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EGR1 Gene(Protein Coding)

Early Growth Response 1

GCID:
GC05P138465
GIFtS:
53
Genes Participants
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Aliases for EGR1 Gene

Aliases for EGR1 Gene

  • Early Growth Response 1 2 3 5
  • Nerve Growth Factor-Induced Protein A 2 3 4
  • Transcription Factor ETR103 2 3 4
  • Zinc Finger Protein 225 2 3 4
  • Early Growth Response Protein 1 2 3
  • Transcription Factor Zif268 3 4
  • Zinc Finger Protein Krox-24 3 4
  • NGFI-A 3 4
  • ZNF225 3 4
  • AT225 3 4
  • EGR-1 3 4
  • KROX-24 3
  • ZIF-268 3
  • KROX24 4
  • G0S30 3
  • TIS8 3

External Ids for EGR1 Gene

Previous GeneCards Identifiers for EGR1 Gene

  • GC05P137675
  • GC05P138476
  • GC05P137832
  • GC05P137877
  • GC05P137829
  • GC05P137801
  • GC05P132991

Summaries for EGR1 Gene

Entrez Gene Summary for EGR1 Gene

  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for EGR1 Gene

EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Ischemia and Familial Tumoral Calcinosis. Among its related pathways are Signaling events mediated by PRL and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot for EGR1 Gene

  • Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).

Gene Wiki entry for EGR1 Gene

Additional gene information for EGR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR1 Gene

Genomics for EGR1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for EGR1 Gene

Promoters and enhancers for EGR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I138463 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565 -0.2 -241 4.1 CLOCK IRF4 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 ZNF585B GLIS1 EGR1 HNRNPA0 CDC23 KDM3B BRD8 RPL7P19 ETF1 FAM13B FAM53C REEP2
GH05I138490 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +27.0 26984 3.3 FOXA2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 GC05P138492 HNRNPA0 CDC23 KDM3B RPL7P19 HSPA9 EGR1
GH05I137620 Enhancer 0.9 Ensembl ENCODE 5 -843.3 -843260 2.7 GTF2F1 FOXA2 MAX EBF1 CEBPG YY1 FOS SOX5 RXRA CEBPB GC05M137622 PIR48538 SPOCK1 MIR874 KLHL3 NME5 EGR1 GC05M137619
GH05I138486 Enhancer 0.3 FANTOM5 13.4 +21.1 21136 0.1 EGR1 SNORD63 SNORD63B HSPA9 BRD8 KIF20A GC05P138492 RPL7P19
GH05I138458 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -6.0 -6030 2 ELF3 PKNOX1 MLX ARID4B DNMT3B ZSCAN9 RARA SLC30A9 ATF7 CREM GC05M138244 REEP2 SNORD63B SNORD63 HSPA9 LRRTM2 CDC25C FAM53C FAM13B ETF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EGR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EGR1 gene promoter:

Genomic Locations for EGR1 Gene

Genomic Locations for EGR1 Gene
chr5:138,465,490-138,469,315
(GRCh38/hg38)
Size:
3,826 bases
Orientation:
Plus strand
chr5:137,801,179-137,805,004
(GRCh37/hg19)

Genomic View for EGR1 Gene

Genes around EGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EGR1 Gene

Proteins for EGR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18146-EGR1_HUMAN
    Recommended name:
    Early growth response protein 1
    Protein Accession:
    P18146

    Protein attributes for EGR1 Gene

    Size:
    543 amino acids
    Molecular mass:
    57507 Da
    Quaternary structure:
    • Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.

    Three dimensional structures from OCA and Proteopedia for EGR1 Gene

neXtProt entry for EGR1 Gene

Post-translational modifications for EGR1 Gene

No Post-translational modifications

Other Protein References for EGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGR1 Gene

Domains & Families for EGR1 Gene

Gene Families for EGR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EGR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18146

UniProtKB/Swiss-Prot:

EGR1_HUMAN :
  • Binds to DNA motifs with the sequence 5-GCG(T/G)GGGCG-3 via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Domain:
  • Binds to DNA motifs with the sequence 5-GCG(T/G)GGGCG-3 via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR1: view

Function for EGR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for EGR1 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
UniProtKB/Swiss-Prot Induction:
By growth factors.

Phenotypes From GWAS Catalog for EGR1 Gene

Gene Ontology (GO) - Molecular Function for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA,IEA 14979875
GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with EGR1: view
genes like me logo Genes that share phenotypes with EGR1: view

Animal Models for EGR1 Gene

MGI Knock Outs for EGR1:

Animal Model Products

Transcription Factor Targets for EGR1 Gene

Selected GeneGlobe predicted Target genes for EGR1
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
  • Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465

Clone Products

  • Addgene plasmids for EGR1

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for EGR1 Gene

Localization for EGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with EGR1: view

Pathways & Interactions for EGR1 Gene

genes like me logo Genes that share pathways with EGR1: view

SIGNOR curated interactions for EGR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001666 response to hypoxia ISS,IEA --
GO:0002931 response to ischemia ISS,IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EGR1: view

Drugs & Compounds for EGR1 Gene

Products:

  1. Drug

(76) Drugs for EGR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(46) Additional Compounds for EGR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR1: view

Transcripts for EGR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for EGR1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR1 Gene

Early growth response 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for EGR1

Alternative Splicing Database (ASD) splice patterns (SP) for EGR1 Gene

No ASD Table

Relevant External Links for EGR1 Gene

GeneLoc Exon Structure for
EGR1
ECgene alternative splicing isoforms for
EGR1

Expression for EGR1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGR1 Gene

mRNA expression in normal human tissues for EGR1 Gene
mRNA expression by GTEx for EGR1 GenemRNA expression by BioGPS for EGR1 Gene

mRNA differential expression in normal tissues according to GTEx for EGR1 Gene

This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of EGR1 Gene:

EGR1

SOURCE GeneReport for Unigene cluster for EGR1 Gene:

Hs.326035

mRNA Expression by UniProt/SwissProt for EGR1 Gene:

P18146-EGR1_HUMAN
Tissue specificity: Detected in neutrophils (at protein level).

Evidence on tissue expression from TISSUES for EGR1 Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Kidney(3.7)
  • Muscle(3.7)
  • Intestine(3.5)
  • Adrenal gland(3.4)
  • Heart(3.2)
  • Blood(3)
  • Liver(3)
  • Stomach(2.9)
  • Thyroid gland(2.9)
  • Pancreas(2.8)
  • Bone marrow(2.7)
  • Gall bladder(2.3)
  • Eye(2.2)
  • Skin(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with EGR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR1 Gene

Orthologs for EGR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia EGR1 33
  • 98.11 (n)
cow
(Bos Taurus)
 Mammalia EGR1 33 34
  • 89.67 (n)
dog
(Canis familiaris)
 Mammalia EGR1 33 34
  • 89.59 (n)
mouse
(Mus musculus)
 Mammalia Egr1 33 16 34
  • 86.77 (n)
rat
(Rattus norvegicus)
 Mammalia Egr1 33
  • 86.13 (n)
chicken
(Gallus gallus)
 Aves EGR1 33 34
  • 72.74 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia egr1 33
  • 71.51 (n)
Str.19374 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.637 33
zebrafish
(Danio rerio)
 Actinopterygii egr1 33 34
  • 69.1 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9236 33
fruit fly
(Drosophila melanogaster)
 Insecta sr 35 34
  • 76 (a)
worm
(Caenorhabditis elegans)
 Secernentea C27C12.2 35
  • 84 (a)
Y55F3AM.7 35
  • 64 (a)
egrh-3 34
  • 24 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MIG2 34
  • 14 (a)
 ManyToMany
MIG3 34
  • 14 (a)
 ManyToMany
Species where no ortholog for EGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR1 Gene

ENSEMBL:
Gene Tree for EGR1 (if available)
TreeFam:
Gene Tree for EGR1 (if available)

Paralogs for EGR1 Gene

Paralogs for EGR1 Gene

(2) SIMAP similar genes for EGR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR1: view

Variants for EGR1 Gene

Sequence variations from dbSNP and Humsavar for EGR1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000738349 -- 138,464,067(+) C/T upstream_transcript_variant
rs1001030752 -- 138,465,031(+) G/C upstream_transcript_variant
rs1001138967 -- 138,464,225(+) A/G upstream_transcript_variant
rs1001386200 -- 138,464,933(+) G/A upstream_transcript_variant
rs1002341171 -- 138,464,336(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EGR1 Gene

Variant ID Type Subtype PubMed ID
nsv528851 CNV loss 19592680
nsv5025 CNV deletion 18451855
nsv5024 CNV insertion 18451855
nsv1034030 CNV loss 25217958
dgv5814n100 CNV loss 25217958
dgv5813n100 CNV loss 25217958
dgv10088n54 CNV loss 21841781

Variation tolerance for EGR1 Gene

Residual Variation Intolerance Score: 9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR1 Gene

Human Gene Mutation Database (HGMD)
EGR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene

Disorders for EGR1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for EGR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search EGR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EGR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene

Publications for EGR1 Gene

  1. Mature human neutrophils constitutively express the transcription factor EGR-1. (PMID: 20363028) Cullen EM … O'Connor CM (Molecular immunology 2010) 3 4 22 58
  2. A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PMID: 1569051) Shimizu N … Utiyama H (Journal of biochemistry 1992) 3 4 22 58
  3. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. (PMID: 25258363) Hashimoto H … Cheng X (Genes & development 2014) 3 4 58
  4. Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549. (PMID: 19786090) Fang L … Huizhong Z (Cellular signalling 2010) 3 22 58
  5. High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. (PMID: 19833116) Chan IH … Lam CW (Clinica chimica acta; international journal of clinical chemistry 2010) 3 44 58

Products for EGR1 Gene

  • Addgene plasmids for EGR1

Sources for EGR1 Gene

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