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The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] See more...
Aliases for EGR1 Gene
Aliases for EGR1 Gene
External Ids for EGR1 Gene
- HGNC: 3238
- Entrez Gene: 1958
- Ensembl: ENSG00000120738
- OMIM: 128990
- UniProtKB: P18146
Previous GeneCards Identifiers for EGR1 Gene
- GC05P137675
- GC05P138476
- GC05P137832
- GC05P137877
- GC05P137829
- GC05P137801
- GC05P132991
Summaries for EGR1 Gene
-
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for EGR1 Gene
EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Ischemia and Embryonal Carcinoma. Among its related pathways are Neuroscience and Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is EGR2.
UniProtKB/Swiss-Prot Summary for EGR1 Gene
-
Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
Additional gene information for EGR1 Gene
- HGNC(3238)
- Entrez Gene(1958)
- Ensembl(ENSG00000120738)
- OMIM(128990)
- UniProtKB(P18146)
- Open Targets Platform(ENSG00000120738)
- Monarch Initiative
- Search for EGR1 at DataMed
- Search for EGR1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EGR1 Gene
Genomics for EGR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EGR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EGR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EGR1
- Top Transcription factor binding sites by QIAGEN in the EGR1 gene promoter:
-
- c-Ets-1
- CREB
- deltaCREB
- GR
- GR-alpha
- GR-beta
Genomic Locations for EGR1 Gene
Genomic Locations for EGR1 Gene
- chr5:138,465,479-138,469,303
- (GRCh38/hg38)
- Size:
- 3,825 bases
- Orientation:
- Plus strand
- chr5:137,801,179-137,805,004
- (GRCh37/hg19)
- Size:
- 3,826 bases
- Orientation:
- Plus strand
Genomic View for EGR1 Gene
Genes around EGR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.2 by HGNC
- 5q31.2 by Entrez Gene
- 5q31.2 by Ensembl
EGR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EGR1 Gene
Proteins for EGR1 Gene
-
Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18146-EGR1_HUMAN
- Recommended name:
- Early growth response protein 1
- Protein Accession:
- P18146
Protein attributes for EGR1 Gene
- Size:
- 543 amino acids
- Molecular mass:
- 57507 Da
- Quaternary structure:
-
- Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.
Post-translational modifications for EGR1 Gene
Other Protein References for EGR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZIF268 / EGR1 Antibody
- NSJ Bioreagents EGR1 Antibody
- Creative Diagnostics Anti-EGR1 monoclonal antibody, clone 7F9
-
Custom Antibody ServicesOriGene Antibodies for EGR1
- Novus Biologicals Antibodies for EGR1
-
Abcam antibodies for EGR1
- Invitrogen Antibodies for EGR1 (AFLGC-EGR1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for EGR1
- Sino Biological Antibodies for EGR1
Protein Products
- G Biosciences Human Zinc finger protein 225/EGR1/ZNF225, Lyophilized
-
OriGene Purified Proteins for EGR1
- Search Origene for MassSpec and Protein Over-expression Lysates for EGR1
- Origene Custom Protein Services for EGR1
-
ProSci Proteins for EGR1
-
Abcam proteins for EGR1
Assay Products
- RayBiotech Human EGR1 ELISA
- antibodies-online: Show 60 available EGR1 Elisa Kits ranked by validation data
- Compare Top EGR1 Elisa Kits
-
Quality Products:
- ABIN6730895
- ABIN1114686
- ABIN414979
- ABIN856951
- ABIN1028565
- ABIN5520470
- ABIN5668532
- ABIN5592013
- ABIN626414
- ABIN6384491
- ABIN415740
- ABIN1569552
- ABIN1114688
- ABIN5520471
- ABIN5669779
- ABIN627784
- ABIN5653773
- ABIN2543995
- ABIN4968802
- ABIN2947149
- ABIN1114687
- ABIN5520472
- ABIN5670448
- ABIN510093
- ABIN2947150
- ABIN6204022
- ABIN5072618
- ABIN1131420
- ABIN5592012
- ABIN991146
- ABIN1131417
-
Boster Bio ELISA Kits for EGR1
-
Signalway ELISA kits for EGR1
No data available for DME Specific Peptides for EGR1 Gene
Domains & Families for EGR1 Gene
Gene Families for EGR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for EGR1 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for EGR1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ56577, highly similar to Early growth response protein 1 (B4DNX4_HUMAN)
- Zinc finger protein Krox-24 (EGR1_HUMAN)
- Early growth response protein 1 (Q546S1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18146UniProtKB/Swiss-Prot:
EGR1_HUMAN :- Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
- Belongs to the EGR C2H2-type zinc-finger protein family.
- Domain:
-
- Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
- Family:
-
- Belongs to the EGR C2H2-type zinc-finger protein family.
Function for EGR1 Gene
Molecular function for EGR1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By growth factors.
- GENATLAS Biochemistry:
- immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
Phenotypes From GWAS Catalog for EGR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18718911 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IDA | 14979875 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IDA | 19307576 |
| GO:0003676 | nucleic acid binding | IEA | -- |
Phenotypes for EGR1 Gene
- MGI mutant phenotypes for EGR1:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for EGR1:
Animal Models for EGR1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for EGR1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EGR1 - Select products 50% OFF >
- * EGR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EGR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EGR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR1
miRNA for EGR1 Gene
- miRTarBase miRNAs that target EGR1
-
- mmu-miR-181a-5p (MIRT003908)
- hsa-miR-192-5p (MIRT004130)
- hsa-miR-183-5p (MIRT006540)
- mmu-miR-7578 (MIRT007114)
- mmu-miR-26a-5p (MIRT011124)
- mmu-miR-9-5p (MIRT015239)
- hsa-miR-124-3p (MIRT023192)
- hsa-miR-215-5p (MIRT024271)
- hsa-miR-191-5p (MIRT054161)
- hsa-miR-377-3p (MIRT440744)
- hsa-miR-487a-3p (MIRT440745)
- hsa-miR-181a-5p (MIRT734446)
- mmu-miR-146a-5p (MIRT735213)
Transcription Factor Targets for EGR1 Gene
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
- Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EGR1
- Browse OriGene Inhibitory RNA Products For EGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1
Clone Products
- Applied Biological Materials (abm): Clones for EGR1 - Select products 50% OFF >
- * EGR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EGR1
- Addgene plasmids for EGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR1
Cell Line Products
-
Horizon Cell Lines for EGR1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for EGR1 Gene
Localization for EGR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA,ISA | -- |
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for EGR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Apoptosis and survival Role of CDK5 in neuronal death and survival
.37
|
|
| 2 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
| 3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
Immune response Oncostatin M signaling via MAPK in human cells
.39
|
|
| 4 | Neuroscience | ||
| 5 | NF-kappaB Signaling | ||
Pathways by source for EGR1 Gene
1 Sino Biological pathway for EGR1 Gene
20 BioSystems pathways for EGR1 Gene
4 Reactome pathways for EGR1 Gene
10 GeneGo (Thomson Reuters) pathways for EGR1 Gene
- Apoptosis and survival Role of CDK5 in neuronal death and survival
- Development ACM2 and ACM4 activation of ERK
- Development Growth hormone signaling via PI3K/AKT and MAPK cascades
- Development HGF signaling pathway
- Development_Hedgehog and PTH signaling pathways in bone and cartilage development
1 Qiagen pathway for EGR1 Gene
- CDK5 Pathway
2 Cell Signaling Technology pathways for EGR1 Gene
Interacting Proteins for EGR1 Gene
Selected Interacting proteins:
P18146-EGR1_HUMAN
ENSP00000239938
for EGR1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EGR1
SIGNOR curated interactions for EGR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001666 | response to hypoxia | IEA,ISS | -- |
| GO:0002931 | response to ischemia | IEA,ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
Drugs & Compounds for EGR1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human Zinc finger protein 225/EGR1/ZNF225, Lyophilized
Transcripts for EGR1 Gene
mRNA/cDNA for EGR1 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000239938 3137 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EGR1 - Select products 50% OFF >
- * EGR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EGR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EGR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EGR1
- Browse OriGene Inhibitory RNA Products For EGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1
Clone Products
- Applied Biological Materials (abm): Clones for EGR1 - Select products 50% OFF >
- * EGR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for EGR1
- Addgene plasmids for EGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR1
Relevant External Links for EGR1 Gene
- GeneLoc Exon Structure for
- EGR1
Expression for EGR1 Gene
mRNA differential expression in normal tissues according to GTEx for EGR1 Gene
This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EGR1
SOURCE GeneReport for Unigene cluster for EGR1 Gene:
Hs.326035mRNA Expression by UniProt/SwissProt for EGR1 Gene:
P18146-EGR1_HUMAN
Tissue specificity:
Detected in neutrophils (at protein level).
Evidence on tissue expression from TISSUES for EGR1 Gene
- Nervous system(4.8)
- Lung(4.3)
- Kidney(3.9)
- Muscle(3.9)
- Intestine(3.9)
- Adrenal gland(3.6)
- Heart(3.6)
- Liver(3.5)
- Blood(3.5)
- Thyroid gland(3.4)
- Pancreas(3.3)
- Stomach(3.3)
- Bone marrow(3.2)
- Lymph node(3.1)
- Skin(3.1)
- Spleen(3)
- Gall bladder(2.8)
- Eye(2.7)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for EGR1
-
OriGene qPCR primer pairs and template standards for EGR1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR1 Gene
Orthologs for EGR1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EGR1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | EGR1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EGR1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Egr1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Egr1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | EGR1 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | egr1 30 |
|
||
| Str.19374 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.637 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | egr1 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9236 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | sr 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C27C12.2 32 |
|
|
|
| Y55F3AM.7 32 |
|
|
|||
| egrh-3 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MIG3 31 |
|
ManyToMany | |
| MIG2 31 |
|
ManyToMany |
- Species where no ortholog for EGR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for EGR1 Gene
- ENSEMBL:
- Gene Tree for EGR1 (if available)
- TreeFam:
- Gene Tree for EGR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EGR1: view image
Paralogs for EGR1 Gene
Variants for EGR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EGR1 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 768032 | Benign: not provided | 138,466,962(+) | G/C | SYNONYMOUS_VARIANT | |
| 773935 | Benign: not provided | 138,467,466(+) | T/G | SYNONYMOUS_VARIANT | |
| 780115 | Likely Benign: not provided | 138,465,943(+) | ACAG/A | INFRAME_DELETION | |
| rs13181973 | - | p.Thr28Ile | |||
| rs28365164 | - | p.Ser145Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10088n54 | CNV | loss | 21841781 |
| dgv5813n100 | CNV | loss | 25217958 |
| dgv5814n100 | CNV | loss | 25217958 |
| nsv1034030 | CNV | loss | 25217958 |
| nsv5024 | CNV | insertion | 18451855 |
| nsv5025 | CNV | deletion | 18451855 |
| nsv528851 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EGR1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene
Disorders for EGR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ischemia |
|
|
| embryonal carcinoma |
|
|
| fibrosarcoma |
|
|
| monocytic leukemia |
|
|
| fraser syndrome 2 |
|
|
Search EGR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EGR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene
Publications for EGR1 Gene
- Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu CT … Wu WS (The FEBS journal 2010) 3 4 23
- Mature human neutrophils constitutively express the transcription factor EGR-1. (PMID: 20363028) Cullen EM … O'Connor CM (Molecular immunology 2010) 3 4 23
- A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PMID: 1569051) Shimizu N … Utiyama H (Journal of biochemistry 1992) 3 4 23
- Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. (PMID: 25258363) Hashimoto H … Cheng X (Genes & development 2014) 3 4
- The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. (PMID: 20204305) Parra E … Ferreira J (Oncology reports 2010) 3 23
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