Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF1 Gene

Aliases for EIF1 Gene

  • Eukaryotic Translation Initiation Factor 1 2 3 3 5
  • Protein Translation Factor SUI1 Homolog 3 4
  • Sui1iso1 3 4
  • A121 3 4
  • SUI1 3 4
  • EIF-1 3
  • EIF1A 3
  • ISO1 3
  • EIF1 4

External Ids for EIF1 Gene

Previous GeneCards Identifiers for EIF1 Gene

  • GC00U990093
  • GC17P037099
  • GC17P039845
  • GC17P035607

Summaries for EIF1 Gene

GeneCards Summary for EIF1 Gene

EIF1 (Eukaryotic Translation Initiation Factor 1) is a Protein Coding gene. Among its related pathways are Translation Factors and Translational Control. Gene Ontology (GO) annotations related to this gene include translation factor activity, RNA binding. An important paralog of this gene is EIF1B.

UniProtKB/Swiss-Prot for EIF1 Gene

  • Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Gene Wiki entry for EIF1 Gene

Additional gene information for EIF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1 Gene

Genomics for EIF1 Gene

GeneHancer (GH) Regulatory Elements for EIF1 Gene

Promoters and enhancers for EIF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.5 1524 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 EIF1 GC17P041692 GC17P041691 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A
GH17J041645 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -43.0 -42990 1.3 HDAC1 HDGF ATF1 NFRKB ARID2 ATF7 CREM SMARCC1 ZNF592 MAFF EIF1 C17orf113 DHX58 NKIRAS2 KRT42P ENSG00000278954
GH17J041674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -11.2 -11166 5.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF2 YY1 POLR2B ENSG00000267758 RETREG3 NKIRAS2 DHX58 ACLY ENSG00000266962 TTC25 STAT5A HSD17B1 KAT2A
GH17J041673 Enhancer 0.9 FANTOM5 ENCODE 4.7 -15.5 -15456 1 PKNOX1 BACH1 CEBPG NCOR1 ZSCAN29 ZNF639 RFX1 ZNF197 STAT1 L3MBTL2 ACLY HAP1 EIF1 RAB5C NKIRAS2 DHX58 GC17M041665
GH17J041672 Enhancer 0.5 FANTOM5 6.6 -16.5 -16451 0.2 ZNF687 ZKSCAN8 MLLT1 EIF1 RAB5C NKIRAS2 DHX58 DNAJC7 GC17M041665
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF1 gene promoter:
  • C/EBPbeta
  • AREB6
  • Cart-1
  • C/EBPalpha
  • CBF(2)
  • NF-Y
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for EIF1 Gene

Genomic Locations for EIF1 Gene
chr17:41,688,875-41,692,668
(GRCh38/hg38)
Size:
3,794 bases
Orientation:
Plus strand
chr17:39,845,127-39,848,920
(GRCh37/hg19)
Size:
3,794 bases
Orientation:
Plus strand

Genomic View for EIF1 Gene

Genes around EIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1 Gene

Proteins for EIF1 Gene

  • Protein details for EIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41567-EIF1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1
    Protein Accession:
    P41567
    Secondary Accessions:
    • Q9UNQ9

    Protein attributes for EIF1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12732 Da
    Quaternary structure:
    • Interacts with RENT2.

    Three dimensional structures from OCA and Proteopedia for EIF1 Gene

neXtProt entry for EIF1 Gene

Post-translational modifications for EIF1 Gene

  • Ubiquitination at Lys91
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1 Gene

Domains & Families for EIF1 Gene

Gene Families for EIF1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EIF1 Gene

Suggested Antigen Peptide Sequences for EIF1 Gene

Graphical View of Domain Structure for InterPro Entry

P41567

UniProtKB/Swiss-Prot:

EIF1_HUMAN :
  • Belongs to the SUI1 family.
Family:
  • Belongs to the SUI1 family.
genes like me logo Genes that share domains with EIF1: view

Function for EIF1 Gene

Molecular function for EIF1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Gene Ontology (GO) - Molecular Function for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003743 translation initiation factor activity IEA,NAS 10347211
GO:0005515 protein binding IPI 23623729
GO:0008135 translation factor activity, RNA binding TAS 10347211
genes like me logo Genes that share ontologies with EIF1: view
genes like me logo Genes that share phenotypes with EIF1: view

Animal Model Products

CRISPR Products

miRNA for EIF1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1 Gene

Localization for EIF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12426392
GO:0005737 cytoplasm TAS,IDA 12426392
genes like me logo Genes that share ontologies with EIF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EIF1 Gene

Pathways & Interactions for EIF1 Gene

genes like me logo Genes that share pathways with EIF1: view

Pathways by source for EIF1 Gene

1 BioSystems pathway for EIF1 Gene
1 KEGG pathway for EIF1 Gene
1 Cell Signaling Technology pathway for EIF1 Gene

Gene Ontology (GO) - Biological Process for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation IDA 22156057
genes like me logo Genes that share ontologies with EIF1: view

No data available for SIGNOR curated interactions for EIF1 Gene

Drugs & Compounds for EIF1 Gene

(2) Additional Compounds for EIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF1: view

Transcripts for EIF1 Gene

mRNA/cDNA for EIF1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2215) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF1 Gene

Eukaryotic translation initiation factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF1

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for EIF1 Gene

GeneLoc Exon Structure for
EIF1
ECgene alternative splicing isoforms for
EIF1

Expression for EIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF1 Gene

This gene is overexpressed in Fetal ovary (8.7), NK cells (7.6), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF1 Gene



Protein tissue co-expression partners for EIF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF1 Gene:

EIF1

SOURCE GeneReport for Unigene cluster for EIF1 Gene:

Hs.150580

Evidence on tissue expression from TISSUES for EIF1 Gene

  • Nervous system(5)
  • Eye(4.9)
  • Lung(4.9)
  • Pancreas(4.7)
  • Skin(4.3)
  • Muscle(4.2)
  • Intestine(4)
  • Liver(4)
  • Heart(3.9)
  • Blood(3.8)
  • Kidney(3.7)
  • Stomach(3)
  • Bone marrow(2.9)
  • Adrenal gland(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with EIF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1 Gene

Orthologs for EIF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SUI1ISO1 34
  • 100 (a)
OneToOne
EIF1 33
  • 97.94 (n)
mouse
(Mus musculus)
Mammalia Eif1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF1 34 33
  • 97.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif1l1 33
  • 97.64 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF1 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF1 34 33
  • 89.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF1 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1 33
  • 77.88 (n)
zebrafish
(Danio rerio)
Actinopterygii eif1b 34 33
  • 82.01 (n)
ManyToMany
wufb54a12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11829 33
fruit fly
(Drosophila melanogaster)
Insecta CG17737 34
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1 34
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI1 34
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6142 34
  • 67 (a)
OneToMany
Species where no ortholog for EIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1 Gene

ENSEMBL:
Gene Tree for EIF1 (if available)
TreeFam:
Gene Tree for EIF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF1: view image

Paralogs for EIF1 Gene

Paralogs for EIF1 Gene

(3) SIMAP similar genes for EIF1 Gene using alignment to 3 proteins:

  • EIF1_HUMAN
  • K7EM18_HUMAN
  • K7EQP2_HUMAN
genes like me logo Genes that share paralogs with EIF1: view

Variants for EIF1 Gene

Sequence variations from dbSNP and Humsavar for EIF1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000229444 -- 41,690,429(+) C/G intron_variant
rs1000261615 -- 41,689,272(+) C/G intron_variant
rs1000558790 -- 41,689,376(+) A/G intron_variant
rs1001668086 -- 41,687,025(+) C/A upstream_transcript_variant
rs1002244211 -- 41,687,727(+) ACACA/ACA upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv960105 CNV duplication 23825009

Variation tolerance for EIF1 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1 Gene

Disorders for EIF1 Gene

Additional Disease Information for EIF1

No disorders were found for EIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1 Gene

Publications for EIF1 Gene

  1. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). (PMID: 10347211) Sheikh MS … Fornace AJ (The Journal of biological chemistry 1999) 2 3 4 58
  2. Expressed sequence tags identify a human isolog of the suil translation initiation factor. (PMID: 7904817) Fields C … Adams MD (Biochemical and biophysical research communications 1994) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. (PMID: 11073994) Mendell JT … Dietz HC (Molecular and cellular biology 2000) 3 4 58
  5. Structure and interactions of the translation initiation factor eIF1. (PMID: 10228174) Fletcher CM … Wagner G (The EMBO journal 1999) 3 4 58

Products for EIF1 Gene

Sources for EIF1 Gene

Content
Loading form....