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Aliases for EGR3 Gene

Aliases for EGR3 Gene

  • Early Growth Response 3 2 3 5
  • Zinc Finger Protein Pilot 2 3 4
  • EGR-3 3 4
  • PILOT 3 4
  • Early Growth Response Protein 3 3

External Ids for EGR3 Gene

Previous GeneCards Identifiers for EGR3 Gene

  • GC08P022058
  • GC08M022898
  • GC08M022365
  • GC08M022567
  • GC08M022601
  • GC08M022545
  • GC08M021088

Summaries for EGR3 Gene

Entrez Gene Summary for EGR3 Gene

  • This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for EGR3 Gene

EGR3 (Early Growth Response 3) is a Protein Coding gene. Diseases associated with EGR3 include Patella, Chondromalacia Of and Ancylostomiasis. Among its related pathways are Kaposi's sarcoma-associated herpesvirus infection and C-type lectin receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot for EGR3 Gene

  • Probable transcription factor involved in muscle spindle development.

Gene Wiki entry for EGR3 Gene

Additional gene information for EGR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR3 Gene

Genomics for EGR3 Gene

GeneHancer (GH) Regulatory Elements for EGR3 Gene

Promoters and enhancers for EGR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652 -1.3 -1281 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 E2F8 EGR3 LOC105379322 LOC105379321 ENSG00000253200 FAM160B2 ENSG00000245025 BMP1 C8orf58 LOXL2 CCAR2
GH08J022691 Enhancer 0.6 ENCODE 650.7 +1.7 1669 0.1 SUZ12 ZSCAN4 CHD1 SIN3A DPF2 E2F1 POLR2A SCRT2 CTBP2 MLLT1 ENSG00000253125 EGR3
GH08J022998 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 -308.4 -308362 5.9 HDGF ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 RUNX3 SP3 YY2 RHOBTB2 PEBP4 EGR3 ENSG00000251034 PIR37908 ENSG00000245025
GH08J023550 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -859.8 -859750 5.7 FOXA2 ATF1 BRCA1 RAD21 RARA RFX5 YY1 EGR1 SCRT2 RCOR1 GC08M023551 ENTPD4 ENSG00000253200 SLC25A37 CCAR2 C8orf58 ENSG00000245025 ENSG00000253390 EGR3 TNFRSF10B
GH08J023557 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5 -866.8 -866790 4.8 CLOCK FOXA2 ZNF48 YY1 FOS RXRA PPARG KAT8 NFIL3 MIER3 SLC25A37 ENTPD4 ENSG00000253390 NKX3-1 RNU4-71P ENSG00000253200 EGR3 TNFRSF10C TNFRSF10B GC08M023551
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EGR3 gene promoter:
  • AREB6
  • PPAR-alpha
  • Nkx3-1
  • c-Ets-1
  • HSF2
  • Nkx3-1 v1
  • Nkx3-1 v2

Genomic Locations for EGR3 Gene

Genomic Locations for EGR3 Gene
chr8:22,687,659-22,693,302
(GRCh38/hg38)
Size:
5,644 bases
Orientation:
Minus strand
chr8:22,545,172-22,550,815
(GRCh37/hg19)
Size:
5,644 bases
Orientation:
Minus strand

Genomic View for EGR3 Gene

Genes around EGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR3 Gene

Proteins for EGR3 Gene

  • Protein details for EGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06889-EGR3_HUMAN
    Recommended name:
    Early growth response protein 3
    Protein Accession:
    Q06889
    Secondary Accessions:
    • A8K8U9
    • B4DHJ5
    • E7EW38
    • Q2M3W2

    Protein attributes for EGR3 Gene

    Size:
    387 amino acids
    Molecular mass:
    42613 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EGR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGR3 Gene

Post-translational modifications for EGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR3 Gene

No data available for DME Specific Peptides for EGR3 Gene

Domains & Families for EGR3 Gene

Gene Families for EGR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q06889

UniProtKB/Swiss-Prot:

EGR3_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR3: view

Function for EGR3 Gene

Molecular function for EGR3 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in muscle spindle development.
GENATLAS Biochemistry:
immediate early growth response,gene 3,homologous to EGR1,EGR2

Phenotypes From GWAS Catalog for EGR3 Gene

Gene Ontology (GO) - Molecular Function for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 1906159
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EGR3: view
genes like me logo Genes that share phenotypes with EGR3: view

Animal Models for EGR3 Gene

MGI Knock Outs for EGR3:

Animal Model Products

Transcription Factor Targets for EGR3 Gene

Selected GeneGlobe predicted Target genes for EGR3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for EGR3 Gene

Localization for EGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EGR3: view

Pathways & Interactions for EGR3 Gene

genes like me logo Genes that share pathways with EGR3: view

Pathways by source for EGR3 Gene

1 Cell Signaling Technology pathway for EGR3 Gene

Gene Ontology (GO) - Biological Process for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 18059339
GO:0002042 cell migration involved in sprouting angiogenesis IDA 18059339
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with EGR3: view

No data available for SIGNOR curated interactions for EGR3 Gene

Drugs & Compounds for EGR3 Gene

(4) Drugs for EGR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EGR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR3: view

Transcripts for EGR3 Gene

Unigene Clusters for EGR3 Gene

Early growth response 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR3 Gene

No ASD Table

Relevant External Links for EGR3 Gene

GeneLoc Exon Structure for
EGR3
ECgene alternative splicing isoforms for
EGR3

Expression for EGR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGR3 Gene

mRNA differential expression in normal tissues according to GTEx for EGR3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of EGR3 Gene:

EGR3

SOURCE GeneReport for Unigene cluster for EGR3 Gene:

Hs.534313

Evidence on tissue expression from TISSUES for EGR3 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with EGR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR3 Gene

Orthologs for EGR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR3 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EGR3 34 33
  • 96.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EGR3 34 33
  • 95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Egr3 16 34 33
  • 94.32 (n)
rat
(Rattus norvegicus)
Mammalia Egr3 33
  • 93.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EGR3 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EGR3 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr3 33
  • 68.01 (n)
zebrafish
(Danio rerio)
Actinopterygii egr3 34 33
  • 68.74 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sr 34 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 35
  • 80 (a)
Y55F3AM.7 35
  • 72 (a)
ZC328.2 34
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 34
  • 12 (a)
ManyToMany
MIG3 34
  • 11 (a)
ManyToMany
RIM101 36
Species where no ortholog for EGR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR3 Gene

ENSEMBL:
Gene Tree for EGR3 (if available)
TreeFam:
Gene Tree for EGR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EGR3: view image

Paralogs for EGR3 Gene

Paralogs for EGR3 Gene

(3) SIMAP similar genes for EGR3 Gene using alignment to 2 proteins:

  • EGR3_HUMAN
  • E5RIM5_HUMAN
genes like me logo Genes that share paralogs with EGR3: view

Variants for EGR3 Gene

Sequence variations from dbSNP and Humsavar for EGR3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1085307474 uncertain-significance, not specified 22,691,435(-) G/C coding_sequence_variant, missense_variant
rs1000336113 -- 22,690,439(-) G/A 3_prime_UTR_variant
rs1000451981 -- 22,690,289(-) C/T 3_prime_UTR_variant
rs1000672938 -- 22,692,112(-) G/C 5_prime_UTR_variant, intron_variant
rs1000787092 -- 22,691,910(-) C/T coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for EGR3 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1112959 CNV deletion 24896259
nsv6117 CNV insertion 18451855
nsv8322 CNV gain 18304495

Variation tolerance for EGR3 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR3 Gene

Human Gene Mutation Database (HGMD)
EGR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR3 Gene

Disorders for EGR3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EGR3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
patella, chondromalacia of
  • chondromalacia patellae
ancylostomiasis
  • ancylostoma duodenale infection
bipolar i disorder
plexopathy
- elite association - COSMIC cancer census association via MalaCards
Search EGR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EGR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EGR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR3 Gene

Publications for EGR3 Gene

  1. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. (PMID: 1906159) Patwardhan S … Sukhatme VP (Oncogene 1991) 2 3 4 22 58
  2. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C … Kumagai S (Psychiatry research 2011) 3 44 58
  3. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J … Minami T (Blood 2010) 3 22 58
  4. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu BC … He G (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 44 58
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58

Products for EGR3 Gene

Sources for EGR3 Gene

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