Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Ischemia and Embryonal Carcinoma. Among its related pathways are Neuroscience and Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is EGR2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18718911 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IDA | 14979875 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISA | -- |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IDA | 19307576 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA,ISA | -- |
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Apoptosis and survival Role of CDK5 in neuronal death and survival
.37
|
|
2 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
Immune response Oncostatin M signaling via MAPK in human cells
.39
|
|
4 | Neuroscience | ||
5 | NF-kappaB Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0001666 | response to hypoxia | IEA,ISS | -- |
GO:0002931 | response to ischemia | IEA,ISS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EGR1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | EGR1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EGR1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Egr1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Egr1 30 |
|
||
Chicken (Gallus gallus) |
Aves | EGR1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | egr1 30 |
|
||
Str.19374 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.637 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | egr1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9236 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sr 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | C27C12.2 32 |
|
|
|
Y55F3AM.7 32 |
|
|
|||
egrh-3 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MIG3 31 |
|
ManyToMany | |
MIG2 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
768032 | Benign: not provided | 138,466,962(+) | G/C | SYNONYMOUS_VARIANT | |
773935 | Benign: not provided | 138,467,466(+) | T/G | SYNONYMOUS_VARIANT | |
780115 | Likely Benign: not provided | 138,465,943(+) | ACAG/A | INFRAME_DELETION | |
rs13181973 | - | p.Thr28Ile | |||
rs28365164 | - | p.Ser145Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10088n54 | CNV | loss | 21841781 |
dgv5813n100 | CNV | loss | 25217958 |
dgv5814n100 | CNV | loss | 25217958 |
nsv1034030 | CNV | loss | 25217958 |
nsv5024 | CNV | insertion | 18451855 |
nsv5025 | CNV | deletion | 18451855 |
nsv528851 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ischemia |
|
|
embryonal carcinoma |
|
|
fibrosarcoma |
|
|
monocytic leukemia |
|
|
fraser syndrome 2 |
|
|