Aliases for EID3 Gene

Aliases for EID3 Gene

  • EP300 Interacting Inhibitor Of Differentiation 3 2 3 5
  • Non-Structural Maintenance Of Chromosomes Element 4 Homolog B 3 4
  • EP300-Interacting Inhibitor Of Differentiation 3 3 4
  • EID-1-Like Inhibitor Of Differentiation 3 3 4
  • E1A-Like Inhibitor Of Differentiation 3 3 4
  • Non-SMC Element 4 Homolog B 3 4
  • NSE4 Homolog B 2 3
  • EID-3 3 4
  • NS4EB 3 4
  • Testis Tissue Sperm-Binding Protein Li 96mP 3
  • NSMCE4B 3
  • NSE4B 3

External Ids for EID3 Gene

Previous GeneCards Identifiers for EID3 Gene

  • GC12U900507
  • GC12P103221
  • GC12P104697

Summaries for EID3 Gene

GeneCards Summary for EID3 Gene

EID3 (EP300 Interacting Inhibitor Of Differentiation 3) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is NSMCE4A.

UniProtKB/Swiss-Prot Summary for EID3 Gene

  • Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
  • Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Additional gene information for EID3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EID3 Gene

Genomics for EID3 Gene

GeneHancer (GH) Regulatory Elements for EID3 Gene

Promoters and enhancers for EID3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J104302 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 795.4 0.0 -31 2.6 SIN3A NFIB ZBTB33 NKRF ELF1 ZNF687 CREM POLR2A BACH1 SP1 EID3 piR-38005-007 NONHSAG012141.2 TXNRD1
GH12J104283 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 43.8 -15.4 -15434 8.6 FOXK2 SIN3A ZNF24 SP1 MLX FOXA1 SMARCE1 RBPJ POLR2A USF2 NONHSAG012141.2 TXNRD1 EID3 TDG WASHC4 RPL18AP3 APPL2 C12orf73 piR-38005-007
GH12J104293 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 44.3 -7.4 -7431 5.4 SIN3A CTCF POLR2A USF2 ZBTB33 NCOA3 CTBP1 GATAD2B ATF3 SP1 EID3 TDG NFYB piR-38005-007 NONHSAG012141.2 TXNRD1
GH12J104357 Enhancer 1 Ensembl ENCODE 30.9 +52.6 52635 6.4 SIN3A CTCF SREBF1 POLR2A MYC CC2D1A MAX RAD21 ZNF280D ZBTB33 EID3 TDG CHST11 NFYB RPL18AP3 piR-30123 lnc-TXNRD1-1
GH12J104215 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.7 -85.0 -84995 7.1 SIN3A GATA3 ZBTB6 RBPJ SMARCE1 POLR2A TCF7L2 ZNF217 ZNF362 MYC TXNRD1 TDG WASHC4 RPL18AP3 EID3 CHST11 hsa-miR-5095-100
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EID3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EID3 gene promoter:
  • c-Myb
  • c-Rel
  • CP2
  • Elk-1
  • GATA-3
  • LCR-F1
  • NF-kappaB1
  • Nkx2-5
  • p53
  • RP58

Genomic Locations for EID3 Gene

Genomic Locations for EID3 Gene
chr12:104,303,732-104,305,205
(GRCh38/hg38)
Size:
1,474 bases
Orientation:
Plus strand
chr12:104,697,517-104,698,983
(GRCh37/hg19)
Size:
1,467 bases
Orientation:
Plus strand

Genomic View for EID3 Gene

Genes around EID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID3 Gene

Proteins for EID3 Gene

  • Protein details for EID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N140-EID3_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 3
    Protein Accession:
    Q8N140

    Protein attributes for EID3 Gene

    Size:
    333 amino acids
    Molecular mass:
    38168 Da
    Quaternary structure:
    • Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.

neXtProt entry for EID3 Gene

Post-translational modifications for EID3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID3 Gene

Domains & Families for EID3 Gene

Gene Families for EID3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EID3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EID3 Gene

GenScript: Design optimal peptide antigens:
  • EID-1-like inhibitor of differentiation 3 (EID3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N140

UniProtKB/Swiss-Prot:

EID3_HUMAN :
  • Belongs to the NSE4 family.
Family:
  • Belongs to the NSE4 family.
genes like me logo Genes that share domains with EID3: view

Function for EID3 Gene

Molecular function for EID3 Gene

UniProtKB/Swiss-Prot Function:
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
UniProtKB/Swiss-Prot Function:
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Phenotypes From GWAS Catalog for EID3 Gene

Gene Ontology (GO) - Molecular Function for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21364888
genes like me logo Genes that share ontologies with EID3: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EID3 Gene

Localization for EID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID3 Gene

Nucleus. Cytoplasm. Chromosome, telomere. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269 PubMed:15987788}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EID3 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IDA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with EID3: view

Pathways & Interactions for EID3 Gene

genes like me logo Genes that share pathways with EID3: view

Gene Ontology (GO) - Biological Process for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IBA 21873635
GO:0006310 DNA recombination IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:2001022 positive regulation of response to DNA damage stimulus IBA 21873635
genes like me logo Genes that share ontologies with EID3: view

No data available for SIGNOR curated interactions for EID3 Gene

Drugs & Compounds for EID3 Gene

No Compound Related Data Available

Transcripts for EID3 Gene

mRNA/cDNA for EID3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EID3 Gene

No ASD Table

Relevant External Links for EID3 Gene

GeneLoc Exon Structure for
EID3
ECgene alternative splicing isoforms for
EID3

Expression for EID3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EID3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EID3 Gene

This gene is overexpressed in Testis (x15.9).

Protein differential expression in normal tissues from HIPED for EID3 Gene

This gene is overexpressed in Monocytes (39.3) and Lung (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EID3 Gene



Protein tissue co-expression partners for EID3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EID3 Gene:

EID3

SOURCE GeneReport for Unigene cluster for EID3 Gene:

Hs.659857

mRNA Expression by UniProt/SwissProt for EID3 Gene:

Q8N140-EID3_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with EID3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EID3 Gene

Orthologs for EID3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EID3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EID3 32
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia EID3 32
  • 86.07 (n)
cow
(Bos Taurus)
Mammalia EID3 32
  • 83.65 (n)
rat
(Rattus norvegicus)
Mammalia Eid3 32
  • 79.73 (n)
mouse
(Mus musculus)
Mammalia Eid3 17 32
  • 77.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nsmce4a 33
  • 40 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nse4 32
  • 41.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 27 (a)
OneToMany
Species where no ortholog for EID3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EID3 Gene

ENSEMBL:
Gene Tree for EID3 (if available)
TreeFam:
Gene Tree for EID3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EID3: view image

Paralogs for EID3 Gene

Paralogs for EID3 Gene

(1) SIMAP similar genes for EID3 Gene using alignment to 1 proteins:

  • EID3_HUMAN
genes like me logo Genes that share paralogs with EID3: view

Variants for EID3 Gene

Sequence variations from dbSNP and Humsavar for EID3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000106768 -- 104,303,449(+) T/G upstream_transcript_variant
rs1000293297 -- 104,302,742(+) G/T upstream_transcript_variant
rs1002688695 -- 104,303,027(+) TTT/TT upstream_transcript_variant
rs1003058269 -- 104,301,911(+) T/G upstream_transcript_variant
rs1003631224 -- 104,305,228(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EID3 Gene

Variant ID Type Subtype PubMed ID
esv3580448 CNV loss 25503493
esv3630634 CNV gain 21293372
nsv52994 CNV deletion 16902084

Variation tolerance for EID3 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EID3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EID3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID3 Gene

Disorders for EID3 Gene

Additional Disease Information for EID3

No disorders were found for EID3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID3 Gene

Publications for EID3 Gene

  1. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. (PMID: 15987788) Båvner A … Treuter E (Nucleic acids research 2005) 2 3 4 56
  2. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson JJ … Palecek J (PloS one 2011) 3 4 56
  3. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PMID: 18086888) Taylor EM … Lehmann AR (Molecular and cellular biology 2008) 3 4 56
  4. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. (PMID: 15752197) Hu B … Panaretou B (Molecular microbiology 2005) 2 3 56
  5. Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. (PMID: 30114644) Wang Y … Guo Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56

Products for EID3 Gene

Sources for EID3 Gene