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Aliases for EIF1AD Gene

Aliases for EIF1AD Gene

  • Eukaryotic Translation Initiation Factor 1A Domain Containing 2 3 5
  • Eukaryotic Translation Initiation Factor 1A Domain-Containing Protein 3 4
  • Haponin 3 4
  • Probable RNA-Binding Protein EIF1AD 3

External Ids for EIF1AD Gene

Previous GeneCards Identifiers for EIF1AD Gene

  • GC11M065522
  • GC11M065764
  • GC11M062090

Summaries for EIF1AD Gene

GeneCards Summary for EIF1AD Gene

EIF1AD (Eukaryotic Translation Initiation Factor 1A Domain Containing) is a Protein Coding gene. Diseases associated with EIF1AD include Nestor-Guillermo Progeria Syndrome. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF1AD Gene

  • Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

Additional gene information for EIF1AD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AD Gene

Genomics for EIF1AD Gene

GeneHancer (GH) Regulatory Elements for EIF1AD Gene

Promoters and enhancers for EIF1AD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066000 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 728.4 -0.1 -107 3 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EIF1AD BANF1 ENSG00000258297 ZFPL1 PCNX3 POLA2 RBM14 SART1 RBM4 SF3B2
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 173.8 +512.1 512092 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 109.4 +578.0 577995 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000278144 GC11P065538 ENSG00000278050 ENSG00000277599 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 106.9 +144.7 144692 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD ENSG00000258297 POLA2 RBM14 SART1 PCNX3 RBM4 ZFPL1
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 72.7 +106.7 106718 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF1AD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF1AD gene promoter:

Genomic Locations for EIF1AD Gene

Genomic Locations for EIF1AD Gene
chr11:65,996,545-66,002,176
(GRCh38/hg38)
Size:
5,632 bases
Orientation:
Minus strand
chr11:65,764,016-65,769,647
(GRCh37/hg19)

Genomic View for EIF1AD Gene

Genes around EIF1AD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AD Gene

Proteins for EIF1AD Gene

  • Protein details for EIF1AD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N8-EIF1A_HUMAN
    Recommended name:
    Probable RNA-binding protein EIF1AD
    Protein Accession:
    Q8N9N8
    Secondary Accessions:
    • B2R4N5
    • Q9BSC1

    Protein attributes for EIF1AD Gene

    Size:
    165 amino acids
    Molecular mass:
    19053 Da
    Quaternary structure:
    • Interacts with GAPDH and STAT1.

    Three dimensional structures from OCA and Proteopedia for EIF1AD Gene

neXtProt entry for EIF1AD Gene

Post-translational modifications for EIF1AD Gene

  • Ubiquitination at Lys112, Lys98, and Lys56
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF1AD Gene

Domains & Families for EIF1AD Gene

Gene Families for EIF1AD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF1AD Gene

Suggested Antigen Peptide Sequences for EIF1AD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9N8

UniProtKB/Swiss-Prot:

EIF1A_HUMAN :
  • Belongs to the EIF1AD family.
Family:
  • Belongs to the EIF1AD family.
genes like me logo Genes that share domains with EIF1AD: view

Function for EIF1AD Gene

Molecular function for EIF1AD Gene

UniProtKB/Swiss-Prot Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

Phenotypes From GWAS Catalog for EIF1AD Gene

Gene Ontology (GO) - Molecular Function for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF1AD: view
genes like me logo Genes that share phenotypes with EIF1AD: view

Animal Model Products

miRNA for EIF1AD Gene

miRTarBase miRNAs that target EIF1AD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AD Gene

Localization for EIF1AD Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF1AD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AD gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with EIF1AD: view

Pathways & Interactions for EIF1AD Gene

SuperPathways for EIF1AD Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF1AD: view

No data available for Pathways by source and SIGNOR curated interactions for EIF1AD Gene

Drugs & Compounds for EIF1AD Gene

No Compound Related Data Available

Transcripts for EIF1AD Gene

Unigene Clusters for EIF1AD Gene

Eukaryotic translation initiation factor 1A domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for EIF1AD Gene

GeneLoc Exon Structure for
EIF1AD
ECgene alternative splicing isoforms for
EIF1AD

Expression for EIF1AD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1AD Gene

Protein differential expression in normal tissues from HIPED for EIF1AD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Breast (11.1), Lung (9.7), CD8 Tcells (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF1AD Gene



Protein tissue co-expression partners for EIF1AD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF1AD Gene:

EIF1AD

SOURCE GeneReport for Unigene cluster for EIF1AD Gene:

Hs.425178

mRNA Expression by UniProt/SwissProt for EIF1AD Gene:

Q8N9N8-EIF1A_HUMAN
Tissue specificity: Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.

Evidence on tissue expression from TISSUES for EIF1AD Gene

  • Muscle(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with EIF1AD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AD Gene

Orthologs for EIF1AD Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF1AD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1AD 34 33
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EIF1AD 34 33
  • 92.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF1AD 34 33
  • 91.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif1ad 16 34 33
  • 88.24 (n)
rat
(Rattus norvegicus)
Mammalia Eif1ad 33
  • 87.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF1AD 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ad 33
  • 66.45 (n)
zebrafish
(Danio rerio)
Actinopterygii eif1ad 34 33
  • 59.91 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG31957 34 33
  • 59.06 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010181 33
  • 58.85 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK856.11 34 33
  • 47.38 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for EIF1AD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1AD Gene

ENSEMBL:
Gene Tree for EIF1AD (if available)
TreeFam:
Gene Tree for EIF1AD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF1AD: view image

Paralogs for EIF1AD Gene

No data available for Paralogs for EIF1AD Gene

Variants for EIF1AD Gene

Sequence variations from dbSNP and Humsavar for EIF1AD Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs117774800 uncertain-significance, Nestor-Guillermo progeria syndrome 66,002,122(-) C/T 5_prime_UTR_variant
rs14157 benign, Nestor-Guillermo progeria syndrome 66,002,309(-) T/G upstream_transcript_variant
rs141605220 uncertain-significance, Nestor-Guillermo progeria syndrome 66,002,233(-) G/A upstream_transcript_variant
rs142270527 uncertain-significance, Nestor-Guillermo progeria syndrome 66,004,045(-) C/G upstream_transcript_variant
rs144367403 uncertain-significance, Nestor-Guillermo progeria syndrome 66,003,900(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AD Gene

Variant ID Type Subtype PubMed ID
nsv819658 CNV loss 19587683
nsv832191 CNV loss 17160897

Variation tolerance for EIF1AD Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF1AD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AD Gene

Disorders for EIF1AD Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF1AD Gene - From: GeneCards

Disorder Aliases PubMed IDs
nestor-guillermo progeria syndrome
  • ngps
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for EIF1AD

genes like me logo Genes that share disorders with EIF1AD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF1AD Gene

Publications for EIF1AD Gene

  1. Novel protein haponin regulates cellular response to oxidative stress. (PMID: 22095125) Smirnova EV … Lipkin VM (Doklady. Biochemistry and biophysics 2011) 3 4 58
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EIF1AD Gene