This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes in... See more...

Aliases for EGR3 Gene

Aliases for EGR3 Gene

  • Early Growth Response 3 2 3 5
  • Zinc Finger Protein Pilot 2 3 4
  • PILOT 2 3 4
  • Early Growth Response Protein 3 3 4
  • EGR-3 3 4
  • EGR3 5

External Ids for EGR3 Gene

Previous GeneCards Identifiers for EGR3 Gene

  • GC08P022058
  • GC08M022898
  • GC08M022365
  • GC08M022567
  • GC08M022601
  • GC08M022545
  • GC08M021088

Summaries for EGR3 Gene

Entrez Gene Summary for EGR3 Gene

  • This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for EGR3 Gene

EGR3 (Early Growth Response 3) is a Protein Coding gene. Diseases associated with EGR3 include Patella, Chondromalacia Of and Bipolar I Disorder. Among its related pathways are Neuroscience and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot Summary for EGR3 Gene

  • Probable transcription factor involved in muscle spindle development.

Gene Wiki entry for EGR3 Gene

Additional gene information for EGR3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EGR3 Gene

Genomics for EGR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EGR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EGR3

Top Transcription factor binding sites by QIAGEN in the EGR3 gene promoter:
  • AREB6
  • c-Ets-1
  • HSF2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • PPAR-alpha

Genomic Locations for EGR3 Gene

Genomic Locations for EGR3 Gene
chr8:22,687,659-22,693,480
(GRCh38/hg38)
Size:
5,822 bases
Orientation:
Minus strand
chr8:22,545,172-22,550,815
(GRCh37/hg19)
Size:
5,644 bases
Orientation:
Minus strand

Genomic View for EGR3 Gene

Genes around EGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR3 Gene

Proteins for EGR3 Gene

  • Protein details for EGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06889-EGR3_HUMAN
    Recommended name:
    Early growth response protein 3
    Protein Accession:
    Q06889
    Secondary Accessions:
    • A8K8U9
    • B4DHJ5
    • E7EW38
    • Q2M3W2

    Protein attributes for EGR3 Gene

    Size:
    387 amino acids
    Molecular mass:
    42613 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EGR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGR3 Gene

Post-translational modifications for EGR3 Gene

  • Glycosylation at Asn80
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for EGR3 Gene

No data available for DME Specific Peptides for EGR3 Gene

Domains & Families for EGR3 Gene

Gene Families for EGR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR3 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for EGR3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54287, highly similar to Early growth response protein 3 (B4DIY6_HUMAN)
  • Zinc finger protein pilot (EGR3_HUMAN)
  • Transcription factor (Q6LAL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06889

UniProtKB/Swiss-Prot:

EGR3_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR3: view

Function for EGR3 Gene

Molecular function for EGR3 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in muscle spindle development.
GENATLAS Biochemistry:
immediate early growth response,gene 3,homologous to EGR1,EGR2

Phenotypes From GWAS Catalog for EGR3 Gene

Gene Ontology (GO) - Molecular Function for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with EGR3: view
genes like me logo Genes that share phenotypes with EGR3: view

Animal Models for EGR3 Gene

MGI Knock Outs for EGR3:

Animal Model Products

CRISPR Products

Transcription Factor Targets for EGR3 Gene

Selected GeneGlobe predicted Target genes for EGR3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for EGR3 Gene

Localization for EGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with EGR3: view

Pathways & Interactions for EGR3 Gene

genes like me logo Genes that share pathways with EGR3: view

Pathways by source for EGR3 Gene

1 Cell Signaling Technology pathway for EGR3 Gene

SIGNOR curated interactions for EGR3 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 18059339
GO:0002042 cell migration involved in sprouting angiogenesis IDA 18059339
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0007274 neuromuscular synaptic transmission IEA --
GO:0007422 peripheral nervous system development IEA --
genes like me logo Genes that share ontologies with EGR3: view

Drugs & Compounds for EGR3 Gene

(4) Drugs for EGR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EGR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR3: view

Transcripts for EGR3 Gene

mRNA/cDNA for EGR3 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR3

Alternative Splicing Database (ASD) splice patterns (SP) for EGR3 Gene

No ASD Table

Relevant External Links for EGR3 Gene

GeneLoc Exon Structure for
EGR3

Expression for EGR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EGR3 Gene

mRNA differential expression in normal tissues according to GTEx for EGR3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EGR3

SOURCE GeneReport for Unigene cluster for EGR3 Gene:

Hs.534313

Evidence on tissue expression from TISSUES for EGR3 Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Skin(2.6)
  • Muscle(2.5)
  • Adrenal gland(2.3)
  • Lymph node(2.2)
  • Liver(2.2)
  • Intestine(2.2)
  • Kidney(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with EGR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR3 Gene

Orthologs for EGR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EGR3 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EGR3 30 31
  • 96.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EGR3 30 31
  • 95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Egr3 30 17 31
  • 94.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Egr3 30
  • 93.97 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia EGR3 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EGR3 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia egr3 30
  • 68.01 (n)
Zebrafish
(Danio rerio)
Actinopterygii egr3 30 31
  • 68.74 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta sr 31 32
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C27C12.2 32
  • 80 (a)
Y55F3AM.7 32
  • 72 (a)
ZC328.2 31
  • 18 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 31
  • 12 (a)
ManyToMany
MIG3 31
  • 11 (a)
ManyToMany
RIM101 33
Species where no ortholog for EGR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EGR3 Gene

ENSEMBL:
Gene Tree for EGR3 (if available)
TreeFam:
Gene Tree for EGR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EGR3: view image

Paralogs for EGR3 Gene

Paralogs for EGR3 Gene

(3) SIMAP similar genes for EGR3 Gene using alignment to 2 proteins:

  • EGR3_HUMAN
  • E5RIM5_HUMAN
genes like me logo Genes that share paralogs with EGR3: view

Variants for EGR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EGR3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
720390 Benign: not provided 22,690,623(-) G/A SYNONYMOUS_VARIANT
722384 Benign: not provided 22,690,557(-) C/T SYNONYMOUS_VARIANT
742997 Likely Benign: not provided 22,690,509(-) G/A SYNONYMOUS_VARIANT
744221 Likely Benign: not provided 22,691,271(-) C/A SYNONYMOUS_VARIANT
749609 Likely Benign: not provided 22,690,515(-) C/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for EGR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for EGR3 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1112959 CNV deletion 24896259
nsv6117 CNV insertion 18451855
nsv8322 CNV gain 18304495

Variation tolerance for EGR3 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR3 Gene

Human Gene Mutation Database (HGMD)
EGR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR3 Gene

Disorders for EGR3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EGR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
patella, chondromalacia of
  • chondromalacia patellae
bipolar i disorder
ancylostomiasis
  • ancylostoma duodenale infection
neuropathy, congenital hypomyelinating, 1, autosomal recessive
  • chn1
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search EGR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EGR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with EGR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR3 Gene

Publications for EGR3 Gene

  1. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. (PMID: 1906159) Patwardhan S … Sukhatme VP (Oncogene 1991) 2 3 4 23
  2. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C … Kumagai S (Psychiatry research 2011) 3 41
  3. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J … Minami T (Blood 2010) 3 23
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  5. EGR3 as a potential susceptibility gene for schizophrenia in Korea. (PMID: 20687139) Kim SH … Kim YS (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41

Products for EGR3 Gene

  • Signalway Proteins for EGR3

Sources for EGR3 Gene