Aliases for EFNB2 Gene
External Ids for EFNB2 Gene
Previous HGNC Symbols for EFNB2 Gene
Previous GeneCards Identifiers for EFNB2 Gene
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNB2 Gene
EFNB2 (Ephrin B2) is a Protein Coding gene. Diseases associated with EFNB2 include Nodular Regenerative Hyperplasia and Arteriovenous Malformation. Among its related pathways are EPH-Ephrin signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and ephrin receptor binding. An important paralog of this gene is EFNB1.
UniProtKB/Swiss-Prot Summary for EFNB2 Gene
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.