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This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008] See more...
Aliases for EIF1AX Gene
Aliases for EIF1AX Gene
External Ids for EIF1AX Gene
- HGNC: 3250
- Entrez Gene: 1964
- Ensembl: ENSG00000173674
- OMIM: 300186
- UniProtKB: P47813
Previous HGNC Symbols for EIF1AX Gene
- EIF4C
- EIF1A
Previous GeneCards Identifiers for EIF1AX Gene
- GC0XU990358
- GC0XM019505
- GC0XM019902
- GC0XM020052
- GC0XM017884
Summaries for EIF1AX Gene
-
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF1AX Gene
EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include Differentiated Thyroid Carcinoma and Melanoma, Uveal. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF1AY.
UniProtKB/Swiss-Prot Summary for EIF1AX Gene
-
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
Additional gene information for EIF1AX Gene
- HGNC(3250)
- Entrez Gene(1964)
- Ensembl(ENSG00000173674)
- OMIM(300186)
- UniProtKB(P47813)
- Open Targets Platform(ENSG00000173674)
- Monarch Initiative
- Search for EIF1AX at DataMed
- Search for EIF1AX at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF1AX Gene
Genomics for EIF1AX Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EIF1AX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EIF1AX on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF1AX
- Top Transcription factor binding sites by QIAGEN in the EIF1AX gene promoter:
-
- C/EBPalpha
- CHOP-10
- FOXO1
- FOXO1a
- Max1
- Nkx6-1
- Pax-6
- POU2F1
- POU2F1a
- Spz1
Genomic Locations for EIF1AX Gene
Genomic Locations for EIF1AX Gene
- chrX:20,124,525-20,141,838
- (GRCh38/hg38)
- Size:
- 17,314 bases
- Orientation:
- Minus strand
- chrX:20,142,636-20,159,966
- (GRCh37/hg19)
- Size:
- 17,331 bases
- Orientation:
- Minus strand
Genomic View for EIF1AX Gene
Genes around EIF1AX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.12 by HGNC
- Xp22.12 by Entrez Gene
- Xp22.12 by Ensembl
EIF1AX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF1AX Gene
Proteins for EIF1AX Gene
-
Protein details for EIF1AX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P47813-IF1AX_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 1A, X-chromosomal
- Protein Accession:
- P47813
- B2R5U5
- Q0VGC2
- Q5JPS5
- Q5JPS6
Protein attributes for EIF1AX Gene
- Size:
- 144 amino acids
- Molecular mass:
- 16460 Da
- Quaternary structure:
- No Data Available
Protein Expression for EIF1AX Gene
Post-translational modifications for EIF1AX Gene
Other Protein References for EIF1AX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EIF1AX
- Novus Biologicals Antibodies for EIF1AX
-
Abcam antibodies for EIF1AX
- Invitrogen Antibodies for EIF1AX (AFLGC-EIF1AX)
-
Boster Bio Antibodies for EIF1AX
Protein Products
- G Biosciences Human EIF1AX, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF1AX
- Origene Custom Protein Services for EIF1AX
- ProSpec Recombinant Proteins for EIF1AX
- antibodies-online: Show 10 available EIF1AX Proteins ranked by validation data
- Compare Top EIF1AX Proteins
-
Quality Products:
-
ProSci Proteins for EIF1AX
No data available for DME Specific Peptides for EIF1AX Gene
Domains & Families for EIF1AX Gene
Gene Families for EIF1AX Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for EIF1AX Gene
- InterPro:
- Blocks:
-
- Eukaryotic initiation factor 1A (eIF-1A)
- ProtoNet:
Suggested Antigen Peptide Sequences for EIF1AX Gene
- GenScript: Design optimal peptide antigens:
-
- Eukaryotic translation initiation factor 4C (IF1AX_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P47813- Family:
-
- Belongs to the eIF-1A family.
Function for EIF1AX Gene
Molecular function for EIF1AX Gene
- UniProtKB/Swiss-Prot Function:
- Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
- GENATLAS Biochemistry:
- eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0003743 | translation initiation factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21139563 |
| GO:0008135 | translation factor activity, RNA binding | TAS | 8106356 |
Phenotypes for EIF1AX Gene
- GenomeRNAi human phenotypes for EIF1AX:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
- Increased gamma-H2AX phosphorylation
- Strongly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Multipolar spindles
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF1AX - Select products 50% OFF >
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF1AX
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF1AX
miRNA for EIF1AX Gene
- miRTarBase miRNAs that target EIF1AX
-
- mmu-miR-7b-5p (MIRT009401)
- hsa-miR-26b-5p (MIRT029813)
- hsa-miR-18a-3p (MIRT040809)
- hsa-miR-345-5p (MIRT042730)
- hsa-miR-497-3p (MIRT125196)
- hsa-miR-4666a-5p (MIRT229501)
- hsa-miR-7849-3p (MIRT229503)
- hsa-miR-7850-5p (MIRT259520)
- hsa-miR-21-5p (MIRT259537)
- hsa-miR-590-5p (MIRT259542)
- hsa-miR-4495 (MIRT259547)
- hsa-miR-129-5p (MIRT326949)
- hsa-miR-1250-3p (MIRT326963)
- hsa-miR-6885-3p (MIRT326970)
- hsa-miR-382-5p (MIRT326971)
- hsa-miR-5579-3p (MIRT326973)
- hsa-miR-3158-5p (MIRT326987)
- hsa-miR-5007-3p (MIRT329658)
- hsa-miR-3065-5p (MIRT366380)
- hsa-miR-7159-5p (MIRT366381)
- hsa-miR-6875-3p (MIRT366384)
- hsa-miR-4699-5p (MIRT366414)
- hsa-miR-505-3p (MIRT379680)
- hsa-miR-4659a-3p (MIRT409574)
- hsa-miR-4659b-3p (MIRT409575)
- hsa-miR-3978 (MIRT477546)
- hsa-miR-152-5p (MIRT477547)
- hsa-miR-5093 (MIRT477548)
- hsa-miR-570-3p (MIRT477549)
- hsa-miR-4766-5p (MIRT477550)
- hsa-miR-4726-3p (MIRT477551)
- hsa-miR-548as-3p (MIRT477552)
- hsa-miR-5011-3p (MIRT477553)
- hsa-miR-4536-5p (MIRT477554)
- hsa-miR-8065 (MIRT477555)
- hsa-miR-6124 (MIRT477556)
- hsa-miR-4795-5p (MIRT477557)
- hsa-miR-550b-3p (MIRT477558)
- hsa-miR-6838-5p (MIRT477559)
- hsa-miR-497-5p (MIRT477560)
- hsa-miR-424-5p (MIRT477561)
- hsa-miR-195-5p (MIRT477562)
- hsa-miR-16-5p (MIRT477563)
- hsa-miR-15b-5p (MIRT477564)
- hsa-miR-15a-5p (MIRT477565)
- hsa-miR-3908 (MIRT477566)
- hsa-miR-5700 (MIRT477567)
- hsa-miR-548e-5p (MIRT477568)
- hsa-miR-4662b (MIRT477569)
- hsa-miR-4426 (MIRT477570)
- hsa-miR-4647 (MIRT477571)
- hsa-miR-613 (MIRT477572)
- hsa-miR-206 (MIRT477573)
- hsa-miR-1-3p (MIRT477574)
- hsa-miR-653-5p (MIRT507452)
- hsa-miR-568 (MIRT507453)
- hsa-miR-6853-3p (MIRT507454)
- hsa-miR-1206 (MIRT507455)
- hsa-miR-1279 (MIRT507456)
- hsa-miR-617 (MIRT507457)
- hsa-miR-616-5p (MIRT507458)
- hsa-miR-373-5p (MIRT507459)
- hsa-miR-371b-5p (MIRT507460)
- hsa-miR-8063 (MIRT507461)
- hsa-miR-4698 (MIRT507462)
- hsa-miR-888-5p (MIRT507463)
- hsa-miR-6866-5p (MIRT511967)
- hsa-miR-3152-3p (MIRT511968)
- hsa-miR-6859-5p (MIRT511969)
- hsa-miR-3916 (MIRT511970)
- hsa-miR-3125 (MIRT511971)
- hsa-miR-562 (MIRT511972)
- hsa-miR-5583-5p (MIRT511973)
- hsa-miR-3129-3p (MIRT511974)
- hsa-miR-548x-3p (MIRT511975)
- hsa-miR-548j-3p (MIRT511976)
- hsa-miR-548aq-3p (MIRT511977)
- hsa-miR-548am-3p (MIRT511978)
- hsa-miR-548aj-3p (MIRT511979)
- hsa-miR-548ah-3p (MIRT511980)
- hsa-miR-548ae-3p (MIRT511981)
- hsa-miR-877-5p (MIRT511982)
- hsa-miR-4496 (MIRT511983)
- hsa-miR-1243 (MIRT511984)
- hsa-miR-3654 (MIRT511985)
- hsa-miR-2054 (MIRT523936)
- hsa-miR-488-3p (MIRT537795)
- hsa-miR-1303 (MIRT548442)
- hsa-miR-1273e (MIRT548443)
- hsa-miR-376a-2-5p (MIRT548444)
- hsa-miR-1253 (MIRT548445)
- hsa-miR-3123 (MIRT548446)
- hsa-miR-3925-5p (MIRT548447)
- hsa-miR-544a (MIRT548448)
- hsa-miR-6797-3p (MIRT548449)
- hsa-miR-6076 (MIRT548450)
- hsa-miR-17-3p (MIRT548451)
- hsa-miR-1205 (MIRT548452)
- hsa-miR-1184 (MIRT548453)
- hsa-miR-6787-3p (MIRT548454)
- hsa-miR-4778-5p (MIRT548455)
- hsa-miR-103a-3p (MIRT548456)
- hsa-miR-107 (MIRT548457)
- hsa-miR-1224-5p (MIRT558196)
- hsa-miR-4751 (MIRT558197)
- hsa-miR-5004-5p (MIRT558198)
- hsa-miR-548o-3p (MIRT558199)
- hsa-miR-1323 (MIRT558200)
- hsa-miR-580-5p (MIRT558201)
- hsa-miR-6505-3p (MIRT562423)
- hsa-miR-466 (MIRT567698)
- hsa-miR-4672 (MIRT567699)
- hsa-miR-3941 (MIRT567700)
- hsa-miR-4643 (MIRT567701)
- hsa-miR-4789-3p (MIRT567702)
- hsa-miR-411-5p (MIRT767925)
miRNA Products
Inhibitory RNA Products
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF1AX
Clone Products
- Applied Biological Materials (abm): Clones for EIF1AX - Select products 50% OFF >
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-
- MG200947
- MG200954
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- RC210335L1
- RC210335L2
- RC210335L3
- RC210335L4
- RG210335
- RR210524
- RR210524L3
- RR210524L4
- RR211986
- RR211986L3
- RR211986L4
- MR200947L3V
- MR200947L4V
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- RC210335L1V
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- RC210335L4V
- RR210524L3V
- RR210524L4V
- RR211986L3V
- RR211986L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF1AX
- Sino Biological Human cDNA Clone for EIF1AX
- Addgene plasmids for EIF1AX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF1AX
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AX Gene
Localization for EIF1AX Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1AX Gene
Pathways & Interactions for EIF1AX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | RNA transport | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
|
| 5 | Beta-Adrenergic Signaling |
Insulin Receptor Pathway
.37
|
|
Pathways by source for EIF1AX Gene
1 BioSystems pathway for EIF1AX Gene
12 Reactome pathways for EIF1AX Gene
1 KEGG pathway for EIF1AX Gene
2 Qiagen pathways for EIF1AX Gene
- eIF2 Pathway
- Insulin Receptor Pathway
Interacting Proteins for EIF1AX Gene
Selected Interacting proteins:
P47813-IF1AX_HUMAN
ENSP00000368927
for EIF1AX Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EIF1AX
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA,TAS | -- |
No data available for SIGNOR curated interactions for EIF1AX Gene
Drugs & Compounds for EIF1AX Gene
No Compound Related Data Available
Drug Products
- G Biosciences Human EIF1AX, Lyophilized
Transcripts for EIF1AX Gene
mRNA/cDNA for EIF1AX Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000379607 4414 nts (view in UCSC)
- ENST00000379593 765 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EIF1AX - Select products 50% OFF >
- * EIF1AX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EIF1AX
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF1AX
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EIF1AX
- Browse OriGene Inhibitory RNA Products For EIF1AX
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Clone Products
- Applied Biological Materials (abm): Clones for EIF1AX - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200947
- MG200954
- MR200947
- MR200947L3
- MR200947L4
- MR200954
- MR200954L3
- MR200954L4
- RC210335
- RC210335L1
- RC210335L2
- RC210335L3
- RC210335L4
- RG210335
- RR210524
- RR210524L3
- RR210524L4
- RR211986
- RR211986L3
- RR211986L4
- MR200947L3V
- MR200947L4V
- MR200954L3V
- MR200954L4V
- RC210335L1V
- RC210335L2V
- RC210335L3V
- RC210335L4V
- RR210524L3V
- RR210524L4V
- RR211986L3V
- RR211986L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF1AX
- Sino Biological Human cDNA Clone for EIF1AX
- Addgene plasmids for EIF1AX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EIF1AX
Relevant External Links for EIF1AX Gene
- GeneLoc Exon Structure for
- EIF1AX
Expression for EIF1AX Gene
This gene is overexpressed in Islet of Langerhans (9.1) and Pancreas (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF1AX Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF1AX
SOURCE GeneReport for Unigene cluster for EIF1AX Gene:
Hs.522590Evidence on tissue expression from TISSUES for EIF1AX Gene
- Nervous system(4.8)
- Thyroid gland(2.9)
- Liver(2.8)
- Skin(2.5)
- Lung(2.3)
- Heart(2.3)
- Kidney(2.3)
- Lymph node(2.2)
- Eye(2.1)
- Intestine(2)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AX Gene
Germ Layers:
- endoderm
Systems:
- endocrine
Regions:
Head and neck:
- neck
- thyroid
Primer Products
-
OriGene qPCR primer pairs for EIF1AX
-
OriGene qPCR primer pairs and template standards for EIF1AX
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1AX Gene
Orthologs for EIF1AX Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | EIF1AX 31 |
|
OneToOne | |
| LOC611715 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Eif1ax 31 |
|
OneToOne | |
| Eif1a 30 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | EIF1AX 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | EIF1AX 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Eif1a 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif1ax 30 |
|
||
| Str.7119 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24811 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eif1axb 30 31 |
|
ManyToMany | |
| Dr.15002 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.679 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | eIF-1A 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | eif-1.A 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E11287g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF11 30 31 33 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER275C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G04520 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.8105 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.5683 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0342200 30 |
|
||
| Os.4711 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12801 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.14227 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.16531 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07437 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif11 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11104 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10045 30 |
|
- Species where no ortholog for EIF1AX was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for EIF1AX Gene
- ENSEMBL:
- Gene Tree for EIF1AX (if available)
- TreeFam:
- Gene Tree for EIF1AX (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EIF1AX: view image
Paralogs for EIF1AX Gene
(1) SIMAP similar genes for EIF1AX Gene using alignment to 2 proteins:
- IF1AX_HUMAN
- L8E8T0_HUMAN
Pseudogenes.org Pseudogenes for EIF1AX Gene
Variants for EIF1AX Gene
Residual Variation Intolerance Score:
45.3% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EIF1AX Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EIF1AX
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AX Gene
Disorders for EIF1AX Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiated thyroid carcinoma |
|
|
| melanoma, uveal |
|
|
| central nervous system melanocytic neoplasm |
|
|
| meningeal melanocytoma |
|
|
| malignant conjunctival melanoma |
|
|
Search EIF1AX in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EIF1AX
No data available for UniProtKB/Swiss-Prot and Genatlas for EIF1AX Gene
Publications for EIF1AX Gene
- Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PMID: 8106356) Dever TE … Hershey JW (The Journal of biological chemistry 1994) 2 3 4
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PMID: 12514125) Olsen DS … Hinnebusch AG (The EMBO journal 2003) 3 23
- Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot JM … Görlich D (The EMBO journal 2001) 3 23
ExternalLinks
Products for EIF1AX Gene
- Custom Antibody ServicesOriGene Antibodies for EIF1AX
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Custom and pre-made DNA vectors for EIF1AX (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 21 available EIF1AX Antibodies ranked by validation data
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- Boster Bio Antibodies for EIF1AX
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Sources for EIF1AX Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB