Aliases for EGR3 Gene
Aliases for EGR3 Gene
External Ids for EGR3 Gene
- HGNC: 3240
- Entrez Gene: 1960
- Ensembl: ENSG00000179388
- OMIM: 602419
- UniProtKB: Q06889
Previous GeneCards Identifiers for EGR3 Gene
- GC08P022058
- GC08M022898
- GC08M022365
- GC08M022567
- GC08M022601
- GC08M022545
- GC08M021088
Summaries for EGR3 Gene
-
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
GeneCards Summary for EGR3 Gene
EGR3 (Early Growth Response 3) is a Protein Coding gene. Diseases associated with EGR3 include Patella, Chondromalacia Of and Ancylostomiasis. Among its related pathways are Kaposi's sarcoma-associated herpesvirus infection and C-type lectin receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is EGR2.
UniProtKB/Swiss-Prot for EGR3 Gene
-
Probable transcription factor involved in muscle spindle development.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR3 Gene
Genomics for EGR3 Gene
GeneHancer (GH) Regulatory Elements for EGR3 Gene
Promoters and enhancers for EGR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EGR3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EGR3 gene promoter:
-
- AREB6
- PPAR-alpha
- Nkx3-1
- c-Ets-1
- HSF2
- Nkx3-1 v1
- Nkx3-1 v2
Regulatory Element Products
Genomic Locations for EGR3 Gene
Genomic Locations for EGR3 Gene
- chr8:22,687,659-22,693,302
- (GRCh38/hg38)
- Size:
- 5,644 bases
- Orientation:
- Minus strand
- chr8:22,545,172-22,550,815
- (GRCh37/hg19)
- Size:
- 5,644 bases
- Orientation:
- Minus strand
Genomic View for EGR3 Gene
Genes around EGR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
- 8p21.3 by Ensembl
EGR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EGR3 Gene
Proteins for EGR3 Gene
-
Protein details for EGR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06889-EGR3_HUMAN
- Recommended name:
- Early growth response protein 3
- Protein Accession:
- Q06889
- A8K8U9
- B4DHJ5
- E7EW38
- Q2M3W2
Protein attributes for EGR3 Gene
- Size:
- 387 amino acids
- Molecular mass:
- 42613 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for EGR3 Gene
Other Protein References for EGR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EGR3
-
Abcam antibodies for EGR3
- Invitrogen Antibodies for EGR3
- GeneTex EGR3 Antibody for EGR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for EGR3
Protein Products
-
OriGene Purified Proteins for EGR3
- Search Origene for MassSpec and Protein Over-expression Lysates for EGR3
- Origene Custom Protein Services for EGR3
- antibodies-online: Search results for 6 available EGR3 Proteins ranked by validation data
- Compare Top EGR3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for EGR3
-
Abcam proteins for EGR3
Assay Products
No data available for DME Specific Peptides for EGR3 Gene
Domains & Families for EGR3 Gene
Gene Families for EGR3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for EGR3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EGR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q06889- Family:
-
- Belongs to the EGR C2H2-type zinc-finger protein family.
Function for EGR3 Gene
Molecular function for EGR3 Gene
- UniProtKB/Swiss-Prot Function:
- Probable transcription factor involved in muscle spindle development.
- GENATLAS Biochemistry:
- immediate early growth response,gene 3,homologous to EGR1,EGR2
Phenotypes From GWAS Catalog for EGR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 1906159 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for EGR3 Gene
- MGI mutant phenotypes for EGR3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for EGR3:
Animal Models for EGR3 Gene
- MGI Knock Outs for EGR3:
-
- Egr3 Egr3<tm1Jmi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EGR3
-
CRISPR Products
-
OriGene CRISPR knockouts for EGR3
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- Overview of 99 available EGR3 gene related products
- Applied Biological Materials CRISPR for EGR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR3
- GenScript: Design CRISPR guide RNA sequences for EGR3
miRNA for EGR3 Gene
- miRTarBase miRNAs that target EGR3
-
- hsa-let-7a-5p (MIRT004963)
- hsa-mir-335-5p (MIRT018262)
- hsa-mir-26b-5p (MIRT029689)
- hsa-mir-377-3p (MIRT542149)
- hsa-mir-342-3p (MIRT542150)
- hsa-mir-4789-3p (MIRT542151)
- hsa-mir-603 (MIRT542152)
- hsa-mir-8485 (MIRT542153)
- hsa-mir-3941 (MIRT629106)
- hsa-mir-362-3p (MIRT629107)
- hsa-mir-329-3p (MIRT629108)
- hsa-mir-3672 (MIRT742099)
- hsa-mir-3688-3p (MIRT742220)
- hsa-mir-3978 (MIRT743225)
- hsa-mir-4463 (MIRT744872)
- hsa-mir-503-3p (MIRT749536)
- hsa-mir-6770-5p (MIRT755275)
- hsa-mir-6861-5p (MIRT757874)
- hsa-mir-6864-3p (MIRT757900)
- hsa-mir-873-3p (MIRT760293)
Transcription Factor Targets for EGR3 Gene
miRNA Products
Inhibitory RNA Products
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- Overview of 99 available EGR3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EGR3
- VectorBuilder custom plasmid, inducible vectors for EGR3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR3
- Applied Biological Materials Clones for EGR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EGR3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for EGR3 Gene
Localization for EGR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EGR3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| extracellular | 1 |
- Nucleus (1)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for EGR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | C-type lectin receptor signaling pathway | ||
| 2 | Kaposi's sarcoma-associated herpesvirus infection |
.33
|
|
| 3 | Viral carcinogenesis | ||
| 4 | Neuroscience | ||
| 5 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||
Pathways by source for EGR3 Gene
2 BioSystems pathways for EGR3 Gene
3 KEGG pathways for EGR3 Gene
1 Cell Signaling Technology pathway for EGR3 Gene
Interacting Proteins for EGR3 Gene
GPS-Prot Interaction Network for EGR3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 18059339 |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IDA | 18059339 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for EGR3 Gene
Transcripts for EGR3 Gene
mRNA/cDNA for EGR3 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000317216 4336 bps (uc003xcm.2)
- ENST00000522910 1553 bps (uc011kzn.2)
- ENST00000519492 1500 bps (uc064lcl.1)
- ENST00000524088 1230 bps (uc064lcm.1)
- ENST00000518773 505 bps (uc064lcn.1)
Unigene Clusters for EGR3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EGR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EGR3
- genomics-online: gRNA clones - Search results for 99 available EGR3 gene related products
- Overview of 99 available EGR3 gene related products
- Applied Biological Materials CRISPR for EGR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR3
- GenScript: Design CRISPR guide RNA sequences for EGR3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for EGR3
- Browse OriGene Inhibitory RNA Products For EGR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR3
- genomics-online: shRNA clones - Search results for 99 available EGR3 gene related products
- Overview of 99 available EGR3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EGR3
- VectorBuilder custom plasmid, inducible vectors for EGR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EGR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR3
- Applied Biological Materials Clones for EGR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for EGR3 Gene
mRNA differential expression in normal tissues according to GTEx for EGR3 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.0).
NURSA nuclear receptor signaling pathways regulating expression of EGR3 Gene:
EGR3SOURCE GeneReport for Unigene cluster for EGR3 Gene:
Hs.534313Evidence on tissue expression from TISSUES for EGR3 Gene
- Nervous system(4.8)
- Blood(4.3)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for EGR3
-
OriGene qPCR primer pairs for EGR3
- genomics-online: primer clones - Search results for 99 available EGR3 gene related products
- Overview of 99 available EGR3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR3 Gene
Orthologs for EGR3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EGR3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EGR3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EGR3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Egr3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Egr3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EGR3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | EGR3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | egr3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | egr3 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | sr 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C27C12.2 35 |
|
|
|
| Y55F3AM.7 35 |
|
|
|||
| ZC328.2 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MIG2 34 |
|
ManyToMany | |
| MIG3 34 |
|
ManyToMany | |||
| RIM101 36 |
|
|
- Species where no ortholog for EGR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EGR3 Gene
- ENSEMBL:
- Gene Tree for EGR3 (if available)
- TreeFam:
- Gene Tree for EGR3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EGR3: view image
Paralogs for EGR3 Gene
Variants for EGR3 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1085307474 | uncertain-significance, not specified | 22,691,435(-) | G/C | coding_sequence_variant, missense_variant | |
| rs1000336113 | -- | 22,690,439(-) | G/A | 3_prime_UTR_variant | |
| rs1000451981 | -- | 22,690,289(-) | C/T | 3_prime_UTR_variant | |
| rs1000672938 | -- | 22,692,112(-) | G/C | 5_prime_UTR_variant, intron_variant | |
| rs1000787092 | -- | 22,691,910(-) | C/T | coding_sequence_variant, intron_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759604 | CNV | loss | 17122850 |
| nsv1112959 | CNV | deletion | 24896259 |
| nsv6117 | CNV | insertion | 18451855 |
| nsv8322 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.38;
8.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EGR3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR3 Gene
Disorders for EGR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| patella, chondromalacia of |
|
|
| ancylostomiasis |
|
|
| bipolar i disorder |
|
|
| plexopathy |
|
|
Search EGR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EGR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EGR3 Gene
Publications for EGR3 Gene
- EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. (PMID: 1906159) Patwardhan S … Sukhatme VP (Oncogene 1991) 2 3 4 22 58
- Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C … Kumagai S (Psychiatry research 2011) 3 44 58
- Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J … Minami T (Blood 2010) 3 22 58
- No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu BC … He G (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 44 58
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
Products for EGR3 Gene
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- VectorBuilder custom plasmid, inducible vectors for EGR3
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 56 available EGR3 Antibodies ranked by validation data
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Sources for EGR3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
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