 1.2 EPDnew ENCODE 650.7 +0.1 121 2.8 CTCF DRAP1 MXI1 SAP130 ARID4B SIN3A DMAP1 KMT2B GATAD1 POLR2A EIF1AY FAM8A9P
GH0YJ020573 Enhancer 0.2 FANTOM5 17.3 -2.0 -2030 0.2 EIF1AY KDM5DP1
GH0YJ021073 Enhancer 0.3 FANTOM5 2.3 +498.2 498185 0.5 EIF1AY ENSG00000254488 TOMM22P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF1AY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF1AY gene promoter:
  • GATA-3
  • GATA-2
  • GATA-1
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • STAT5A
  • STAT1
  • Pax-4a
  • FOXO4

Genomic Locations for EIF1AY Gene

Genomic Locations for EIF1AY Gene
17,444 bases
Plus strand
17,430 bases
Plus strand

Genomic View for EIF1AY Gene

Genes around EIF1AY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AY Gene

Proteins for EIF1AY Gene

  • Protein details for EIF1AY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Eukaryotic translation initiation factor 1A, Y-chromosomal
    Protein Accession:
    Secondary Accessions:
    • Q9BS77

    Protein attributes for EIF1AY Gene

    144 amino acids
    Molecular mass:
    16442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF1AY Gene

Post-translational modifications for EIF1AY Gene

  • Ubiquitination at isoforms=88 and Lys56
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1AY Gene

Domains & Families for EIF1AY Gene

Gene Families for EIF1AY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EIF1AY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eIF-1A family.
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AY: view

Function for EIF1AY Gene

Molecular function for EIF1AY Gene

UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome Y,ubiquitous in a AZF deleted region

Gene Ontology (GO) - Molecular Function for EIF1AY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 12569173
genes like me logo Genes that share ontologies with EIF1AY: view

Phenotypes for EIF1AY Gene

genes like me logo Genes that share phenotypes with EIF1AY: view

Animal Model Products

miRNA for EIF1AY Gene

miRTarBase miRNAs that target EIF1AY

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AY Gene

Localization for EIF1AY Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AY gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF1AY Gene

Pathways & Interactions for EIF1AY Gene

genes like me logo Genes that share pathways with EIF1AY: view

Pathways by source for EIF1AY Gene

1 BioSystems pathway for EIF1AY Gene
1 KEGG pathway for EIF1AY Gene
1 Qiagen pathway for EIF1AY Gene

Gene Ontology (GO) - Biological Process for EIF1AY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF1AY: view

No data available for SIGNOR curated interactions for EIF1AY Gene

Drugs & Compounds for EIF1AY Gene

No Compound Related Data Available

Transcripts for EIF1AY Gene

mRNA/cDNA for EIF1AY Gene

Unigene Clusters for EIF1AY Gene

Eukaryotic translation initiation factor 1A, Y-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AY Gene

No ASD Table

Relevant External Links for EIF1AY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EIF1AY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1AY Gene

mRNA differential expression in normal tissues according to GTEx for EIF1AY Gene

This gene is overexpressed in Heart - Left Ventricle (x6.5) and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for EIF1AY Gene

This gene is overexpressed in Frontal cortex (9.9), Pancreas (9.7), Blymphocyte (8.7), and CD4 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF1AY Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF1AY Gene:


SOURCE GeneReport for Unigene cluster for EIF1AY Gene:


mRNA Expression by UniProt/SwissProt for EIF1AY Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EIF1AY Gene

  • Heart(4.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EIF1AY: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AY Gene

Orthologs for EIF1AY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1AY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EIF1AY 34 33
  • 99.54 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
(Mus musculus)
Mammalia Eif1a 34
  • 98 (a)
Gm5039 34
  • 94 (a)
Gm8300 34
  • 93 (a)
Gm8332 34
  • 93 (a)
Gm2056 34
  • 93 (a)
Gm21319 34
  • 92 (a)
Gm2035 34
  • 92 (a)
Gm16368 34
  • 92 (a)
Gm2016 34
  • 92 (a)
Gm5662 34
  • 92 (a)
Gm21936 34
  • 91 (a)
Gm4027 34
  • 90 (a)
Gm2075 34
  • 90 (a)
Gm6803 34
  • 90 (a)
Gm2046 34
  • 90 (a)
BB287469 34
  • 90 (a)
Eif1ax 16 33
  • 89.12 (n)
Gm10264 34
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Eif1ax 33
  • 88.66 (n)
(Bos Taurus)
Mammalia EIF1AY 34
  • 81 (a)
(Gallus gallus)
Aves EIF1AY 34 33
  • 88.89 (n)
(Anolis carolinensis)
Reptilia EIF1AY 34
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29347 33
(Danio rerio)
Actinopterygii eif1axa 34 33
  • 80.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 34 35 33
  • 67.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003119 33
  • 67.18 (n)
(Caenorhabditis elegans)
Secernentea H06H21.3 35
  • 65 (a)
eif-1.A 34 33
  • 64.58 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 34
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 34
  • 51 (a)
Species where no ortholog for EIF1AY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF1AY Gene

Gene Tree for EIF1AY (if available)
Gene Tree for EIF1AY (if available)
Evolutionary constrained regions (ECRs) for EIF1AY: view image

Paralogs for EIF1AY Gene

Paralogs for EIF1AY Gene

(1) SIMAP similar genes for EIF1AY Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF1AY: view

Variants for EIF1AY Gene

Sequence variations from dbSNP and Humsavar for EIF1AY Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1000190714 -- 20,586,834(+) T/C intron_variant
rs1000556477 -- 20,581,531(+) C/T intron_variant
rs1000624790 -- 20,587,583(+) T/C intron_variant
rs1000919475 -- 20,580,345(+) G/T intron_variant
rs1004212641 -- 20,575,073(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AY Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV gain 18304495

Additional Variant Information for EIF1AY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for EIF1AY Gene

Disorders for EIF1AY Gene

Additional Disease Information for EIF1AY

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EIF1AY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AY Gene

Publications for EIF1AY Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn BT … Page DC (Science (New York, N.Y.) 1997) 2 3 4 58
  2. Association of Y chromosome haplotypes with autism. (PMID: 19605777) Serajee FJ … Mahbubul Huq AH (Journal of child neurology 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EIF1AY Gene

Sources for EIF1AY Gene

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