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This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include Differentiated Thyroid Carcinoma and Melanoma, Uveal. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF1AY.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA,HDA | 22658674 |
GO:0003743 | translation initiation factor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 21139563 |
GO:0008135 | translation factor activity, RNA binding | TAS | 8106356 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | RNA transport | ||
4 | Apoptotic Pathways in Synovial Fibroblasts |
eIF2 Pathway
.60
|
|
5 | Beta-Adrenergic Signaling |
Insulin Receptor Pathway
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006413 | translational initiation | IEA,TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | EIF1AX 31 |
|
OneToOne | |
LOC611715 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Eif1ax 31 |
|
OneToOne | |
Eif1a 30 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | EIF1AX 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
ManyToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | EIF1AX 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Eif1a 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eif1ax 30 |
|
||
Str.7119 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24811 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eif1axb 30 31 |
|
ManyToMany | |
Dr.15002 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.679 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | eIF-1A 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | eif-1.A 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E11287g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TIF11 30 31 33 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER275C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G04520 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.8105 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.5683 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0342200 30 |
|
||
Os.4711 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12801 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.14227 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.16531 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07437 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tif11 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11104 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10045 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
differentiated thyroid carcinoma |
|
|
melanoma, uveal |
|
|
central nervous system melanocytic neoplasm |
|
|
meningeal melanocytoma |
|
|
malignant conjunctival melanoma |
|
|