Aliases for EFNB1 Gene
External Ids for EFNB1 Gene
Previous HGNC Symbols for EFNB1 Gene
Previous GeneCards Identifiers for EFNB1 Gene
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNB1 Gene
EFNB1 (Ephrin B1) is a Protein Coding gene. Diseases associated with EFNB1 include Craniofrontonasal Syndrome and Hemifacial Hyperplasia. Among its related pathways are EphB-EphrinB Signaling and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNB2.
UniProtKB/Swiss-Prot Summary for EFNB1 Gene
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).