EGFR Gene (Protein Coding)

Epidermal Growth Factor Receptor

GC07P055019
GIFtS:
54
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in th... See more...

Aliases for EGFR Gene

Aliases for EGFR Gene

  • Epidermal Growth Factor Receptor 2 3 4 5
  • ERBB1 2 3 4
  • Receptor Tyrosine-Protein Kinase ErbB-1 3 4
  • Erb-B2 Receptor Tyrosine Kinase 1 2 3
  • Proto-Oncogene C-ErbB-1 3 4
  • EC 2.7.10.1 4 50
  • ERBB 3 4
  • ERRP 2 3
  • HER1 3 4
  • Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog) 2
  • Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian) 2
  • Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog 3
  • Epidermal Growth Factor Receptor Tyrosine Kinase Domain 3
  • Cell Proliferation-Inducing Protein 61 3
  • Cell Growth Inhibiting Protein 40 3
  • EC 2.7.10 50
  • NISBD2 3
  • PIG61 3
  • MENA 3
  • EGFR 5

External Ids for EGFR Gene

Previous HGNC Symbols for EGFR Gene

  • ERBB

Previous GeneCards Identifiers for EGFR Gene

  • GC07P054550
  • GC07P054794
  • GC07P054828
  • GC07P054860
  • GC07P055054

Summaries for EGFR Gene

Entrez Gene Summary for EGFR Gene

  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]

CIViC Summary for EGFR Gene

  • EGFR is widely recognized for its importance in cancer. Amplification and mutations have been shown to be driving events in many cancer types. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancers has spurred many research and drug development efforts. Tyrosine kinase inhibitors have shown efficacy in EGFR amplfied tumors, most notably gefitinib and erlotinib. Mutations in EGFR have been shown to confer resistance to these drugs, particularly the variant T790M, which has been functionally characterized as a resistance marker for both of these drugs. The later generation TKI's have seen some success in treating these resistant cases, and targeted sequencing of the EGFR locus has become a common practice in treatment of non-small cell lung cancer. Overproduction of ligands is another possible mechanism of activation of EGFR. ERBB ligands include EGF, TGF-a, AREG, EPG, BTC, HB-EGF, EPR and NRG1-4 (for detailed information please refer to the respective ligand section).

GeneCards Summary for EGFR Gene

EGFR (Epidermal Growth Factor Receptor) is a Protein Coding gene. Diseases associated with EGFR include Inflammatory Skin And Bowel Disease, Neonatal, 2 and Lung Cancer. Among its related pathways are Endocytic Trafficking of EGFR and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is ERBB4.

UniProtKB/Swiss-Prot Summary for EGFR Gene

  • Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).
  • Isoform 2 may act as an antagonist of EGF action.
  • (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

Tocris Summary for EGFR Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Gene Wiki entry for EGFR Gene

PharmGKB "VIP" Summary for EGFR Gene

Additional gene information for EGFR Gene

No data available for Rfam classification and piRNA Summary for EGFR Gene

Genomics for EGFR Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for EGFR Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J055017 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +3.8 3752 10.2 CEBPA ZIC2 YY1 CEBPB ZNF341 MAX SP2 RXRA SMC3 GABPB1 EGFR HSALNG0058160 HSALNG0058159 LOC105375284 AF288738 LANCL2
GH07J055060 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 19.9 +51.2 51239 19.4 BCLAF1 SP1 ZNF600 JUND ATF2 CEBPA ATF3 BRCA1 CHD4 YY1 EGFR EGFR-AS1 SEC61G HSALNG0058161 AF288738 LANCL2
GH07J055124 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.8 +111.1 111085 11.4 MYC IKZF1 JUND NFIC CEBPB DEK BHLHE40 FEZF1 ZNF639 ZNF341 EGFR EGFR-AS1 SEC61G HSALNG0058163 HSALNG0058161 LANCL2
GH07J055080 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.9 +65.5 65528 8.7 CEBPA ZIC2 YY1 CEBPB ZNF592 TRIM22 FOXA2 MAFF RXRA SAP130 EGFR EGFR-AS1 HSALNG0058161 HSALNG0058163 LANCL2
GH07J055043 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.3 +31.6 31627 14.8 CEBPA ATF3 ZSCAN16 YY1 CEBPB FOXA2 RXRA SMAD4 SAP130 CUX1 EGFR EGFR-AS1 AF288738 HSALNG0058161 LANCL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGFR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EGFR

Top Transcription factor binding sites by QIAGEN in the EGFR gene promoter:
  • c-Myc
  • Max1
  • p53
  • STAT3

Genomic Locations for EGFR Gene

Latest Assembly
chr7:55,019,017-55,211,628
(GRCh38/hg38)
Size:
192,612 bases
Orientation:
Plus strand

Previous Assembly
chr7:55,086,710-55,279,321
(GRCh37/hg19 by Entrez Gene)
Size:
192,612 bases
Orientation:
Plus strand

chr7:55,086,714-55,324,313
(GRCh37/hg19 by Ensembl)
Size:
237,600 bases
Orientation:
Plus strand

Genomic View for EGFR Gene

Genes around EGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGFR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EGFR Gene

Proteins for EGFR Gene

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  • Protein details for EGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00533-EGFR_HUMAN
    Recommended name:
    Epidermal growth factor receptor
    Protein Accession:
    P00533
    Secondary Accessions:
    • O00688
    • O00732
    • P06268
    • Q14225
    • Q68GS5
    • Q92795
    • Q9BZS2
    • Q9GZX1
    • Q9H2C9
    • Q9H3C9
    • Q9UMD7
    • Q9UMD8
    • Q9UMG5

    Protein attributes for EGFR Gene

    Size:
    1210 amino acids
    Molecular mass:
    134277 Da
    Quaternary structure:
    • Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2 (PubMed:10805725). Forms a complex with CCDC88A/GIV (via SH2-like regions) and GNAI3 which leads to enhanced EGFR signaling and triggering of cell migration; binding to CCDC88A requires autophosphorylation of the EGFR C-terminal region, and ligand stimulation is required for recruitment of GNAI3 to the complex (PubMed:20462955, PubMed:25187647). Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation (PubMed:18046415). Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B (PubMed:10805725). Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through ELOC- and ELOB-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA (PubMed:17115032). Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2 (PubMed:10026169). Interacts with ATX2. Interacts with GAREM1. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts (via C-terminal cytoplasmic kinase domain) with ZPR1 (via zinc fingers). Interacts with RNF115 and RNF126 (PubMed:23418353). Interacts with GPRC5A (via its transmembrane domain) (PubMed:25311788). Interacts with FAM83B; positively regulates EGFR inducing its autophosphorylation in absence of stimulation by EGF (PubMed:23912460). Interacts with LAPTM4B; positively correlates with EGFR activation (PubMed:28479384). Interacts with STX19 (PubMed:16420529). Interacts with CD44 (PubMed:23589287). Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization (PubMed:26988023). Interacts with PIKFYVE (PubMed:17909029). Interacts with NEU3.

    Three dimensional structures from OCA and Proteopedia for EGFR Gene

    Alternative splice isoforms for EGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGFR Gene

Protein Expression for EGFR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for EGFR Gene

P00533:
  • GGKVPIKW
  • KPYDGIP
  • GPGLEGCP
  • QCAAGCTGP
  • LGLRSLKE
  • RDLAARN
  • LDEAYVMA
  • RLLGICLTS
  • MVKCWMID
  • MARDPQR
  • VKIPVAIK
  • GERLPQP
  • VHRDLAARNVLVKTPQHVKITDFGLAK
  • SDVWSYGVT
  • YGVTVWE
  • LLNWCVQIAKGM
  • TLVWKYADA
  • LREATSPK
  • RYLVIQG
  • TCKDTCPP
  • YTHQSDVWS
  • GERLPQPPICTI
  • EHKDNIGSQ
  • SPSTSRTPLLSSLSATSNNS
  • IDGPHCVK
  • ELVEPLTPSG
  • AARNVLV

Post-translational modifications for EGFR Gene

  • Phosphorylated on Tyr residues in response to EGF (PubMed:20462955, PubMed:27153536). Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
  • Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting (PubMed:27153536). Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity).
  • Palmitoylated on Cys residues by ZDHHC20. Palmitoylation inhibits internalization after ligand binding, and increases the persistence of tyrosine-phosphorylated EGFR at the cell membrane. Palmitoylation increases the amplitude and duration of EGFR signaling.
  • Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
  • Glycosylation at Asn56, Asn73, Asn128, Asn175, Asn196, Asn352, Asn361, Asn413, Asn444, Asn468, Asn528, Asn568, Asn603, Asn623, and Asn816
  • Ubiquitination at Lys716, Lys737, Lys754, Lys860, Lys867, Lys929, and Lys970
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • EGFR_HUMAN (137)

Other Protein References for EGFR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for EGFR

Protein products for research

  • Abcam proteins for EGFR

Domains & Families for EGFR Gene

Gene Families for EGFR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for EGFR Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
  • Epidermal growth-factor receptor (EGFR), L domain
  • Furin-like cysteine rich region
  • Furin-like repeat

Suggested Antigen Peptide Sequences for EGFR Gene

GenScript: Design optimal peptide antigens:
  • EGFR protein (A2VCQ7_HUMAN)
  • Epidermal growth factor receptor (A7VMV4_HUMAN)
  • Epidermal growth factor receptor (A7VN05_HUMAN)
  • Epidermal growth factor receptor (A7VN06_HUMAN)
  • Epidermal growth factor receptor (A7VN07_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P00533

UniProtKB/Swiss-Prot:

EGFR_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with EGFR: view

Function for EGFR Gene

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  6. Cell Lines for research

Molecular function for EGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 2 may act as an antagonist of EGF action.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:18046415, ECO:0000269|PubMed:18227510, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:19563760};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling. Up-regulated by NEU3-mediated desialylation of N-linked glycan at Asn-528.
GENATLAS Biochemistry:
epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes

Enzyme Numbers (IUBMB) for EGFR Gene

Phenotypes From GWAS Catalog for EGFR Gene

Gene Ontology (GO) - Molecular Function for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0003682 chromatin binding IDA 20551055
GO:0003690 double-stranded DNA binding NAS 6325948
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with EGFR: view

Phenotypes for EGFR Gene

MGI mutant phenotypes for EGFR:
inferred from 16 alleles
GenomeRNAi human phenotypes for EGFR:
genes like me logo Genes that share phenotypes with EGFR: view

Human Phenotype Ontology for EGFR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EGFR Gene

MGI Knock Outs for EGFR:
  • Egfr Egfr<tm1.1Dwt>
  • Egfr Egfr<tm1Mag>
  • Egfr Egfr<tm2(EGFR)Wag>
  • Egfr Egfr<tm1Rdk>
  • Egfr Egfr<tm1Wag>
  • Egfr Egfr<tm1a(EUCOMM)Wtsi>
  • Egfr Egfr<tm1Arge>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGFR

Clone products for research

  • Addgene plasmids for EGFR

No data available for Transcription Factor Targets and HOMER Transcription for EGFR Gene

Localization for EGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGFR Gene

Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Golgi apparatus membrane. Single-pass type I membrane protein. Nucleus membrane. Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). {ECO:0000269 PubMed:17182860, ECO:0000269 PubMed:17909029, ECO:0000269 PubMed:20674546, ECO:0000269 PubMed:27153536, ECO:0000269 PubMed:2790960}.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGFR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endosome 5
cytosol 4
golgi apparatus 4
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
lysosome 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space NAS 9103388
GO:0005634 nucleus IEA,IDA 12828935
GO:0005737 cytoplasm IDA 7588596
genes like me logo Genes that share ontologies with EGFR: view

Pathways & Interactions for EGFR Gene

PathCards logo

SuperPathways for EGFR Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 Signaling by ERBB2
Downregulation of ERBB2 signaling
.59
Signaling by ERBB2
.59
SHC1 events in ERBB2 signaling
.43
ERBB2 Activates PTK6 Signaling
.01
ERBB2 Regulates Cell Motility
.01
GRB2 events in ERBB2 signaling
.01
PI3K events in ERBB2 signaling
.01
genes like me logo Genes that share pathways with EGFR: view

Pathways by source for EGFR Gene

1 Sino Biological pathway for EGFR Gene
24 GeneGo (Thomson Reuters) pathways for EGFR Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell adhesion PLAU signaling
  • Cell adhesion_ECM remodeling
  • Development ACM2 and ACM4 activation of ERK
  • Development Alpha-2 adrenergic receptor activation of ERK
78 Qiagen pathways for EGFR Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
1 Cell Signaling Technology pathway for EGFR Gene
1 GeneTex pathway for EGFR Gene

SIGNOR curated interactions for EGFR Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0001503 ossification NAS 12925580
GO:0001889 liver development IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20551055
genes like me logo Genes that share ontologies with EGFR: view

Drugs & Compounds for EGFR Gene

Products:

  1. Drug products for research

(303) Drugs for EGFR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek