Aliases for EID2 Gene

Aliases for EID2 Gene

  • EP300 Interacting Inhibitor Of Differentiation 2 2 3 5
  • CREBBP/EP300 Inhibitor 2 2 3 4
  • EID-2 2 3 4
  • EP300-Interacting Inhibitor Of Differentiation 2 3 4
  • EID-1-Like Inhibitor Of Differentiation 2 3 4
  • CREBBP/EP300 Inhibitory Protein 2 2 3
  • CRI2 3 4
  • E1A Like Inhibitor Of Differentiation 2 3
  • MGC20452 2
  • EID2 5

External Ids for EID2 Gene

Previous HGNC Symbols for EID2 Gene

  • CRI2

Previous GeneCards Identifiers for EID2 Gene

  • GC19M044722
  • GC19M040028
  • GC19M036475

Summaries for EID2 Gene

GeneCards Summary for EID2 Gene

EID2 (EP300 Interacting Inhibitor Of Differentiation 2) is a Protein Coding gene. Diseases associated with EID2 include Cutaneous Diphtheria and Epidemic Pleurodynia. Among its related pathways are TGF-beta Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include SMAD binding. An important paralog of this gene is EID2B.

UniProtKB/Swiss-Prot Summary for EID2 Gene

  • Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EID2 Gene

Genomics for EID2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EID2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EID2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EID2

Top Transcription factor binding sites by QIAGEN in the EID2 gene promoter:
  • c-Rel
  • En-1
  • GATA-1
  • MyoD
  • p53
  • POU6F1 (c2)
  • RelA
  • STAT3
  • YY1
  • Zic3

Genomic Locations for EID2 Gene

Genomic Locations for EID2 Gene
chr19:39,538,707-39,540,161
(GRCh38/hg38)
Size:
1,455 bases
Orientation:
Minus strand
chr19:40,028,890-40,030,870
(GRCh37/hg19)
Size:
1,981 bases
Orientation:
Minus strand

Genomic View for EID2 Gene

Genes around EID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID2 Gene

Proteins for EID2 Gene

  • Protein details for EID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6I1-EID2_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 2
    Protein Accession:
    Q8N6I1
    Secondary Accessions:
    • A7YQ71
    • Q6X7T0
    • Q6ZR61

    Protein attributes for EID2 Gene

    Size:
    236 amino acids
    Molecular mass:
    25190 Da
    Quaternary structure:
    • Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3.

    Alternative splice isoforms for EID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EID2 Gene

Post-translational modifications for EID2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EID2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID2 Gene

Domains & Families for EID2 Gene

Gene Families for EID2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EID2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EID2 Gene

GenScript: Design optimal peptide antigens:
  • EID-1-like inhibitor of differentiation 2 (EID2_HUMAN)
  • EID2 protein (Q6IPM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6I1

UniProtKB/Swiss-Prot:

EID2_HUMAN :
  • The N-terminal portion of EID2 is required for nuclear localization.
Domain:
  • The N-terminal portion of EID2 is required for nuclear localization.
genes like me logo Genes that share domains with EID2: view

Function for EID2 Gene

Molecular function for EID2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

Phenotypes From GWAS Catalog for EID2 Gene

Gene Ontology (GO) - Molecular Function for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IPI 14612439
GO:0046332 SMAD binding IDA 14612439
genes like me logo Genes that share ontologies with EID2: view
genes like me logo Genes that share phenotypes with EID2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EID2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EID2 Gene

Localization for EID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EID2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 14612439
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with EID2: view

Pathways & Interactions for EID2 Gene

PathCards logo

SuperPathways for EID2 Gene

genes like me logo Genes that share pathways with EID2: view

Pathways by source for EID2 Gene

1 BioSystems pathway for EID2 Gene

SIGNOR curated interactions for EID2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0007181 transforming growth factor beta receptor complex assembly IDA 14612439
GO:0007183 SMAD protein complex assembly IDA 14612439
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with EID2: view

Drugs & Compounds for EID2 Gene

No Compound Related Data Available

Transcripts for EID2 Gene

mRNA/cDNA for EID2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EID2

Alternative Splicing Database (ASD) splice patterns (SP) for EID2 Gene

No ASD Table

Relevant External Links for EID2 Gene

GeneLoc Exon Structure for
EID2

Expression for EID2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EID2 Gene

This gene is overexpressed in Bone (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EID2 Gene



Protein tissue co-expression partners for EID2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EID2

SOURCE GeneReport for Unigene cluster for EID2 Gene:

Hs.18949

mRNA Expression by UniProt/SwissProt for EID2 Gene:

Q8N6I1-EID2_HUMAN
Tissue specificity: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney.

Evidence on tissue expression from TISSUES for EID2 Gene

  • Skin(2.3)
genes like me logo Genes that share expression patterns with EID2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EID2 Gene

Orthologs for EID2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for EID2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EID2 30 31
  • 99.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EID2 30 31
  • 83.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EID2 30 31
  • 74.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eid2 30
  • 74.5 (n)
Mouse
(Mus musculus)
Mammalia Eid2 30 17 31
  • 72.79 (n)
OneToOne
Species where no ortholog for EID2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for EID2 Gene

ENSEMBL:
Gene Tree for EID2 (if available)
TreeFam:
Gene Tree for EID2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EID2: view image

Paralogs for EID2 Gene

Paralogs for EID2 Gene

Pseudogenes.org Pseudogenes for EID2 Gene

genes like me logo Genes that share paralogs with EID2: view

Variants for EID2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EID2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3746086 - p.Glu60Ala
rs7252027 - p.Ala6Thr

Additional dbSNP identifiers (rs#s) for EID2 Gene

Structural Variations from Database of Genomic Variants (DGV) for EID2 Gene

Variant ID Type Subtype PubMed ID
nsv579509 CNV gain 21841781

Variation tolerance for EID2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EID2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EID2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID2 Gene

Disorders for EID2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EID2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cutaneous diphtheria
epidemic pleurodynia
  • bamble disease
lymph node tuberculosis
  • king's evil
- elite association - COSMIC cancer census association via MalaCards
Search EID2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with EID2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EID2 Gene

Publications for EID2 Gene

  1. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. (PMID: 14585496) Ji A … MacLellan WR (Gene 2003) 2 3 4
  2. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. (PMID: 15970276) Sasajima Y … Yuasa Y (Biochemical and biophysical research communications 2005) 3 4
  3. A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes. (PMID: 14612439) Lee HJ … Kim SJ (The Journal of biological chemistry 2004) 3 4
  4. A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. (PMID: 12586827) Miyake S … Yuasa Y (The Journal of biological chemistry 2003) 3 4
  5. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. (PMID: 30631154) Hu Q … Yang L (Cell research 2019) 3

Products for EID2 Gene

Sources for EID2 Gene