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This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
EI24 (EI24 Autophagy Associated Transmembrane Protein) is a Protein Coding gene. Diseases associated with EI24 include Breast Cancer. Among its related pathways are Apoptosis and Autophagy and DNA Damage Response.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IBA,IDA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis and Autophagy | ||
2 | DNA Damage Response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006914 | autophagy | IEA | -- |
GO:0006915 | apoptotic process | TAS,IEA | -- |
GO:0016236 | macroautophagy | IBA | 21873635 |
GO:0030308 | negative regulation of cell growth | IDA | 10594026 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EI24 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | EI24 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EI24 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ei24 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ei24 30 |
|
||
Cow (Bos Taurus) |
Mammalia | EI24 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EI24 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EI24 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EI24 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ei24 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ei24 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15626 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008107 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | epg-4 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs375652371 | Some patients with early onset breast cancer | p.Thr319Ala | |||
VAR_065459 | Some patients with early onset breast cancer | p.Asp30Gly | |||
VAR_065460 | Some patients with early onset breast cancer | p.Pro195Trp | |||
VAR_065461 | Some patients with early onset breast cancer | p.Ile196Asp | |||
VAR_065462 | Some patients with early onset breast cancer | p.His197Tyr |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|