This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affini... See more...

Aliases for EGF Gene

Aliases for EGF Gene

  • Epidermal Growth Factor 2 3 5
  • Pro-Epidermal Growth Factor 2 3 4
  • Epidermal Growth Factor (Beta-Urogastrone) 2
  • Beta-Urogastrone 3
  • HOMG4 3
  • URG 3

External Ids for EGF Gene

Previous GeneCards Identifiers for EGF Gene

  • GC04P111240
  • GC04P111104
  • GC04P111292
  • GC04P111191
  • GC04P110834
  • GC04P106566

Summaries for EGF Gene

Entrez Gene Summary for EGF Gene

  • This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

CIViC Summary for EGF Gene

GeneCards Summary for EGF Gene

EGF (Epidermal Growth Factor) is a Protein Coding gene. Diseases associated with EGF include Hypomagnesemia 4, Renal and Familial Primary Hypomagnesemia With Normocalciuria And Normocalcemia. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and epidermal growth factor receptor binding. An important paralog of this gene is LRP2.

UniProtKB/Swiss-Prot Summary for EGF Gene

  • EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

Tocris Summary for EGF Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Gene Wiki entry for EGF Gene

Additional gene information for EGF Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EGF Gene

Genomics for EGF Gene

GeneHancer (GH) Regulatory Elements for EGF Gene

Promoters and enhancers for EGF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J109912 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 508.7 +1.7 1656 4.6 GTF2E2 REST TRIM28 CTBP1 LEF1 ZNF316 POLR2H PBX2 NFE2 FOSL1 EGF LRIT3 HSALNG0036348
GH04J109980 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 516 +66.7 66704 3.2 CTCF RAD21 TEAD1 SMC3 MAFK ZNF335 ZNF654 CEBPB ARID3A HLF EGF HSALNG0036348 ENSG00000250511 LRIT3 GAR1
GH04J109974 Enhancer 0.9 Ensembl ENCODE 19.4 +60.2 60218 1.4 FOXK2 NCOR1 FOXA1 TBX3 FOXA2 SAP130 ZNF205 FOXP1 YBX1 HOMEZ EGF ENSG00000250511 HSALNG0036348
GH04J109969 Promoter/Enhancer 0.9 Ensembl ENCODE 17.1 +57.2 57218 0.9 CEBPB NR2F2 FOS VEZF1 GATA2 CEBPG POLR2A RBPJ FOXA2 SP5 EGF ENSG00000250511 HSALNG0036348
GH04J109944 Enhancer 0.7 Ensembl 18.2 +32.2 32218 1 NRF1 CREB1 CEBPB FOSL1 FOS FOSL2 EHMT2 IRF1 JUND NR2F1 EGF LRIT3 HSALNG0036348
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EGF on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EGF

Top Transcription factor binding sites by QIAGEN in the EGF gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • STAT1
  • STAT5A
  • STAT5B

Genomic Locations for EGF Gene

Genomic Locations for EGF Gene
chr4:109,912,883-110,013,766
(GRCh38/hg38)
Size:
100,884 bases
Orientation:
Plus strand
chr4:110,834,040-110,934,118
(GRCh37/hg19)
Size:
100,079 bases
Orientation:
Plus strand

Genomic View for EGF Gene

Genes around EGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGF Gene

Proteins for EGF Gene

  • Protein details for EGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01133-EGF_HUMAN
    Recommended name:
    Pro-epidermal growth factor
    Protein Accession:
    P01133
    Secondary Accessions:
    • B4DRK7
    • E7EVD2
    • E9PBF0
    • Q52LZ6

    Protein attributes for EGF Gene

    Size:
    1207 amino acids
    Molecular mass:
    133994 Da
    Quaternary structure:
    • Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
    SequenceCaution:
    • Sequence=AAR84237.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EGF Gene

    Alternative splice isoforms for EGF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGF Gene

Post-translational modifications for EGF Gene

  • O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).
  • Glycosylation at Asn38, Asn104, Asn117, Asn148, Asn324, Asn404, Asn596, Asn815, and Asn926
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • EGF_HUMAN (709)

Antibody Products

  • Abcam antibodies for EGF

Assay Products

  • Signalway ELISA kits for EGF
  • Abcam assays for EGF

No data available for DME Specific Peptides for EGF Gene

Domains & Families for EGF Gene

Gene Families for EGF Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for EGF Gene

Blocks:
  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
  • Type I EGF signature
  • Low-density lipoprotein receptor, YWTD repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EGF Gene

GenScript: Design optimal peptide antigens:
  • Pro-epidermal growth factor (EGF_HUMAN)
  • Epidermal growth factor (Q6QBS2_HUMAN)
genes like me logo Genes that share domains with EGF: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EGF Gene

Function for EGF Gene

Molecular function for EGF Gene

UniProtKB/Swiss-Prot Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
GENATLAS Biochemistry:
epidermal growth factor,6kDa,synthesized as a large preprotein,EGF membrane glycoprotein also containing nine EGF repeats and urogastrone

LifeMap Function Summary for EGF Gene

EGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for EGF Gene

Gene Ontology (GO) - Molecular Function for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity IDA 20353436
GO:0005154 epidermal growth factor receptor binding TAS 9712850
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 2790960
GO:0008083 growth factor activity IDA 7736574
genes like me logo Genes that share ontologies with EGF: view
genes like me logo Genes that share phenotypes with EGF: view

Human Phenotype Ontology for EGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EGF Gene

MGI Knock Outs for EGF:
  • Egf Egf<tm1Dle>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGF

Clone Products

  • Addgene plasmids for EGF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EGF Gene

Localization for EGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGF Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGF gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EGF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EGF Gene

Pathways & Interactions for EGF Gene

PathCards logo

SuperPathways for EGF Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.66
.65
.64
.62
.61
.60
.57
.57
3 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
4 GAB1 signalosome
5 Signaling by ERBB2
genes like me logo Genes that share pathways with EGF: view

Pathways by source for EGF Gene

14 GeneGo (Thomson Reuters) pathways for EGF Gene
  • Cell adhesion PLAU signaling
  • Development EGFR signaling pathway
  • Development EGFR signaling via PIP3
  • Development EGFR signaling via small GTPases
  • Development ERBB-family signaling
67 Qiagen pathways for EGF Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKC through GPCR
  • Akt Signaling
1 Cell Signaling Technology pathway for EGF Gene

SIGNOR curated interactions for EGF Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0001525 angiogenesis IDA 15611079
GO:0002092 positive regulation of receptor internalization IDA 22732145
genes like me logo Genes that share ontologies with EGF: view

Drugs & Compounds for EGF Gene

(83) Drugs for EGF Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucralfate Approved Pharma Target, inducer 14
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 852
Calcium Approved Nutra 7884
Cholecystokinin Approved, Investigational Pharma Target 24
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3570

(65) Additional Compounds for EGF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-alpha-Aminobutyric acid
  • (-)-2-Aminobutyric acid
  • (2S)-2-Aminobutyric acid
  • (S)-2-Aminobutanoate
  • (S)-2-Aminobutanoic acid
  • (S)-2-Aminobutyric acid
1492-24-6
AG 490
133550-30-8
CP 724714
383432-38-0

(4) Tocris Compounds for EGF Gene

Compound Action Cas Number
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor 133550-30-8
CGP 52411 EGFR inhibitor. Also inhibits Abeta42 fibril formation 145915-58-8
CP 724714 Potent and selective ErbB2 inhibitor 383432-38-0
Genistein EGFR kinase inhibitor. Also estrogen and PPARgamma ligand 446-72-0
genes like me logo Genes that share compounds with EGF: view

Transcripts for EGF Gene

mRNA/cDNA for EGF Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EGF

Clone Products

  • Addgene plasmids for EGF

Alternative Splicing Database (ASD) splice patterns (SP) for EGF Gene

No ASD Table

Relevant External Links for EGF Gene

GeneLoc Exon Structure for
EGF

Expression for EGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGF Gene

This gene is overexpressed in Muscle - Skeletal (x18.0), Pancreas (x15.0), and Kidney - Cortex (x5.9).

Protein differential expression in normal tissues from HIPED for EGF Gene

This gene is overexpressed in Urine (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EGF Gene



Protein tissue co-expression partners for EGF Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EGF

SOURCE GeneReport for Unigene cluster for EGF Gene:

Hs.419815

mRNA Expression by UniProt/SwissProt for EGF Gene:

P01133-EGF_HUMAN
Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate.

Evidence on tissue expression from TISSUES for EGF Gene

  • Kidney(4.7)
  • Intestine(4.5)
  • Nervous system(3.2)
  • Blood(3)
  • Muscle(3)
  • Pancreas(2.9)
  • Heart(2.7)
  • Liver(2.7)
  • Lung(2.7)
  • Skin(2.7)
  • Eye(2.6)
  • Adrenal gland(2.4)
  • Stomach(2.3)
  • Thyroid gland(2.2)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EGF Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • head
  • meninges
  • neck
  • parathyroid
  • skull
  • thyroid
Thorax:
  • heart
Abdomen:
  • kidney
  • pancreas
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with EGF: view

Orthologs for EGF Gene

This gene was present in the common ancestor of animals.

Orthologs for EGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGF 31 30
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EGF 31 30
  • 85.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EGF 30
  • 80.85 (n)
mouse
(Mus musculus)
Mammalia Egf 17 31 30
  • 76.73 (n)
rat
(Rattus norvegicus)
Mammalia Egf 30
  • 76.67 (n)
oppossum
(Monodelphis domestica)
Mammalia EGF 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EGF 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves EGF 31 30
  • 65.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EGF 31
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egf 30
  • 58.85 (n)
zebrafish
(Danio rerio)
Actinopterygii egf 31 30
  • 53.87 (n)
OneToOne
Dr.27130 30
fruit fly
(Drosophila melanogaster)
Insecta yl 31
  • 11 (a)
ManyToMany
LRP1 31
  • 6 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egg-2 31
  • 18 (a)
ManyToMany
rme-2 31
  • 17 (a)
ManyToMany
egg-1 31
  • 16 (a)
ManyToMany
ZC101.1 31
  • 12 (a)
ManyToMany
lrp-2 31
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
ManyToMany
Species where no ortholog for EGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGF Gene

ENSEMBL:
Gene Tree for EGF (if available)
TreeFam:
Gene Tree for EGF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EGF: view image

Paralogs for EGF Gene

(8) SIMAP similar genes for EGF Gene using alignment to 3 proteins:

  • EGF_HUMAN
  • L8EC91_HUMAN
  • Q6QBS2_HUMAN
genes like me logo Genes that share paralogs with EGF: view

Variants for EGF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EGF Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
708788 Benign: not provided 109,959,303(+) C/A INTRON_VARIANT
709736 Benign: not provided 109,945,210(+) T/A MISSENSE_VARIANT
709774 Likely Benign: not provided 109,941,010(+) C/A SYNONYMOUS_VARIANT
711911 Benign: not provided 109,980,902(+) G/A SYNONYMOUS_VARIANT
713095 Benign: not provided 109,976,096(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for EGF Gene

Structural Variations from Database of Genomic Variants (DGV) for EGF Gene

Variant ID Type Subtype PubMed ID
esv22936 CNV loss 19812545
esv2618042 CNV insertion 19546169
esv2672203 CNV deletion 23128226
esv3601750 CNV loss 21293372
esv3601752 CNV loss 21293372
nsv290769 CNV deletion 16902084
nsv595143 CNV loss 21841781
nsv820232 CNV loss 19587683

Variation tolerance for EGF Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGF Gene

Human Gene Mutation Database (HGMD)
EGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGF Gene

Disorders for EGF Gene

MalaCards: The human disease database

(160) MalaCards diseases for EGF Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypomagnesemia 4, renal
  • homg4
familial primary hypomagnesemia with normocalciuria and normocalcemia
breast cyst
  • cyst of the breast
adamantinoma of long bones
  • long bone adamantinoma
short bowel syndrome
  • acquired short bowel syndrome
- elite association - COSMIC cancer census association via MalaCards
Search EGF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EGF_HUMAN
  • Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269 PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for EGF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EGF: view

No data available for Genatlas for EGF Gene

Publications for EGF Gene

  1. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. (PMID: 18571008) Vishnoi M … Mittal B (Human immunology 2008) 3 23 41 54
  2. Polymorphisms in angiogenesis-related genes and prostate cancer. (PMID: 18398039) Jacobs EJ … Rodriguez C (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41 54
  3. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. (PMID: 18483390) Lanuti M … Christiani DC (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 41 54
  4. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. (PMID: 18167406) Tanabe KK … Fuchs BC (JAMA 2008) 3 23 41 54
  5. EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women. (PMID: 17940864) Wang Y … Shen H (Breast cancer research and treatment 2008) 3 23 41 54

Products for EGF Gene