EHMT2 Gene (Protein Coding)

Euchromatic Histone Lysine Methyltransferase 2

GC06M031879
GIFtS:
47
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple tr... See more...

Aliases for EHMT2 Gene

Aliases for EHMT2 Gene

  • Euchromatic Histone Lysine Methyltransferase 2 2 3 5
  • Euchromatic Histone-Lysine N-Methyltransferase 2 3 4
  • Histone-Lysine N-Methyltransferase EHMT2 3 4
  • Histone H3-K9 Methyltransferase 3 3 4
  • Lysine N-Methyltransferase 1C 3 4
  • HLA-B Associated Transcript 8 2 3
  • H3-K9-HMTase 3 3 4
  • C6orf30 3 4
  • KMT1C 3 4
  • BAT8 3 4
  • NG36 3 4
  • G9A 3 4
  • Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 3 3
  • Chromosome 6 Open Reading Frame 30 2
  • Ankyrin Repeat-Containing Protein 3
  • G9A Histone Methyltransferase 3
  • HLA-B-Associated Transcript 8 4
  • Protein G9a 4
  • EC 2.1.1.43 4
  • EC 2.1.1.- 4
  • GAT8 3

External Ids for EHMT2 Gene

Previous HGNC Symbols for EHMT2 Gene

  • C6orf30
  • BAT8

Previous GeneCards Identifiers for EHMT2 Gene

  • GC06M031956
  • GC06M031847
  • GC06M031633

Summaries for EHMT2 Gene

Entrez Gene Summary for EHMT2 Gene

  • This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for EHMT2 Gene

EHMT2 (Euchromatic Histone Lysine Methyltransferase 2) is a Protein Coding gene. Diseases associated with EHMT2 include Ocular Hyperemia and Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii. Among its related pathways are Cellular Senescence (REACTOME) and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include p53 binding and C2H2 zinc finger domain binding. An important paralog of this gene is EHMT1.

UniProtKB/Swiss-Prot Summary for EHMT2 Gene

  • Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

Tocris Summary for EHMT2 Gene

  • Lysine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the lysine residues on histones, particularly histones H3 and H4. The dysregulation of this methylation is critical in the development of cancer.

Gene Wiki entry for EHMT2 Gene

Additional gene information for EHMT2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EHMT2 Gene

Genomics for EHMT2 Gene

GeneHancer (GH) Regulatory Elements for EHMT2 Gene

Promoters and enhancers for EHMT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J031896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 760.3 -2.1 -2143 7.7 SIX5 ZBTB6 RBPJ POLR2A USF2 ATF1 CREB1 HCFC1 MIXL1 MYC EHMT2 C2 ZBTB12 DXO CCHCR1 LY6G5B CSNK2B LSM2 PRRC2A HLA-C
GH06J031813 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.4 +71.5 71475 26.3 E2F8 SIN3A SP1 ZBTB40 CTCF SREBF1 FOXA1 LCORL RBPJ SMARCE1 SNHG32 HSPA1B HSPA1A HSPA1L RF00495-002 DDX39B ATF6B LY6G5B LSM2 GPANK1
GH06J032184 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 28.7 -293.9 -293875 12.8 SP1 ZBTB40 CTCF FOXA1 SMARCE1 RBPJ POLR2A USF2 NR2F6 ATF1 NOTCH4 GPSM3 HSALNG0049384 PBX2 piR-33614-237 DDX39B BRD2 LSM2 ATF6B LY6G5B
GH06J031650 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 28.7 +245.2 245242 3.3 E2F8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 LCORL FOXA1 ZBTB6 SMARCE1 BAG6 APOM lnc-BAG6-1 DDX39B LY6G5B MDC1 ATF6B LSM2 DHX16 CSNK2B
GH06J030907 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 29.2 +989.3 989250 2.2 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SIX5 RBPJ SMARCE1 CTBP1 GTF2H4 VARS2 lnc-GTF2H4-1 MDC1 DDX39B TRIM39 LY6G5B PPP1R10 LSM2 HCG18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EHMT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EHMT2 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • IRF-1
  • p300

Genomic Locations for EHMT2 Gene

Genomic Locations for EHMT2 Gene
chr6:31,879,759-31,897,707
(GRCh38/hg38)
Size:
17,949 bases
Orientation:
Minus strand
chr6:31,847,536-31,865,464
(GRCh37/hg19)
Size:
17,929 bases
Orientation:
Minus strand

Genomic View for EHMT2 Gene

Genes around EHMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EHMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EHMT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EHMT2 Gene

Proteins for EHMT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for EHMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KQ7-EHMT2_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase EHMT2
    Protein Accession:
    Q96KQ7
    Secondary Accessions:
    • B0UZY2
    • Q14349
    • Q5JP83
    • Q5JQ92
    • Q5JQA1
    • Q5JQG3
    • Q6PK06
    • Q96MH5
    • Q96QD0
    • Q9UQL8
    • Q9Y331

    Protein attributes for EHMT2 Gene

    Size:
    1210 amino acids
    Molecular mass:
    132370 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with EHMT1/GLP. Interacts with GFI1B and WIZ. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with UHRF1. Interacts with CDYL. Interacts with REST only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
    SequenceCaution:
    • Sequence=AAD21811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD21812.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH02686.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH18718.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20970.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB63294.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB63295.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA49491.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EHMT2 Gene

    Alternative splice isoforms for EHMT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EHMT2 Gene

Protein Expression for EHMT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for EHMT2 Gene

  • Methylated at Lys-185; automethylated.
  • Ubiquitination at Lys882, Lys1047, and Lys1164
  • Modification sites at PhosphoSitePlus

Other Protein References for EHMT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for EHMT2

No data available for DME Specific Peptides for EHMT2 Gene

Domains & Families for EHMT2 Gene

Gene Families for EHMT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for EHMT2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EHMT2 Gene

GenScript: Design optimal peptide antigens:
  • Euchromatic histone-lysine N-methyltransferase 2 (A2BED6_HUMAN)
  • Euchromatic histone-lysine N-methyltransferase 2 (A2BED7_HUMAN)
  • Protein G9a (EHMT2_HUMAN)
  • Euchromatic histone-lysine N-methyltransferase 2 (Q5JQA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KQ7

UniProtKB/Swiss-Prot:

EHMT2_HUMAN :
  • The SET domain mediates interaction with WIZ.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Domain:
  • The SET domain mediates interaction with WIZ.
  • The ANK repeats bind H3K9me1 and H3K9me2.
  • In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
genes like me logo Genes that share domains with EHMT2: view

Function for EHMT2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for EHMT2 Gene

UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43; Evidence={ECO:0000269 PubMed:11316813, ECO:0000269 PubMed:20084102};.

Enzyme Numbers (IUBMB) for EHMT2 Gene

Phenotypes From GWAS Catalog for EHMT2 Gene

Gene Ontology (GO) - Molecular Function for EHMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0002039 p53 binding IPI,IEA 20118233
GO:0005515 protein binding IEA,IPI 16189514
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with EHMT2: view
genes like me logo Genes that share phenotypes with EHMT2: view

Animal Models for EHMT2 Gene

MGI Knock Outs for EHMT2:

Animal Model Products

CRISPR Products

miRNA for EHMT2 Gene

miRTarBase miRNAs that target EHMT2

Clone Products

  • Addgene plasmids for EHMT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EHMT2 Gene

Localization for EHMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EHMT2 Gene

Nucleus. Chromosome. Note=Associates with euchromatic regions. Does not associate with heterochromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EHMT2 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EHMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19144645
GO:0005634 nucleus IDA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with EHMT2: view

Pathways & Interactions for EHMT2 Gene

genes like me logo Genes that share pathways with EHMT2: view

Pathways by source for EHMT2 Gene

2 KEGG pathways for EHMT2 Gene
1 R&D Systems pathway for EHMT2 Gene
1 Cell Signaling Technology pathway for EHMT2 Gene
1 GeneTex pathway for EHMT2 Gene

SIGNOR curated interactions for EHMT2 Gene

Activates:

Gene Ontology (GO) - Biological Process for EHMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19144645
GO:0006275 regulation of DNA replication IMP 22387026
GO:0006306 DNA methylation ISS --
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with EHMT2: view

Drugs & Compounds for EHMT2 Gene

Products:

  1. Drug

(21) Drugs for EHMT2 Gene - From: PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Entacapone Approved, Investigational Pharma COMT inhibitor, Potent COMT inhibitor; blocks alpha-synuclein aggregation 55
D-Lysine Approved, Experimental Nutra Full agonist, Agonist 0
s-adenosylhomocysteine Experimental Pharma 0
UNC0638 Pharma G9a/GLP HMTase inhibitor, potent and selective 0
Antithyroid Preparations Pharma 0

(4) Additional Compounds for EHMT2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
Furamidine dihydrochloride
55368-40-6
SGC 707
UNC 2327
1426152-53-5

(5) Tocris Compounds for EHMT2 Gene

Compound Action Cas Number
C 21 Selective PRMT1 inhibitor 1229236-78-5
Furamidine dihydrochloride Selective PRMT1 inhibitor 55368-40-6
SGC 707 Potent and selective allosteric inhibitor of PRMT3
TC-E 5003 Selective PRMT1 inhibitor 17328-16-4
UNC 2327 Allosteric inhibitor of PRMT3 1426152-53-5

(12) ApexBio Compounds for EHMT2 Gene

Compound Action Cas Number
A 366 G9a/GLP histone lysine methyltransferase inhibitor 1527503-11-2
BIX 01294 G9a and GLP inhibitor 935693-62-2
Entacapone COMT inhibitor 130929-57-6
EPZ004777 DOT1L inhibitor 1338466-77-5
PFI-2 1627676-59-8
SGI-1027 DNMT inhibitor 1020149-73-8
UNC 0224 G9a histone methyltransferase inhibitor 1197196-48-7
UNC 0631 G9a inhibitor 1320288-19-4
UNC 0642 G9a and GLP histone lysine methyltransferase inhibitor 1481677-78-4
UNC 0646 G9a and GLP inhibitor 1320288-17-2
UNC0321 G9a inhibitor 1238673-32-9
UNC0638 G9a/GLP HMTase inhibitor, potent and selective 1255580-76-7
genes like me logo Genes that share compounds with EHMT2: view

Transcripts for EHMT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for EHMT2 Gene

(5) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(332) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for EHMT2

Alternative Splicing Database (ASD) splice patterns (SP) for EHMT2 Gene

No ASD Table

Relevant External Links for EHMT2 Gene

GeneLoc Exon Structure for
EHMT2
ECgene alternative splicing isoforms for
EHMT2

Expression for EHMT2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EHMT2 Gene

mRNA expression in normal human tissues for EHMT2 Gene
mRNA expression by GTEx for EHMT2 GenemRNA expression by BioGPS for EHMT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EHMT2 Gene

This gene is overexpressed in CD8 Tcells (17.9), Bone (11.1), Fetal ovary (8.1), Blymphocyte (6.7), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EHMT2 Gene



Protein tissue co-expression partners for EHMT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EHMT2 Gene:

EHMT2

SOURCE GeneReport for Unigene cluster for EHMT2 Gene:

Hs.709218

mRNA Expression by UniProt/SwissProt for EHMT2 Gene:

Q96KQ7-EHMT2_HUMAN
Tissue specificity: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.

Evidence on tissue expression from TISSUES for EHMT2 Gene

  • Muscle(4.4)
  • Liver(4.3)
  • Nervous system(4.2)
  • Lung(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with EHMT2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EHMT2 Gene

Orthologs for EHMT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EHMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia EHMT2 33 32
  • 99.36 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia EHMT2 33
  • 92 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia BAT8 33
  • 92 (a)
 OneToOne
EHMT2 32
  • 91.98 (n)
dog
(Canis familiaris)
 Mammalia EHMT2 33 32
  • 90.85 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ehmt2 17 33 32
  • 88.03 (n)
rat
(Rattus norvegicus)
 Mammalia Ehmt2 32
  • 87.78 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia EHMT2 33
  • 68 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia EHMT2 33
  • 70 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ehmt2 32
  • 66.19 (n)
Str.3432 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7568 32
zebrafish
(Danio rerio)
 Actinopterygii ehmt2 33 32
  • 63.46 (n)
 OneToOne
bat8 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.7796 32
fruit fly
(Drosophila melanogaster)
 Insecta G9a 33
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.117 33
  • 43 (a)
 OneToMany
Cin.2694 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2694 32
Species where no ortholog for EHMT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EHMT2 Gene

ENSEMBL:
Gene Tree for EHMT2 (if available)
TreeFam:
Gene Tree for EHMT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EHMT2: view image

Paralogs for EHMT2 Gene

Paralogs for EHMT2 Gene

(7) SIMAP similar genes for EHMT2 Gene using alignment to 4 proteins:

  • EHMT2_HUMAN
  • A2ABF8_HUMAN
  • A2ABF9_HUMAN
  • H0Y4K5_HUMAN
genes like me logo Genes that share paralogs with EHMT2: view

Variants for EHMT2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for EHMT2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000109467 -- 31,885,525(-) A/T intron_variant
rs1000164594 -- 31,881,238(-) T/C