Aliases for EID1 Gene

Aliases for EID1 Gene

  • EP300 Interacting Inhibitor Of Differentiation 1 2 3 5
  • CREBBP/EP300 Inhibitory Protein 1 2 3 4
  • EID-1 2 3 4
  • EP300-Interacting Inhibitor Of Differentiation 1 3 4
  • E1A-Like Inhibitor Of Differentiation 1 3 4
  • 21 KDa PRb-Associated Protein 3 4
  • CREBBP/EP300 Inhibitor 1 2 3
  • C15orf3 3 4
  • RBP21 3 4
  • CRI1 3 4
  • Retinoblastoma Protein-Associated Protein 3
  • Rb- And P300-Binding Protein EID-1 3
  • NB4 Apoptosis Related Protein 3
  • IRO45620 3
  • PNAS-22 3
  • PTD014 3
  • EID1 5

External Ids for EID1 Gene

Previous HGNC Symbols for EID1 Gene

  • C15orf3
  • CRI1

Previous GeneCards Identifiers for EID1 Gene

  • GC15P046958
  • GC15P049171
  • GC15P049172

Summaries for EID1 Gene

GeneCards Summary for EID1 Gene

EID1 (EP300 Interacting Inhibitor Of Differentiation 1) is a Protein Coding gene. Diseases associated with EID1 include Prader-Willi Syndrome. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and histone acetyltransferase regulator activity. An important paralog of this gene is EID2.

UniProtKB/Swiss-Prot Summary for EID1 Gene

  • Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Gene Wiki entry for EID1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EID1 Gene

Genomics for EID1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EID1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J048878 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.7 667 3.2 CEBPG TEAD4 PRDM10 ZNF629 RFX1 IKZF1 KDM1A ZNF692 POLR2A BACH1 EID1 lnc-CEP152-1 lnc-CEP152-2 SHC4
GH15J048877 Enhancer 0.3 ENCODE 600.7 -1.0 -1008 0.1 MLLT1 EID1 lnc-CEP152-2 CEP152 SHC4
GH15J048896 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas 0.4 +19.4 19419 2.3 PRDM10 ZNF629 ZNF512 ZNF692 ZSCAN4 PATZ1 CEBPB ZBTB48 MYC EP400 SHC4 CEP152 SECISBP2L piR-50444-128 EID1 ENSG00000259602
GH15J048858 Enhancer 1 Ensembl ENCODE 0.4 -19.4 -19433 1.4 LEF1 IKZF1 JUND PKNOX1 ZNF24 DPF2 HDAC1 SOX6 FOXJ2 TCF12 SHC4 lnc-CEP152-2 EID1 CEP152
GH15J048864 Enhancer 0.9 Ensembl ENCODE 0.4 -11.0 -10963 4.5 CEBPB FOS CHD2 OSR2 JUN RCOR1 ELK1 ELK4 JUND EP300 SHC4 CEP152 EID1 lnc-CEP152-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EID1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EID1

Top Transcription factor binding sites by QIAGEN in the EID1 gene promoter:
  • c-Ets-1
  • CUTL1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p53
  • POU3F2
  • Sox5

Genomic Locations for EID1 Gene

Genomic Locations for EID1 Gene
chr15:48,878,134-48,880,173
(GRCh38/hg38)
Size:
2,040 bases
Orientation:
Plus strand
chr15:49,170,083-49,172,380
(GRCh37/hg19)
Size:
2,298 bases
Orientation:
Plus strand

Genomic View for EID1 Gene

Genes around EID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID1 Gene

Proteins for EID1 Gene

  • Protein details for EID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6B2-EID1_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 1
    Protein Accession:
    Q9Y6B2
    Secondary Accessions:
    • B2RD11
    • Q8N7I4
    • Q9BZT9

    Protein attributes for EID1 Gene

    Size:
    187 amino acids
    Molecular mass:
    20876 Da
    Quaternary structure:
    • Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.
    SequenceCaution:
    • Sequence=AAK07524.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity.

    Alternative splice isoforms for EID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EID1 Gene

Post-translational modifications for EID1 Gene

  • Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.
  • Ubiquitination at Lys72 and Lys133
  • Modification sites at PhosphoSitePlus

Other Protein References for EID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID1 Gene

Domains & Families for EID1 Gene

Gene Families for EID1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EID1 Gene

GenScript: Design optimal peptide antigens:
  • E1A-like inhibitor of differentiation 1 (EID1_HUMAN)
genes like me logo Genes that share domains with EID1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EID1 Gene

Function for EID1 Gene

Molecular function for EID1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
UniProtKB/Swiss-Prot Induction:
Down-regulated in differentiating U-937 leukemia cells.

Phenotypes From GWAS Catalog for EID1 Gene

Gene Ontology (GO) - Molecular Function for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA,ISS --
GO:0005515 protein binding IPI 11073990
GO:0035034 histone acetyltransferase regulator activity IDA 11073990
GO:0035035 histone acetyltransferase binding IDA 11073990
genes like me logo Genes that share ontologies with EID1: view
genes like me logo Genes that share phenotypes with EID1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EID1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EID1 Gene

Localization for EID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID1 Gene

Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm. {ECO:0000250 UniProtKB:Q9DCR4, ECO:0000269 PubMed:11223246}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EID1 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IPI 11073990
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with EID1: view

Pathways & Interactions for EID1 Gene

PathCards logo

SuperPathways for EID1 Gene

No Data Available

SIGNOR curated interactions for EID1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,IDA 11073990
GO:0007049 cell cycle IEA --
GO:0030154 cell differentiation IEA,IDA 11073989
GO:0035065 regulation of histone acetylation IEA --
GO:0045595 regulation of cell differentiation IEA --
genes like me logo Genes that share ontologies with EID1: view

No data available for Pathways by source for EID1 Gene

Drugs & Compounds for EID1 Gene

No Compound Related Data Available

Transcripts for EID1 Gene

mRNA/cDNA for EID1 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EID1

Alternative Splicing Database (ASD) splice patterns (SP) for EID1 Gene

No ASD Table

Relevant External Links for EID1 Gene

GeneLoc Exon Structure for
EID1

Expression for EID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EID1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EID1

SOURCE GeneReport for Unigene cluster for EID1 Gene:

Hs.255973

mRNA Expression by UniProt/SwissProt for EID1 Gene:

Q9Y6B2-EID1_HUMAN
Tissue specificity: Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
genes like me logo Genes that share expression patterns with EID1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EID1 Gene

Orthologs for EID1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for EID1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EID1 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EID1 30 31
  • 89.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EID1 30 31
  • 88.95 (n)
OneToMany
-- 31
  • 85 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Eid1 30
  • 73.81 (n)
Mouse
(Mus musculus)
Mammalia Eid1 30 17 31
  • 73.59 (n)
OneToOne
Species where no ortholog for EID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for EID1 Gene

ENSEMBL:
Gene Tree for EID1 (if available)
TreeFam:
Gene Tree for EID1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EID1: view image

Paralogs for EID1 Gene

Paralogs for EID1 Gene

genes like me logo Genes that share paralogs with EID1: view

Variants for EID1 Gene

Additional dbSNP identifiers (rs#s) for EID1 Gene

Structural Variations from Database of Genomic Variants (DGV) for EID1 Gene

Variant ID Type Subtype PubMed ID
nsv833001 CNV gain 17160897

Variation tolerance for EID1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EID1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EID1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EID1 Gene

Disorders for EID1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EID1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prader-willi syndrome
  • pws
- elite association - COSMIC cancer census association via MalaCards
Search EID1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with EID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EID1 Gene

Publications for EID1 Gene

  1. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. (PMID: 11073989) Miyake S … Kaelin WG (Molecular and cellular biology 2000) 3 4 23
  2. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. (PMID: 11073990) MacLellan WR … Schneider MD (Molecular and cellular biology 2000) 2 3 4
  3. Selective ablation of retinoblastoma protein function by the RET finger protein. (PMID: 15837424) Krützfeldt M … Mittnacht S (Molecular cell 2005) 3 4
  4. Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein. (PMID: 11223246) Wen H … Ao S (Gene 2001) 3 4
  5. Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1-->q21.2. (PMID: 10828624) Carim L … Escarceller M (Cytogenetics and cell genetics 2000) 2 3

Products for EID1 Gene

  • Signalway Proteins for EID1

Sources for EID1 Gene