Aliases for EGR4 Gene

Aliases for EGR4 Gene

  • Early Growth Response 4 2 3 5
  • Early Growth Response Protein 4 3 4
  • AT133 3 4
  • NGFI-C 3
  • PAT133 3
  • NGFIC 3
  • EGR-4 4

External Ids for EGR4 Gene

Previous GeneCards Identifiers for EGR4 Gene

  • GC02M073527
  • GC02M073728
  • GC02M073493
  • GC02M073494
  • GC02M073430
  • GC02M073253
  • GC02M073518

Summaries for EGR4 Gene

GeneCards Summary for EGR4 Gene

EGR4 (Early Growth Response 4) is a Protein Coding gene. Diseases associated with EGR4 include Schizophrenia 19 and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Downstream signaling in naive CD8+ T cells. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot Summary for EGR4 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).

Gene Wiki entry for EGR4 Gene

Additional gene information for EGR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EGR4 Gene

Genomics for EGR4 Gene

GeneHancer (GH) Regulatory Elements for EGR4 Gene

Promoters and enhancers for EGR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J073294 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 500.7 +0.0 1 1 HNRNPK EP300 NRF1 POLR2A ZBTB26 RCOR1 CTBP1 EZH2 HCFC1 SIN3A EGR4 ALMS1 ALMS1P1 lnc-CCT7-1
GH02J073175 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 1.4 +116.8 116803 2.4 HNRNPK ZNF217 CTCF PHF8 ZFX ZNF639 ZIC2 ZBTB10 ZBTB11 GABPA lnc-RAB11FIP5-3 SMYD5 SFXN5 RAB11FIP5 PRADC1 NOTO SPR EMX1 CCT7 EGR4
GH02J073291 Enhancer 0.8 ENCODE 0.7 +2.4 2393 0.2 SIN3A REST AFF1 ZBTB26 SAP30 TGIF2 ZEB1 HDAC2 ZNF341 ZSCAN9 EGR4 lnc-CCT7-1
GH02J073295 Enhancer 0.5 Ensembl 0.7 -3.7 -3738 0.9 EP300 RFX1 CTCF RFX5 PKNOX1 POLR2A PRDM1 RF00026-555 RNU6-111P ALMS1 SPR EGR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGR4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EGR4

Top Transcription factor binding sites by QIAGEN in the EGR4 gene promoter:
  • CP2
  • GATA-3
  • MyoD
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • STAT1
  • STAT1alpha
  • ZIC2

Genomic Locations for EGR4 Gene

Genomic Locations for EGR4 Gene
chr2:73,290,929-73,293,701
(GRCh38/hg38)
Size:
2,773 bases
Orientation:
Minus strand
chr2:73,518,057-73,520,833
(GRCh37/hg19)
Size:
2,777 bases
Orientation:
Minus strand

Genomic View for EGR4 Gene

Genes around EGR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR4 Gene

Proteins for EGR4 Gene

  • Protein details for EGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05215-EGR4_HUMAN
    Recommended name:
    Early growth response protein 4
    Protein Accession:
    Q05215
    Secondary Accessions:
    • B2RAE3
    • G3V1T5
    • Q2Z1P5

    Protein attributes for EGR4 Gene

    Size:
    589 amino acids
    Molecular mass:
    61623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88903.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG36840.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA42698.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA49214.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for EGR4 Gene

Post-translational modifications for EGR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGR4 Gene

Domains & Families for EGR4 Gene

Gene Families for EGR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR4 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EGR4 Gene

GenScript: Design optimal peptide antigens:
  • EGR4 protein (B7ZKU3_HUMAN)
  • AT133 (EGR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05215

UniProtKB/Swiss-Prot:

EGR4_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR4: view

Function for EGR4 Gene

Molecular function for EGR4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By PHA/PMA or by serum.
GENATLAS Biochemistry:
immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C

Phenotypes From GWAS Catalog for EGR4 Gene

Gene Ontology (GO) - Molecular Function for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 1584812
genes like me logo Genes that share ontologies with EGR4: view
genes like me logo Genes that share phenotypes with EGR4: view

Animal Models for EGR4 Gene

MGI Knock Outs for EGR4:
  • Egr4 Egr4<tm1Jmi>
  • Egr4 Egr4<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Transcription Factor Targets for EGR4 Gene

Selected GeneGlobe predicted Target genes for EGR4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and HOMER Transcription for EGR4 Gene

Localization for EGR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR4 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with EGR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EGR4 Gene

Pathways & Interactions for EGR4 Gene

genes like me logo Genes that share pathways with EGR4: view

Pathways by source for EGR4 Gene

Gene Ontology (GO) - Biological Process for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008284 positive regulation of cell proliferation TAS 1658795
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 12560487
genes like me logo Genes that share ontologies with EGR4: view

No data available for SIGNOR curated interactions for EGR4 Gene

Drugs & Compounds for EGR4 Gene

No Compound Related Data Available

Transcripts for EGR4 Gene

mRNA/cDNA for EGR4 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR4 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for EGR4 Gene

GeneLoc Exon Structure for
EGR4

Expression for EGR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EGR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGR4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.8), Brain - Cerebellum (x7.0), Brain - Putamen (basal ganglia) (x6.3), Brain - Nucleus accumbens (basal ganglia) (x4.8), and Brain - Caudate (basal ganglia) (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EGR4

SOURCE GeneReport for Unigene cluster for EGR4 Gene:

Hs.3052

Evidence on tissue expression from TISSUES for EGR4 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with EGR4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR4 Gene

Orthologs for EGR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR4 31 30
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EGR4 31 30
  • 86.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EGR4 31 30
  • 86.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Egr4 30
  • 85.05 (n)
mouse
(Mus musculus)
Mammalia Egr4 17 31 30
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia EGR4 31
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EGR4 31 30
  • 60.64 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr4 30
  • 52.2 (n)
zebrafish
(Danio rerio)
Actinopterygii EGR4 (1 of 2) 31
  • 34 (a)
OneToMany
EGR4 (2 of 2) 31
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sr 31
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 32
  • 75 (a)
Y55F3AM.7 32
  • 68 (a)
egrh-3 31
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG1 31
  • 10 (a)
ManyToMany
MIG2 31
  • 9 (a)
ManyToMany
MIG3 31
  • 9 (a)
ManyToMany
Species where no ortholog for EGR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR4 Gene

ENSEMBL:
Gene Tree for EGR4 (if available)
TreeFam:
Gene Tree for EGR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EGR4: view image

Paralogs for EGR4 Gene

Paralogs for EGR4 Gene

genes like me logo Genes that share paralogs with EGR4: view

Variants for EGR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EGR4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
719069 Benign: not provided 73,291,997(-) C/T SYNONYMOUS_VARIANT
729556 Likely Benign: not provided 73,292,300(-) C/A SYNONYMOUS_VARIANT
750726 Likely Benign: not provided 73,292,049(-) G/A MISSENSE_VARIANT
753990 Likely Benign: not provided 73,291,658(-) G/A SYNONYMOUS_VARIANT
783333 Benign: not provided 73,291,607(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for EGR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for EGR4 Gene

Variant ID Type Subtype PubMed ID
nsv1013190 CNV loss 25217958

Variation tolerance for EGR4 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR4 Gene

Disorders for EGR4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EGR4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search EGR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EGR4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EGR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR4 Gene

Publications for EGR4 Gene

  1. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu BC … He G (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 41 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PMID: 8504297) Holst C … Zipfel PF (Human molecular genetics 1993) 3 4 54
  4. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PMID: 1584812) Crosby SD … Milbrandt J (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 54
  5. Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PMID: 1658795) Müller HJ … Zipfel PF (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 54

Products for EGR4 Gene

Sources for EGR4 Gene