EGR1 Gene (Protein Coding)

Early Growth Response 1

GC05P138465
GIFtS:
45
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] See more...

Aliases for EGR1 Gene

Aliases for EGR1 Gene

  • Early Growth Response 1 2 3 5
  • Nerve Growth Factor-Induced Protein A 2 3 4
  • Early Growth Response Protein 1 2 3 4
  • Transcription Factor ETR103 2 3 4
  • Zinc Finger Protein 225 2 3 4
  • Transcription Factor Zif268 3 4
  • Zinc Finger Protein Krox-24 3 4
  • NGFI-A 3 4
  • ZNF225 3 4
  • AT225 3 4
  • EGR-1 3 4
  • KROX-24 3
  • ZIF-268 3
  • KROX24 4
  • G0S30 3
  • TIS8 3

External Ids for EGR1 Gene

Previous GeneCards Identifiers for EGR1 Gene

  • GC05P137675
  • GC05P138476
  • GC05P137832
  • GC05P137877
  • GC05P137829
  • GC05P137801
  • GC05P132991

Summaries for EGR1 Gene

Entrez Gene Summary for EGR1 Gene

  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for EGR1 Gene

EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Ischemia and Familial Tumoral Calcinosis. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot Summary for EGR1 Gene

  • Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).

Gene Wiki entry for EGR1 Gene

Additional gene information for EGR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EGR1 Gene

Genomics for EGR1 Gene

GeneHancer (GH) Regulatory Elements for EGR1 Gene

Promoters and enhancers for EGR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EGR1 gene promoter:
  • c-Ets-1
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for EGR1 Gene

Genomic Locations for EGR1 Gene
chr5:138,465,479-138,469,315
(GRCh38/hg38)
Size:
3,837 bases
Orientation:
Plus strand
chr5:137,801,179-137,805,004
(GRCh37/hg19)
Size:
3,826 bases
Orientation:
Plus strand

Genomic View for EGR1 Gene

Genes around EGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EGR1 Gene

Proteins for EGR1 Gene

Products:

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  • Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18146-EGR1_HUMAN
    Recommended name:
    Early growth response protein 1
    Protein Accession:
    P18146

    Protein attributes for EGR1 Gene

    Size:
    543 amino acids
    Molecular mass:
    57507 Da
    Quaternary structure:
    • Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.

    Three dimensional structures from OCA and Proteopedia for EGR1 Gene

neXtProt entry for EGR1 Gene

Post-translational modifications for EGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for EGR1

No data available for DME Specific Peptides for EGR1 Gene

Domains & Families for EGR1 Gene

Gene Families for EGR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EGR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56577, highly similar to Early growth response protein 1 (B4DNX4_HUMAN)
  • Zinc finger protein Krox-24 (EGR1_HUMAN)
  • Early growth response protein 1 (Q546S1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18146

UniProtKB/Swiss-Prot:

EGR1_HUMAN :
  • Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Domain:
  • Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR1: view

Function for EGR1 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for EGR1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
UniProtKB/Swiss-Prot Induction:
By growth factors.
GENATLAS Biochemistry:
immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP

Phenotypes From GWAS Catalog for EGR1 Gene

Gene Ontology (GO) - Molecular Function for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA,IEA 14979875
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with EGR1: view
genes like me logo Genes that share phenotypes with EGR1: view

Animal Models for EGR1 Gene

MGI Knock Outs for EGR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EGR1

CRISPR Products

Transcription Factor Targets for EGR1 Gene

Selected GeneGlobe predicted Target genes for EGR1
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
  • Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1

Clone Products

  • Addgene plasmids for EGR1

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for EGR1 Gene

Localization for EGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with EGR1: view

Pathways & Interactions for EGR1 Gene

genes like me logo Genes that share pathways with EGR1: view

SIGNOR curated interactions for EGR1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001666 response to hypoxia IEA,ISS --
GO:0002931 response to ischemia IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with EGR1: view

Drugs & Compounds for EGR1 Gene

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  1. Drug

(75) Drugs for EGR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(47) Additional Compounds for EGR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR1: view

Transcripts for EGR1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for EGR1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1

Clone Products

  • Addgene plasmids for EGR1

Alternative Splicing Database (ASD) splice patterns (SP) for EGR1 Gene

No ASD Table

Relevant External Links for EGR1 Gene

GeneLoc Exon Structure for
EGR1
ECgene alternative splicing isoforms for
EGR1

Expression for EGR1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGR1 Gene

mRNA expression in normal human tissues for EGR1 Gene
mRNA expression by GTEx for EGR1 GenemRNA expression by BioGPS for EGR1 Gene

mRNA differential expression in normal tissues according to GTEx for EGR1 Gene

This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of EGR1 Gene:

EGR1

SOURCE GeneReport for Unigene cluster for EGR1 Gene:

Hs.326035

mRNA Expression by UniProt/SwissProt for EGR1 Gene:

P18146-EGR1_HUMAN
Tissue specificity: Detected in neutrophils (at protein level).

Evidence on tissue expression from TISSUES for EGR1 Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Kidney(3.7)
  • Muscle(3.7)
  • Intestine(3.5)
  • Adrenal gland(3.4)
  • Heart(3.2)
  • Blood(3)
  • Liver(3)
  • Stomach(2.9)
  • Thyroid gland(2.9)
  • Pancreas(2.8)
  • Bone marrow(2.7)
  • Gall bladder(2.3)
  • Eye(2.2)
  • Skin(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with EGR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR1 Gene

Orthologs for EGR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia EGR1 32
  • 98.11 (n)
cow
(Bos Taurus)
 Mammalia EGR1 33 32
  • 89.67 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia EGR1 33 32
  • 89.59 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Egr1 17 33 32
  • 86.77 (n)
rat
(Rattus norvegicus)
 Mammalia Egr1 32
  • 86.13 (n)
chicken
(Gallus gallus)
 Aves EGR1 33 32
  • 72.74 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia egr1 32
  • 71.51 (n)
Str.19374 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.637 32
zebrafish
(Danio rerio)
 Actinopterygii egr1 33 32 32
  • 69.1 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9236 32
fruit fly
(Drosophila melanogaster)
 Insecta sr 33 34
  • 12 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C27C12.2 34
  • 84 (a)
Y55F3AM.7 34
  • 64 (a)
egrh-3 33
  • 24 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MIG3 33
  • 14 (a)
 ManyToMany
MIG2 33
  • 14 (a)
 ManyToMany
Species where no ortholog for EGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR1 Gene

ENSEMBL:
Gene Tree for EGR1 (if available)
TreeFam:
Gene Tree for EGR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EGR1: view image

Paralogs for EGR1 Gene

Paralogs for EGR1 Gene

(2) SIMAP similar genes for EGR1 Gene using alignment to 2 proteins:

  • EGR1_HUMAN
  • Q546S1_HUMAN
genes like me logo Genes that share paralogs with EGR1: view

Variants for EGR1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for EGR1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000738349 -- 138,464,067(+) C/T upstream_transcript_variant
rs1001030752 -- 138,465,031(+) G/C upstream_transcript_variant
rs1001138967 -- 138,464,225(+) A/G upstream_transcript_variant
rs1001386200 -- 138,464,933(+) G/A upstream_transcript_variant
rs1002341171 -- 138,464,336(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EGR1 Gene

Variant ID Type Subtype PubMed ID
dgv10088n54 CNV loss 21841781
dgv5813n100 CNV loss 25217958
dgv5814n100 CNV loss 25217958
nsv1034030 CNV loss 25217958
nsv5024 CNV insertion 18451855
nsv5025 CNV deletion 18451855
nsv528851 CNV loss 19592680

Variation tolerance for EGR1 Gene

Residual Variation Intolerance Score: 9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR1 Gene

Human Gene Mutation Database (HGMD)
EGR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene

Disorders for EGR1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for EGR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search EGR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EGR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene

Publications for EGR1 Gene

  1. Mature human neutrophils constitutively express the transcription factor EGR-1. (PMID: 20363028) Cullen EM … O'Connor CM (Molecular immunology 2010) 3 4 23 56
  2. A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PMID: 1569051) Shimizu N … Utiyama H (Journal of biochemistry 1992) 3 4 23 56
  3. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. (PMID: 25258363) Hashimoto H … Cheng X (Genes & development 2014) 3 4 56
  4. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu CT … Wu WS (The FEBS journal 2010) 3 4 56
  5. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. (PMID: 20018936) Wang B … Khachigian LM (Arteriosclerosis, thrombosis, and vascular biology 2010) 3 23 56

ExternalLinks

View latest publications for EGR1 gene in Mastermind

Products for EGR1 Gene

  • Addgene plasmids for EGR1

Sources for EGR1 Gene