This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008] See more...

Aliases for EIF1AX Gene

Aliases for EIF1AX Gene

  • Eukaryotic Translation Initiation Factor 1A X-Linked 2 3 5
  • EIF-4C 2 3 4
  • Eukaryotic Translation Initiation Factor 1A, X-Chromosomal 3 4
  • Eukaryotic Translation Initiation Factor 1A, X Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A 2 3
  • EIF1A 3 4
  • EIF4C 3 4
  • Eukaryotic Translation Initiation Factor 1A, X-Linked 2
  • Putative Eukaryotic Translation Initiation Factor 1A 3
  • EIF-1A X Isoform 4
  • EIF1AP1 3
  • EIF1AX 5

External Ids for EIF1AX Gene

Previous HGNC Symbols for EIF1AX Gene

  • EIF4C
  • EIF1A

Previous GeneCards Identifiers for EIF1AX Gene

  • GC0XU990358
  • GC0XM019505
  • GC0XM019902
  • GC0XM020052
  • GC0XM017884

Summaries for EIF1AX Gene

Entrez Gene Summary for EIF1AX Gene

  • This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

CIViC Summary for EIF1AX Gene

GeneCards Summary for EIF1AX Gene

EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include Differentiated Thyroid Carcinoma and Plasma Cell Neoplasm. Among its related pathways are Beta-Adrenergic Signaling and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF1AY.

UniProtKB/Swiss-Prot Summary for EIF1AX Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Gene Wiki entry for EIF1AX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF1AX Gene

Genomics for EIF1AX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF1AX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ020139 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 458 4.8 ZSCAN16 TBP ZBTB10 SP1 FEZF1 MNT SMAD5 ZEB1 SIN3A REST EIF1AX EIF1AX-AS1 lnc-PDHA1-3 BCLAF3 RF00017-8210 MAP7D2
GH0XJ019835 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +302.0 302038 8.4 POLR2A EBF1 CBFB JUND TAF1 SPI1 BHLHE40 BATF ZNF24 ELF1 BCLAF3 EIF1AX SH3KBP1 piR-41306-273 RF00017-8205 RF00017-8202 MAP3K15
GH0XJ019372 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 4.2 +768.8 768837 1.6 ZSCAN16 ZNF217 CTCF ZIC2 SIN3A REST TRIM22 SMC3 RAD21 ZBTB48 EIF1AX ENSG00000202144 HSALNG0136902 PDHA1 MAP3K15
GH0XJ020251 Enhancer 0.7 ENCODE dbSUPER 4.2 -111.0 -110957 1.7 POLR2A CTCF ELF1 SMC3 RAD21 SMARCA5 RBM22 ZNF143 ZFP36 FOS BCLAF3 EIF1AX hsa-miR-5096-189 RPS6KA3 RF00017-8212
GH0XJ020315 Enhancer 0.6 Ensembl 4.2 -171.8 -171763 5.2 IRF4 ZNF146 SPI1 PKNOX1 ELF1 JUNB IKZF1 IKZF2 EED RUNX3 BCLAF3 EIF1AX ENSG00000283631 lnc-PDHA1-2 RPS6KA3 RF00017-8212
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF1AX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF1AX

Top Transcription factor binding sites by QIAGEN in the EIF1AX gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FOXO1
  • FOXO1a
  • Max1
  • Nkx6-1
  • Pax-6
  • POU2F1
  • POU2F1a
  • Spz1

Genomic Locations for EIF1AX Gene

Latest Assembly
chrX:20,124,525-20,141,838
(GRCh38/hg38)
Size:
17,314 bases
Orientation:
Minus strand

Previous Assembly
chrX:20,142,643-20,159,956
(GRCh37/hg19 by Entrez Gene)
Size:
17,314 bases
Orientation:
Minus strand

chrX:20,142,636-20,159,962
(GRCh37/hg19 by Ensembl)
Size:
17,327 bases
Orientation:
Minus strand

Genomic View for EIF1AX Gene

Genes around EIF1AX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AX Gene

Proteins for EIF1AX Gene

  • Protein details for EIF1AX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47813-IF1AX_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, X-chromosomal
    Protein Accession:
    P47813
    Secondary Accessions:
    • B2R5U5
    • Q0VGC2
    • Q5JPS5
    • Q5JPS6

    Protein attributes for EIF1AX Gene

    Size:
    144 amino acids
    Molecular mass:
    16460 Da
    Quaternary structure:
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) nucleoprotein; this interaction recruits EIF1AX to the viral replication complex to facilitate viral genomic RNA synthesis and virus production.

    Three dimensional structures from OCA and Proteopedia for EIF1AX Gene

neXtProt entry for EIF1AX Gene

Post-translational modifications for EIF1AX Gene

  • Ubiquitination at Lys56
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for EIF1AX
  • Boster Bio Antibodies for EIF1AX

No data available for DME Specific Peptides for EIF1AX Gene

Domains & Families for EIF1AX Gene

Gene Families for EIF1AX Gene

Protein Domains for EIF1AX Gene

InterPro:
Blocks:
  • Eukaryotic initiation factor 1A (eIF-1A)
ProtoNet:

Suggested Antigen Peptide Sequences for EIF1AX Gene

GenScript: Design optimal peptide antigens:
  • Eukaryotic translation initiation factor 4C (IF1AX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47813

UniProtKB/Swiss-Prot:

IF1AX_HUMAN :
  • Belongs to the eIF-1A family.
Family:
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AX: view

Function for EIF1AX Gene

Molecular function for EIF1AX Gene

UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous

Phenotypes From GWAS Catalog for EIF1AX Gene

Gene Ontology (GO) - Molecular Function for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 21139563
GO:0008135 translation factor activity, RNA binding TAS 8106356
genes like me logo Genes that share ontologies with EIF1AX: view
genes like me logo Genes that share phenotypes with EIF1AX: view

miRNA for EIF1AX Gene

miRTarBase miRNAs that target EIF1AX

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF1AX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AX Gene

Localization for EIF1AX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AX gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1AX Gene

Pathways & Interactions for EIF1AX Gene

genes like me logo Genes that share pathways with EIF1AX: view

Pathways by source for EIF1AX Gene

Gene Ontology (GO) - Biological Process for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for SIGNOR curated interactions for EIF1AX Gene

Drugs & Compounds for EIF1AX Gene

No Compound Related Data Available

Transcripts for EIF1AX Gene

mRNA/cDNA for EIF1AX Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF1AX

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AX Gene

No ASD Table

Relevant External Links for EIF1AX Gene

GeneLoc Exon Structure for
EIF1AX

Expression for EIF1AX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF1AX Gene

Protein differential expression in normal tissues from HIPED for EIF1AX Gene

This gene is overexpressed in Islet of Langerhans (9.1) and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF1AX Gene



Protein tissue co-expression partners for EIF1AX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF1AX

SOURCE GeneReport for Unigene cluster for EIF1AX Gene:

Hs.522590

Evidence on tissue expression from TISSUES for EIF1AX Gene

  • Nervous system(4.8)
  • Thyroid gland(2.7)
  • Liver(2.7)
  • Skin(2.4)
  • Heart(2.3)
  • Kidney(2.2)
  • Lymph node(2.1)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AX Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
Regions:
Head and neck:
  • neck
  • thyroid
genes like me logo Genes that share expression patterns with EIF1AX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1AX Gene

Orthologs for EIF1AX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF1AX Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia EIF1AX 31
  • 100 (a)
OneToOne
LOC611715 30
  • 94.21 (n)
Mouse
(Mus musculus)
Mammalia Eif1ax 31
  • 100 (a)
OneToOne
Eif1a 30 17
  • 87.73 (n)
Oppossum
(Monodelphis domestica)
Mammalia EIF1AX 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 99 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia EIF1AX 30 31
  • 90.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif1a 30
  • 85.5 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif1ax 30
  • 86.81 (n)
Str.7119 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24811 30
Zebrafish
(Danio rerio)
Actinopterygii eif1axb 30 31
  • 81.48 (n)
ManyToMany
Dr.15002 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.679 30
Fruit Fly
(Drosophila melanogaster)
Insecta eIF-1A 31
  • 78 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea eif-1.A 31
  • 46 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11287g 30
  • 66.16 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 30 31 33
  • 65.14 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER275C 30
  • 61.32 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G04520 30
  • 65.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8105 30
Soybean
(Glycine max)
eudicotyledons Gma.5683 30
Rice
(Oryza sativa)
Liliopsida Os06g0342200 30
  • 63.61 (n)
Os.4711 30
Barley
(Hordeum vulgare)
Liliopsida Hv.12801 30
Wheat
(Triticum aestivum)
Liliopsida Ta.14227 30
Corn
(Zea mays)
Liliopsida Zm.16531 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU07437 30
  • 67.94 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif11 30
  • 67.18 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11104 31
  • 52 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.10045 30
Species where no ortholog for EIF1AX was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF1AX Gene

ENSEMBL:
Gene Tree for EIF1AX (if available)
TreeFam:
Gene Tree for EIF1AX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF1AX: view image

Paralogs for EIF1AX Gene

Paralogs for EIF1AX Gene

(1) SIMAP similar genes for EIF1AX Gene using alignment to 2 proteins:

  • IF1AX_HUMAN
  • L8E8T0_HUMAN

Pseudogenes.org Pseudogenes for EIF1AX Gene

genes like me logo Genes that share paralogs with EIF1AX: view

Variants for EIF1AX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF1AX Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs112617226 Benign: not provided 20,130,537(-) A/G
NM_001412.4(EIF1AX):c.408T>C (p.Asp136=)
SYNONYMOUS
rs1603415028 Likely Pathogenic: Multiple myeloma 20,132,224(-) C/T
NM_001412.4(EIF1AX):c.295G>A (p.Glu99Lys)
MISSENSE
rs5955886 Benign: not provided 20,135,846(-) C/T
NM_001412.4(EIF1AX):c.101-5G>A
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EIF1AX Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EIF1AX Gene

Variant ID Type Subtype PubMed ID
esv25136 CNV gain+loss 19812545
nsv820390 CNV duplication 20802225

Variation tolerance for EIF1AX Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF1AX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AX

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AX Gene

Disorders for EIF1AX Gene

MalaCards: The human disease database

(12) MalaCards diseases for EIF1AX Gene - From: CVR, ORP, and COP

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
plasma cell neoplasm
  • plasma cell dyscrasia
myeloma, multiple
  • multiple myeloma, susceptibility to
thyroid gland cancer
  • malignant neoplasm of thyroid gland
malignant conjunctival melanoma
  • conjunctival melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF1AX

genes like me logo Genes that share disorders with EIF1AX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF1AX Gene

Publications for EIF1AX Gene

  1. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PMID: 8106356) Dever TE … Hershey JW (The Journal of biological chemistry 1994) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PMID: 12514125) Olsen DS … Hinnebusch AG (The EMBO journal 2003) 3 23
  5. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot JM … Görlich D (The EMBO journal 2001) 3 23

Products for EIF1AX Gene

Sources for EIF1AX Gene