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Aliases for EID2B Gene

Aliases for EID2B Gene

  • EP300 Interacting Inhibitor Of Differentiation 2B 2 3 5
  • EID-2B 3 4
  • EID-3 3 4
  • EP300-Interacting Inhibitor Of Differentiation 2B 3
  • EID-2-Like Inhibitor Of Differentiation-3 3
  • EID-2-Like Inhibitor Of Differentiation 3 4
  • EID3 4

External Ids for EID2B Gene

Previous GeneCards Identifiers for EID2B Gene

  • GC19M044715
  • GC19M040021
  • GC19M036467

Summaries for EID2B Gene

GeneCards Summary for EID2B Gene

EID2B (EP300 Interacting Inhibitor Of Differentiation 2B) is a Protein Coding gene. An important paralog of this gene is EID2.

UniProtKB/Swiss-Prot for EID2B Gene

  • Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.

Additional gene information for EID2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID2B Gene

Genomics for EID2B Gene

GeneHancer (GH) Regulatory Elements for EID2B Gene

Promoters and enhancers for EID2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I039531 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 560.9 +0.4 382 2 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF207 EID2B ENSG00000269792 GC19P039533 GC19P039535 TDGF1P7 FBL HNRNPL ZNF780B ENSG00000269688 PSMC4
GH19I039397 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.2 +125.8 125792 20 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36 PLEKHG2 HNRNPL ZNF780B FBL ZNF780A SUPT5H AKT2 RN7SL566P RPS16
GH19I038647 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.2 +873.1 873074 25.6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZC3H11A ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
GH19I039427 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30 +100.7 100721 9.7 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF416 ZNF143 SP3 NFYC RPS16 HNRNPL FBL ZNF780B AKT2 PLEKHG2 RN7SL566P SUPT5H ENSG00000269688 EID2B
GH19I039389 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 36 +142.1 142081 3.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MED29 PAF1 HNRNPL EID2B PAK4 ZNF780B FBL PSMC4 RPS16 SUPT5H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EID2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EID2B gene promoter:

Genomic Locations for EID2B Gene

Genomic Locations for EID2B Gene
chr19:39,530,990-39,532,867
(GRCh38/hg38)
Size:
1,878 bases
Orientation:
Minus strand
chr19:40,021,630-40,023,494
(GRCh37/hg19)

Genomic View for EID2B Gene

Genes around EID2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID2B Gene

Proteins for EID2B Gene

  • Protein details for EID2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D98-EID2B_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 2B
    Protein Accession:
    Q96D98
    Secondary Accessions:
    • Q8N8S0

    Protein attributes for EID2B Gene

    Size:
    161 amino acids
    Molecular mass:
    16985 Da
    Quaternary structure:
    • Homodimer and heterodimer with EID2. Interacts with HDAC1 and HDAC2.

neXtProt entry for EID2B Gene

Post-translational modifications for EID2B Gene

No Post-translational modifications

Other Protein References for EID2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID2B Gene

Domains & Families for EID2B Gene

Gene Families for EID2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EID2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EID2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D98

UniProtKB/Swiss-Prot:

EID2B_HUMAN :
  • The C-terminal portion of EID2B is required for nuclear localization.
Domain:
  • The C-terminal portion of EID2B is required for nuclear localization.
genes like me logo Genes that share domains with EID2B: view

Function for EID2B Gene

Molecular function for EID2B Gene

UniProtKB/Swiss-Prot Function:
Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.

Phenotypes From GWAS Catalog for EID2B Gene

Gene Ontology (GO) - Molecular Function for EID2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15970276
GO:0042802 identical protein binding IPI 15970276
genes like me logo Genes that share ontologies with EID2B: view
genes like me logo Genes that share phenotypes with EID2B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EID2B Gene

Localization for EID2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EID2B gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for EID2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 15970276
genes like me logo Genes that share ontologies with EID2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EID2B Gene

Pathways & Interactions for EID2B Gene

SuperPathways for EID2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for EID2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with EID2B: view

No data available for Pathways by source and SIGNOR curated interactions for EID2B Gene

Drugs & Compounds for EID2B Gene

No Compound Related Data Available

Transcripts for EID2B Gene

mRNA/cDNA for EID2B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EID2B Gene

EP300 interacting inhibitor of differentiation 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EID2B Gene

No ASD Table

Relevant External Links for EID2B Gene

GeneLoc Exon Structure for
EID2B
ECgene alternative splicing isoforms for
EID2B

Expression for EID2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EID2B Gene

Protein differential expression in normal tissues from HIPED for EID2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EID2B Gene



Protein tissue co-expression partners for EID2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EID2B Gene:

EID2B

SOURCE GeneReport for Unigene cluster for EID2B Gene:

Hs.135181
genes like me logo Genes that share expression patterns with EID2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EID2B Gene

Orthologs for EID2B Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for EID2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EID2B 33 34
  • 99.17 (n)
rat
(Rattus norvegicus)
Mammalia Eid2b 33
  • 69.09 (n)
mouse
(Mus musculus)
Mammalia Eid2b 33 16 34
  • 68.43 (n)
Species where no ortholog for EID2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EID2B Gene

ENSEMBL:
Gene Tree for EID2B (if available)
TreeFam:
Gene Tree for EID2B (if available)

Paralogs for EID2B Gene

Paralogs for EID2B Gene

genes like me logo Genes that share paralogs with EID2B: view

Variants for EID2B Gene

Sequence variations from dbSNP and Humsavar for EID2B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000412867 -- 39,532,551(-) C/G coding_sequence_variant, missense_variant
rs1001216997 -- 39,531,085(-) C/G downstream_transcript_variant
rs1002893859 -- 39,532,570(-) G/A coding_sequence_variant, missense_variant
rs1003222618 -- 39,534,095(-) T/G upstream_transcript_variant
rs1003253775 -- 39,533,672(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EID2B Gene

Variant ID Type Subtype PubMed ID
esv3644331 CNV loss 21293372
nsv137930 CNV deletion 16902084
nsv579509 CNV gain 21841781

Variation tolerance for EID2B Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EID2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EID2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID2B Gene

Disorders for EID2B Gene

Additional Disease Information for EID2B

No disorders were found for EID2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID2B Gene

Publications for EID2B Gene

  1. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. (PMID: 15970276) Sasajima Y … Yuasa Y (Biochemical and biophysical research communications 2005) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson JJ … Palecek J (PloS one 2011) 3 58

Products for EID2B Gene

Sources for EID2B Gene

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