Aliases for EGR1 Gene
Aliases for EGR1 Gene
External Ids for EGR1 Gene
- HGNC: 3238
- Entrez Gene: 1958
- Ensembl: ENSG00000120738
- OMIM: 128990
- UniProtKB: P18146
Previous GeneCards Identifiers for EGR1 Gene
- GC05P137675
- GC05P138476
- GC05P137832
- GC05P137877
- GC05P137829
- GC05P137801
- GC05P132991
Summaries for EGR1 Gene
-
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for EGR1 Gene
EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Ischemia and Familial Tumoral Calcinosis. Among its related pathways are Signaling events mediated by PRL and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is EGR2.
UniProtKB/Swiss-Prot for EGR1 Gene
-
Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
Additional gene information for EGR1 Gene
- Monarch Initiative
- Search for EGR1 at DataMed
- Search for EGR1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR1 Gene
Genomics for EGR1 Gene
GeneHancer (GH) Regulatory Elements for EGR1 Gene
Promoters and enhancers for EGR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EGR1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EGR1 gene promoter:
-
- deltaCREB
- CREB
- GR-beta
- GR-alpha
- GR
- c-Ets-1
Regulatory Element Products
Genomic Locations for EGR1 Gene
Genomic Locations for EGR1 Gene
- chr5:138,465,490-138,469,315
- (GRCh38/hg38)
- Size:
- 3,826 bases
- Orientation:
- Plus strand
- chr5:137,801,179-137,805,004
- (GRCh37/hg19)
- Size:
- 3,826 bases
- Orientation:
- Plus strand
Genomic View for EGR1 Gene
Genes around EGR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.2 by Entrez Gene
- 5q31.2 by HGNC
- 5q31.2 by Ensembl
EGR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EGR1 Gene
Proteins for EGR1 Gene
-
Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18146-EGR1_HUMAN
- Recommended name:
- Early growth response protein 1
- Protein Accession:
- P18146
Protein attributes for EGR1 Gene
- Size:
- 543 amino acids
- Molecular mass:
- 57507 Da
- Quaternary structure:
-
- Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.
Post-translational modifications for EGR1 Gene
Other Protein References for EGR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EGR1 (EGR1)
-
Custom Antibody ServicesOriGene Antibodies for EGR1
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-
Santa Cruz Biotechnology (SCBT) Antibodies for EGR1
- Sino Biological Antibodies for EGR1
Protein Products
-
OriGene Purified Proteins for EGR1
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- Search GeneTex for Proteins for EGR1
-
ProSci Proteins for EGR1
Assay Products
No data available for DME Specific Peptides for EGR1 Gene
Domains & Families for EGR1 Gene
Gene Families for EGR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for EGR1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EGR1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P18146UniProtKB/Swiss-Prot:
EGR1_HUMAN :- Binds to DNA motifs with the sequence 5-GCG(T/G)GGGCG-3 via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
- Belongs to the EGR C2H2-type zinc-finger protein family.
- Domain:
-
- Binds to DNA motifs with the sequence 5-GCG(T/G)GGGCG-3 via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).
- Family:
-
- Belongs to the EGR C2H2-type zinc-finger protein family.
Function for EGR1 Gene
Molecular function for EGR1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By growth factors.
- GENATLAS Biochemistry:
- immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
Phenotypes From GWAS Catalog for EGR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18718911 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA,IEA | 14979875 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
Phenotypes for EGR1 Gene
- MGI mutant phenotypes for EGR1:
-
inferred from 5 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for EGR1:
Animal Models for EGR1 Gene
Animal Model Products
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Taconic Biosciences Mouse Models for EGR1
- Cyagen custom Knockout/knockin (KOKI) mouse models for EGR1
-
CRISPR Products
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OriGene CRISPR knockouts for EGR1
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- Overview of 112 available EGR1 gene related products
- Applied Biological Materials CRISPR for EGR1
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR1
- GenScript: Design CRISPR guide RNA sequences for EGR1
miRNA for EGR1 Gene
- miRTarBase miRNAs that target EGR1
Transcription Factor Targets for EGR1 Gene
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
- Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EGR1
- VectorBuilder custom plasmid, inducible vectors for EGR1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR1
- Applied Biological Materials Clones for EGR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EGR1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for EGR1 Gene
Localization for EGR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for EGR1 Gene
Pathways by source for EGR1 Gene
1 Sino Biological pathway for EGR1 Gene
20 BioSystems pathways for EGR1 Gene
4 Reactome pathways for EGR1 Gene
10 GeneGo (Thomson Reuters) pathways for EGR1 Gene
1 Qiagen pathway for EGR1 Gene
2 Cell Signaling Technology pathways for EGR1 Gene
Interacting Proteins for EGR1 Gene
Selected Interacting proteins:
P18146-EGR1_HUMAN
ENSP00000239938
for EGR1 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for EGR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001666 | response to hypoxia | IEA,ISS | -- |
| GO:0002931 | response to ischemia | IEA,ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for EGR1 Gene
mRNA/cDNA for EGR1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (292) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000239938 3138 bps (uc003ldb.2)
Unigene Clusters for EGR1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EGR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EGR1
- genomics-online: gRNA clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- Applied Biological Materials CRISPR for EGR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EGR1
- GenScript: Design CRISPR guide RNA sequences for EGR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EGR1
- Browse OriGene Inhibitory RNA Products For EGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1
- genomics-online: shRNA clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for EGR1
- VectorBuilder custom plasmid, inducible vectors for EGR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EGR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR1
- Applied Biological Materials Clones for EGR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for EGR1 Gene
mRNA differential expression in normal tissues according to GTEx for EGR1 Gene
This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of EGR1 Gene:
EGR1SOURCE GeneReport for Unigene cluster for EGR1 Gene:
Hs.326035mRNA Expression by UniProt/SwissProt for EGR1 Gene:
P18146-EGR1_HUMAN
Tissue specificity:
Detected in neutrophils (at protein level).
Evidence on tissue expression from TISSUES for EGR1 Gene
- Nervous system(4.8)
- Lung(4.2)
- Kidney(3.7)
- Muscle(3.7)
- Intestine(3.5)
- Adrenal gland(3.4)
- Heart(3.2)
- Blood(3)
- Liver(3)
- Stomach(2.9)
- Thyroid gland(2.9)
- Pancreas(2.8)
- Bone marrow(2.7)
- Gall bladder(2.3)
- Eye(2.2)
- Skin(2.2)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for EGR1
-
OriGene qPCR primer pairs for EGR1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR1 Gene
Orthologs for EGR1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EGR1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | EGR1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EGR1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Egr1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Egr1 33 |
|
||
| chicken (Gallus gallus) |
Aves | EGR1 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | egr1 33 |
|
||
| Str.19374 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.637 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | egr1 34 33 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9236 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sr 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C27C12.2 35 |
|
|
|
| Y55F3AM.7 35 |
|
|
|||
| egrh-3 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MIG3 34 |
|
ManyToMany | |
| MIG2 34 |
|
ManyToMany |
- Species where no ortholog for EGR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EGR1 Gene
- ENSEMBL:
- Gene Tree for EGR1 (if available)
- TreeFam:
- Gene Tree for EGR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EGR1: view image
Paralogs for EGR1 Gene
Variants for EGR1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000738349 | -- | 138,464,067(+) | C/T | upstream_transcript_variant | |
| rs1001030752 | -- | 138,465,031(+) | G/C | upstream_transcript_variant | |
| rs1001138967 | -- | 138,464,225(+) | A/G | upstream_transcript_variant | |
| rs1001386200 | -- | 138,464,933(+) | G/A | upstream_transcript_variant | |
| rs1002341171 | -- | 138,464,336(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv528851 | CNV | loss | 19592680 |
| nsv5025 | CNV | deletion | 18451855 |
| nsv5024 | CNV | insertion | 18451855 |
| nsv1034030 | CNV | loss | 25217958 |
| dgv5814n100 | CNV | loss | 25217958 |
| dgv5813n100 | CNV | loss | 25217958 |
| dgv10088n54 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EGR1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene
Disorders for EGR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ischemia |
|
|
| familial tumoral calcinosis |
|
|
| tumoral calcinosis, normophosphatemic, familial |
|
|
| wilms tumor 1 |
|
|
| corticosteroid-binding globulin deficiency |
|
|
Search EGR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EGR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene
Publications for EGR1 Gene
- Mature human neutrophils constitutively express the transcription factor EGR-1. (PMID: 20363028) Cullen EM … O'Connor CM (Molecular immunology 2010) 3 4 22 58
- A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PMID: 1569051) Shimizu N … Utiyama H (Journal of biochemistry 1992) 3 4 22 58
- Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. (PMID: 25258363) Hashimoto H … Cheng X (Genes & development 2014) 3 4 58
- No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu BC … He G (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 44 58
- Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu CT … Wu WS (The FEBS journal 2010) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EGR1
- antibodies-online: Search results for 133 available EGR1 Antibodies ranked by validation data
- Compare Top EGR1 Antibodies
- antibodies-online: Search results for 44 available EGR1 Elisa Kits ranked by validation data
- Compare Top EGR1 Elisa Kits
- antibodies-online: Search results for 19 available EGR1 Proteins ranked by validation data
- Compare Top EGR1 Proteins
- GeneTex EGR1 Antibody for EGR1
- Search GeneTex for Proteins for EGR1
- Santa Cruz Biotechnology (SCBT) Antibodies for EGR1
- Search Santa Cruz Biotechnology (SCBT) for EGR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EGR1
- Search for EGR1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for EGR1
- Horizon Cell Lines for EGR1
- genomics-online: cdna clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- orf clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- genomics-online: gRNA clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- genomics-online: primer clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- genomics-online: shRNA clones - Search results for 112 available EGR1 gene related products
- Overview of 112 available EGR1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EGR1
- GeneCopoeia miRNA 3'UTR Target clone products for EGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGR1
Sources for EGR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt