This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequen... See more...

Aliases for EI24 Gene

Aliases for EI24 Gene

  • EI24 Autophagy Associated Transmembrane Protein 2 3 5
  • PIG8 2 3 4
  • Etoposide-Induced Protein 2.4 Homolog 3 4
  • P53-Induced Gene 8 Protein 3 4
  • Etoposide Induced 2.4 2 3
  • TP53I8 2 3
  • EPG4 2 3
  • Ectopic P-Granules Autophagy Protein 4 Homolog (C. Elegans) 2
  • Ectopic P-Granules Autophagy Protein 4 Homolog 3
  • Tumor Protein P53 Inducible Protein 8 3
  • Etoposide Induced 2.4 MRNA 2
  • EI24 5

External Ids for EI24 Gene

Previous GeneCards Identifiers for EI24 Gene

  • GC11P126952
  • GC11P125473
  • GC11P124977
  • GC11P124945
  • GC11P125441
  • GC11P121382

Summaries for EI24 Gene

Entrez Gene Summary for EI24 Gene

  • This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

GeneCards Summary for EI24 Gene

EI24 (EI24 Autophagy Associated Transmembrane Protein) is a Protein Coding gene. Diseases associated with EI24 include Breast Cancer. Among its related pathways are Apoptosis and Autophagy and DNA Damage Response.

UniProtKB/Swiss-Prot Summary for EI24 Gene

  • Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).

Gene Wiki entry for EI24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EI24 Gene

Genomics for EI24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EI24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EI24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EI24

Top Transcription factor binding sites by QIAGEN in the EI24 gene promoter:
  • CUTL1
  • FOXF2
  • FOXJ2
  • FOXJ2 (long isoform)
  • HTF
  • p53
  • POU2F1
  • POU2F1a
  • SRY

Genomic Locations for EI24 Gene

Genomic Locations for EI24 Gene
chr11:125,569,216-125,584,684
(GRCh38/hg38)
Size:
15,469 bases
Orientation:
Plus strand
chr11:125,439,112-125,454,575
(GRCh37/hg19)
Size:
15,464 bases
Orientation:
Plus strand

Genomic View for EI24 Gene

Genes around EI24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EI24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EI24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EI24 Gene

Proteins for EI24 Gene

  • Protein details for EI24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14681-EI24_HUMAN
    Recommended name:
    Etoposide-induced protein 2.4 homolog
    Protein Accession:
    O14681
    Secondary Accessions:
    • A8K7D6
    • B4DKL6
    • Q9BUQ1

    Protein attributes for EI24 Gene

    Size:
    340 amino acids
    Molecular mass:
    38965 Da
    Quaternary structure:
    • Interacts with BCL2.
    SequenceCaution:
    • Sequence=AAC39531.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for EI24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EI24 Gene

Post-translational modifications for EI24 Gene

  • Ubiquitination at Lys323
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EI24 Gene

Domains & Families for EI24 Gene

Gene Families for EI24 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for EI24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EI24 Gene

GenScript: Design optimal peptide antigens:
  • p53-induced gene 8 protein (EI24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14681

UniProtKB/Swiss-Prot:

EI24_HUMAN :
  • Belongs to the EI24 family.
Family:
  • Belongs to the EI24 family.
genes like me logo Genes that share domains with EI24: view

Function for EI24 Gene

Molecular function for EI24 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for EI24 Gene

genes like me logo Genes that share phenotypes with EI24: view

Animal Models for EI24 Gene

MGI Knock Outs for EI24:
  • Ei24 Ei24<tm1.1Hzha>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EI24

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EI24 Gene

Localization for EI24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EI24 Gene

Nucleus membrane. Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EI24 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4
plasma membrane 3
peroxisome 2
lysosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EI24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IBA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with EI24: view

Pathways & Interactions for EI24 Gene

PathCards logo

SuperPathways for EI24 Gene

genes like me logo Genes that share pathways with EI24: view

Pathways by source for EI24 Gene

1 KEGG pathway for EI24 Gene
1 Cell Signaling Technology pathway for EI24 Gene

Interacting Proteins for EI24 Gene

Gene Ontology (GO) - Biological Process for EI24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process TAS,IEA --
GO:0016236 macroautophagy IBA 21873635
GO:0030308 negative regulation of cell growth IDA 10594026
genes like me logo Genes that share ontologies with EI24: view

No data available for SIGNOR curated interactions for EI24 Gene

Drugs & Compounds for EI24 Gene

No Compound Related Data Available

Transcripts for EI24 Gene

mRNA/cDNA for EI24 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EI24

Alternative Splicing Database (ASD) splice patterns (SP) for EI24 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for EI24 Gene

GeneLoc Exon Structure for
EI24

Expression for EI24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EI24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)
  • Esophagus (Gastrointestinal Tract)
  • Liver (Hepatobiliary System)

Protein differential expression in normal tissues from HIPED for EI24 Gene

This gene is overexpressed in Bone (12.2), Islet of Langerhans (11.3), Fetal gut (10.5), and Breast (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EI24 Gene



Protein tissue co-expression partners for EI24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EI24

SOURCE GeneReport for Unigene cluster for EI24 Gene:

Hs.643514

Evidence on tissue expression from TISSUES for EI24 Gene

  • Intestine(4.7)
  • Lung(4.7)
  • Liver(4.6)
  • Nervous system(4.6)
  • Skin(3)
  • Pancreas(2.9)
  • Muscle(2.5)
  • Kidney(2.3)
  • Heart(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with EI24: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EI24 Gene

Orthologs for EI24 Gene

This gene was present in the common ancestor of animals.

Orthologs for EI24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EI24 30 31
  • 99.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EI24 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EI24 30 31
  • 92.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ei24 30 17 31
  • 92.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ei24 30
  • 92.25 (n)
Cow
(Bos Taurus)
Mammalia EI24 30 31
  • 91.15 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EI24 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EI24 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EI24 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ei24 30
  • 77.55 (n)
Zebrafish
(Danio rerio)
Actinopterygii ei24 30 31
  • 75.12 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG15626 30 31
  • 52.96 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008107 30
  • 50.11 (n)
Worm
(Caenorhabditis elegans)
Secernentea epg-4 30 31
  • 44.97 (n)
OneToOne
Species where no ortholog for EI24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EI24 Gene

ENSEMBL:
Gene Tree for EI24 (if available)
TreeFam:
Gene Tree for EI24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EI24: view image

Paralogs for EI24 Gene

(2) SIMAP similar genes for EI24 Gene using alignment to 8 proteins:

  • EI24_HUMAN
  • A6NES3_HUMAN
  • E9PK61_HUMAN
  • E9PL33_HUMAN
  • E9PLB8_HUMAN
  • E9PM05_HUMAN
  • E9PQN7_HUMAN
  • E9PS58_HUMAN
genes like me logo Genes that share paralogs with EI24: view

No data available for Paralogs for EI24 Gene

Variants for EI24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EI24 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs375652371 Some patients with early onset breast cancer p.Thr319Ala
VAR_065459 Some patients with early onset breast cancer p.Asp30Gly
VAR_065460 Some patients with early onset breast cancer p.Pro195Trp
VAR_065461 Some patients with early onset breast cancer p.Ile196Asp
VAR_065462 Some patients with early onset breast cancer p.His197Tyr

Additional dbSNP identifiers (rs#s) for EI24 Gene

Structural Variations from Database of Genomic Variants (DGV) for EI24 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
nsv983073 CNV duplication 23825009

Variation tolerance for EI24 Gene

Gene Damage Index Score: 0.85; 17.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EI24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EI24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EI24 Gene

Disorders for EI24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EI24 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search EI24 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EI24_HUMAN
  • Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
genes like me logo Genes that share disorders with EI24: view

No data available for Genatlas for EI24 Gene

Publications for EI24 Gene

  1. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K … Vogelstein B (Nature 1997) 2 3 4
  2. Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications. (PMID: 21154811) Mazumder Indra D … Panda CK (International journal of cancer 2011) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  4. Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. (PMID: 11753653) Gentile M … Wingren S (Oncogene 2001) 3 4
  5. The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9. (PMID: 10965130) Gu Z … Zambetti GP (Cytogenetics and cell genetics 2000) 3 23

Products for EI24 Gene

Sources for EI24 Gene